Aztreonam (BioDeep_00000006355)
Secondary id: BioDeep_00001870263
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-{[(Z)-[(2-amino-1,3-thiazol-4-yl)({[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]carbamoyl})methylidene]amino]oxy}-2-methylpropanoic acid
化学式: C13H17N5O8S2 (435.0519)
中文名称: 氨曲南
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N
InChI: InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
描述信息
Aztreonam is only found in individuals that have used or taken this drug. It is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. [PubChem]The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that aztreonam interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DF - Monobactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
23 个代谢物同义名
2-{[(Z)-[(2-amino-1,3-thiazol-4-yl)({[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]carbamoyl})methylidene]amino]oxy}-2-methylpropanoic acid; (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulphO-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid; (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfO-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid; (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulphO-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionate; (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfO-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionate; Bristol myers squibb brand OF aztreonam; Bristol-myers squibb brand OF aztreonam; Sanofi winthrop brand OF aztreonam; Squibb brand OF aztreonam; Esteve brand OF aztreonam; Aztreonam esteve brand; Aztreonam squibb brand; Aztreonamum; Az-threonam; Az threonam; Azthreonam; Primbactam; Monobactam; Urobactam; aztreonam; Azactam; AZT; Aztreonam
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:161680
- KEGG: C06840
- KEGGdrug: D00240
- PubChem: 135398736
- PubChem: 5742832
- PubChem: 2274
- HMDB: HMDB0014499
- Metlin: METLIN1230
- DrugBank: DB00355
- ChEMBL: CHEMBL158
- Wikipedia: Aztreonam
- MeSH: Monobactams
- MeSH: Aztreonam
- chemspider: 4674940
- CAS: 149496-40-2
- CAS: 78110-38-0
- CAS: 80951-91-3
- PMhub: MS000019383
- PubChem: 9058
- NIKKAJI: J20.598B
- RefMet: Aztreonam
- KNApSAcK: 161680
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Kroneislová, Jan Závora, Vanda Gabriela Adámková, Anna Rýdlová, Václava Adámková. In vitro activity of antibiotics potentially effective against difficult-to-treat strains of Gram-negative rods: retrospective study.
Scientific reports.
2024 04; 14(1):8310. doi:
10.1038/s41598-024-59036-0. [PMID: 38594467] - Sun Miao, Yanyan Zhang, Cong Men, Yiou Mao, Jiane Zuo. A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process.
Journal of environmental sciences (China).
2024 Apr; 138(?):626-636. doi:
10.1016/j.jes.2023.04.002. [PMID: 38135426] - Ruixian Guo, Xinyan Ma, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Binan Lu, Jingpu Zhang, Ying Han. In silico prediction and a systematic toxicology-based in vivo investigation uncovering the mechanism of aquatic toxicity caused by beta-lactam antibiotics.
Chemosphere.
2024 Feb; 349(?):140884. doi:
10.1016/j.chemosphere.2023.140884. [PMID: 38065262] - Jiankang Zhao, Danni Pu, Ziyao Li, Xinmeng Liu, Yulin Zhang, Yongli Wu, Feilong Zhang, Chen Li, Xianxia Zhuo, Binghuai Lu, Bin Cao. In vitro activity of cefiderocol, a siderophore cephalosporin, against carbapenem-resistant hypervirulent Klebsiella pneumoniae in China.
Antimicrobial agents and chemotherapy.
2023 12; 67(12):e0073523. doi:
10.1128/aac.00735-23. [PMID: 38014944] - Jian-Guo Li, Xiao-Feng Chen, Ting-Yin Lu, Jing Zhang, Shu-He Dai, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao, Yu-Feng Zhou. Increased Activity of β-Lactam Antibiotics in Combination with Carvacrol against MRSA Bacteremia and Catheter-Associated Biofilm Infections.
ACS infectious diseases.
2023 Dec; 9(12):2482-2493. doi:
10.1021/acsinfecdis.3c00338. [PMID: 38019707] - Hye-Ri Jung, Yu Jin Lee, Serim Hong, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee. Current status of β-lactam antibiotic use and characterization of β-lactam-resistant Escherichia coli from commercial farms by integrated broiler chicken operations in Korea.
Poultry science.
2023 Dec; 102(12):103091. doi:
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PLoS biology.
2023 Dec; 21(12):e3002433. doi:
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Pharmaceutical nanotechnology.
2023 Jun; 11(3):294-302. doi:
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2022 Feb; 210(?):114587. doi:
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2021 08; 65(9):e0032621. doi:
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2021 Aug; 34(4):653-657. doi:
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Medicina (Kaunas, Lithuania).
2021 Apr; 57(5):. doi:
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Internal and emergency medicine.
2021 01; 16(1):237-239. doi:
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Chemical communications (Cambridge, England).
2020 Oct; 56(80):11973-11976. doi:
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Scientific reports.
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2019 09; 63(9):. doi:
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2019 04; 63(4):. doi:
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2019 01; 74(1):108-116. doi:
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2019; 68(2):185-191. doi:
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2018 11; 62(11):. doi:
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Antimicrobial resistance and infection control.
2018; 7(?):142. doi:
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Antimicrobial agents and chemotherapy.
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Antimicrobial agents and chemotherapy.
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