Methylarsonate (BioDeep_00000006458)
Secondary id: BioDeep_00001868138
human metabolite Endogenous
代谢物信息卡片
Monomethylarsonic acid, ammonium, iron (3+) salt
化学式: CH5AsO3 (139.9455)
中文名称: 甲基胂酸
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 10.49%
分子结构信息
SMILES: C[As](=O)(O)O
InChI: InChI=1S/CH5AsO3/c1-2(3,4)5/h1H3,(H2,3,4,5)
描述信息
Methylarsonate is used as a contact herbicide in either the monosodium or disodium salt form. It goes by the trade names Weed-E-Rad, Ansar 170 H.C., Ansar 529 H.C., DiTac and others. Methylarsonate is considered only slightly toxic, having an oral LD50 of 2200 mg/Kg for rats. The inhalation risk is greater with LD50 Rats >20 mg. Long term studies with people exposed to organoarsenicals has shown an increased risk of skin cancer (Spiewak, 2001), lung cancer and some liver cancers, although some recent studies have shown some arsenic containing compounds (specifically Arsine trioxide) may have anticarcinogenic properties (Wang, 2001). In mammals, Methylarsonate is also an intermediate in the detoxification of inorganic arsenic. In the arsenate detoxification I pathway, arsenite reacts with S-adenosyl-L-methionine to produce methylarsonate and S-adenosyl-L-homocysteine. Arsenite methyltransferase catalyzes this reaction. Methylarsonate then reacts with 2 glutathione molecules to produce glutathione disulfide and methylarsonite. This reaction is catalyzed by methylarsonate reductase. Methylarsonate is an organic arsenic compound with adverse effects similar to those of arsenic trioxide. Arsenic is found in the environment primarily as arsenate and arsenite species. Arsenate is reduced to arsenite by arsenate reductase and can be subsequently methylated to Methylarsonate. This is then reduced and methylated to Dimethylarsinate, which can excreted and is considerably less toxic to the organism than any of the previous intermediate compounds. Methylarsonate was formerly included in some vitamin and mineral preparations. It was once used to treat tuberculosis, chorea, and other affections in which the cacodylates were used.
Methylarsonate is used as a contact herbicide in either the monosodium or disodium salt form. It goes by the trade names Weed-E-Rad, Ansar 170 H.C., Ansar 529 H.C., DiTac and others. Methylarsonate is considered only slightly toxic, having an oral LD50 of 2200 mg/Kg for rats. The inhalation risk is greater with LD50 Rats >20 mg. Long term studies with people exposed to organoarsenicals has shown an increased risk of skin cancer (Spiewak, 2001), lung cancer and some liver cancers, although some recent studies have shown some arsenic containing compounds (specifically Arsine trioxide) may have anticarcinogenic properties (Wang, 2001). In mammals, Methylarsonate is also an intermediate in the detoxification of inorganic arsenic.
D010575 - Pesticides > D006540 - Herbicides
D009676 - Noxae > D013723 - Teratogens
D016573 - Agrochemicals
同义名列表
34 个代谢物同义名
Monomethylarsonic acid, ammonium, iron (3+) salt; Monomethylarsonic acid, iron (2+) salt (3:2); Monomethylarsonic acid, dimercury (1+) salt; Monomethylarsonic acid, calcium salt (2:1); Monomethylarsonic acid, monoammonium salt; Monomethylarsonic acid, monocalcium salt; Monomethylarsonic acid, dipotassium salt; Monomethylarsonic acid, monosodium salt; Monomethylarsonic acid, disodium salt; Monomethylarsonic acid, zinc salt; Monomethylarsonic acid, iron salt; Kyselina methylarsonova [czech]; Monosodium methanearsonate; Methylarsonic acid [iso]; Disodium methanearsonate; Kyselina methylarsonova; Sodium methanearsonate; Monomethylarsinic acid; Monomethylarsonic acid; methylarsonous acid; Methanearsonic acid; Methyl arsonic acid; Methylarsinic acid; Methylarsenic acid; Methylarsonic acid; Monomethylarsonate; Methanearsonate; Methylarsonate; Dsma (jmaf); MeAsO(OH)2; MSMA; MAA; Methylarsonate; Methylarsonic acid
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:29852
- KEGG: C07294
- PubChem: 8948
- HMDB: HMDB0012258
- Metlin: METLIN62894
- ChEMBL: CHEMBL1743208
- Wikipedia: Methylarsonic acid
- MetaCyc: METHYLARSONATE
- foodb: FDB028897
- chemspider: 8604
- CAS: 4950-59-8
- CAS: 124-58-3
- PMhub: MS000019503
- ChEBI: CHEBI:16005
- PubChem: 9503
- NIKKAJI: J3.259J
- KNApSAcK: 16005
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Arsenate Detoxification:
Dimethylarsinate + Hydrogen Ion + reduced electron acceptor ⟶ Dimethylarsinous acid + Water + oxidized electron acceptor
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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