Methylprednisolone acetate (BioDeep_00000006678)

   


代谢物信息卡片


6α-METHYLPREDNISOLONE ACETATE

化学式: C24H32O6 (416.2199)
中文名称: 6α-甲基泼尼松龙21-乙酸盐
谱图信息: 最多检出来源 Homo sapiens(plant) 5.43%

分子结构信息

SMILES: CC(=O)OCC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3C(O)CC21C
InChI: InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

3 个代谢物同义名

Methylprednisolone acetate; 6α-METHYLPREDNISOLONE ACETATE; Methylprednisolone acetate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, AXIN2, CASP3, MMP3, POMC, PTGS2, VEGFA
Peripheral membrane protein 2 AP1S2, PTGS2
Endoplasmic reticulum membrane 2 CD4, PTGS2
Nucleus 5 ALB, AXIN2, CASP3, MMP3, VEGFA
cytosol 5 ALB, AP1S2, AXIN2, CASP3, MMP3
centrosome 2 ALB, AXIN2
nucleoplasm 1 CASP3
Cell membrane 3 CD4, CD8A, TNF
Cytoplasmic side 1 AP1S2
Synapse 1 ACAN
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 ACAN, CASP3
Golgi apparatus 3 ALB, AP1S2, VEGFA
Golgi membrane 2 AP1S2, INS
lysosomal membrane 1 AP1S2
neuronal cell body 2 CASP3, TNF
plasma membrane 5 AXIN2, CD4, CD8A, IFNLR1, TNF
Membrane 3 IFNLR1, MMP13, VEGFA
caveola 1 PTGS2
extracellular exosome 1 ALB
endoplasmic reticulum 3 ALB, PTGS2, VEGFA
extracellular space 13 ACAN, ALB, CRP, CXCL8, IL10, IL6, INS, MMP1, MMP13, MMP3, POMC, TNF, VEGFA
lysosomal lumen 1 ACAN
adherens junction 1 VEGFA
mitochondrion 1 MMP3
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 1 AP1S2
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, CD8A, IFNLR1
Secreted 10 ALB, CRP, CXCL8, IL10, IL6, INS, MMP13, MMP3, POMC, VEGFA
extracellular region 14 ACAN, ALB, CD8A, CRP, CXCL8, IL10, IL6, INS, MMP1, MMP13, MMP3, POMC, TNF, VEGFA
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, CD8A, TNF
Secreted, extracellular space, extracellular matrix 4 ACAN, MMP1, MMP13, VEGFA
beta-catenin destruction complex 1 AXIN2
Early endosome 2 AP1S2, CD4
Membrane, clathrin-coated pit 1 AP1S2
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
GABA-ergic synapse 1 ACAN
extracellular matrix 4 MMP1, MMP13, MMP3, VEGFA
basement membrane 1 ACAN
collagen-containing extracellular matrix 1 ACAN
secretory granule 2 POMC, VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 CD8A
neuron projection 1 PTGS2
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 1 AP1S2
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AP1S2
trans-Golgi network membrane 1 AP1S2
plasma membrane raft 1 CD8A
secretory granule lumen 2 INS, POMC
Golgi lumen 2 ACAN, INS
endoplasmic reticulum lumen 5 ALB, CD4, IL6, INS, PTGS2
platelet alpha granule lumen 2 ALB, VEGFA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perineuronal net 1 ACAN
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
perisynaptic extracellular matrix 1 ACAN
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • I Koca, M Ucar, H O Arik, M Yilmaz, R Dokuyucu. Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis. European review for medical and pharmacological sciences. 2022 10; 26(20):7404-7412. doi: 10.26355/eurrev_202210_30009. [PMID: 36314310]
  • Karine Marchioro Leal, Mariana Barcelos Rocha, Fernanda Venzon Varela, Luana Rodrigues, Priscila Viau Furtado, Fernanda Vieira Amorim da Costa, Álan Gomes Pöppl. Is Methylprednisolone Acetate-Related Insulin Resistance Preventable in Cats?. Topics in companion animal medicine. 2022 Jul; 49(?):100648. doi: 10.1016/j.tcam.2022.100648. [PMID: 35202848]
  • Esther M Millares-Ramirez, Khristine Picotte, Jean-Pierre Lavoie. Pulmonary response of severely asthmatic horses after intra-articular administration of methylprednisolone. Equine veterinary journal. 2021 Jan; 53(1):78-84. doi: 10.1111/evj.13272. [PMID: 32348605]
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  • Aleem Jameel Abdul, Babita Ghai, Dipika Bansal, Naresh Sachdeva, Anil Bhansali, Saravdeep Singh Dhatt. Hypothalamic Pituitary Adrenocortical Axis Suppression following a Single Epidural Injection of Methylprednisolone Acetate. Pain physician. 2017 11; 20(7):E991-E1001. doi: . [PMID: 29149147]
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  • Alessia Panusa, Marica Orioli, Giancarlo Aldini, Marina Carini. A rapid and sensitive LC-ESI-MS/MS method for detection and quantitation of methylprednisolone and methylprednisolone acetate in rat plasma after intra-articular administration. Journal of pharmaceutical and biomedical analysis. 2010 Feb; 51(3):691-7. doi: 10.1016/j.jpba.2009.09.041. [PMID: 19875262]
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