Nojirimycin (BioDeep_00000006326)

   

natural product


代谢物信息卡片


6-(hydroxymethyl)-2,3,4,5-Piperidinetetrol

化学式: C6H13NO5 (179.0794)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(C(N1)O)O)O)O)O
InChI: InChI=1S/C6H13NO5/c8-1-2-3(9)4(10)5(11)6(12)7-2/h2-12H,1H2/t2-,3-,4+,5+,6+/m0/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D004791 - Enzyme Inhibitors

同义名列表

8 个代谢物同义名

Nojirimycin; 6-(hydroxymethyl)-2,3,4,5-Piperidinetetrol; (+)-Nojirimycin; U 51640; R 468; 6-(hydroxymethyl)piperidine-2,3,4,5-tetrol; 5-Amino-5-deoxy-D-glucopyranose; Nojirimycin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 HMGB1, ITPR3, MYC, PNP, PTGS2
Peripheral membrane protein 4 COQ10A, GBA1, HMGB1, PTGS2
Endosome membrane 2 CTSD, HLA-A
Endoplasmic reticulum membrane 4 HLA-A, ITPR3, MOGS, PTGS2
Nucleus 3 HMGB1, MYC, OGA
cytosol 2 OGA, PNP
trans-Golgi network 1 GBA1
nucleoplasm 3 HMGB1, ITPR3, MYC
Cell membrane 5 HLA-A, HMGB1, SLC6A1, TNF, TREH
Early endosome membrane 1 HLA-A
Multi-pass membrane protein 3 ITPR3, SLC6A1, UGCG
Golgi apparatus membrane 1 UGCG
cell surface 5 ARSB, HLA-A, HMGB1, SLC6A1, TNF
Golgi apparatus 2 GBA1, HLA-A
Golgi membrane 3 HLA-A, INS, UGCG
lysosomal membrane 4 CTSD, GAA, GBA1, HLA-A
mitochondrial inner membrane 1 COQ10A
neuronal cell body 3 ITPR3, SLC6A1, TNF
presynaptic membrane 1 SLC6A1
Lysosome 4 ARSB, CTSD, GAA, GBA1
Presynapse 1 SLC6A1
endosome 1 HMGB1
plasma membrane 7 GAA, HLA-A, HMGB1, ITPR3, SLC6A1, TNF, TREH
Membrane 9 GAA, HLA-A, ITPR3, MOGS, MYC, OGA, SLC6A1, TREH, UGCG
axon 1 SLC6A1
brush border 1 ITPR3
caveola 1 PTGS2
extracellular exosome 8 ARSB, CTSD, GAA, GBA1, HLA-A, MOGS, PNP, TREH
Lysosome membrane 3 GAA, GBA1, HLA-A
Lumenal side 1 GBA1
endoplasmic reticulum 6 GBA1, HLA-A, HMGB1, ITPR3, MOGS, PTGS2
extracellular space 8 CTSD, HLA-A, HMGB1, IL4, IL6, INS, PNP, TNF
lysosomal lumen 4 ARSB, CTSD, GAA, GBA1
mitochondrion 1 COQ10A
protein-containing complex 2 MYC, PTGS2
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 HLA-A
Secreted 6 GAA, HMGB1, IL4, IL6, INS, PNP
extracellular region 9 ARSB, CTSD, GAA, HMGB1, IL4, IL6, INS, PNP, TNF
Single-pass membrane protein 1 HLA-A
Extracellular side 1 HMGB1
external side of plasma membrane 2 HLA-A, TNF
nucleolus 2 ITPR3, MYC
apical part of cell 1 ITPR3
recycling endosome 1 TNF
Single-pass type II membrane protein 2 MOGS, TNF
postsynaptic membrane 1 SLC6A1
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 2 CTSD, TNF
GABA-ergic synapse 1 SLC6A1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 CTSD
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 2 ITPR3, PTGS2
receptor complex 1 ITPR3
neuron projection 1 PTGS2
chromatin 1 MYC
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 HLA-A
Chromosome 1 HMGB1
[Isoform 3]: Nucleus 1 OGA
Nucleus, nucleolus 1 MYC
Lipid-anchor, GPI-anchor 1 TREH
nuclear envelope 1 MYC
Recycling endosome membrane 1 HLA-A
endosome lumen 2 CTSD, INS
Nucleus, nucleoplasm 1 MYC
tertiary granule membrane 1 GAA
Melanosome 1 CTSD
side of membrane 1 TREH
[Isoform 1]: Cytoplasm 1 OGA
ficolin-1-rich granule lumen 4 ARSB, CTSD, HMGB1, PNP
secretory granule lumen 3 HMGB1, INS, PNP
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ARSB, IL6, INS, PTGS2
transcription repressor complex 1 HMGB1
specific granule lumen 1 CTSD
tertiary granule lumen 1 CTSD
transport vesicle 1 INS
azurophil granule membrane 1 GAA
RNA polymerase II transcription repressor complex 1 MYC
azurophil granule lumen 1 ARSB
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 HLA-A
ER to Golgi transport vesicle membrane 1 HLA-A
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
platelet dense tubular network membrane 1 ITPR3
ficolin-1-rich granule membrane 1 GAA
lumenal side of endoplasmic reticulum membrane 1 HLA-A
MHC class I peptide loading complex 1 HLA-A
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Rough endoplasmic reticulum 1 MYC
condensed chromosome 1 HMGB1
Golgi medial cisterna 1 HLA-A
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
MHC class I protein complex 1 HLA-A
MHC class II protein complex 1 HLA-A
transport vesicle membrane 1 ITPR3
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Berna Elya, Katrin Basah, Abdul Mun'im, Wulan Yuliastuti, Anastasia Bangun, Eva Kurnia Septiana. Screening of α-glucosidase inhibitory activity from some plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Journal of biomedicine & biotechnology. 2012; 2012(?):281078. doi: 10.1155/2012/281078. [PMID: 22187534]
  • Richard F G Fröhlich, Richard H Furneaux, Don J Mahuran, Robert Saf, Arnold E Stütz, Michael B Tropak, Jacqueline Wicki, Stephen G Withers, Tanja M Wrodnigg. 1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines. Carbohydrate research. 2011 Sep; 346(12):1592-8. doi: 10.1016/j.carres.2011.05.010. [PMID: 21645885]
  • Jing-Yu Zhang, Jing Yang. (3R,3aS,6R,6aR)-3-(1-Nitro-eth-yl)perhydro-furo[3,2-b]furan-3,6-diol. Acta crystallographica. Section E, Structure reports online. 2010 Jun; 66(Pt 7):o1704. doi: 10.1107/s1600536810022774. [PMID: 21587924]
  • H C Yohe, T J Kitzmiller, W J Bement, B E Dwyer, J F Sinclair. Reduced inflammatory potential of peritoneal macrophages recruited in mice pretreated with a glycolipid synthesis inhibitor. Inflammopharmacology. 2006 Aug; 14(3-4):170-5. doi: 10.1007/s10787-006-1517-5. [PMID: 16983496]
  • Y Zeng, Y T Pan, N Asano, R J Nash, A D Elbein. Homonojirimycin and N-methyl-homonojirimycin inhibit N-linked oligosaccharide processing. Glycobiology. 1997 Mar; 7(2):297-304. doi: 10.1093/glycob/7.2.297. [PMID: 9134436]
  • C P Kubicek. Involvement of a conidial endoglucanase and a plasma-membrane-bound beta-glucosidase in the induction of endoglucanase synthesis by cellulose in Trichoderma reesei. Journal of general microbiology. 1987 Jun; 133(6):1481-7. doi: 10.1099/00221287-133-6-1481. [PMID: 3117961]
  • T Valle, G Nicolás. Role of indole-3-acetic acid, gibberellic acid and kinetin on epicotyl growth in Cicer arietinum L. Revista espanola de fisiologia. 1982 Dec; 38(4):441-5. doi: ". [PMID: 7170429]
  • H Hettkamp, E Bause, G Legler. Inhibition by nojirimycin and 1-deoxynojirimycin of microsomal glucosidases from calf liver acting on the glycoprotein oligosaccharides Glc1-3Man9GlcNAc2. Bioscience reports. 1982 Nov; 2(11):899-906. doi: 10.1007/bf01114896. [PMID: 6218840]
  • P Lalégerie, G Legler, J M Yon. The use of inhibitors in the study of glycosidases. Biochimie. 1982 Nov; 64(11-12):977-1000. doi: 10.1016/s0300-9084(82)80379-9. [PMID: 6819005]
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