Fluphenazine decanoate (BioDeep_00000006638)
Secondary id: BioDeep_00001868394
human metabolite blood metabolite
代谢物信息卡片
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl decanoate
化学式: C32H44F3N3O2S (591.3106)
中文名称: 癸氟奋乃静
谱图信息:
最多检出来源 Homo sapiens(blood) 80.33%
分子结构信息
SMILES: CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
InChI: InChI=1S/C32H44F3N3O2S/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research[1][2][3].
同义名列表
27 个代谢物同义名
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl decanoate; Fluorophenazine decanoic acid; Fluphenazine O-decanoic acid; Fluphenaline decanoic acid; Fluphenazine decanoic acid; Fluorophenazine decanoate; Flufenazine decanoic acid; Fluphenazine O-decanoate; Ftorphenazine decanoate; Anatensol decanoic acid; Fluphenazine decanoate; Prolixin decanoic acid; Fluphenaline decanoate; Flufenazine decanoate; Anatensol decanoate; Fluphenazine depot; Prolixin decanoate; Dapotum depot; Moditen depot; Moditen-depot; Modecic acid; Dapotum D; Modecate; Mirenil; Lyogen; Liogen; Fluphenazine depot
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:5124
- KEGG: C07956
- KEGGdrug: D00793
- PubChem: 3388
- HMDB: HMDB0252400
- DrugBank: DBSALT000776
- ChEMBL: CHEMBL1200854
- Wikipedia: Fluphenazine
- chemspider: 3271
- CAS: 5002-47-1
- PMhub: MS000019709
- PubChem: 10157
- NIKKAJI: J13.702B
- RefMet: Fluphenazine decanoate
- medchemexpress: HY-B1904
- KNApSAcK: 5124
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jason D Wagman, Barbara A Wolfe, Mandi W Schook. The effect of fluphenazine decanoate on glucocorticoid production, reproductive cyclicity, and the behavioral stress response in the Persian onager (Equus hemionus onager).
Zoo biology.
2015 Nov; 34(6):525-34. doi:
10.1002/zoo.21250. [PMID: 26491959] - Rachael B Weiss, Mandi W Schook, Barbara A Wolfe. Long-acting neuroleptic use for reproductive management of non-domestic ungulates using the domestic goat (Capra hircus) as a model.
Zoo biology.
2014 May; 33(3):204-11. doi:
10.1002/zoo.21125. [PMID: 24644127] - Sara Costello, Brendan Heffron, Lisa Taddei, Marc Benoit, Laura Hurt, Lindsay Simpson, Jennifer Bishop, Dawn Folker-Calderon, Adam Negrusz. Quantitation of fluphenazine in equine serum following fluphenazine decanoate administration.
Journal of analytical toxicology.
2013 Oct; 37(8):594-9. doi:
10.1093/jat/bkt073. [PMID: 23986099] - John D Baird, Luis G Arroyo, Modest Vengust, M Kimberly J McGurrin, Alexander Rodriguez-Palacios, Daniel G Kenney, Manickam Aravagiri, George A Maylin. Adverse extrapyramidal effects in four horse given fluphenazine decanoate.
Journal of the American Veterinary Medical Association.
2006 Jul; 229(1):104-10. doi:
10.2460/javma.229.1.104. [PMID: 16817724] - Joseph P McEvoy. Risks versus benefits of different types of long-acting injectable antipsychotics.
The Journal of clinical psychiatry.
2006; 67 Suppl 5(?):15-8. doi:
NULL. [PMID: 16822092] - S R Marder, M Aravagiri, W C Wirshing, D A Wirshing, M Lebell, J Mintz. Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate.
Schizophrenia research.
2002 Jan; 53(1-2):25-30. doi:
10.1016/s0920-9964(00)00184-5. [PMID: 11728835] - G S Linn, K Lifshitz, R T O'Keeffe, K Lee, J Camp-Lifshitz. Increased incidence of dyskinesias and other behavioral effects of re-exposure to neuroleptic treatment in social colonies of Cebus apella monkeys.
Psychopharmacology.
2001 Jan; 153(3):285-94. doi:
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Pharmaceutical research.
1998 Sep; 15(9):1485-9. doi:
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Schizophrenia research.
1988 Nov; 1(6):425-9. doi:
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European archives of psychiatry and neurological sciences.
1988 Sep; 237(6):320-6. doi:
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The British journal of psychiatry : the journal of mental science.
1988 Sep; 153(?):382-4. doi:
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The Journal of clinical psychiatry.
1988 Jun; 49(6):245. doi:
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Clinical chemistry.
1988 May; 34(5):837-40. doi:
NULL. [PMID: 3286051] - S G Siris, F Adan, A Lee, T B Cooper, J Mandeli, E Casey. Patterns of plasma imipramine-desipramine concentrations in patients receiving concomitant fluphenazine decanoate.
The Journal of clinical psychiatry.
1988 Feb; 49(2):64-5. doi:
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Journal of clinical psychopharmacology.
1988 Feb; 8(1):53-6. doi:
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Schizophrenia research.
1988 Jan; 1(1):31-5. doi:
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Psychopharmacology.
1988; 94(3):293-7. doi:
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Journal of neurology.
1987 Dec; 235(2):120-1. doi:
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Psychological medicine.
1987 Nov; 17(4):875-81. doi:
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Neuroscience letters.
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International clinical psychopharmacology.
1987 Oct; 2(4):299-305. doi:
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The British journal of psychiatry : the journal of mental science.
1987 Sep; 151(?):333-6. doi:
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