Accent (BioDeep_00000000720)
Secondary id: BioDeep_00001028325, BioDeep_00001033734
PANOMIX_OTCML-2023
代谢物信息卡片
N-(Oleoyl, cocoyl)glutamic acid monosodium salt
化学式: C5H8NNaO4 (169.03510079999998)
中文名称: L-谷氨酸单钠盐, 谷氨酸单钠盐, 谷氨酸钠
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 1.37%
分子结构信息
SMILES: C(CC(=O)O)C(C(=O)[O-])N.[Na+]
InChI: /q
描述信息
One of the FLAVORING AGENTS used to impart a meat-like flavor.
See also: Monosodium Glutamate (preferred); Glutamic Acid (has active moiety) ... View More ...
D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases[1][2][3][4][5].
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
同义名列表
24 个代谢物同义名
N-(Oleoyl, cocoyl)glutamic acid monosodium salt; sodium (4S)-4-amino-4-carboxybutanoate; L-GlutamicAcidMonoSodiumSalt99+\\%; L-Glutamic acid (monosodium salt); L-Glutamic acid, monosodium salt; L-Glutamic acid monosodium salt; L-Glutamic Acid Monosodium; Glutamate monosodium salt; Sodium hydrogen glutamate; Monosodium glutamate|MSG; Sodium cocoyl glutamate; L-(+)Sodium glutamate; Monosodium Glutamate; Chinese seasoning; Glutamate, Sodium; Sodium glutamate; Glutamate Sodium; UNII-BMT4RCZ3HG; na-l-glutamate; BMT4RCZ3HG; Accent; Vestin; RL-50; MSG
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:64220
- ChEBI: CHEBI:64243
- KEGG: C72668
- PubChem: 23672308
- PubChem: 70788954
- PubChem: 23676143
- ChEMBL: CHEMBL2107256
- MeSH: Sodium Glutamate
- ChemIDplus: ChemIDplus_tree
- CAS: 68187-33-7
- CAS: 68187-34-8
- CAS: 16177-21-2
- CAS: 6106-04-3
- CAS: 142-47-2
- medchemexpress: HY-14608A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiawu Wu, Yingjiao Tang, Ming Zhang, Wenxue Chen, Haiming Chen, Qiuping Zhong, Jianfei Pei, Rongrong He, Weijun Chen. Mechanism for improving the in vitro digestive properties of coconut milk by modifying the structure and properties of coconut proteins with monosodium glutamate.
Food research international (Ottawa, Ont.).
2024 Jun; 185(?):114288. doi:
10.1016/j.foodres.2024.114288. [PMID: 38658074] - Debasmita Das, Arnab Banerjee, Krishnendu Manna, Deotima Sarkar, Aparna Shil, Mausumi Sikdar Ne E Bhakta, Sandip Mukherjee, Bithin Kumar Maji. Quercetin counteracts monosodium glutamate to mitigate immunosuppression in the thymus and spleen via redox-guided cellular signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Apr; 126(?):155226. doi:
10.1016/j.phymed.2023.155226. [PMID: 38387276] - Wenhao Yuan, Zeyu Zhao, Shunsuke Kimura, Kiyoshi Toko. Development of Taste Sensor with Lipid/Polymer Membranes for Detection of Umami Substances Using Surface Modification.
Biosensors.
2024 Feb; 14(2):. doi:
10.3390/bios14020095. [PMID: 38392014] - Jiawu Wu, Yingjiao Tang, Wenxue Chen, Haiming Chen, Qiuping Zhong, Jianfei Pei, Tao Han, Weijun Chen, Ming Zhang. Mechanism for improving coconut milk emulsions viscosity by modifying coconut protein structure and coconut milk properties with monosodium glutamate.
International journal of biological macromolecules.
2023 Dec; 252(?):126139. doi:
10.1016/j.ijbiomac.2023.126139. [PMID: 37543272] - Medine Sibel Karagac, Hamid Ceylan. Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex.
Neurotoxicity research.
2023 Sep; ?(?):. doi:
10.1007/s12640-023-00667-y. [PMID: 37713032] - Maha Saud Alrashidi, Heba Fawzy Gomaa. Testicular Effect of Selenium Nanoparticles on Monosodium Glutamate Induced Alteration in Male Albino Rats.
Pakistan journal of biological sciences : PJBS.
2023 Jan; 26(7):347-359. doi:
10.3923/pjbs.2023.347.359. [PMID: 37902076] - Iswar Hazarika, Geetha Kannoth Mukundan, P Sivakami Sundari. Neuroprotective effect of Hydrocotyle sibthorpioides against monosodium glutamate-induced excitotoxicity.
Natural product research.
2022 Dec; 36(23):6156-6159. doi:
10.1080/14786419.2022.2057493. [PMID: 35356842] - Joanna Depciuch, Paweł Jakubczyk, Wiesław Paja, Jaromir Sarzyński, Krzysztof Pancerz, Merve Açıkel Elmas, Elif Keskinöz, Özlem Bingöl Özakpınar, Serap Arbak, Gökçe Özgün, Sevde Altuntaş, Zozan Guleken. Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Oct; 279(?):121495. doi:
10.1016/j.saa.2022.121495. [PMID: 35700610] - Artitaya Buatong, Ratchanu Meidong, Yanee Trongpanich, Saowanit Tongpim. Production of plant-based fermented beverages possessing functional ingredients antioxidant, γ-aminobutyric acid and antimicrobials using a probiotic Lactiplantibacillus plantarum strain L42g as an efficient starter culture.
Journal of bioscience and bioengineering.
2022 Sep; 134(3):226-232. doi:
10.1016/j.jbiosc.2022.05.008. [PMID: 35764446] - David O Oyeniran, Abdulfatai O Ojewale, Adebanji M Akingbade, Babatunde J Dare, Mario A Adelaja, Latifat O Oseni. The ameliorative potentials of aqueous leaf extract of Amaranthus hybridus on monosodium glutamate-induced testicular damage in Wistar rats.
JBRA assisted reproduction.
2022 08; 26(3):469-474. doi:
10.5935/1518-0557.20210091. [PMID: 34850617] - Reza Rezaei, Ana San Gabriel, Guoyao Wu. Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets.
Amino acids.
2022 Jul; 54(7):1055-1068. doi:
10.1007/s00726-022-03147-3. [PMID: 35292855] - Domwesley Wendreo de Souza, Vanessa Marieli Ceglarek, Bruna Schumaker Siqueira, Caroline Zanella Volinski, Juliane Zanon Nenevê, João Paulo de Amorin Arruda, Jean Franciesco Vettorazzi, Sabrina Grassiolli. Phenylhydrazine-induced anaemia reduces subcutaneous white and brown adipose tissues in hypothalamic obese rats.
Experimental physiology.
2022 06; 107(6):575-588. doi:
10.1113/ep089883. [PMID: 35396880] - Elezabeth John, Bharat Mishra, Alok Shiomurti Tripathi, R Aleesha. Protective effect of Celastrus paniculatus on cognitive function in glutamate-induced brain-injured mice by reducing the intracellular influx of Ca.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2022 Jun; 82(4):331-338. doi:
10.1002/jdn.10182. [PMID: 35338672] - Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji. Coccinia grandis alleviates flavor-enhancing high-lipid diet induced hepatocellular inflammation and apoptosis.
Journal of food biochemistry.
2022 05; 46(5):e14092. doi:
10.1111/jfbc.14092. [PMID: 35092065] - Rami B Kassab, Abdulrahman Theyab, Ali O Al-Ghamdy, Mohammad Algahtani, Ahmad H Mufti, Khalaf F Alsharif, Ehab M Abdella, Ola A Habotta, Mohamed M Omran, Maha S Lokman, Amira A Bauomy, Ashraf Albrakati, Roua S Baty, Khalid E Hassan, Maha A Alshiekheid, Ahmed E Abdel Moneim, Heba A Elmasry. Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats.
Environmental science and pollution research international.
2022 Feb; 29(8):12208-12221. doi:
10.1007/s11356-021-16578-4. [PMID: 34562213] - Huichia Chao, Masanori Komura. Comments on 'Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa)and their potential effects on monosodium glutamate-induced testicular damage in rat'.
Environmental science and pollution research international.
2021 12; 28(47):67901-67903. doi:
10.1007/s11356-021-16609-0. [PMID: 34585350] - Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji. Monosodium glutamate causes hepato-cardiac derangement in male rats.
Human & experimental toxicology.
2021 Dec; 40(12_suppl):S359-S369. doi:
10.1177/09603271211049550. [PMID: 34560825] - Fatma Abdel-Monem Gad, Sameh Mohamed Farouk, Mahmoud Abdelghaffar Emam. Reply to 'Comments on Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa) and their potential effects on monosodium glutamate-induced testicular damage in rat'.
Environmental science and pollution research international.
2021 12; 28(47):67898-67899. doi:
10.1007/s11356-021-16320-0. [PMID: 34482467] - Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji. Efficacy of Coccinia grandis against monosodium glutamate induced hepato-cardiac anomalies by inhibiting NF-kB and caspase 3 mediated signalling in rat model.
Human & experimental toxicology.
2021 Nov; 40(11):1825-1851. doi:
10.1177/09603271211010895. [PMID: 33887972] - Adeola Oluwakemi Olowofolahan, Olufunso Olabode Olorunsogo. Fractions of Ageratum conyzoides L. (Compositae) induce mitochondrial-mediated apoptosis in rats: Possible option in monosodium glutamate-induced hepatic and uterine pathological disorder.
Journal of ethnopharmacology.
2021 Sep; 277(?):114192. doi:
10.1016/j.jep.2021.114192. [PMID: 33974943] - Karline da Costa Rodrigues, Cristiani Folharini Bortolatto, Renata Leivas de Oliveira, Jaini Janke Paltian, Allya Larroza, Mauro Pereira Soares, Diego Alves, Ethel Antunes Wilhelm, Cristiane Luchese. 4-Phenylselanyl-7-chloroquinoline attenuates hepatic injury triggered by neonatal exposure to monosodium glutamate in rats.
Life sciences.
2021 Sep; 280(?):119751. doi:
10.1016/j.lfs.2021.119751. [PMID: 34174321] - Heba N Gad El-Hak, Heba M A Abdelrazek, Dalia W Zeidan, Amani A Almallah, Howayda E Khaled. Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration.
Environmental science and pollution research international.
2021 Aug; 28(32):44432-44441. doi:
10.1007/s11356-021-13557-7. [PMID: 33847887] - Mahmoud Abd-Elkareem, Mokhless A M Abd El-Rahman, Nasser S Abou Khalil, Ayman S Amer. Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats.
Scientific reports.
2021 06; 11(1):13519. doi:
10.1038/s41598-021-92977-4. [PMID: 34188150] - Aya M Helal, Mohamed S Abdel-Latif, Mosleh Mohammed Abomughaid, Doaa A Ghareeb, Mohamed M El-Sayed. Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats.
Environmental science and pollution research international.
2021 Jun; 28(23):29629-29642. doi:
10.1007/s11356-021-12387-x. [PMID: 33559824] - Kanokwan Nahok, Jutarop Phetcharaburanin, Jia V Li, Atit Silsirivanit, Raynoo Thanan, Piyanard Boonnate, Jarus Joonhuathon, Amod Sharma, Sirirat Anutrakulchai, Carlo Selmi, Ubon Cha'on. Monosodium Glutamate Induces Changes in Hepatic and Renal Metabolic Profiles and Gut Microbiome of Wistar Rats.
Nutrients.
2021 May; 13(6):. doi:
10.3390/nu13061865. [PMID: 34070818] - Farhad Koohpeyma, Morvarid Siri, Shaghayegh Allahyari, Marzieh Mahmoodi, Forough Saki, Sanaz Dastghaib. The effects of L-carnitine on renal function and gene expression of caspase-9 and Bcl-2 in monosodium glutamate-induced rats.
BMC nephrology.
2021 05; 22(1):162. doi:
10.1186/s12882-021-02364-4. [PMID: 33933022] - Ali Acar. Ameliorative effects of cape gooseberry (Physalis peruviana L.) against monosodium glutamate (MSG)-induced toxicity: genetic and biochemical approach.
Environmental science and pollution research international.
2021 Apr; 28(14):18035-18049. doi:
10.1007/s11356-020-11800-1. [PMID: 33405109] - Adeola Oluwakemi Olowofolahan, Funmilayo O Adewoye, Olufunso Olabode Olorunsogo. Modulatory effect of methanol extract of Annona muricata stem bark on mitochondrial membrane permeability transition pore in normal rat liver and monosodium glutamate-induced uterine hyperplasia.
Journal of complementary & integrative medicine.
2021 Mar; 18(2):355-361. doi:
10.1515/jcim-2019-0341. [PMID: 33787189] - Douglas Pedro, Erick Saldaña, José Manuel Lorenzo, Mirian Pateiro, Ruben Dominguez, Bibiana Alves Dos Santos, Alexandre José Cichoski, Paulo Cezar Bastianello Campagnol. Low-sodium dry-cured rabbit leg: A novel meat product with healthier properties.
Meat science.
2021 Mar; 173(?):108372. doi:
10.1016/j.meatsci.2020.108372. [PMID: 33229105] - Adeola Oluwakemi Olowofolahan, Olufunso Olabode Olorunsogo. Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model.
Journal of ethnopharmacology.
2021 Mar; 267(?):113498. doi:
10.1016/j.jep.2020.113498. [PMID: 33091496] - Bárbara Zanardini de Andrade, Matheus Felipe Zazula, Ana Tereza Bittencourt Guimarães, Sara Cristina Sagae Schneider, Mariana Laís Boaretto, Ana Claudia Felicio Poncio, Jhyslayne Ignacia Hoff Nunes Maciel, Camila Maria Toigo de Oliveira, Rose Meire Costa, Gladson Ricardo Flor Bertolini, Lucinéia de Fátima Chasko Ribeiro. Whole-body vibration promotes lipid mobilization in hypothalamic obesity rat.
Tissue & cell.
2021 Feb; 68(?):101456. doi:
10.1016/j.tice.2020.101456. [PMID: 33202347] - Melek Tunc-Ata, Fatih Altintas, Hande Senol, Erol Nizamoglu, Vural Kucukatay. Ileal interposition improves metabolic syndrome parameters in a rat model of metabolic syndrome induced by monosodium glutamate.
Life sciences.
2021 Feb; 266(?):118846. doi:
10.1016/j.lfs.2020.118846. [PMID: 33309719] - Michele Celestino, Valeria Balmaceda Valdez, Paola Brun, Ignazio Castagliuolo, Carla Mucignat-Caretta. Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice.
Scientific reports.
2021 01; 11(1):481. doi:
10.1038/s41598-020-80048-z. [PMID: 33436880] - Marwa Khaled Abd-Elhaleim El Azazy, Enas Ali Kamel Mohamed, Huda M Ismail Abo El-Fadl, Fatma Hassan Abd El-Razik, Karema Abu Elfotuh. Omega-3 Rich Oils Attenuate ADHD-Like Behaviour Induced by Dietary Monosodium Glutamate in Rats.
Pakistan journal of biological sciences : PJBS.
2021 Jan; 24(8):868-880. doi:
10.3923/pjbs.2021.868.880. [PMID: 34486354] - Reham Mohammed Atef, Islam Omar Abdel Fattah, Omayma Mahfouz Mahmoud, Gamal Mohamed Abdel-Rahman, Noha Ahmed Salem. Protective effects of Rosemary extract and/or Fluoxetine on Monosodium Glutamate-induced hippocampal neurotoxicity in rat.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.
2021 Jan; 62(1):169-177. doi:
10.47162/rjme.62.1.16. [PMID: 34609419] - Sara Harsini, Heather Saprunoff, Tina Alden, Behnoud Mohammadi, Don Wilson, François Bénard. The Effects of Monosodium Glutamate on PSMA Radiotracer Uptake in Men with Recurrent Prostate Cancer: A Prospective, Randomized, Double-Blind, Placebo-Controlled Intraindividual Imaging Study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2021 01; 62(1):81-87. doi:
10.2967/jnumed.120.246983. [PMID: 32385167] - Fatma Abdel-Monem Gad, Sameh Mohamed Farouk, Mahmoud Abdelghaffar Emam. Antiapoptotic and antioxidant capacity of phytochemicals from Roselle (Hibiscus sabdariffa) and their potential effects on monosodium glutamate-induced testicular damage in rat.
Environmental science and pollution research international.
2021 Jan; 28(2):2379-2390. doi:
10.1007/s11356-020-10674-7. [PMID: 32888148] - I A Gusev, E Yu Samarina, Z A Plotonenko, G D Kostyrko, M V Маlykh, A V Ilinykh, E N Sazonova. [Influence of monosodium glutamate consumption by albino rats during pregnancy and lactation on their offspring].
Voprosy pitaniia.
2021 ; 90(3):58-66. doi:
10.33029/0042-8833-2021-90-3-58-66. [PMID: 34264557] - Adeola Oluwakemi Olowofolahan, Oluwatobi Andrew Adeosun, Olufunso Olabode Olorunsogo. Monosodium Glutamate Induces Cytotoxicity in Rat Liver via Mitochondrial Permeability Transition Pore Opening.
Cell biochemistry and biophysics.
2020 Dec; 78(4):429-437. doi:
10.1007/s12013-020-00944-z. [PMID: 32964329] - Reham Z Hamza, Fawziah A Al-Salmi, Nahla S El-Shenawy. Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity.
Journal of basic and clinical physiology and pharmacology.
2020 Nov; 32(5):979-985. doi:
10.1515/jbcpp-2020-0164. [PMID: 33180034] - Chaolong Liu, Yanting Yuan, Ji Zhou, Ruixin Hu, Lixia Ji, Guohui Jiang. Piperine ameliorates insulin resistance via inhibiting metabolic inflammation in monosodium glutamate-treated obese mice.
BMC endocrine disorders.
2020 Oct; 20(1):152. doi:
10.1186/s12902-020-00617-1. [PMID: 33028294] - Yannick Bekono Fouda, Esther Ngo Lemba Tom, Albert Donatien Atsamo, Christian Bonabe, Théophile Dimo. Effects of stem bark aqueous extract of Fagara tessmannii Engl (Rutaceae) on cardiovascular risks related to monosodium glutamate-induced obesity in rat: In vivo and in vitro assessments.
Journal of ethnopharmacology.
2020 Oct; 260(?):112972. doi:
10.1016/j.jep.2020.112972. [PMID: 32446928] - Aya M Mekkawy, Yasmine H Ahmed, Abdel Azeem A Khalaf, Mohamed A El-Sakhawy. Ameliorative effect of Nigella sativa oil and vitamin C on the thyroid gland and cerebellum of adult male albino rats exposed to Monosodium glutamate (histological, immunohistochemical and biochemical studies).
Tissue & cell.
2020 Oct; 66(?):101391. doi:
10.1016/j.tice.2020.101391. [PMID: 32933714] - Arnab Banerjee, Debasmita Das, Rajarshi Paul, Sandipan Roy, Ujjal Das, Samrat Saha, Sanjit Dey, Arghya Adhikary, Sandip Mukherjee, Bithin Kumar Maji. Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis.
Scientific reports.
2020 09; 10(1):15443. doi:
10.1038/s41598-020-72076-6. [PMID: 32963259] - Feng Yang, Wen Zhu, Xiaofang Cai, Wen Zhang, Zhonghai Yu, Xiangting Li, Jingsi Zhang, Min Cai, Jun Xiang, Dingfang Cai. Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats.
Biochemical and biophysical research communications.
2020 06; 526(3):553-559. doi:
10.1016/j.bbrc.2020.02.149. [PMID: 32245616] - Suzan M Hazzaa, Eman S El-Roghy, Mabrouk A Abd Eldaim, Ghada E Elgarawany. Monosodium glutamate induces cardiac toxicity via oxidative stress, fibrosis, and P53 proapoptotic protein expression in rats.
Environmental science and pollution research international.
2020 Jun; 27(16):20014-20024. doi:
10.1007/s11356-020-08436-6. [PMID: 32236804] - Hanaa A Hassan, Wafaa M El-Kholy, Mamdouh R F El-Sawi, Nadine A Galal, Mohamed Fawzy Ramadan. Myrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest.
Environmental science and pollution research international.
2020 Jun; 27(18):23188-23198. doi:
10.1007/s11356-020-08780-7. [PMID: 32333355] - Suzan M Hazzaa, Seham Ahmed Mohamed Abdelaziz, Mabrouk A Abd Eldaim, Mohamed M Abdel-Daim, Ghada E Elgarawany. Neuroprotective Potential of Allium sativum against Monosodium Glutamate-Induced Excitotoxicity: Impact on Short-Term Memory, Gliosis, and Oxidative Stress.
Nutrients.
2020 Apr; 12(4):. doi:
10.3390/nu12041028. [PMID: 32290031] - Daniel Ejim Uti, Item Justin Atangwho, Eyong Ubana Eyong, Grace Ufedo Umoru, Godwin Eneji Egbung, Victor Udo Nna, Precious A Udeozor. African walnuts attenuate ectopic fat accumulation and associated peroxidation and oxidative stress in monosodium glutamate-obese Wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Apr; 124(?):109879. doi:
10.1016/j.biopha.2020.109879. [PMID: 31991383] - Mehmet Soner Türküner, Ferruh Özcan. Monosodium glutamate restricts the adipogenic potential of 3T3-L1 preadipocytes through mitotic clonal expansion.
Cell biology international.
2020 Mar; 44(3):744-754. doi:
10.1002/cbin.11269. [PMID: 31769558] - Atsuko Takai, Kentaro Kikuchi, Mayuko Ichimura, Koichi Tsuneyama, Yuki Moritoki, Kotaro Matsumoto, Hiromichi Tsunashima, Takeshi Onda, Noriyuki Kuniyoshi, Tomoyuki Nariyama, Sho Ohyatsu, Juri Kubota, Kozue Nagumo, Shinpei Sato, Masumi Hara, Hiroshi Miyakawa. Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis.
BMC gastroenterology.
2020 Feb; 20(1):46. doi:
10.1186/s12876-020-01194-2. [PMID: 32103741] - KÉsia Zanuzo, ZoÉ M Guareschi, Anna Caroliny Detogni, Luiz Pierre Huning, Patrick F Rodrigues, Elaine M Porto, Sabrina Grassiolli, JoÃo Paulo A Amorim. Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate.
Anais da Academia Brasileira de Ciencias.
2020; 92(4):e20201097. doi:
10.1590/0001-3765202020201097. [PMID: 33331449] - Thatsanapong Pongking, Ornuma Haonon, Rungtiwa Dangtakot, Sudarat Onsurathum, Apinya Jusakul, Kitti Intuyod, Arunnee Sangka, Sirirat Anutrakulchai, Ubon Cha'on, Somchai Pinlaor, Porntip Pinlaor. A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism.
PloS one.
2020; 15(4):e0231237. doi:
10.1371/journal.pone.0231237. [PMID: 32267892] - Yanchun Zhong, Yueling Ding, Laiqing Li, Meina Ge, Guangguo Ban, Hongxia Yang, Jun Dai, Licheng Zhang. Effects and Mechanism of Chlorogenic Acid on Weight Loss.
Current pharmaceutical biotechnology.
2020; 21(11):1099-1106. doi:
10.2174/1389201021666200318124922. [PMID: 32188382] - Joel A DA Silva JÚnior, Amanda C V F DA Silva, LetÍcia S Figueiredo, Thiago R Araujo, Israelle N Freitas, Everardo M Carneiro, Elane S Ribeiro, Rosane A Ribeiro. D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice.
Anais da Academia Brasileira de Ciencias.
2020; 92(4):e20201382. doi:
10.1590/0001-3765202020201382. [PMID: 33237150] - Zhaobin Wang, Jun Zhang, Pei Wu, Shiyu Luo, Jianzhong Li, Qiye Wang, Pengfei Huang, Yali Li, Xueqin Ding, Zhenping Hou, Duanqin Wu, Jing Huang, Qiang Tu, Huansheng Yang. Effects of oral monosodium glutamate administration on serum metabolomics of suckling piglets.
Journal of animal physiology and animal nutrition.
2020 Jan; 104(1):269-279. doi:
10.1111/jpn.13212. [PMID: 31553089] - Reham Z Hamza, Fawziah A Al-Salmi, Hebatullah Laban, Nahla S El-Shenawy. Ameliorative Role of Green Tea and Zinc Oxide Nanoparticles Complex Against Monosodium Glutamate-Induced Testicular Toxicity in Male Rats.
Current pharmaceutical biotechnology.
2020; 21(6):488-501. doi:
10.2174/1389201020666191203095036. [PMID: 31793422] - Shangci Wang, Brandon D Tonnis, Ming Li Wang, Shaokang Zhang, Koushik Adhikari. Investigation of Monosodium Glutamate Alternatives for Content of Umami Substances and Their Enhancement Effects in Chicken Soup Compared to Monosodium Glutamate.
Journal of food science.
2019 Nov; 84(11):3275-3283. doi:
10.1111/1750-3841.14834. [PMID: 31602667] - Olga Victorovna Pershina, Angelina Vladimirovna Pakhomova, Darius Widera, Natalia Nicolaevna Ermakova, Anton Alexandrovich Epanchintsev, Edgar Sergeevich Pan, Vyacheslav Andreevich Krupin, Olga Evgenevna Vaizova, Olesia Dmitrievna Putrova, Lubov Alexandrovna Sandrikina, Irina Vitalevna Kurochkina, Sergey Georgievich Morozov, Aslan Amirkhanovich Kubatiev, Alexander Mikhaylovich Dygai, Evgenii Germanovich Skurikhin. Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema.
International journal of molecular sciences.
2019 Oct; 20(21):. doi:
10.3390/ijms20215414. [PMID: 31671663] - Kanokwan Nahok, Jia V Li, Jutarop Phetcharaburanin, Hasina Abdul, Chaisiri Wongkham, Raynoo Thanan, Atit Silsirivanit, Sirirat Anutrakulchai, Carlo Selmi, Ubon Cha'on. Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats.
Biomolecules.
2019 09; 9(10):. doi:
10.3390/biom9100542. [PMID: 31569818] - Josiah Okwudili Nnadozie, Udunma Olive Chijioke, Okechukwu Charles Okafor, Daniel Bankole Olusina, Angus Nnamdi Oli, Patience Chiebonam Nwonu, Herbert Orji Mbagwu, Chioli Pascal Chijioke. Chronic toxicity of low dose monosodium glutamate in albino Wistar rats.
BMC research notes.
2019 Sep; 12(1):593. doi:
10.1186/s13104-019-4611-7. [PMID: 31533812] - Caroline B Quines, Natália S Jardim, Paulo Cesar O Araujo, José Luiz Cechella, Vinicius C Prado, Cristina W Nogueira. Resistance training restores metabolic alterations induced by monosodium glutamate in a sex-dependent manner in male and female rats.
Journal of cellular biochemistry.
2019 08; 120(8):13426-13440. doi:
10.1002/jcb.28617. [PMID: 30916837] - O T Kunle-Alabi, O O Akindele, K J Charles, Y Raji. Coconut Water Prevents Renal and Hepatic Changes in Offspring of Monosodium Glutamate-Treated Wistar Rat Dams.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2019 Jun; 34(1):11-16. doi:
. [PMID: 31449266] - Jianan Zhang, Mouming Zhao, Guowan Su, Lianzhu Lin. Identification and taste characteristics of novel umami and umami-enhancing peptides separated from peanut protein isolate hydrolysate by consecutive chromatography and UPLC-ESI-QTOF-MS/MS.
Food chemistry.
2019 Apr; 278(?):674-682. doi:
10.1016/j.foodchem.2018.11.114. [PMID: 30583429] - C F F Coelho, L M França, J R Nascimento, A M Dos Santos, A P S Azevedo-Santos, F R F Nascimento, A M A Paes. Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice.
Journal of developmental origins of health and disease.
2019 04; 10(2):188-195. doi:
10.1017/s2040174418000284. [PMID: 29855396] - Fu Li, Michelle L Ulrich, Vincent Feng-Sheng Shih, Julia H Cochran, Joshua H Hunter, Lori Westendorf, Jason Neale, Dennis R Benjamin. Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction.
Molecular cancer therapeutics.
2019 04; 18(4):780-787. doi:
10.1158/1535-7163.mct-18-0977. [PMID: 30824607] - Evgenii Germanovich Skurikhin, Olga Victorovna Pershina, Angelina Vladimirovna Pakhomova, Edgar Sergeevich Pan, Vyacheslav Andreevich Krupin, Natalia Nicolaevna Ermakova, Olga Evgenevna Vaizova, Anna Sergeevna Pozdeeva, Mariia Andreevna Zhukova, Viktoriia Evgenevna Skurikhina, Wolf-Dieter Grimm, Alexander Mikhaylovich Dygai. Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease.
International journal of molecular sciences.
2019 Mar; 20(5):. doi:
10.3390/ijms20051105. [PMID: 30836679] - Rene J Hernández Bautista, Ayman M Mahmoud, Mina Königsberg, Norma E López Díaz Guerrero. Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Mar; 111(?):503-516. doi:
10.1016/j.biopha.2018.12.108. [PMID: 30597304] - R O A Benevides, C C Vale, J L L Fontelles, L M França, T S Teófilo, S N Silva, A M A Paes, R S Gaspar. Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.
Journal of ovarian research.
2019 Feb; 12(1):13. doi:
10.1186/s13048-019-0490-8. [PMID: 30717749] - Sarmistha Banerjee, Rajat K Das, Bernard H Shapiro. Feminization imprinted by developmental growth hormone.
Molecular and cellular endocrinology.
2019 01; 479(?):27-38. doi:
10.1016/j.mce.2018.08.011. [PMID: 30170181] - Refaat A Eid, Mubarak Al-Shraim, Mohamed Sa Zaki, Samaa S Kamar, Noha S Abdel Latif, Sally Negm, Bahjat Al-Ani, Mohamed A Haidara. Vitamin E protects against monosodium glutamate-induced acute liver injury and hepatocyte ultrastructural alterations in rats.
Ultrastructural pathology.
2019; 43(4-5):199-208. doi:
10.1080/01913123.2019.1673860. [PMID: 31599191] - Lucas Martins França, Caio Fernando Ferreira Coêlho, Larissa Nara Costa Freitas, Ivana Letícia Santos Souza, Vinicyus Teles Chagas, Victor Debbas, Thais Martins de Lima, Heraldo Possolo de Souza, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes. Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats.
Oxidative medicine and cellular longevity.
2019; 2019(?):9417498. doi:
10.1155/2019/9417498. [PMID: 31015892] - A Y Onaolapo, I Odetunde, A S Akintola, M O Ogundeji, A Ajao, A Y Obelawo, O J Onaolapo. Dietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):417-428. doi:
10.1016/j.biopha.2018.10.172. [PMID: 30399577] - Fawziah A Al-Salmi, Reham Z Hamza, Nahla S El-Shenawy. The Interaction of Zinc Oxide/Green Tea Extract Complex Nanoparticles and its Effect on Monosodium Glutamate Toxicity in Liver of Rats.
Current pharmaceutical biotechnology.
2019; 20(6):465-475. doi:
10.2174/1389201020666190408120532. [PMID: 30961481] - Nahla S El-Shenawy, Reham Z Hamza, Fawziah A Al-Salmi, Rasha A Al-Eisa. Evaluation of the Effect of Nanoparticles Zinc Oxide/Camellia sinensis Complex on the Kidney of Rats Treated with Monosodium Glutamate: Antioxidant and Histological Approaches.
Current pharmaceutical biotechnology.
2019; 20(7):542-550. doi:
10.2174/1389201020666190522075928. [PMID: 31113341] - Reham Z Hamza, Najah M Al-Baqami. Testicular protective effects of ellagic acid on monosodium glutamate-induced testicular structural alterations in male rats.
Ultrastructural pathology.
2019; 43(4-5):170-183. doi:
10.1080/01913123.2019.1671569. [PMID: 31658851] - Yun Su, Zemeng Feng, Yumin He, Lingling Hong, Gang Liu, Tiejun Li, Yulong Yin. Monosodium L-glutamate and fats change free fatty acid concentrations in intestinal contents and affect free fatty acid receptors express profile in growing pigs.
Food & nutrition research.
2019; 63(?):. doi:
10.29219/fnr.v63.1444. [PMID: 31360149] - Etienne Rousseau, Joseph Lau, Hsiou-Ting Kuo, Zhengxing Zhang, Helen Merkens, Navjit Hundal-Jabal, Nadine Colpo, Kuo-Shyan Lin, François Bénard. Monosodium Glutamate Reduces 68Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2018 12; 59(12):1865-1868. doi:
10.2967/jnumed.118.215350. [PMID: 30097503] - Akira Sonoda, Naganori Kamiyama, Sotaro Ozaka, Yoshiko Gendo, Takashi Ozaki, Haruna Hirose, Kaori Noguchi, Benjawan Saechue, Nozomi Sachi, Kumiko Sakai, Kazuhiro Mizukami, Shinya Hidano, Kazunari Murakami, Takashi Kobayashi. Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice.
Genes to cells : devoted to molecular & cellular mechanisms.
2018 Dec; 23(12):1043-1055. doi:
10.1111/gtc.12649. [PMID: 30353943] - Eman A Elbassuoni, Merhan M Ragy, Sabreen M Ahmed. Evidence of the protective effect of l-arginine and vitamin D against monosodium glutamate-induced liver and kidney dysfunction in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):799-808. doi:
10.1016/j.biopha.2018.09.093. [PMID: 30253372] - Kun Yang, Miaomiao Liu, Jing Wang, Hamada Hassan, Jie Zhang, Yiman Qi, Xinyuan Wei, Mingtao Fan, Guoqiang Zhang. Surface characteristics and proteomic analysis insights on the response of Oenococcus oeni SD-2a to freeze-drying stress.
Food chemistry.
2018 Oct; 264(?):377-385. doi:
10.1016/j.foodchem.2018.04.137. [PMID: 29853390] - Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng. Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):637-644. doi:
10.1016/j.biopha.2018.04.043. [PMID: 29679905] - Ruriko Nishigaki, Yoshihiro Yokoyama, Yuko Shimizu, Ryosuke Marumoto, Sachiyo Misumi, Yoshitomo Ueda, Akimasa Ishida, Yasuyuki Shibuya, Hideki Hida. Monosodium glutamate ingestion during the development period reduces aggression mediated by the vagus nerve in a rat model of attention deficit-hyperactivity disorder.
Brain research.
2018 07; 1690(?):40-50. doi:
10.1016/j.brainres.2018.04.006. [PMID: 29649467] - Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Ginus Partadiredja. The effects of black garlic on the working memory and pyramidal cell number of medial prefrontal cortex of rats exposed to monosodium glutamate.
Drug and chemical toxicology.
2018 Jul; 41(3):324-329. doi:
10.1080/01480545.2017.1414833. [PMID: 29280389] - Corinna A Noel, Graham Finlayson, Robin Dando. Prolonged Exposure to Monosodium Glutamate in Healthy Young Adults Decreases Perceived Umami Taste and Diminishes Appetite for Savory Foods.
The Journal of nutrition.
2018 06; 148(6):980-988. doi:
10.1093/jn/nxy055. [PMID: 29796671] - Qing-Chun Li, Qing-Feng Li, Yan-Lin Wang, Hong-Liang Sun, Zheng-Yao Jiang. Arcuate nucleus neurons are not essential for the preprandial peak in plasma ghrelin after neonatal monosodium glutamate treatment.
International journal of molecular medicine.
2018 Mar; 41(3):1635-1642. doi:
10.3892/ijmm.2018.3365. [PMID: 29328403] - Juliana Bernera Ramalho, Aryele Pinto Izaguirry, Melina Bucco Soares, Cristiano Chiapinotto Spiazzi, Natasha Frasson Pavin, Ricardo Ferreira Affeldt, Diogo Seibert Lüdtke, Simone Pinton, Francielli Weber Santos, Marina Prigol. Selenofuranoside improves long-term memory deficits in rats after exposure to monosodium glutamate: Involvement of Na+, K+-ATPase activity.
Physiology & behavior.
2018 02; 184(?):27-33. doi:
10.1016/j.physbeh.2017.10.028. [PMID: 29097195] - Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Goutam Paul. Monosodium glutamate suppresses the female reproductive function by impairing the functions of ovary and uterus in rat.
Environmental toxicology.
2018 Feb; 33(2):198-208. doi:
10.1002/tox.22508. [PMID: 29119727] - Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar. Combined Administration of Monosodium Glutamate and High Sucrose Diet Accelerates the Induction of Type 2 Diabetes, Vascular Dysfunction, and Memory Impairment in Rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2018; 37(1):63-80. doi:
10.1615/jenvironpatholtoxicoloncol.2018017186. [PMID: 29773001] - Usama K Hussein, Nour El-Houda Y Hassan, Manal E A Elhalwagy, Amr R Zaki, Huda O Abubakr, Kalyan C Nagulapalli Venkata, Kyu Yun Jang, Anupam Bishayee. Ginger and Propolis Exert Neuroprotective Effects against Monosodium Glutamate-Induced Neurotoxicity in Rats.
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111928. [PMID: 29117134] - Gabriela Moreira Soares, Kathia Regina Cantelli, Sandra Lucinei Balbo, Rosane Aparecida Ribeiro, Ana Claudia Paiva Alegre-Maller, Helena Cristina Barbosa-Sampaio, Antonio Carlos Boschero, Allan Cezar Faria Araújo, Maria Lúcia Bonfleur. Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway.
Life sciences.
2017 Nov; 188(?):68-75. doi:
10.1016/j.lfs.2017.08.035. [PMID: 28866102] - Sowmya Madhavadas, Sarada Subramanian. Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on non-transgenic Alzheimer's disease rat model: Biochemical, histological, and behavioural studies.
Nutritional neuroscience.
2017 Nov; 20(9):526-537. doi:
10.1080/1028415x.2016.1194593. [PMID: 27308892] - María Del Carmen Contini, Ana Fabro, Néstor Millen, Adriana Benmelej, Stella Mahieu. Adverse effects in kidney function, antioxidant systems and histopathology in rats receiving monosodium glutamate diet.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2017 Sep; 69(7):547-556. doi:
10.1016/j.etp.2017.03.003. [PMID: 28522248] - Camille Schwartz, Claire Chabanet, Emilie Szleper, Valérie Feyen, Sylvie Issanchou, Sophie Nicklaus. Infant Acceptance of Primary Tastes and Fat Emulsion: Developmental Changes and Links with Maternal and Infant Characteristics.
Chemical senses.
2017 Sep; 42(7):593-603. doi:
10.1093/chemse/bjx040. [PMID: 28821180] - Patricia Lucio Alves, Fernando Mauricio Francis Abdalla, Rafaela Fadoni Alponti, Paulo Flavio Silveira. Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster.
Toxicon : official journal of the International Society on Toxinology.
2017 Sep; 135(?):1-11. doi:
10.1016/j.toxicon.2017.06.001. [PMID: 28579479] - Caio Y Yonamine, Erika Pinheiro-Machado, Maria L Michalani, Ana B Alves-Wagner, João V Esteves, Helayne S Freitas, Ubiratan F Machado. Resveratrol Improves Glycemic Control in Type 2 Diabetic Obese Mice by Regulating Glucose Transporter Expression in Skeletal Muscle and Liver.
Molecules (Basel, Switzerland).
2017 Jul; 22(7):. doi:
10.3390/molecules22071180. [PMID: 28708105] - Nazarii Kobyliak, Tetyana Falalyeyeva, Petro Bodnar, Tetyana Beregova. Probiotics Supplemented with Omega-3 Fatty Acids are More Effective for Hepatic Steatosis Reduction in an Animal Model of Obesity.
Probiotics and antimicrobial proteins.
2017 06; 9(2):123-130. doi:
10.1007/s12602-016-9230-1. [PMID: 27660157] - I Boušová, Š Košťáková, P Matoušková, H Bártíková, B Szotáková, L Skálová. Monosodium glutamate-induced obesity changed the expression and activity of glutathione S-transferases in mouse heart and kidney.
Die Pharmazie.
2017 May; 72(5):257-259. doi:
10.1691/ph.2017.6886. [PMID: 29441869] - Natalia Belemets, Nazarii Kobyliak, Oleksandr Virchenko, Tetyana Falalyeyeva, Tsyryuk Olena, Petro Bodnar, Oleksiy Savchuk, Tetyana Galenova, Martin Caprnda, Luis Rodrigo, Lubomir Skladany, Delian Delev, Radka Opatrilova, Peter Kruzliak, Tetyana Beregova, Lyudmyla Ostapchenko. Effects of polyphenol compounds melanin on NAFLD/NASH prevention.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):267-276. doi:
10.1016/j.biopha.2017.01.028. [PMID: 28110193]