Hyperforin (BioDeep_00000000640)

 

Secondary id: BioDeep_00000288205

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)-

化学式: C35H52O4 (536.3865)
中文名称: 贯叶金丝桃素 二环己基铵盐, 贯叶金丝桃素
谱图信息: 最多检出来源 Homo sapiens(otcml) 1.87%

分子结构信息

SMILES: CC(=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@]2(CC=C(C)C)C(=O)C(=C([C@@]1(C(=O)C(C)C)C2=O)O)CC=C(C)C)C
InChI: InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3

描述信息

Hyperforin is a cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. Johns Wort, Hypericum perforatum. It has a role as a GABA reuptake inhibitor, a plant metabolite, an anti-inflammatory agent, an antidepressant, an antibacterial agent, an antineoplastic agent and an apoptosis inducer. It is a cyclic terpene ketone, a sesquarterpenoid and a carbobicyclic compound.
Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is Hypericum perforatum, also known as St Johns wort.
Hyperforin is a natural product found in Hypericum linarioides, Hypericum rumeliacum, and other organisms with data available.
Hyperforin is found in alcoholic beverages. Hyperforin is a constituent of Hypericum perforatum (St Johns Wort) Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St Johns wort). The structure of hyperforin was elucidated by a research group from the Shemyakin Institute of Bio-organic Chemistry (USSR Academy of Sciences in Moscow) and published in 1975. Hyperforin is a prenylated phloroglucinol derivative. Total synthesis of hyperforin has not yet been accomplished, despite attempts by several research groups
Constituent of Hypericum perforatum (St Johns Wort)

同义名列表

25 个代谢物同义名

Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)-; BICYCLO(3.3.1)NON-3-ENE-2,9-DIONE, 4-HYDROXY-6-METHYL-1,3,7-TRIS(3-METHYL-2-BUTEN-1-YL)-5-(2-METHYL-1-OXOPROPYL)-6-(4-METHYL-3-PENTEN-1-YL)-, (1R,5S,6R,7S)-; Bicyclo(3.3.1)(1,4)benzodiazepin-5-one, 4-Hydroxy-6-methyl-1,3,7-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-pentenyl)-, (1R,5S,6R,7S)-; Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-; (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; (1R,5S,6R,7S)-4-hydroxy-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione; 5-hydroxy-6R-methyl-1R,3,7S-tris(3-methyl-2-butenyl)-5S-(2-methyl-1-oxopropyl)-6R-(4-methyl-3-pentenyl)-bicyclo[3.3.1]non-3-ene-2,9-dione; 4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione; 4-Hydroxy-6-methyl-1,3,7-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-pentenyl) bicyclo(3.3.1)non-3-ene-2,9-dione; HYPERFORIN (CONSTITUENT OF ST. JOHNS WORT) [DSC]; KGSZHKRKHXOAMG-HQKKAZOISA-N; IWBJJCOKGLUQIZ-HQKKAZOISA-N; Hyperforin, >=85\\% (HPLC); tetrahydrohyperforin; HYPERFORIN [WHO-DD]; octahydrohyperforin; HYPERFORIN [HSDB]; Spectrum5_002025; HYPERFORIN [MI]; (+)-Hyperforin; PDSP2_001346; hyperforine; hiperforina; Hyperforin; Hyperforin



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

103 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, AKT1, ALOX5, ANG, BCL2, BDNF, CASP3, CASP9, CYP2C19, CYP2C9, CYP3A4, PTGS2, TRPC6, VEGFA
Peripheral membrane protein 4 ACHE, ALOX5, CYP1B1, PTGS2
Endoplasmic reticulum membrane 7 BCL2, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, PTGS2
Nucleus 8 ACHE, AKT1, ANG, BCL2, CASP3, CASP9, NR1I2, VEGFA
cytosol 6 AKT1, ALOX5, ANG, BCL2, CASP3, CASP9
dendrite 1 BDNF
nuclear body 1 NR1I2
nucleoplasm 4 AKT1, ALOX5, CASP3, NR1I2
Cell membrane 5 ABCB1, ACHE, AKT1, TRPC3, TRPC6
lamellipodium 1 AKT1
Multi-pass membrane protein 3 ABCB1, TRPC3, TRPC6
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ABCB1, ACHE, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ACHE, VEGFA
growth cone 1 ANG
neuromuscular junction 1 ACHE
neuronal cell body 2 ANG, CASP3
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 ALOX5
plasma membrane 7 ABCB1, ACHE, AKT1, CYP2C19, CYP2C9, TRPC3, TRPC6
Membrane 10 ABCB1, ACHE, AKT1, BCL2, BDNF, CYP1B1, CYP3A4, TRPC3, TRPC6, VEGFA
apical plasma membrane 1 ABCB1
axon 1 BDNF
caveola 1 PTGS2
extracellular exosome 1 ABCB1
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 6 ACHE, ALOX5, ANG, BDNF, IL6, VEGFA
perinuclear region of cytoplasm 3 ACHE, ALOX5, BDNF
adherens junction 1 VEGFA
mitochondrion 3 BCL2, CASP9, CYP1B1
protein-containing complex 4 AKT1, BCL2, CASP9, PTGS2
intracellular membrane-bounded organelle 5 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
Microsome membrane 5 CYP1A2, CYP1B1, CYP2C9, CYP3A4, PTGS2
postsynaptic density 1 CASP3
Secreted 5 ACHE, ANG, BDNF, IL6, VEGFA
extracellular region 6 ACHE, ALOX5, ANG, BDNF, IL6, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Extracellular side 1 ACHE
transcription regulator complex 1 NR1I2
Nucleus membrane 2 ALOX5, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 ALOX5, BCL2
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
slit diaphragm 1 TRPC6
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
cell-cell junction 1 AKT1
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 ALOX5
pore complex 1 BCL2
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 2 ACHE, ANG
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 NR1I2
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
side of membrane 1 ACHE
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 NR1I2
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
endoplasmic reticulum lumen 3 BDNF, IL6, PTGS2
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
apoptosome 1 CASP9
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
cation channel complex 2 TRPC3, TRPC6
caspase complex 1 CASP9


文献列表

  • Myriam El Biali, Michael Wölfl-Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer. St. John's wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier. Clinical and translational science. 2024 May; 17(5):e13804. doi: 10.1111/cts.13804. [PMID: 38700454]
  • Vanessa Fabienne Abegg, Miljenko Valentin Panajatovic, Riccardo Vincenzo Mancuso, Julien Arthur Allard, Urs Duthaler, Alex Odermatt, Stephan Krähenbühl, Jamal Bouitbir. Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. Toxicology letters. 2024 Jan; 393(?):1-13. doi: 10.1016/j.toxlet.2024.01.008. [PMID: 38219807]
  • Alexandre Bouron. Cellular neurobiology of hyperforin. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8063. [PMID: 37963759]
  • Anima M Schäfer, Marta A Rysz, Julia Schädeli, Michelle Hübscher, Haleh Khosravi, Michelle Fehr, Isabell Seibert, Olivier Potterat, Martin Smieško, Henriette E Meyer Zu Schwabedissen. St. John's wort formulations induce rat CYP3A23-3A1 independent of their hyperforin content. Molecular pharmacology. 2023 Oct; ?(?):. doi: 10.1124/molpharm.123.000725. [PMID: 37863663]
  • Moritz Winker, Antoine Chauveau, Martin Smieško, Olivier Potterat, Alexander Areesanan, Amy Zimmermann-Klemd, Carsten Gründemann. Immunological evaluation of herbal extracts commonly used for treatment of mental diseases during pregnancy. Scientific reports. 2023 Jun; 13(1):9630. doi: 10.1038/s41598-023-35952-5. [PMID: 37316493]
  • Antoine Chauveau, Andrea Treyer, Annelies Geirnaert, Lea Bircher, Angela Babst, Vanessa Fabienne Abegg, Ana Paula Simões-Wüst, Christophe Lacroix, Olivier Potterat, Matthias Hamburger. Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Apr; 162(?):114652. doi: 10.1016/j.biopha.2023.114652. [PMID: 37027987]
  • Aleksandra Brankiewicz, Sara Trzos, Magdalena Mrożek, Małgorzata Opydo, Elżbieta Szostak, Michał Dziurka, Monika Tuleja, Agnieszka Łoboda, Ewa Pocheć. Cytotoxic and Antioxidant Activity of Hypericum perforatum L. Extracts against Human Melanoma Cells from Different Stages of Cancer Progression, Cultured under Normoxia and Hypoxia. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031509. [PMID: 36771178]
  • Xin-Xin Li, Yu Yan, Jia Zhang, Kang Ding, Cong-Yuan Xia, Xue-Ge Pan, Yan-Jing Shi, Jie-Kun Xu, Jun He, Wei-Ku Zhang. Hyperforin: A natural lead compound with multiple pharmacological activities. Phytochemistry. 2023 Feb; 206(?):113526. doi: 10.1016/j.phytochem.2022.113526. [PMID: 36442576]
  • Zheng Zhang, Chuan Yao, Min Li, Li-Chuang Wang, Wei Huang, Qing-Jie Chen. Prophylactic effects of hyperforin on anhedonia-like phenotype in chronic restrain stress model: A role of gut microbiota. Letters in applied microbiology. 2022 Nov; 75(5):1103-1110. doi: 10.1111/lam.13710. [PMID: 35348232]
  • Song Wu, Ana Luisa Malaco Morotti, Shanshan Wang, Ya Wang, Xiaoyan Xu, Jianghua Chen, Guodong Wang, Evangelos C Tatsis. Convergent gene clusters underpin hyperforin biosynthesis in St John's wort. The New phytologist. 2022 07; 235(2):646-661. doi: 10.1111/nph.18138. [PMID: 35377483]
  • Esra Saçıcı, Erdem Yesilada. Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species. Phytochemical analysis : PCA. 2022 Apr; 33(3):355-364. doi: 10.1002/pca.3093. [PMID: 34734668]
  • Aneliya Knauthe, Sonnhild Mittag, Laura Bloch, Kai Frederik Albring, Martin Schmidt, Oliver Werz, Otmar Huber. Hyperforin and Myrtucommulone Derivatives Act as Natural Modulators of Wnt/β-Catenin Signaling in HCT116 Colon Cancer Cells. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23062984. [PMID: 35328403]
  • Suzhen Chen, Xiaoxiao Liu, Chao Peng, Chang Tan, Honglin Sun, He Liu, Yao Zhang, Ping Wu, Can Cui, Chuchu Liu, Di Yang, Zhiqiang Li, Junxi Lu, Jian Guan, Xisong Ke, Renxiao Wang, Xiaohai Bo, Xiaojun Xu, Junfeng Han, Junli Liu. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell metabolism. 2021 03; 33(3):565-580.e7. doi: 10.1016/j.cmet.2021.02.007. [PMID: 33657393]
  • Noriko Shinjyo, Hideyuki Nakayama, Li Li, Kanji Ishimaru, Kenji Hikosaka, Noriyuki Suzuki, Hiroki Yoshida, Kazumi Norose. Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro. Journal of ethnopharmacology. 2021 Mar; 267(?):113525. doi: 10.1016/j.jep.2020.113525. [PMID: 33129946]
  • Katerina Makarova, Joanna J Sajkowska-Kozielewicz, Katarzyna Zawada, Ewa Olchowik-Grabarek, Michał Aleksander Ciach, Krzysztof Gogolewski, Natalia Dobros, Paulina Ciechowicz, Hélène Freichels, Anna Gambin. Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John's wort's (Hypericum perforatum L.) flowers. Scientific reports. 2021 02; 11(1):3989. doi: 10.1038/s41598-021-83409-4. [PMID: 33597594]
  • Michela Novelli, Pellegrino Masiello, Pascale Beffy, Marta Menegazzi. Protective Role of St. John's Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies. International journal of molecular sciences. 2020 Oct; 21(21):. doi: 10.3390/ijms21218108. [PMID: 33143088]
  • Paride Rizzo, Lothar Altschmied, Beena M Ravindran, Twan Rutten, John C D'Auria. The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum Perforatum L., One of the Largest Medicinal Crops in Europe. Genes. 2020 10; 11(10):. doi: 10.3390/genes11101210. [PMID: 33081197]
  • Chia-Hung Kuo, Yi-Chin Chou, Kuo-Chun Liao, Chwen-Jen Shieh, Tzu-Shing Deng. Optimization of Light Intensity, Temperature, and Nutrients to Enhance the Bioactive Content of Hyperforin and Rutin in St. John's Wort. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184256. [PMID: 32948004]
  • Anja Traeger, Susanna Voelker, Blerina Shkodra-Pula, Christian Kretzer, Stephanie Schubert, Michael Gottschaldt, Ulrich S Schubert, Oliver Werz. Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles. Molecular pharmaceutics. 2020 03; 17(3):810-816. doi: 10.1021/acs.molpharmaceut.9b01051. [PMID: 31967843]
  • Catherine Zahner, Esther Kruttschnitt, Julia Uricher, Michael Lissy, Martin Hirsch, Simon Nicolussi, Stephan Krähenbühl, Jürgen Drewe. No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein. Clinical pharmacology and therapeutics. 2019 08; 106(2):432-440. doi: 10.1002/cpt.1392. [PMID: 30739325]
  • Jeffry Adiwidjaja, Alan V Boddy, Andrew J McLachlan. Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John's Wort. Clinical pharmacokinetics. 2019 07; 58(7):911-926. doi: 10.1007/s40262-019-00736-6. [PMID: 30675694]
  • Ilkay Erdogan Orhan, F Sezer Senol Deniz, Steinar Traedal-Henden, José P Cerón-Carrasco, Helena den Haan, Jorge Peña-García, Horacio Pérez-Sánchez, Esra Emerce, Krystyna Skalicka-Wozniak. Profiling Auspicious Butyrylcholinesterase Inhibitory Activity of Two Herbal Molecules: Hyperforin and Hyuganin C. Chemistry & biodiversity. 2019 May; 16(5):e1900017. doi: 10.1002/cbdv.201900017. [PMID: 30891904]
  • Nelli Keksel, Hendrik Bussmann, Matthias Unger, Jürgen Drewe, Georg Boonen, Hanns Häberlein, Sebastian Franken. St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 54(?):66-76. doi: 10.1016/j.phymed.2018.06.013. [PMID: 30668384]
  • Haoran Wang, Bing Shao, Hongyan Yu, Feibo Xu, Peiyan Wang, Kaiyuan Yu, Yanfei Han, Miao Song, Yanfei Li, Zheng Cao. Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells. Chemico-biological interactions. 2019 Feb; 299(?):15-26. doi: 10.1016/j.cbi.2018.11.016. [PMID: 30481499]
  • Sigrun Chrubasik-Hausmann, Julia Vlachojannis, Andrew J McLachlan. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. The Journal of pharmacy and pharmacology. 2019 Jan; 71(1):129-138. doi: 10.1111/jphp.12858. [PMID: 29411879]
  • Michela Novelli, Pascale Beffy, Alex Gregorelli, Svetlana Porozov, Fabrizio Mascia, Chiara Vantaggiato, Pellegrino Masiello, Marta Menegazzi. Persistence of STAT-1 inhibition and induction of cytokine resistance in pancreatic β cells treated with St John's wort and its component hyperforin. The Journal of pharmacy and pharmacology. 2019 Jan; 71(1):93-103. doi: 10.1111/jphp.12823. [PMID: 28990659]
  • Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. European journal of medicinal chemistry. 2018 Jun; 153(?):2-28. doi: 10.1016/j.ejmech.2017.12.059. [PMID: 29329790]
  • Sławomir Dresler, Jozef Kováčik, Maciej Strzemski, Ireneusz Sowa, Magdalena Wójciak-Kosior. Methodological aspects of biologically active compounds quantification in the genus Hypericum. Journal of pharmaceutical and biomedical analysis. 2018 Jun; 155(?):82-90. doi: 10.1016/j.jpba.2018.03.048. [PMID: 29621655]
  • Paul Haas, Mariam Gaid, Ajmal Zarinwall, Ludger Beerhues, Stephan Scholl. Downstream processing of hyperforin from Hypericum perforatum root cultures. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2018 May; 126(?):104-107. doi: 10.1016/j.ejpb.2017.06.026. [PMID: 28669795]
  • Mariam Gaid, Eline Biedermann, Jendrik Füller, Paul Haas, Sönke Behrends, Rainer Krull, Stephan Scholl, Ute Wittstock, Christel Müller-Goymann, Ludger Beerhues. Biotechnological production of hyperforin for pharmaceutical formulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2018 May; 126(?):10-26. doi: 10.1016/j.ejpb.2017.03.024. [PMID: 28377273]
  • Li Ma, Xia Pan, Fang Zhou, Kang Liu, Long Wang. Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation. Brain research. 2018 Jan; 1678(?):254-261. doi: 10.1016/j.brainres.2017.08.023. [PMID: 28870826]
  • Tomás Herraiz, Hugo Guillén. Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions. BioMed research international. 2018; 2018(?):4810394. doi: 10.1155/2018/4810394. [PMID: 29568754]
  • Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Abdollahi. Clinical risks of St John's Wort (Hypericum perforatum) co-administration. Expert opinion on drug metabolism & toxicology. 2017 Oct; 13(10):1047-1062. doi: 10.1080/17425255.2017.1378342. [PMID: 28885074]
  • Silvia Lazzara, Marcello Militello, Alessandra Carrubba, Edoardo Napoli, Sergio Saia. Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate. Mycorrhiza. 2017 May; 27(4):345-354. doi: 10.1007/s00572-016-0756-6. [PMID: 27999964]
  • Qin Xiang Ng, Nandini Venkatanarayanan, Collin Yih Xian Ho. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. Journal of affective disorders. 2017 Mar; 210(?):211-221. doi: 10.1016/j.jad.2016.12.048. [PMID: 28064110]
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