Chemical Formula: C21H34O5
Chemical Formula C21H34O5
Found 93 metabolite its formula value is C21H34O5
3b-Allotetrahydrocortisol
3b-Allotetrahydrocortisol is one of the tetrahydrometabolites of cortisol. The 11-beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol, which has implications in the pathogenesis of numerous diseases, as reflected in the ratio of tetrahydrometabolites of cortisol. (PMID: 16310418). The daily excretion of allotetrahydrocortisol is above normal in hyperthyroid patients; In contrast, in hyperthyroidism the excretion is diminished below normal levels to approximately half that of normal subjects. (PMID 13906284). A decreased activity of the enzyme 11beta-HSD produces a pattern of urinary steroid metabolites with an abnormal elevation of tetrahydrocortisol and allo-tetrahydrocortisol compared to tetrahydrocortisone; this pattern of steroid excretion is essential for the diagnosis of the syndrome of apparent mineralocorticoid excess type 1. (PMID: 8834992). 3b-Allotetrahydrocortisol is one of the tetrahydrometabolites of cortisol. The 11-beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol, which has implications in the pathogenesis of numerous diseases, as reflected in the ratio of tetrahydrometabolites of cortisol. (PMID: 16310418) D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
Cortolone
It is one of the steriod metabolites. It is found in the urine of pregnant (36-40 weeks of gestation) and nonpregnant women and in amniotic fluid from nearly fullterm pregnant women.(PMID: 7419663) [HMDB] It is one of the steriod metabolites. It is found in the urine of pregnant (36-40 weeks of gestation) and nonpregnant women and in amniotic fluid from nearly fullterm pregnant women.(PMID: 7419663).
5alpha-Tetrahydrocortisol
5a-Tetrahydrocortisol is a normal human metabolite. However its increased ratio (5alpha-Tetrahydrocortisol + Tetrahydrocortisol) over Tetrahydrocortisone in urine is the biochemical marker for the syndrome of apparent mineralocorticoid excess (AME). AME is a heritable form of hypertension due to an inborn error of cortisol metabolism and is characterized by hypokalemia and low renin levels despite subnormal or normal levels of aldosterone and other known mineralocorticoids. The syndrome is attributable to congenital deficiency of the enzyme 11 beta-hydroxydehydrogenase (11 beta-HSD), which converts cortisol to biologically inactive cortisone. This results in a prolonged half-life of Cortisol, which acts at the kidney level as a potent mineralocorticoid. (PMID: 8732999) [HMDB] 5alpha-Tetrahydrocortisol is a normal human metabolite. However its increased ratio (5alpha-tetrahydrocortisol + tetrahydrocortisol) over tetrahydrocortisone in urine is the biochemical marker for the syndrome of apparent mineralocorticoid excess (AME). AME is a heritable form of hypertension due to an inborn error of cortisol metabolism and is characterized by hypokalemia and low renin levels despite subnormal or normal levels of aldosterone and other known mineralocorticoids. The syndrome is attributable to congenital deficiency of the enzyme 11 beta-hydroxydehydrogenase (11-beta-HSD), which converts cortisol to biologically inactive cortisone. This results in a prolonged half-life of cortisol, which acts at the kidney level as a potent mineralocorticoid (PMID: 8732999). D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Tetrahydrocortisol
Tetrahydrocortisol is the most powerful natural angiostatic steroid. It is involved in C21-Steroid hormone metabolism pathway (KEGG). Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
Beta-Cortolone
Beta-Cortolone is a Corticosteroid. Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex and are transformed mainly by cytochrome P450 enzymes. Endogenous corticosteroids can be classified. as gluco- or mineralo-corticosteroids, many of which are intimately. related with biological enzyme activities. (PMID:19100888).
Prostaglandin E2 methyl ester
Betaenone A
A carbotricyclic compound that is tricyclo[6.2.2.0(2,7)]dodecan-9-one which is substituted by hydroxy groups at positions 1, 4, and 11; by methyl groups at positions 4, 6, 8, and 11; by a hydroxymethylene group at position 10; and by a (2R)-butan-2-yl group at position 12 (the 1S,2S,4R,6R,7S,8R,10Z,11S,12R stereoisomer). A phytotoxin produced by Pleospora betae, the causal fungus of leaf spot disease on sugar beet.
Dehydrotomentogenin|Dehydrotomentogenin (Utendin)|Utendin
(3beta,5alpha,14beta,15beta,16alpha)-3,14,15,16-Tetrahydroxypregnan-20-one
3alpha,11beta,15alpha,21-Tetrahydroxy-5alpha-pregnanon-(20)
methyl 2-(1-acetonyl-2,3a,7,7-tetramethyl-spiro[4,5,6,7a-tetrahydro-1H-isobenzofuran-3,5-tetrahydrofuran]-2-yl)acetate
ent-13-epi-8,13-epoxy-2,3-secolabd-14-ene-2,3-dioic acid 3-methyl ester
(-)-<3alpha,16beta,17alpha,20(S)>-3,16,17,20-tetrahydroxypregnane-6-one
1-(3,5-Dihydroxyphenyl)tridecane-2,8-diol 2-acetate
2,3-Dihydro-3,9-dihydroxy-9-deoxo-5-deoxy-5-oxoprotomycinolide IV
[1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-yl] acetate
[1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-yl] acetate
[1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-yl] acetate [IIN-based: Match]
3-ALPHA,11-BETA,17-ALPHA,21-TETRAHYDROXY- 5-ALPHA-PREGNAN-20-ONE
[1-(3,5-dihydroxyphenyl)-12-hydroxytridecan-2-yl] acetate_major
ALLOTETRAHYDROCORTISOL
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Arbaprostil
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents C78568 - Prostaglandin Analogue
5(S),6(R)-Lipoxin A4 methyl ester
15-cyclohexyl pentanor PGF2&alpha
Urocortisol
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
6-(12-Hydroxydodecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
Tetrahydrocortisol
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones Tetrahydrocortisol is the most powerful natural angiostatic steroid. It is involved in C21-Steroid hormone metabolism pathway (KEGG). [HMDB] Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
4-Methylidene-5-oxo-2-(14-oxopentadecyl)oxolane-3-carboxylic acid
2-Hydroxy-1-(3,11,17-trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-ethanone
methyl (E)-7-[3-hydroxy-2-[(E)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoate
4-Hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one
methyl 9-hydroperoxy-omega-hydroxy-(5Z,7E,11Z,14Z)-icosatetraenoate
methyl 8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-icosatetraenoate
methyl 12-hydroperoxy-omega-hydroxy-(5Z,8Z,10E,14Z)-icosatetraenoate
(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E)-3-hydroxy-3-methyloct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
7-[2-(3-Cyclohexyl-3-hydroxyprop-1-en-1-yl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid
(1-acetyloxy-3-hydroxypropan-2-yl) (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate
DG(18:3)
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