Cefoxitin (BioDeep_00000006369)
Secondary id: BioDeep_00001868004
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C16H17N3O7S2 (427.0508)
中文名称: 头孢西丁
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: COC1(C2N(C1=O)C(=C(CS2)COC(=O)N)C(=O)O)NC(=O)CC3=CC=CS3
InChI: InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1
描述信息
Cefoxitin is only found in individuals that have used or taken this drug. It is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002513 - Cephamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
22 个代谢物同义名
(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Merck sharp and dohme brand OF cefoxitin sodium; Merck frosst brand OF cefoxitin sodium; Merck brand OF cefoxitin sodium; MSD Brand OF cefoxitin sodium; Sodium, cefoxitin; Cefoxitin sodium; SCHEMBL7766649; Cefoxitinum; Cefoxitine; Rephoxitin; Cephoxitin; Ceftoxitin; Cefoxitina; Mefoxitin; Cefoxitin; Mefoxin; Méfoxin; CFX; Cefoxitin
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:209807
- KEGG: C06887
- KEGGdrug: D02345
- PubChem: 441199
- PubChem: 2638
- HMDB: HMDB0015426
- Metlin: METLIN1591
- DrugBank: DB01331
- ChEMBL: CHEMBL996
- Wikipedia: Cefoxitin
- MeSH: Cefoxitin
- chemspider: 389981
- CAS: 73356-24-8
- CAS: 35607-66-0
- PMhub: MS000019397
- PubChem: 9104
- PDB-CCD: CFX
- NIKKAJI: J17.441F
- KNApSAcK: 209807
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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PloS one.
2012; 7(6):e38420. doi:
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TheScientificWorldJournal.
2012; 2012(?):158237. doi:
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The Journal of antimicrobial chemotherapy.
2012 Jan; 67(1):174-81. doi:
10.1093/jac/dkr430. [PMID: 22016151] - Consuelo Esteve, Elena Alcaide, María Dolores Blasco. Aeromonas hydrophila subsp. dhakensis isolated from feces, water and fish in Mediterranean Spain.
Microbes and environments.
2012; 27(4):367-73. doi:
10.1264/jsme2.me12009. [PMID: 22472298] - Wilfried Jonkers, Yanhong Dong, Karen Broz, H Corby Kistler. The Wor1-like protein Fgp1 regulates pathogenicity, toxin synthesis and reproduction in the phytopathogenic fungus Fusarium graminearum.
PLoS pathogens.
2012; 8(5):e1002724. doi:
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Chonnam medical journal.
2011 Dec; 47(3):181-4. doi:
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American journal of infection control.
2011 Nov; 39(9):e55-60. doi:
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Journal of health, population, and nutrition.
2011 Oct; 29(5):446-53. doi:
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Anesthesia and analgesia.
2011 Oct; 113(4):730-7. doi:
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Korean journal of urology.
2011 May; 52(5):345-9. doi:
10.4111/kju.2011.52.5.345. [PMID: 21687395] - Gönül Özel, Volkan Aslan, Gül Bahar Erdem, Mustafa Çağatay, Irfan Sencan, Ali Mert. [Comparison of oxacillin, cefoxitin, ceftizoxime, and moxalactam disk diffusion methods for detection of methicillin susceptibility in staphylococci].
Mikrobiyoloji bulteni.
2011 Apr; 45(2):258-65. doi:
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The Korean journal of laboratory medicine.
2011 Apr; 31(2):72-80. doi:
10.3343/kjlm.2011.31.2.72. [PMID: 21474979] - Ferit Kuşcu, Doğan Barış Oztürk, Yunus Gürbüz, Emin Ediz Tütüncü, Irfan Sencan, Serdar Gül. [Investigation of reduced vancomycin susceptibility in methicillin-resistant staphylococci].
Mikrobiyoloji bulteni.
2011 Apr; 45(2):248-57. doi:
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Annals of clinical microbiology and antimicrobials.
2011 Mar; 10(?):10. doi:
10.1186/1476-0711-10-10. [PMID: 21406097] - Praveen Rishi, Simran Preet, Prabhjot Kaur. Effect of L. plantarum cell-free extract and co-trimoxazole against Salmonella Typhimurium: a possible adjunct therapy.
Annals of clinical microbiology and antimicrobials.
2011 Feb; 10(?):9. doi:
10.1186/1476-0711-10-9. [PMID: 21352573] - Gisele Peirano, Jasmine Ahmed-Bentley, Neil Woodford, Johann D Pitout. New Delhi metallo-beta-lactamase from traveler returning to Canada.
Emerging infectious diseases.
2011 Feb; 17(2):242-4. doi:
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Antonie van Leeuwenhoek.
2011 Feb; 99(2):409-16. doi:
10.1007/s10482-010-9476-7. [PMID: 20571861] - Gian Maria Pacifici. Pharmacokinetics of cephalosporins in the neonate: a review.
Clinics (Sao Paulo, Brazil).
2011; 66(7):1267-74. doi:
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International journal of women's health.
2011; 3(?):197-206. doi:
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International journal of nephrology and renovascular disease.
2011; 4(?):85-99. doi:
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TheScientificWorldJournal.
2011; 11(?):2613-9. doi:
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International journal of nanomedicine.
2011; 6(?):2533-42. doi:
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The Journal of the Association of Physicians of India.
2010 Dec; 58 Suppl(?):41-4. doi:
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Klinicka mikrobiologie a infekcni lekarstvi.
2010 Dec; 16(6):196-8. doi:
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The American journal of tropical medicine and hygiene.
2010 Dec; 83(6):1322-9. doi:
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The Journal of veterinary medical science.
2010 Nov; 72(11):1437-42. doi:
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International journal of antimicrobial agents.
2010 Nov; 36(5):420-3. doi:
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The Journal of biological chemistry.
2010 Oct; 285(42):32273-81. doi:
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European journal of clinical pharmacology.
2010 Oct; 66(10):1025-35. doi:
10.1007/s00228-010-0851-0. [PMID: 20552179] - John B Kaneene, RoseAnn Miller, Katherine May, Joseph A Hattey. An outbreak of multidrug-resistant Salmonella enterica serotype Oranienburg in Michigan dairy calves.
Foodborne pathogens and disease.
2010 Oct; 7(10):1193-201. doi:
10.1089/fpd.2010.0551. [PMID: 20939741] - Wen-jing Ji, Xi-wei Xu, Fang Dong. [Detection and drug resistance analysis of extended-spectrum beta-lactamases-producing Shigella in pediatric patients].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2010 Aug; 48(8):617-20. doi:
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Foodborne pathogens and disease.
2010 Aug; 7(8):991-4. doi:
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Journal of laboratory physicians.
2010 Jul; 2(2):78-81. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2010 Jun; 29(6):677-82. doi:
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The Journal of antimicrobial chemotherapy.
2010 May; 65(5):986-90. doi:
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The Journal of antimicrobial chemotherapy.
2010 Apr; 65(4):717-20. doi:
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Preventive veterinary medicine.
2010 Apr; 94(1-2):77-83. doi:
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Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne.
2010 Apr; 59(2):88-91. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Feb; 878(3-4):428-34. doi:
10.1016/j.jchromb.2009.12.025. [PMID: 20060790] - S Faure, A Perrin-Guyomard, J M Delmas, P Chatre, M Laurentie. Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime.
Antimicrobial agents and chemotherapy.
2010 Jan; 54(1):164-9. doi:
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Acta haematologica.
2010; 124(4):197-9. doi:
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Urology annals.
2010 Jan; 2(1):7-11. doi:
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Infectious diseases in obstetrics and gynecology.
2010; 2010(?):984760. doi:
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Anaerobe.
2009 Dec; 15(6):256-60. doi:
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Antimicrobial agents and chemotherapy.
2009 Dec; 53(12):5046-54. doi:
10.1128/aac.00774-09. [PMID: 19770275] - Long-Hua Hu, Jian-Qiu Xiong, Xiao-Jun Yu, Cheng-Lin Yu, Kun-Ru Jia, Xiao-Yan Hu. [Comparison of the antimicrobial resistance of Staphylococcus aureus isolated from children and adults in vitro].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2009 Dec; 11(12):961-3. doi:
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Journal of clinical microbiology.
2009 Nov; 47(11):3742-6. doi:
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