Mibefradil (BioDeep_00000006444)
Volatile Flavor Compounds
代谢物信息卡片
2-methoxyacetic acid [2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] ester
化学式: C29H38FN3O3 (495.289705)
中文名称: 米贝地尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F
InChI: InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6920
- ChEBI: CHEBI:94386
- KEGG: C07222
- KEGGdrug: D08217
- PubChem: 60663
- PubChem: 5230270
- Metlin: METLIN1276
- DrugBank: DB01388
- ChEMBL: CHEMBL45816
- ChEMBL: CHEMBL3706574
- MeSH: Mibefradil
- CAS: 116644-53-2
- PMhub: MS000019486
- PubChem: 9431
- PDB-CCD: MWV
- NIKKAJI: J281.718G
- RefMet: Mibefradil
- KNApSAcK: 6920
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Wu, Y Wu, Y Yang, J Yu, R Fu, Y Sun, Q Xiao. [Mibefradil improves skeletal muscle mass, function and structure in obese mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Jul; 42(7):1032-1037. doi:
10.12122/j.issn.1673-4254.2022.07.10. [PMID: 35869766] - Sudha Priya Soundara Pandi, Michael J Shattock, Bruce M Hendry, Claire C Sharpe. Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1.
BMC nephrology.
2022 06; 23(1):211. doi:
10.1186/s12882-022-02844-1. [PMID: 35710406] - Mohammed Sedeeq, Ahmed Maklad, Taush Dutta, Zikai Feng, Richard Wilson, Nuri Gueven, Iman Azimi. T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity.
Molecular neurobiology.
2022 May; 59(5):2932-2945. doi:
10.1007/s12035-022-02771-0. [PMID: 35243582] - Heng Zhang, Chen Chen, Yue Liu, Lu Ren, Jing Qi, Yang Yang, Wei Chen, Yingjia Yao, Xintong Cai, Zhuang Liu, Miao Hao, Lingkang Li, Zisu Deng, Mingyu Sun, Yongping Lu, Keyan Chen, Ping Hou. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.
Oxidative medicine and cellular longevity.
2022; 2022(?):8488269. doi:
10.1155/2022/8488269. [PMID: 36199421] - Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff. Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas.
Neuro-oncology.
2017 06; 19(6):845-852. doi:
10.1093/neuonc/nox020. [PMID: 28371832] - Rasmus Hassing Frandsen, Max Salomonsson, Pernille B L Hansen, Lars J Jensen, Thomas Hartig Braunstein, Niels-Henrik Holstein-Rathlou, Charlotte Mehlin Sorensen. No apparent role for T-type Ca²⁺ channels in renal autoregulation.
Pflugers Archiv : European journal of physiology.
2016 Apr; 468(4):541-50. doi:
10.1007/s00424-015-1770-9. [PMID: 26658945] - Minsoo Han, Chiman Song, Nakcheol Jeong, Hoh-Gyu Hahn. Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
ACS medicinal chemistry letters.
2014 Sep; 5(9):999-1004. doi:
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Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3234-7. doi:
10.1016/j.bmcl.2014.06.026. [PMID: 24974340] - Yuan Zhang, Junhong Zhang, Dongsheng Jiang, Dong Zhang, Zhiyuan Qian, Chunfeng Liu, Jin Tao. Inhibition of T-type Ca²⁺ channels by endostatin attenuates human glioblastoma cell proliferation and migration.
British journal of pharmacology.
2012 Jun; 166(4):1247-60. doi:
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2011 Dec; 26(12):1634-7. doi:
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2011 Dec; 358(1-2):1-11. doi:
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Hypertension (Dallas, Tex. : 1979).
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American journal of physiology. Lung cellular and molecular physiology.
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2010 Jan; 8(?):7. doi:
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Journal of biomedicine & biotechnology.
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PLoS genetics.
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Journal of medicinal chemistry.
2008 Oct; 51(20):6471-7. doi:
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2008 Sep; 105(1):147-57. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2008 Apr; 38(4):368-81. doi:
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Current pharmaceutical design.
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The American journal of pathology.
2007 Jul; 171(1):162-71. doi:
10.2353/ajpath.2007.070054. [PMID: 17591963] - Akiko Watanabe, Koichi Nakamura, Noriko Okudaira, Osamu Okazaki, Ken-ichi Sudo. Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jul; 35(7):1232-8. doi:
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Circulation research.
2007 Feb; 100(3):342-53. doi:
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Bioorganic & medicinal chemistry.
2007 Feb; 15(3):1409-19. doi:
10.1016/j.bmc.2006.11.004. [PMID: 17150365] - Hayrettin Ozturk, Hulya Ozturk, Hatun Duran, Ali Kemal Uzunlar. Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.
Digestive diseases and sciences.
2006 Aug; 51(8):1454-60. doi:
10.1007/s10620-005-9060-6. [PMID: 16868826] - Walter Raasch, Christian Wittmershaus, Andreas Dendorfer, Inga Voges, Friedrich Pahlke, Christoph Dodt, Peter Dominiak, Olaf Jöhren. Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats.
Endocrinology.
2006 Jul; 147(7):3539-46. doi:
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The Journal of pharmacy and pharmacology.
2006 May; 58(5):633-41. doi:
10.1211/jpp.58.5.0008. [PMID: 16640832] - Florian Gackière, Gabriel Bidaux, Philippe Lory, Natalia Prevarskaya, Pascal Mariot. A role for voltage gated T-type calcium channels in mediating "capacitative" calcium entry?.
Cell calcium.
2006 Apr; 39(4):357-66. doi:
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The Journal of physiology.
2005 Sep; 567(Pt 2):445-57. doi:
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The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G249-53. doi:
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The Keio journal of medicine.
2005 Jun; 54(2):102-8. doi:
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Circulation research.
2005 Apr; 96(8):864-72. doi:
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American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H923-35. doi:
10.1152/ajpheart.01126.2003. [PMID: 15498818] - Amith Panner, Leanne L Cribbs, Gina M Zainelli, Thomas C Origitano, Sanjay Singh, Robert D Wurster. Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.
Cell calcium.
2005 Feb; 37(2):105-19. doi:
10.1016/j.ceca.2004.07.002. [PMID: 15589991] - Ayten Gezici, Hayrettin Ozturk, Hulya Ozturk. The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Renal failure.
2005; 27(6):775-81. doi:
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2005; 23(2):173-96. doi:
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Molecular pharmacology.
2004 12; 66(6):1652-61. doi:
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Biochemical and biophysical research communications.
2004 Nov; 324(1):401-8. doi:
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The American journal of cardiology.
2004 Nov; 94(9):1140-6. doi:
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The Journal of steroid biochemistry and molecular biology.
2004 Oct; 92(3):209-18. doi:
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Kidney international.
2004 Sep; 66(3):1090-8. doi:
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Kidney international.
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American journal of physiology. Renal physiology.
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The Journal of pharmacology and experimental therapeutics.
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European journal of pharmacology.
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Canadian journal of physiology and pharmacology.
2004 Jan; 82(1):30-7. doi:
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2003 Dec; 42(6):697-702. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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Assay and drug development technologies.
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Journal of clinical pharmacology.
2003 Oct; 43(10):1091-100. doi:
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