Isoflurane (BioDeep_00000006521)
Secondary id: BioDeep_00001867792
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
化学式: C3H2ClF5O (183.9714)
中文名称: 1-氯-2,2,2-三氟乙基二氟甲基醚
谱图信息:
最多检出来源 Homo sapiens(blood) 4.09%
分子结构信息
SMILES: C(C(F)(F)F)(OC(F)F)Cl
InChI: InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
描述信息
Isoflurane is only found in individuals that have used or taken this drug. It is a stable, non-explosive inhalation anesthetic, relatively free from significant side effects. [PubChem]Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:6015
- KEGG: C07518
- KEGGdrug: D00545
- PubChem: 3763
- HMDB: HMDB0014891
- Metlin: METLIN847
- DrugBank: DB00753
- ChEMBL: CHEMBL1256
- Wikipedia: Isoflurane
- MeSH: Isoflurane
- chemspider: 3631
- CAS: 26675-46-7
- PMhub: MS000019570
- PubChem: 9721
- NIKKAJI: J2.770G
- KNApSAcK: 6015
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Igor Kissin. Components of General Anesthesia: History of the Concept Transformation.
Anesthesia and analgesia.
2023 09; 137(3):702-707. doi:
10.1213/ane.0000000000006454. [PMID: 36917547] - Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Dhavalkumar Patel, Laurence Wood, Juyang Huang, Muhammad Bilal Siddique, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel. Effects of Volatile Anesthetics Versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes.
The Journal of pharmacology and experimental therapeutics.
2023 Feb; ?(?):. doi:
10.1124/jpet.122.001281. [PMID: 36828631] - Zahra Mohammadi, Sanaz Alaee, Mohammad Reza Namavar, Zahra Khodabandeh, Nahid Ahmadi, Niloofar Rashidipour, Somayyeh Karami-Mohajeri. The antioxidant properties of resveratrol on sperm parameters, testicular tissue, antioxidant capacity, and lipid peroxidation in isoflurane-induced toxicity in mice.
Human & experimental toxicology.
2023 Jan; 42(?):9603271231215036. doi:
10.1177/09603271231215036. [PMID: 37984886] - Hui Yang, YuJun Zhang, ChuiLiang Liu, YangWen Ou, YuHang Zhu, Yun Xue, GaoFeng Zhao, YuShuang Lin, Chun Chen, GuoHai Xu, KaiMing Yuan, Qiang Wang, Min Zhang, LiE Li, Jin Liu, WenSheng Zhang. A Multicenter, Randomized, Double-Blind, Positive-Controlled, Non-Inferiority, Phase III Clinical Trial Evaluating the Efficacy and Safety of Emulsified Isoflurane for Anesthesia Induction in Patients.
CNS drugs.
2022 12; 36(12):1301-1311. doi:
10.1007/s40263-022-00970-w. [PMID: 36385453] - Chenyang Gu, Jiale Liu, Yajing Li, Qiankun Zhang, Chaoqun Lin, Jiajun Huang, Wenjie Duan, Yushu Deng, Waqas Ahmed, Rong Li, Jun Long, Ahsan Ali Khan, Lukui Chen. Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Experimental animals.
2022 Nov; ?(?):. doi:
10.1538/expanim.22-0131. [PMID: 36418078] - Pedro Alves Machado-Junior, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Luiza Oliveira Perucci, André Talvani, Silvia Dantas Cangussú, Frank Silva Bezerra. The deleterious impact of exposure to different inhaled anesthetics is time dependent.
Life sciences.
2022 Nov; 309(?):121004. doi:
10.1016/j.lfs.2022.121004. [PMID: 36170891] - Yuanyuan Ma, Yelong Ji, Li Xu, Zheng Li, Shengjin Ge. Obesity aggravated hippocampal-dependent cognitive impairment after sleeve gastrectomy in C57/BL6J mice via SIRT1/CREB/BDNF pathway.
Experimental brain research.
2022 Nov; 240(11):2897-2906. doi:
10.1007/s00221-022-06465-w. [PMID: 36114835] - Liangyu Peng, Shuai Liu, Jiyan Xu, Wenjia Xie, Xin Fang, Tianjiao Xia, Xiaoping Gu. Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice.
International immunopharmacology.
2022 Aug; 109(?):108903. doi:
10.1016/j.intimp.2022.108903. [PMID: 35709590] - J Robert Sneyd. Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead.
British journal of anaesthesia.
2022 07; 129(1):7-10. doi:
10.1016/j.bja.2022.02.031. [PMID: 35331541] - Kotaro Hori, Tadashi Matsuura, Shogo Tsujikawa, Hideki Hino, Miyuki Kuno, Yutaka Oda, Kiyonobu Nishikawa, Takashi Mori. Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model.
Clinical toxicology (Philadelphia, Pa.).
2022 06; 60(6):716-724. doi:
10.1080/15563650.2021.2020280. [PMID: 34985393] - Duo Qian, Shijie Dai, Yujing Sun, Yawei Yuan, Long Wang. MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia.
Neurotoxicity research.
2022 Jun; 40(3):714-720. doi:
10.1007/s12640-022-00512-8. [PMID: 35486353] - Vesna Benković, Nada Oršolić, Anica Horvat Knežević, Nikola Borojević, Gordana Brozović, Mirta Milić. Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo.
Arhiv za higijenu rada i toksikologiju.
2022 Apr; 73(1):62-70. doi:
10.2478/aiht-2022-73-3600. [PMID: 35390237] - Ji-Yun Sohn, Yeon Chae, Yoonhoi Koo, Taesik Yun, Dohee Lee, Jooyoung Park, Mingyun Son, Yujin Choi, Dayoung Ku, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang. Evaluation of 18F-fluorodeoxyglucose uptake of beagle dogs for different durations of isoflurane anesthesia.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2022 Apr; 86(2):132-139. doi:
NULL. [PMID: 35388230] - Hiroyasu Nishimaki, Yoshikatsu Saitoh, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Ibrahim Fathi, Hiroki Yamana, Kazuo Ohashi, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Masafumi Goto. Short-term inhalation of isoflurane improves the outcomes of intraportal hepatocyte transplantation.
Scientific reports.
2022 03; 12(1):4241. doi:
10.1038/s41598-022-08237-6. [PMID: 35273344] - Kristi Kobluk, Bruno H Pypendop. Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):54-64. doi:
10.1016/j.vaa.2021.11.001. [PMID: 34906421] - Berna Ayanoğlu Taş, Ceren Şanlı Karip, Süheyla Abitağaoğlu, Mehmet Celal Öztürk, Dilek Erdoğan Arı. Comparison of minimal-flow sevoflurane versus desflurane anesthesia: randomized clinical trial.
Brazilian journal of anesthesiology (Elsevier).
2022 Jan; 72(1):77-82. doi:
10.1016/j.bjane.2021.05.012. [PMID: 34119569] - Yujing Sun, Yawei Yuan, Long Wang, Sen Sun. Effect of LncRNA OIP5-AS1/microRNA-186-5p on isoflurane-induced cognitive dysfunction in aged rats.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221116276. doi:
10.1177/09603271221116276. [PMID: 36000339] - Marcela L Machado, Joao H N Soares, Bruno H Pypendop, Natalia Henao-Guerrero, Renato L S Oliveira. Effect of fentanyl, with or without treatment of bradycardia, on the minimum alveolar concentration of isoflurane and cardiovascular function in dogs.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):26-35. doi:
10.1016/j.vaa.2021.09.001. [PMID: 34654643] - Hsin-Yu Huang, Kai-Yueh Liao, Wei-Yau Shia, Chao-Chin Chang, Hsien-Chi Wang. Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs.
The Journal of veterinary medical science.
2021 Dec; 83(12):1869-1876. doi:
10.1292/jvms.20-0657. [PMID: 34629333] - Christoph Steiger, Nhi V Phan, Hen-Wei Huang, Haoying Sun, Jacqueline N Chu, Daniel Reker, Declan Gwynne, Joy Collins, Siddartha Tamang, Rebecca McManus, Aaron Lopes, Alison Hayward, Rebecca M Baron, Edy Y Kim, Giovanni Traverso. Dynamic Monitoring of Systemic Biomarkers with Gastric Sensors.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2021 12; 8(24):e2102861. doi:
10.1002/advs.202102861. [PMID: 34713599] - J Cha, C W Shin, W-G Son. Transient postoperative glycosuria after isoflurane exposure in two dogs.
The Journal of small animal practice.
2021 11; 62(11):1022-1025. doi:
10.1111/jsap.13314. [PMID: 33587300] - Hope Douglas, Klaus Hopster, Michelle Cerullo, Charlotte Hopster-Iversen, Darko Stefanovski, Bernd Driessen. The effects of flumazenil on ventilatory and recovery characteristics in horses following midazolam-ketamine induction and isoflurane anaesthesia.
Equine veterinary journal.
2021 Nov; 53(6):1257-1267. doi:
10.1111/evj.13391. [PMID: 33220066] - Bruno H Pypendop, Yael Shilo-Benjamini. Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane.
Journal of veterinary pharmacology and therapeutics.
2021 Nov; 44(6):883-887. doi:
10.1111/jvp.13014. [PMID: 34558086] - Fumi Kozu, Kanae Shirahama-Noda, Yasuhiro Araki, Shintaro Kira, Hitoshi Niwa, Takeshi Noda. Isoflurane induces Art2-Rsp5-dependent endocytosis of Bap2 in yeast.
FEBS open bio.
2021 11; 11(11):3090-3100. doi:
10.1002/2211-5463.13302. [PMID: 34536986] - Azzeddine Kermad, Jacques Speltz, Guy Danziger, Thilo Mertke, Robert Bals, Thomas Volk, Philipp M Lepper, Andreas Meiser. Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients-a retrospective chart review.
Journal of anesthesia.
2021 10; 35(5):625-632. doi:
10.1007/s00540-021-02960-6. [PMID: 34169362] - Xingwei Li, Qun Yao, Ruijun Li, Yanwu Jin. Isoflurane induces liver injury by modulating the expression of miR-125a-5p.
Clinics and research in hepatology and gastroenterology.
2021 09; 45(5):101732. doi:
10.1016/j.clinre.2021.101732. [PMID: 34139319] - Shuying Zhu, Zeru Wang, Jun Yu, Lin Yin, Anding Zhu. Atractylenolide III alleviates isoflurane-induced injury in rat hippocampal neurons by activating the PI3K/Akt/mTOR pathway.
Journal of food biochemistry.
2021 09; 45(9):e13892. doi:
10.1111/jfbc.13892. [PMID: 34363234] - M M Granados, C Mengual, R Navarrete-Calvo, J A Fernández-Sarmiento, J Morgaz, S Quirós-Carmona, J M Domínguez, A Lora, Juan Manuel Serrano-Rodríguez. Influence of general anaesthesia on the intravenous acetaminophen pharmacokinetics in Beagle dogs.
Veterinary anaesthesia and analgesia.
2021 Sep; 48(5):637-644. doi:
10.1016/j.vaa.2021.02.007. [PMID: 34281773] - Stephan Neudeck, Lara Twele, Veronika Kopp, Sabine Kästner. Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):754-765. doi:
10.1111/jvp.12992. [PMID: 34159620] - Leon J DeLalio, Sean D Stocker. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli.
Journal of neurophysiology.
2021 08; 126(2):668-679. doi:
10.1152/jn.00277.2021. [PMID: 34259043] - Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R Lopez, Xiaochen Liu, Christine Diggle, Paul D Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.
Nature communications.
2021 07; 12(1):4293. doi:
10.1038/s41467-021-24644-1. [PMID: 34257294] - Robert J Brosnan, Bruno H Pypendop. Evaluation of whether acepromazine maleate causes fentanyl to decrease the minimum alveolar concentration of isoflurane in cats.
American journal of veterinary research.
2021 May; 82(5):352-357. doi:
10.2460/ajvr.82.5.352. [PMID: 33904805] - Marius Roaldsen, Timothy Ciosek, Elin Richardsen, Samer Al-Saad, Hiten Rh Patel, Erling Aarsaether. Isoflurane Increases Tolerance to Renal Ischemia Reperfusion Injury Compared to Propofol: An Experimental Study in Pigs.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2021 Apr; 34(4):359-365. doi:
10.1080/08941939.2019.1637038. [PMID: 31288581] - Gertrude J Nieuwenhuijs-Moeke, Dirk J Bosch, Henri G D Leuvenink. Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.
International journal of molecular sciences.
2021 Mar; 22(5):. doi:
10.3390/ijms22052727. [PMID: 33800423] - André Escobar, Michele Barletta, Bruno H Pypendop, Daniel M Sakai, Julie Gordon, Jane E Quandt. Pharmacokinetics and pharmacodynamics of methadone administered intravenously and intramuscularly to isoflurane-anesthetized chickens.
American journal of veterinary research.
2021 Mar; 82(3):181-188. doi:
10.2460/ajvr.82.3.181. [PMID: 33629899] - Claudia Gittel, Ellen Schulz-Kornas, Friederike A Sandbaumhüter, Regula Theurillat, Ingrid Vervuert, M Paula Larenza Menzies, Wolfgang Thormann, Christina Braun. Pharmacokinetics and pharmacodynamics of l-methadone in isoflurane-anaesthetized and mechanically ventilated ponies.
Veterinary anaesthesia and analgesia.
2021 Mar; 48(2):213-222. doi:
10.1016/j.vaa.2020.04.018. [PMID: 33423953] - Kátina Meneghetti Souza, Immaculata De Vivo, Chung-Yen Chen, Flávia Ribeiro Nogueira, Aline Garcia Aun, Nayara Micarelli Arruda, Juliana Rodrigues Lara, Mariane Aparecida P Silva, Drielle Baptista S Figueiredo, Camila Renata Corrêa, Lídia Raquel de Carvalho, José Reinaldo C Braz, Leandro Gobbo Braz, Mariana Gobbo Braz. Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers.
Environmental and molecular mutagenesis.
2021 02; 62(2):155-164. doi:
10.1002/em.22420. [PMID: 33341964] - Vesna Benković, Nikola Borojević, Dunja Šikić, Anica Horvat Knežević, Mirta Milić. DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo.
International journal of radiation biology.
2021; 97(10):1425-1435. doi:
10.1080/09553002.2021.1962565. [PMID: 34328801] - Tanya Duke-Novakovski, Carolina Palacios Jimenez, Masako Fujiyama, Shannon G Beazley. Plasma histamine concentrations in horses administered sodium penicillin, guaifenesin-xylazine-ketamine and isoflurane with morphine or butorphanol.
Veterinary anaesthesia and analgesia.
2021 Jan; 48(1):17-25. doi:
10.1016/j.vaa.2020.10.003. [PMID: 33229232] - Leon J DeLalio, Sean D Stocker. Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity.
American journal of physiology. Heart and circulatory physiology.
2021 01; 320(1):H117-H132. doi:
10.1152/ajpheart.00675.2020. [PMID: 33216622] - Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice.
The Journal of toxicological sciences.
2021; 46(6):289-301. doi:
10.2131/jts.46.289. [PMID: 34078836] - Xia-Nan Tang, Wen Yao, Hai-Xia Yao, Yi Zhang, Jing Yue. Influence of Isoflurane Exposure for 15 Consecutive Days on Ovarian Function in Adult Female Mice.
Current medical science.
2020 Dec; 40(6):1177-1181. doi:
10.1007/s11596-020-2300-3. [PMID: 33428147] - Aaron G Baer, Allen K Bourdon, Joshua M Price, Shawn R Campagna, Daniel A Jacobson, Helen A Baghdoyan, Ralph Lydic. Isoflurane anesthesia disrupts the cortical metabolome.
Journal of neurophysiology.
2020 12; 124(6):2012-2021. doi:
10.1152/jn.00375.2020. [PMID: 33112692] - Robert J Brosnan, Bruno H Pypendop, Scott D Stanley. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats.
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):533-537. doi:
10.1111/jvp.12886. [PMID: 32557697] - Rakesh V Sondekoppam, Karim H Narsingani, Trent A Schimmel, Brie M McConnell, Karen Buro, Timur J-P Özelsel. The impact of sevoflurane anesthesia on postoperative renal function: a systematic review and meta-analysis of randomized-controlled trials.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2020 Nov; 67(11):1595-1623. doi:
10.1007/s12630-020-01791-5. [PMID: 32812189] - Ismar Lima Cavalcanti, Estêvão Luiz Carvalho Braga, Nubia Verçosa, Alberto Schanaider, Louis Barrucand, Hans Donald de Boer, Luiz Vane. [Effects of rocuronium, sugammadex and rocuronium-sugammadex complex on coagulation in rats].
Brazilian journal of anesthesiology (Elsevier).
2020 Nov; 70(6):635-641. doi:
10.1016/j.bjan.2020.08.007. [PMID: 33218691] - Wei He, Songyuan Chi, Xing Jin, Jieyu Lu, Wei Zheng, Jie Yan, Duo Zhang. Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.
Neurochemical research.
2020 Oct; 45(10):2324-2335. doi:
10.1007/s11064-020-03091-2. [PMID: 32681443] - Tu Shen, You Shang, Qiaoling Wu, Hongwei Ren. The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway.
Toxicology.
2020 09; 442(?):152537. doi:
10.1016/j.tox.2020.152537. [PMID: 32663520] - Angela Jerath, Niall D Ferguson, Brian Cuthbertson. Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS.
Intensive care medicine.
2020 Aug; 46(8):1563-1566. doi:
10.1007/s00134-020-06154-8. [PMID: 32588067] - Alonso Guedes, Heather Knych, Laura Tucker, Daniel C Almeida, Caroline F Baldo, Erin Wendt-Hornickle, Sandra Allweiler. Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):369-376. doi:
10.1111/jvp.12855. [PMID: 32166760] - Gareth E Zeiler, Andrea Fuller, Eva Rioja, Peter Kamerman, Roxanne K Buck, Friederike Pohlin, Brighton T Dzikiti. Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score.
Veterinary anaesthesia and analgesia.
2020 Jul; 47(4):499-508. doi:
10.1016/j.vaa.2019.11.008. [PMID: 32507719] - Mahmud Arif Pavel, E Nicholas Petersen, Hao Wang, Richard A Lerner, Scott B Hansen. Studies on the mechanism of general anesthesia.
Proceedings of the National Academy of Sciences of the United States of America.
2020 06; 117(24):13757-13766. doi:
10.1073/pnas.2004259117. [PMID: 32467161] - Xiaoying Wang, Zuojin Liu, Lijuan Shen. [Isoflurane preconditioning inhibits caspase-11-related noncanonical pyroptosis pathway to alleviate hepatic ischemia-reperfusion injury in mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2020 May; 40(5):670-675. doi:
10.12122/j.issn.1673-4254.2020.05.09. [PMID: 32897214] - Genevieve C Luca, Linda S Barter, Bruno H Pypendop. Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus).
Veterinary anaesthesia and analgesia.
2020 May; 47(3):334-340. doi:
10.1016/j.vaa.2020.02.002. [PMID: 32222343] - Durriya Raza, Fauzia Anis Khan. Anaesthetic management for hiatal hernia repair in a child with Bartter's syndrome: A case report.
JPMA. The Journal of the Pakistan Medical Association.
2020 Apr; 70(4):737-739. doi:
10.5455/jpma.302642254. [PMID: 32296226] - Linda S Barter, Bruno H Pypendop. Plasma dopamine concentrations following dopamine infusion to isoflurane-anesthetized New Zealand White rabbits.
Veterinary anaesthesia and analgesia.
2020 Mar; 47(2):219-223. doi:
10.1016/j.vaa.2019.11.007. [PMID: 31982339] - Jigesh Patel, Ekram A Chowdhury, Behnam Noorani, Ulrich Bickel, Juyang Huang. Isoflurane increases cell membrane fluidity significantly at clinical concentrations.
Biochimica et biophysica acta. Biomembranes.
2020 02; 1862(2):183140. doi:
10.1016/j.bbamem.2019.183140. [PMID: 31790694] - Kin-Shing Poon, Yu-Ling Pan, Kate Hsiurong Liao, Hwai-Lee Wang, Kuen-Bao Chen, Hsiao-Yun Chen, Yu-Cheng Liu, Ted Weita Lai. Isoflurane attenuates carbogen-induced blood-brain barrier disruption independent of body temperature in mice and rats.
Neuroreport.
2020 01; 31(2):118-124. doi:
10.1097/wnr.0000000000001390. [PMID: 31895744] - Haiyan Jin, Minyan Wang, Jiangmei Wang, Hongmin Cao, Wanting Niu, Lizhong Du. Paeonol attenuates isoflurane anesthesia-induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2020 Jan; 33(1):81-91. doi:
10.1080/14767058.2018.1487396. [PMID: 29886761] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Pharmacokinetics of dexmedetomidine during administration of vatinoxan in male neutered cats anesthetized with isoflurane.
Journal of veterinary pharmacology and therapeutics.
2020 Jan; 43(1):1-5. doi:
10.1111/jvp.12796. [PMID: 31318080] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Pharmacokinetics of vatinoxan in male neutered cats anesthetized with isoflurane.
Veterinary anaesthesia and analgesia.
2020 Jan; 47(1):70-75. doi:
10.1016/j.vaa.2019.10.004. [PMID: 31806431] - Xin Cao, Yoshinobu Nagasawa, Chengshun Zhang, Hanxiao Zhang, Megumi Aimoto, Akira Takahara. Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model.
Journal of pharmacological sciences.
2019 Dec; 141(4):153-159. doi:
10.1016/j.jphs.2019.10.006. [PMID: 31757741] - Evan Ross, Justin D Thomason, Geoffrey R Browning, Hugues Beaufrère, David Eshar. Comparison of the effects of a dexmedetomidine-ketamine-midazolam anesthetic protocol versus isoflurane inhalation anesthesia on echocardiography variables and plasma cardiac troponin I concentration in black-tailed prairie dogs (Cynomys ludovicianus).
American journal of veterinary research.
2019 Dec; 80(12):1114-1121. doi:
10.2460/ajvr.80.12.1114. [PMID: 31763940] - Ruizhu Liu, Xuefeng Li, Guoqing Zhao. Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells.
Acta biochimica et biophysica Sinica.
2019 Nov; 51(11):1134-1141. doi:
10.1093/abbs/gmz104. [PMID: 31650158] - Marcela L Machado, Joao Hn Soares, Bruno H Pypendop, Natalia Henao-Guerrero, Noah D Pavlisko, Juliet Ross. Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.
Veterinary anaesthesia and analgesia.
2019 Nov; 46(6):736-744. doi:
10.1016/j.vaa.2019.06.005. [PMID: 31353195] - Alison T Jaeger, Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats.
Veterinary anaesthesia and analgesia.
2019 Nov; 46(6):753-764. doi:
10.1016/j.vaa.2019.05.012. [PMID: 31416697] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Konstantin J Tolkmitt, Sakine Simsekyilmaz, Julia Schipke, Christian Mühlfeld, Klaus T Preissner, Andreas Böning. Influence of Medication-Induced Preconditioning or Remote Ischemic Preconditioning on the Intrinsic Vascular Extracellular RNA/Ribonuclease System in Cardioprotection.
The Thoracic and cardiovascular surgeon.
2019 Sep; 67(6):494-501. doi:
10.1055/s-0038-1675398. [PMID: 30452075] - H Rossi, M Raekallio, M Määttä, H Tapio, M Hanifeh, J Junnila, M M Rajamäki, A Mykkänen. Effects of general anaesthesia in dorsal recumbency with and without vatinoxan on bronchoalveolar lavage cytology of healthy horses.
Veterinary journal (London, England : 1997).
2019 Sep; 251(?):105352. doi:
10.1016/j.tvjl.2019.105352. [PMID: 31492391] - H A Tapio, M R Raekallio, A K Mykkänen, D Al-Ramahi, M Scheinin, H J Hautajärvi, S Männikkö, O Vainio. Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Veterinary journal (London, England : 1997).
2019 Sep; 251(?):105345. doi:
10.1016/j.tvjl.2019.105345. [PMID: 31492389] - Vanessa Bettembourg, Daniela Dulgheriu, Henning Andreas Haga. Plasma concentrations at two dexmedetomidine constant rate infusions in isoflurane anaesthetized horses: a clinical study.
Veterinary anaesthesia and analgesia.
2019 Sep; 46(5):627-635. doi:
10.1016/j.vaa.2019.04.013. [PMID: 31395482] - Joakim Nyberg, Husong Li, Pehr Wessmark, Viktor Winther, Donald S Prough, Michael P Kinsky, Christer H Svensén. Population Kinetics of 0.9\% Saline Distribution in Hemorrhaged Awake and Isoflurane-anesthetized Volunteers.
Anesthesiology.
2019 09; 131(3):501-511. doi:
10.1097/aln.0000000000002816. [PMID: 31246604] - Regula Theurillat, Friederike A Sandbaumhüter, Claudia Gittel, M Paula Larenza Menzies, Christina Braun, Wolfgang Thormann. Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane.
Electrophoresis.
2019 08; 40(15):1959-1965. doi:
10.1002/elps.201900044. [PMID: 30900259] - Karen Gjendal, Jan Lund Ottesen, I Anna S Olsson, Dorte Bratbo Sørensen. Burrowing and nest building activity in mice after exposure to grid floor, isoflurane or ip injections.
Physiology & behavior.
2019 07; 206(?):59-66. doi:
10.1016/j.physbeh.2019.02.022. [PMID: 30790576] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats.
Veterinary anaesthesia and analgesia.
2019 Jul; 46(4):443-451. doi:
10.1016/j.vaa.2019.02.004. [PMID: 30982711] - Peng Yang, Ying Du, Haibo Zeng, Haoran Xing, Chunlin Tian, Xuejun Zou. Comparison of Inflammatory Markers Between the Sevoflurane and Isoflurane Anesthesia in a Rat Model of Liver Ischemia/Reperfusion Injury.
Transplantation proceedings.
2019 Jul; 51(6):2071-2075. doi:
10.1016/j.transproceed.2019.04.022. [PMID: 31303406] - Julie A Balko, Dana M Lindemann, Matthew C Allender, Sathya K Chinnadurai. Evaluation of the anesthetic and cardiorespiratory effects of intramuscular alfaxalone administration and isoflurane in budgerigars (Melopsittacus undulatus) and comparison with manual restraint.
Journal of the American Veterinary Medical Association.
2019 06; 254(12):1427-1435. doi:
10.2460/javma.254.12.1427. [PMID: 31149875] - Amirali Toossi, Dirk G Everaert, Richard R E Uwiera, David S Hu, Kevin Robinson, Ferrante S Gragasin, Vivian K Mushahwar. Effect of anesthesia on motor responses evoked by spinal neural prostheses during intraoperative procedures.
Journal of neural engineering.
2019 06; 16(3):036003. doi:
10.1088/1741-2552/ab0938. [PMID: 30790787] - Noemi Romagnoli, Andrea Barbarossa, Marco Cunto, Giulia Ballotta, Daniele Zambelli, Sara Armorini, Anna Zaghini, Carlotta Lambertini. Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: A randomized trial.
Veterinary anaesthesia and analgesia.
2019 May; 46(3):375-383. doi:
10.1016/j.vaa.2018.10.005. [PMID: 30981587] - Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Somasundaram Raghavan, Guru P Maiti, Cade Owens, Trevor Walker, John Wasnick, Steven Idell, Kumuda C Das. Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane.
American journal of physiology. Lung cellular and molecular physiology.
2019 05; 316(5):L903-L917. doi:
10.1152/ajplung.00142.2018. [PMID: 30810065] - Dorte B Sørensen, Stine B Metzdorff, Louise K Jensen, Kamilla H Andersen, Anne C Teilmann, Henrik E Jensen, Hanne Frøkiaer. Time-dependent Pathologic and Inflammatory Consequences of Various Blood Sampling Techniques in Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2019 05; 58(3):362-372. doi:
10.30802/aalas-jaalas-18-000064. [PMID: 30947767] - Ulrich H Frey, Marina Klaassen, Crista Ochsenfarth, Florian Murke, Matthias Thielmann, Eva Kottenberg, Petra Kleinbongard, Stefanie Klenke, Andrea Engler, Gerd Heusch, Bernd Giebel, Jürgen Peters. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients.
Acta anaesthesiologica Scandinavica.
2019 04; 63(4):483-492. doi:
10.1111/aas.13296. [PMID: 30548252] - Marlene Resch, Tania Neels, Alexander Tichy, Rupert Palme, Thomas Rülicke. Impact assessment of tail-vein injection in mice using a modified anaesthesia induction chamber versus a common restrainer without anaesthesia.
Laboratory animals.
2019 Apr; 53(2):190-201. doi:
10.1177/0023677218786982. [PMID: 30089439] - Benjamin Kennedy, Anne-Sophie Warner, Steven A Trim. REFERENCE INTERVALS FOR PLASMA BIOCHEMISTRY OF HEMOLYMPH IN SUBADULT CHILEAN ROSE TARANTULA (GRAMMASTOLA ROSEA) UNDER CHEMICAL RESTRAINT.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2019 03; 50(1):127-136. doi:
10.1638/2018-0037. [PMID: 31120671] - Naoya Iguchi, Junko Kosaka, Lindsea C Booth, Yoko Iguchi, Roger G Evans, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva. Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep.
British journal of anaesthesia.
2019 Mar; 122(3):342-349. doi:
10.1016/j.bja.2018.11.018. [PMID: 30770052] - Xu Lu, Chai Xiao-Qing. Eleutheroside E attenuates isoflurane-induced cognitive dysfunction by regulating the α7-nAChR-NMDAR pathway.
Neuroreport.
2019 02; 30(3):188-194. doi:
10.1097/wnr.0000000000001182. [PMID: 30585907] - Chisato Sumi, Yoshiyuki Matsuo, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Teppei Iwai, Hidemasa Bono, Kiichi Hirota. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma.
PloS one.
2019; 14(4):e0215072. doi:
10.1371/journal.pone.0215072. [PMID: 30986231] - Igor Maksimovic, Song Zhang, Ivan Vuckovic, Maria V Irazabal. Kidney harvesting and metabolite extraction for metabolomics studies in rodents.
Methods in cell biology.
2019; 154(?):15-29. doi:
10.1016/bs.mcb.2019.05.009. [PMID: 31493816] - Pei-Jun Chen, An-Quan Shang, Wei-Wei Wang, Jian-Ping Yang. Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane.
Journal of cellular biochemistry.
2019 01; 120(1):1028-1037. doi:
10.1002/jcb.27599. [PMID: 30277612] - James G Johnson, Jennifer N Langan, Sathya K Chinnadurai, Randi Drees, Mark Warneke, Matthew C Allender. COMPARISON OF TRANSCUTANEOUS ULTRASOUND AND COMPUTED TOMOGRAPHY EVALUATION OF KIDNEY SIZE AND EVALUATION OF ADRENAL GLAND SIZE USING ULTRASOUND IN A COLONY OF CALLIMICOS ( CALLIMICO GOELDII).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2018 12; 49(4):887-892. doi:
10.1638/2017-0078.1. [PMID: 30592929] - Mohamed Said Nakhli, Mohamed Kahloul, Taieb Guizani, Chekib Zedini, Ajmi Chaouch, Walid Naija. Intravenous lidocaine as adjuvant to general anesthesia in renal surgery.
The Libyan journal of medicine.
2018 Dec; 13(1):1433418. doi:
10.1080/19932820.2018.1433418. [PMID: 29433385] - M Abass, S Picek, J F G Garzón, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release.
Equine veterinary journal.
2018 Nov; 50(6):733-738. doi:
10.1111/evj.12947. [PMID: 29660154] - M Ran, Z Wang, H Yang, L Zhang, W Li, Q Yang, H Dong. Orexin-1 receptor is involved in ageing-related delayed emergence from general anaesthesia in rats.
British journal of anaesthesia.
2018 Nov; 121(5):1097-1104. doi:
10.1016/j.bja.2018.05.073. [PMID: 30336854] - David Miller, Sharon R Lewis, Michael W Pritchard, Oliver J Schofield-Robinson, Cliff L Shelton, Phil Alderson, Andrew F Smith. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
The Cochrane database of systematic reviews.
2018 08; 8(?):CD012317. doi:
10.1002/14651858.cd012317.pub2. [PMID: 30129968] - Fang Kang, ChaoLiang Tang, MingMing Han, XiaoQing Chai, Xiang Huang, Juan Li. Effects of Dexmedetomidine-Isoflurane versus Isoflurane Anesthesia on Brain Injury After Cardiac Valve Replacement Surgery.
Journal of cardiothoracic and vascular anesthesia.
2018 08; 32(4):1581-1586. doi:
10.1053/j.jvca.2017.11.028. [PMID: 29277297] - Nurdan Bedirli, Emin Umit Bagriacik, Guldal Yilmaz, Zerrin Ozkose, Mustafa Kavutçu, Aslı Cavunt Bayraktar, Abdulkadir Bedirli. Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis.
The Journal of international medical research.
2018 Jul; 46(7):2828-2842. doi:
10.1177/0300060518773265. [PMID: 29756489] - Manuel Martin-Flores, Daniel M Sakai, Juhana Honkavaara, Luis Campoy, Diego A Portela, Robin D Gleed. Hemodynamic effects of MK-467 following intravenous administration to isoflurane-anesthetized cats concurrently receiving dexmedetomidine.
American journal of veterinary research.
2018 Jul; 79(7):711-717. doi:
10.2460/ajvr.79.7.711. [PMID: 29943632] - R S Mangus, S B Kinsella, D T Farar, J A Fridell, L T Woolf, C A Kubal. Impact of Volatile Anesthetic Agents on Early Clinical Outcomes in Liver Transplantation.
Transplantation proceedings.
2018 Jun; 50(5):1372-1377. doi:
10.1016/j.transproceed.2018.03.001. [PMID: 29880359] - Michelle G Hawkins, Peter J Pascoe, Heather K DiMaio Knych, Tracy L Drazenovich, Philip H Kass, David Sanchez-Migallon Guzman. Effects of three fentanyl plasma concentrations on the minimum alveolar concentration of isoflurane in Hispaniolan Amazon parrots (Amazona ventralis).
American journal of veterinary research.
2018 Jun; 79(6):600-605. doi:
10.2460/ajvr.79.6.600. [PMID: 30085862]
