Urocortisol (BioDeep_00000637531)
Main id: BioDeep_00000002839
PANOMIX_OTCML-2023
代谢物信息卡片
3alpha,11beta,17,21-tetrahydroxy-5beta-pregnan-20-one
化学式: C21H34O5 (366.2406)
中文名称: 四氢皮质醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O)O
InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18-,19+,20+,21+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:28320
- KEGG: C05472
- PubChem: 5864
- ChEMBL: CHEMBL1908047
- LipidMAPS: LMST02030143
- MeSH: Tetrahydrocortisol
- CAS: 53-02-1
- PubChem: 7832
- 3DMET: B05047
- NIKKAJI: J39.547A
- medchemexpress: HY-129630
- KNApSAcK: 28320
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Susanna Bianzano, Matias Nordaby, Leona Plum-Mörschel, Barbara Peil, Tim Heise. Safety, tolerability, pharmacodynamics and pharmacokinetics following once-daily doses of BI 187004, an inhibitor of 11 beta-hydroxysteroid dehydrogenase-1, over 28 days in patients with type 2 diabetes mellitus and overweight or obesity.
Diabetes, obesity & metabolism.
2023 Mar; 25(3):832-843. doi:
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Clinical chemistry and laboratory medicine.
2022 07; 60(8):1225-1233. doi:
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Reproductive sciences (Thousand Oaks, Calif.).
2022 05; 29(5):1498-1505. doi:
10.1007/s43032-021-00822-w. [PMID: 35001327] - Stéphanie Espiard, Johanna McQueen, Mark Sherlock, Oskar Ragnarsson, Ragnhildur Bergthorsdottir, Pia Burman, Per Dahlqvist, Bertil Ekman, Britt Edén Engström, Stanko Skrtic, Jeanette Wahlberg, Paul M Stewart, Gudmundur Johannsson. Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone.
The Journal of clinical endocrinology and metabolism.
2021 03; 106(3):814-825. doi:
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Journal of pharmaceutical and biomedical analysis.
2017 Jun; 140(?):174-181. doi:
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British journal of pharmacology.
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European journal of endocrinology.
2007 Sep; 157(3):319-24. doi:
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Clinical endocrinology.
2007 May; 66(5):659-65. doi:
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Obesity (Silver Spring, Md.).
2007 Apr; 15(4):820-4. doi:
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European journal of applied physiology.
2007 Jan; 99(1):65-71. doi:
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Nihon rinsho. Japanese journal of clinical medicine.
2006 Dec; 64 Suppl 9(?):544-50. doi:
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Journal of the American Society of Nephrology : JASN.
2006 Nov; 17(11):3176-84. doi:
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Metabolism: clinical and experimental.
2006 Aug; 55(8):1022-8. doi:
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Psychosomatic medicine.
2006 Jul; 68(4):578-82. doi:
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European journal of endocrinology.
2006 Apr; 154(4):555-61. doi:
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Journal of psychosomatic research.
2006 Feb; 60(2):145-53. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(2):278-85. doi:
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Scandinavian journal of clinical and laboratory investigation.
2006; 66(2):147-59. doi:
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Clinical endocrinology.
2006 Jan; 64(1):37-45. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2005 Oct; 20(10):2113-9. doi:
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Clinical endocrinology.
2005 Oct; 63(4):442-9. doi:
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European journal of endocrinology.
2005 Aug; 153(2):291-9. doi:
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European heart journal.
2005 Mar; 26(5):498-504. doi:
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Kidney international.
2005 Feb; 67(2):631-7. doi:
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Ethnicity & disease.
2005; 15(3):407-10. doi:
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Hormone research.
2005; 63(5):234-7. doi:
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Analytical and bioanalytical chemistry.
2005 Jan; 381(1):244-54. doi:
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Obesity research.
2004 Sep; 12(9):1421-5. doi:
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Clinical endocrinology.
2004 Jul; 61(1):149-54. doi:
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Kidney international.
2004 Jun; 65(6):2065-70. doi:
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The Journal of clinical endocrinology and metabolism.
2004 May; 89(5):2024-7. doi:
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American journal of hypertension.
2004 Mar; 17(3):283-4. doi:
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American journal of hypertension.
2003 Sep; 16(9 Pt 1):729-33. doi:
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European journal of clinical investigation.
2003 Jul; 33(7):589-94. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 May; 17(8):917-9. doi:
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American journal of physiology. Renal physiology.
2003 Jan; 284(1):F32-40. doi:
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2003; 59(4):205-10. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2002 Dec; 18(12):1309-14. doi:
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2002 Oct; 13(10):2540-6. doi:
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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2002 Sep; 110(6):272-6. doi:
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Steroids.
2002 Sep; 67(10):873-82. doi:
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Endocrine.
2002 Aug; 18(3):279-84. doi:
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The Journal of clinical endocrinology and metabolism.
2002 Jul; 87(7):3330-6. doi:
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European journal of clinical investigation.
2002 Jul; 32(7):513-8. doi:
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Kidney international.
2002 May; 61(5):1859-66. doi:
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