Mibefradil (BioDeep_00000006444)
代谢物信息卡片
2-methoxyacetic acid [2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] ester
化学式: C29H38FN3O3 (495.2897)
中文名称: 米贝地尔
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F
InChI: InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6920
- ChEBI: CHEBI:94386
- KEGG: C07222
- KEGGdrug: D08217
- PubChem: 60663
- PubChem: 5230270
- Metlin: METLIN1276
- DrugBank: DB01388
- ChEMBL: CHEMBL45816
- ChEMBL: CHEMBL3706574
- MeSH: Mibefradil
- CAS: 116644-53-2
- PMhub: MS000019486
- PubChem: 9431
- PDB-CCD: MWV
- NIKKAJI: J281.718G
- RefMet: Mibefradil
- KNApSAcK: 6920
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Wu, Y Wu, Y Yang, J Yu, R Fu, Y Sun, Q Xiao. [Mibefradil improves skeletal muscle mass, function and structure in obese mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Jul; 42(7):1032-1037. doi:
10.12122/j.issn.1673-4254.2022.07.10. [PMID: 35869766] - Sudha Priya Soundara Pandi, Michael J Shattock, Bruce M Hendry, Claire C Sharpe. Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1.
BMC nephrology.
2022 06; 23(1):211. doi:
10.1186/s12882-022-02844-1. [PMID: 35710406] - Mohammed Sedeeq, Ahmed Maklad, Taush Dutta, Zikai Feng, Richard Wilson, Nuri Gueven, Iman Azimi. T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity.
Molecular neurobiology.
2022 May; 59(5):2932-2945. doi:
10.1007/s12035-022-02771-0. [PMID: 35243582] - Heng Zhang, Chen Chen, Yue Liu, Lu Ren, Jing Qi, Yang Yang, Wei Chen, Yingjia Yao, Xintong Cai, Zhuang Liu, Miao Hao, Lingkang Li, Zisu Deng, Mingyu Sun, Yongping Lu, Keyan Chen, Ping Hou. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.
Oxidative medicine and cellular longevity.
2022; 2022(?):8488269. doi:
10.1155/2022/8488269. [PMID: 36199421] - Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff. Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas.
Neuro-oncology.
2017 06; 19(6):845-852. doi:
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Pflugers Archiv : European journal of physiology.
2016 Apr; 468(4):541-50. doi:
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2014 Aug; 24(15):3234-7. doi:
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British journal of pharmacology.
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2008 Oct; 51(20):6471-7. doi:
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The American journal of pathology.
2007 Jul; 171(1):162-71. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2007 Jul; 35(7):1232-8. doi:
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Circulation research.
2007 Feb; 100(3):342-53. doi:
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Bioorganic & medicinal chemistry.
2007 Feb; 15(3):1409-19. doi:
10.1016/j.bmc.2006.11.004. [PMID: 17150365] - Hayrettin Ozturk, Hulya Ozturk, Hatun Duran, Ali Kemal Uzunlar. Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.
Digestive diseases and sciences.
2006 Aug; 51(8):1454-60. doi:
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Endocrinology.
2006 Jul; 147(7):3539-46. doi:
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The Journal of pharmacy and pharmacology.
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Cell calcium.
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The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G249-53. doi:
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The Keio journal of medicine.
2005 Jun; 54(2):102-8. doi:
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Circulation research.
2005 Apr; 96(8):864-72. doi:
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American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H923-35. doi:
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Cell calcium.
2005 Feb; 37(2):105-19. doi:
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Renal failure.
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The American journal of cardiology.
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