Daphnetoxin (BioDeep_00000007155)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Orthobenzoic acid, cyclic 7,8,10a-ester with 5,6-epoxy-4,5,6,6a,7,8,9,10,10a,10b-decahydro-3a,4,7,8,10a-pentahydroxy-5-(hydroxymethyl)-8-isopropenyl-2,10-dimethylbenz(e)azulen-3(3ah)-one

化学式: C27H30O8 (482.194058)
中文名称:
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 6.9%

分子结构信息

SMILES: C=C(C)C12CC(C)C34OC(c5ccccc5)(OC1C3C1OC1(CO)C(O)C1(O)C(=O)C(C)=CC14)O2
InChI: InChI=1S/C27H30O8/c1-13(2)23-11-15(4)26-17-10-14(3)19(29)25(17,31)22(30)24(12-28)21(32-24)18(26)20(23)33-27(34-23,35-26)16-8-6-5-7-9-16/h5-10,15,17-18,20-22,28,30-31H,1,11-12H2,2-4H3/t15-,17-,18-,20-,21+,22-,23-,24+,25-,26+,27-/m1/s1

描述信息

A daphnane-type orthoester diterpene with potential cholesterol-lowering activity, found exclusively in plants of the family Thymelaeaceae.

同义名列表

3 个代谢物同义名

Daphnetoxin; Orthobenzoic acid, cyclic 7,8,10a-ester with 5,6-epoxy-4,5,6,6a,7,8,9,10,10a,10b-decahydro-3a,4,7,8,10a-pentahydroxy-5-(hydroxymethyl)-8-isopropenyl-2,10-dimethylbenz(e)azulen-3(3ah)-one; Genkwanine VIII



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Vincent Vidal, Olivier Potterat, Séverine Louvel, François Hamy, Mahdi Mojarrab, Jean-Jacques Sanglier, Thomas Klimkait, Matthias Hamburger. Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium. Journal of natural products. 2012 Mar; 75(3):414-9. doi: 10.1021/np200855d. [PMID: 22148316]
  • Sheng Zhuo Huang, Xing Jie Zhang, Xing Yao Li, Ling Mei Kong, He Zhong Jiang, Qing Yun Ma, Yu Qing Liu, Jiang Miao Hu, Yong Tang Zheng, Yan Li, Jun Zhou, You Xing Zhao. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd. Phytochemistry. 2012 Mar; 75(?):99-107. doi: 10.1016/j.phytochem.2011.11.013. [PMID: 22196934]
  • Yilin Zhang, Haiqing Zhang, Shineng Hua, Lianghui Ma, Cong Chen, Xiaoyu Liu, Liqun Jiang, Huanming Yang, Peicheng Zhang, Dequan Yu, Yinlong Guo, Xuehai Tan, Jianfeng Liu. Identification of two herbal compounds with potential cholesterol-lowering activity. Biochemical pharmacology. 2007 Sep; 74(6):940-7. doi: 10.1016/j.bcp.2007.06.020. [PMID: 17673184]
  • Guang-Xiong Zhou, Yong-Chun Yang, Jian-Gong Shi. [Study of chemical constituents in stem rind of Daphne giraldii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Apr; 31(7):555-7. doi: . [PMID: 16780156]
  • Francisco Peixoto, Maria J M Carvalho, J Almeida, P A C Matos. Daphnetoxin interacts with mitochondrial oxidative phosphorylation and induces membrane permeability transition in rat liver. Planta medica. 2004 Nov; 70(11):1064-8. doi: 10.1055/s-2004-832648. [PMID: 15549663]
  • L Saraiva, P Fresco, E Pinto, H Portugal, J Gonçalves. Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta. Planta medica. 2001 Dec; 67(9):787-90. doi: 10.1055/s-2001-18843. [PMID: 11745011]
  • H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor. The Biochemical journal. 1975 Dec; 152(3):601-7. doi: 10.1042/bj1520601. [PMID: 5997]