Nedocromil (BioDeep_00000006446)
Secondary id: BioDeep_00001868197
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid
化学式: C19H17NO7 (371.1005)
中文名称: 奈多罗米
谱图信息:
最多检出来源 Homo sapiens(blood) 5.47%
分子结构信息
SMILES: CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)O)C(=O)C=C(N2CC)C(=O)O
InChI: InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
描述信息
Nedocromil is only found in individuals that have used or taken this drug. It is a pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. [PubChem]Nedocromil has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil inhibits activation and release of inflammatory mediators such as histamine, prostaglandin D2 and leukotrienes c4 from different types of cells in the lumen and mucosa of the bronchial tree. These mediators are derived from arachidonic acid metabolism through the lipoxygenase and cyclo-oxygenase pathways. The mechanism of action of nedocromil may be due partly to inhibition of axon reflexes and release of sensory neuropeptides, such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. The result is inhibition of bradykinin-induced bronchoconstriction. Nedocromil does not posess any bronchodilator, antihistamine, or corticosteroid activity.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BC - Antiallergic agents, excl. corticosteroids
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AC - Antiallergic agents, excl. corticosteroids
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D000893 - Anti-Inflammatory Agents > D000082142 - Mast Cell Stabilizers
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D018926 - Anti-Allergic Agents
D007155 - Immunologic Factors
Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
同义名列表
35 个代谢物同义名
9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid; 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylate; 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure; 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno[7,6-b]pyridine-2,8-dicarboxylic acid; Rhône-poulenc rorer brand OF nedocromil sodium; Aventis behring brand OF nedocromil sodium; ASTA medica brand OF nedocromil sodium; Allergan brand OF nedocromil sodium; Pantheon brand OF nedocromil sodium; Aventis brand OF nedocromil sodium; Nedocromil, disodium salt, hydrate; Fisons brand OF nedocromil sodium; Lesvi brand OF nedocromil sodium; Vita brand OF nedocromil sodium; Nedocromil, calcium salt (1:1); Nedocromil, disodium salt; Calcium, nedocromil; Nedocromil calcium; Sodium, nedocromil; NEDOCROMIL SODIUM; Nedocromilum; Nedocromilo; NEDOCROMIL; Tilavist; Cetimil; Rapitil; Tilaire; Halamid; Brionil; Alocril; Tilade; Irtan; Tilad; FPL 59002; Nedocromil
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:7492
- KEGG: C07255
- KEGGdrug: D05129
- PubChem: 50294
- HMDB: HMDB0014854
- Metlin: METLIN1468
- DrugBank: DB00716
- ChEMBL: CHEMBL746
- Wikipedia: Nedocromil
- MeSH: Nedocromil
- chemspider: 45608
- CAS: 69049-73-6
- PMhub: MS000019488
- PubChem: 9464
- NIKKAJI: J32.507D
- RefMet: Nedocromil
- medchemexpress: HY-13448
- KNApSAcK: 7492
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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