Precocene II (BioDeep_00000007114)

 

Secondary id: BioDeep_00001868550

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


6,7-Dimethoxy-2,2-dimethyl-2H-benzo(b)pyran

化学式: C13H16O3 (220.1099)
中文名称: 早熟素Ⅱ
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 83.16%

分子结构信息

SMILES: CC1(C)C=CC2=CC(OC)=C(OC)C=C2O1
InChI: InChI=1S/C13H16O3/c1-13(2)6-5-9-7-11(14-3)12(15-4)8-10(9)16-13/h5-8H,1-4H3

描述信息

D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
Precocene II is the insect antijuvenile hormone[1].

同义名列表

11 个代谢物同义名

6,7-Dimethoxy-2,2-dimethyl-2H-benzo(b)pyran; 6,7-Dimethoxy-2,2-dimethyl2h-1-benzopyran; 6,7-dimethoxy-2,2-dimethyl-2H-chromene; 6,7-Dimethoxy-2,2-dimethylchromene; Ageratochromene; Precocene II; PRICOCENE II; Precocene 2; Precocen 2; Precocene II; Precocene II



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ACLY, CLOCK, CYP2A6, HPGDS, IL13, JAK1, JAK2, JAK3, MAPK14, NOS2, PER2, STAT3, TTK
Peripheral membrane protein 2 JAK2, JAK3
Endoplasmic reticulum membrane 1 CYP2A6
Nucleus 9 CLOCK, FLG, JAK1, JAK2, MAPK14, NOS2, PER2, STAT3, TTK
cytosol 12 ACLY, CLOCK, FLG, GPT, HPGDS, JAK1, JAK2, JAK3, MAPK14, NOS2, PER2, STAT3
nucleoplasm 9 ACLY, CLOCK, HPGDS, JAK2, MAPK14, NOS2, PER2, SCNN1G, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 1 OPRD1
Cytoplasmic granule 1 FLG
Multi-pass membrane protein 4 KCNA3, OPRD1, SCNN1G, SLC25A46
glutamatergic synapse 4 FLG, JAK2, KCNA3, MAPK14
postsynapse 2 FLG, JAK2
presynaptic membrane 2 KCNA3, OPRD1
Cytoplasm, cytosol 3 ACLY, CLOCK, NOS2
endosome 2 JAK1, JAK3
plasma membrane 9 FLG, JAK1, JAK2, JAK3, KCNA3, NOS2, OPRD1, SCNN1G, STAT3
synaptic vesicle membrane 1 OPRD1
Membrane 9 ACLY, CYP2A6, FLG, JAK1, JAK2, JAK3, KCNA3, OPRD1, TTK
apical plasma membrane 1 SCNN1G
axon 1 KCNA3
caveola 1 JAK2
extracellular exosome 3 ACLY, GPT, SCNN1G
extracellular space 2 IL13, IL4
perinuclear region of cytoplasm 3 KCNA3, NOS2, PER2
mitochondrion 2 MAPK14, SLC25A46
intracellular membrane-bounded organelle 3 CLOCK, CYP2A6, HPGDS
Secreted 2 IL13, IL4
extracellular region 5 ACLY, FLG, IL13, IL4, MAPK14
cytoplasmic side of plasma membrane 3 JAK1, JAK2, JAK3
Mitochondrion outer membrane 1 SLC25A46
mitochondrial outer membrane 1 SLC25A46
transcription regulator complex 2 CLOCK, STAT3
external side of plasma membrane 2 IL13, SCNN1G
cytoplasmic vesicle 1 FLG
nucleolus 1 PER2
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 SCNN1G
Cytoplasm, perinuclear region 2 NOS2, PER2
Membrane raft 2 JAK2, KCNA3
focal adhesion 2 JAK1, JAK2
spindle 1 TTK
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
collagen-containing extracellular matrix 1 FLG
nuclear speck 1 MAPK14
receptor complex 1 FLG
neuron projection 1 OPRD1
chromatin 2 CLOCK, STAT3
Chromosome 1 CLOCK
cytoskeleton 3 JAK1, JAK2, JAK3
cytoplasmic ribonucleoprotein granule 1 FLG
spindle pole 1 MAPK14
[Isoform 2]: Cell membrane 1 KCNA3
Endomembrane system 3 JAK1, JAK2, JAK3
endosome lumen 1 JAK2
Cornified envelope 1 FLG
sodium channel complex 1 SCNN1G
euchromatin 1 JAK2
voltage-gated potassium channel complex 1 KCNA3
ficolin-1-rich granule lumen 2 ACLY, MAPK14
secretory granule lumen 1 MAPK14
axon terminus 1 OPRD1
chromatoid body 1 CLOCK
CLOCK-BMAL transcription complex 1 CLOCK
kinetochore 1 TTK
azurophil granule lumen 1 ACLY
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
calyx of Held 1 KCNA3
[Isoform 1]: Nucleus 1 PER2
[Isoform 2]: Nucleus, nucleolus 1 PER2
Cry-Per complex 1 PER2
extrinsic component of cytoplasmic side of plasma membrane 3 JAK1, JAK2, JAK3
cytoplasmic microtubule 1 CYP2A6
[Isoform 1]: Cell membrane 1 KCNA3
dendrite membrane 1 OPRD1
extrinsic component of plasma membrane 2 JAK2, JAK3
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
cortical cytoskeleton 1 NOS2
keratohyalin granule 1 FLG
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
spine apparatus 1 OPRD1


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Shohei Sakuda, Tomoya Yoshinari, Tomohiro Furukawa, Usuma Jermnak, Keiko Takagi, Kurin Iimura, Toshiyoshi Yamamoto, Michio Suzuki, Hiromichi Nagasawa. Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action. Bioscience, biotechnology, and biochemistry. 2016; 80(1):43-54. doi: 10.1080/09168451.2015.1086261. [PMID: 26376763]
  • Yusei Kashima, Satoshi Nakaya, Mitsuo Miyazawa. Volatile composition and sensory properties of Indian herbal medicine-Pavonia odorata-used in Ayurveda. Journal of oleo science. 2014; 63(2):149-58. doi: 10.5650/jos.ess13125. [PMID: 24441709]
  • Vera Lucia Sardá Ribeiro, Jaqueline Campiol dos Santos, João Ricardo Martins, Jan Schripsema, Ionara R Siqueira, Gilsane L von Poser, Miriam A Apel. Acaricidal properties of the essential oil and precocene II obtained from Calea serrata (Asteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Veterinary parasitology. 2011 Jun; 179(1-3):195-8. doi: 10.1016/j.vetpar.2011.02.006. [PMID: 21402447]
  • Zhaorigetu Chen, Robin D Madden, Jack W Dillwith. Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress. Journal of insect physiology. 2005 Apr; 51(4):411-6. doi: 10.1016/j.jinsphys.2005.02.006. [PMID: 15890184]
  • T A Triseleva. [Effect of plants synthesizing biologically active substances-precocenes on insects]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2003 May; ?(3):337-44. doi: ". [PMID: 12816067]
  • A H Hammond, M J Garle, J R Fry. Mechanism of toxicity of precocene II in rat hepatocyte cultures. Journal of biochemical toxicology. 1995 Oct; 10(5):265-273. doi: 10.1002/jbt.2570100507. [PMID: 8847709]
  • A H Hammond, J R Fry. Toxicity of precocene II in rat hepatocyte cultures: effects of serum and culture time. Toxicology letters. 1994 Feb; 70(3):337-42. doi: 10.1016/0378-4274(94)90128-7. [PMID: 8284801]
  • A H Hammond, J R Fry. Effect of serum-free medium on cytochrome P450-dependent metabolism and toxicity in rat cultured hepatocytes. Biochemical pharmacology. 1992 Oct; 44(7):1461-4. doi: 10.1016/0006-2952(92)90549-x. [PMID: 1417966]
  • S K Duddy, M T Hsia. Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels. Chemico-biological interactions. 1989; 71(2-3):187-99. doi: 10.1016/0009-2797(89)90034-3. [PMID: 2598296]
  • S K Duddy, M T Hsia. Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1987 Aug; 9(2):304-13. doi: 10.1016/0272-0590(87)90053-4. [PMID: 3653573]
  • R W Wiseman, E C Miller, J A Miller, A Liem. Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice. Cancer research. 1987 May; 47(9):2275-83. doi: . [PMID: 3567921]
  • K R Schrankel, S J Grossman, M T Hsia. Precocene II nephrotoxicity in the rat. Toxicology letters. 1982 Jul; 12(2-3):95-100. doi: 10.1016/0378-4274(82)90170-9. [PMID: 7112615]