Phenylmethylsulfonyl fluoride (BioDeep_00000006313)

 

Secondary id: BioDeep_00001868069

human metabolite blood metabolite natural product Volatile Flavor Compounds


代谢物信息卡片


Fluoride, benzenemethanesulfonyl

化学式: C7H7FO2S (174.0150774)
中文名称: PMSF溶液
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=CC=C(C=C1)CS(=O)(=O)F
InChI: InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

描述信息

Component of corn gluten (Zea mays). obtained comly. by extraction of corn gluten with alkaline aq. 2-propanol. Moisture control agent. It is used in edible coatings for nuts and other foods and as a binder in confectionery glazes. GRAS approved
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors

同义名列表

18 个代谢物同义名

Fluoride, benzenemethanesulfonyl; Benzenemethanesulphonyl fluoride; Benzenemethanesulfonyl fluoride; alpha-Toluenesulphonyl fluoride; Fluoride, phenylmethanesulfonyl; alpha-Toluenesulfonyl fluoride; Fluoride, phenylmethylsulfonyl; Phenylmethylsulphonyl fluoride; Phenylmethanesulfonyl fluoride; Phenylmethylsulphonylfluoride; Phenylmethylsulfonyl fluoride; a-Toluenesulphonyl fluoride; Α-toluenesulphonyl fluoride; Α-toluenesulfonyl fluoride; a-Toluenesulfonyl fluoride; Zein; PMSF; Phenylmethanesulfonyl fluoride



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cory L Brooks, David A Ostrov, Nicholas C Schumann, Schuchi Kakkad, Danmeng Li, Karla Peña, Brady Paul Williams, Nathan E Goldfarb. 2.1 Å crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1). Biochemical and biophysical research communications. 2022 11; 630(?):57-63. doi: 10.1016/j.bbrc.2022.09.021. [PMID: 36148729]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alejandro A Puchol Tarazona, Daniel Maresch, Annette Grill, Janet Bakalarz, Juan A Torres Acosta, Alexandra Castilho, Herta Steinkellner, Lukas Mach. Identification of two subtilisin-like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana. FEBS letters. 2021 02; 595(3):379-388. doi: 10.1002/1873-3468.14014. [PMID: 33263189]
  • Zhao-Lin Ji, Shuai Peng, Li-Li Chen, Yang Liu, Chun Yan, Feng Zhu. Identification and characterization of a serine protease from Bacillus licheniformis W10: A potential antifungal agent. International journal of biological macromolecules. 2020 Feb; 145(?):594-603. doi: 10.1016/j.ijbiomac.2019.12.216. [PMID: 31891703]
  • María Del Pilar Caro, Nicholas Holton, Gabriela Conti, Andrea Laura Venturuzzi, Martin Gustavo Martínez-Zamora, Cyril Zipfel, Sebastian Asurmendi, Juan Carlos Díaz-Ricci. The fungal subtilase AsES elicits a PTI-like defence response in Arabidopsis thaliana plants independently of its enzymatic activity. Molecular plant pathology. 2020 02; 21(2):147-159. doi: 10.1111/mpp.12881. [PMID: 31769595]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wei Sun, Stacy Ho, Xiaojun Rick Fang, Thomas O'Shea, Hanlan Liu. Simultaneous determination of triamcinolone hexacetonide and triamcinolone acetonide in rabbit plasma using a highly sensitive and selective UPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):267-273. doi: 10.1016/j.jpba.2018.02.052. [PMID: 29550043]
  • Myrna Sabanero López, Lérida L Flores Villavicencio, Karla Soto Arredondo, Gloria Barbosa Sabanero, Julio César Villagómez-Castro, Gustavo Cruz Jiménez, Gerardo Sandoval Bernal, Haydee Torres Guerrero. Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model. Revista iberoamericana de micologia. 2018 Jan; 35(1):32-38. doi: 10.1016/j.riam.2017.05.003. [PMID: 29221633]
  • Jarogniew J Luszczki, Pawel Patrzylas, Miroslaw Zagaja, Marta Andres-Mach, Katarzyna Zaluska, Maria W Kondrat-Wrobel, Monika Szpringer, Jaroslaw Chmielewski, Magdalena Florek-Luszczki. Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice. PloS one. 2017; 12(8):e0183873. doi: 10.1371/journal.pone.0183873. [PMID: 28859122]
  • Murugesan Chandrasekaran, Raman Chandrasekar, Se-Chul Chun, Muthukrishnan Sathiyabama. Isolation, characterization and molecular three-dimensional structural predictions of metalloprotease from a phytopathogenic fungus, Alternaria solani (Ell. and Mart.) Sor. Journal of bioscience and bioengineering. 2016 Aug; 122(2):131-9. doi: 10.1016/j.jbiosc.2015.12.021. [PMID: 26924427]
  • Satoru Inagaki, Ryuta Kimizuka, Eitoyo Kokubu, Atsushi Saito, Kazuyuki Ishihara. Treponema denticola invasion into human gingival epithelial cells. Microbial pathogenesis. 2016 May; 94(?):104-11. doi: 10.1016/j.micpath.2016.01.010. [PMID: 26806000]
  • Satomi Miwa, Achim Treumann, Amy Bell, Giulio Vistoli, Glyn Nelson, Sam Hay, Thomas von Zglinicki. Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays. Free radical biology & medicine. 2016 Jan; 90(?):173-83. doi: 10.1016/j.freeradbiomed.2015.11.011. [PMID: 26577176]
  • Xiaolin Wang, Xiao Gu, Huahua Song, Qingxiang Song, Xiaoling Gao, Yang Lu, Hongzhuan Chen. Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis. Analytica chimica acta. 2015 Sep; 893(?):77-83. doi: 10.1016/j.aca.2015.08.049. [PMID: 26398425]
  • Norio Kamemura, Miwa Takashima, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Hiroshi Kido. Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens. The journal of medical investigation : JMI. 2015; 62(3-4):137-44. doi: 10.2152/jmi.62.137. [PMID: 26399337]
  • Long Yuan, Yunlin Fu, Duxi Zhang, Yuan-Qing Xia, Qianping Peng, Anne-Françoise Aubry, Mark E Arnold. Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Oct; 969(?):60-8. doi: 10.1016/j.jchromb.2014.08.006. [PMID: 25151331]
  • Long Yuan, Wenying Jian, Duxi Zhang, Anne-Françoise Aubry, Mark E Arnold. Application of a stabilizer cocktail of N-ethylmaleimide and phenylmethanesulfonyl fluoride to concurrently stabilize the disulfide and ester containing compounds in a plasma LC-MS/MS assay. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):552-61. doi: 10.1016/j.jpba.2013.10.014. [PMID: 24211707]
  • Jonathan Negrel, Francine Javelle, Dominique Morandi. Detection of a plant enzyme exhibiting chlorogenate-dependant caffeoyltransferase activity in methanolic extracts of arbuscular mycorrhizal tomato roots. Plant physiology and biochemistry : PPB. 2013 May; 66(?):77-83. doi: 10.1016/j.plaphy.2013.02.009. [PMID: 23500709]
  • Marta Andres-Mach, Dorota Zolkowska, Beata Barcicka-Klosowska, Agnieszka Haratym-Maj, Magdalena Florek-Luszczki, Jarogniew J Luszczki. Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Progress in neuro-psychopharmacology & biological psychiatry. 2012 Dec; 39(2):301-9. doi: 10.1016/j.pnpbp.2012.07.001. [PMID: 22789660]
  • Katia Gindro, Valentine Berger, Sophie Godard, Francine Voinesco, Sylvain Schnee, Olivier Viret, Virginia Alonso-Villaverde. Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):74-80. doi: 10.1016/j.plaphy.2012.07.028. [PMID: 22906813]
  • Meghan Johnston, Shachi R Bhatt, Surina Sikka, Richard W Mercier, Jay M West, Alexandros Makriyannis, S John Gatley, Richard I Duclos. Assay and inhibition of diacylglycerol lipase activity. Bioorganic & medicinal chemistry letters. 2012 Jul; 22(14):4585-92. doi: 10.1016/j.bmcl.2012.05.101. [PMID: 22738638]
  • Jaruwan Siritapetawee, Kanjana Thumanu, Punchapat Sojikul, Sompong Thammasirirak. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophyllus latex. Biochimica et biophysica acta. 2012 Jul; 1824(7):907-12. doi: 10.1016/j.bbapap.2012.05.002. [PMID: 22579962]
  • Srinivasan Rengachari, Gustavo A Bezerra, Lina Riegler-Berket, Christian C Gruber, Christian Sturm, Ulrike Taschler, Andras Boeszoermenyi, Ingrid Dreveny, Robert Zimmermann, Karl Gruber, Monika Oberer. The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes. Biochimica et biophysica acta. 2012 Jul; 1821(7):1012-21. doi: 10.1016/j.bbalip.2012.04.006. [PMID: 22561231]
  • Naiyu Zheng, Eliza N Fung, Adela Buzescu, Mark E Arnold, Jianing Zeng. Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2012 Jun; 26(11):1291-304. doi: 10.1002/rcm.6230. [PMID: 22555922]
  • Hui-Kyoung Sun, Yun Mi Lee, Kum Hyun Han, Han-Seong Kim, Seon-Ho Ahn, Sang-Youb Han. Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney. The Korean journal of internal medicine. 2012 Jun; 27(2):163-70. doi: 10.3904/kjim.2012.27.2.163. [PMID: 22707888]
  • Jan Dimberg, Karin Ström, Sture Löfgren, Niklas Zar, Mikael Lindh, Andreas Matussek. DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas. International journal of colorectal disease. 2012 Jun; 27(6):709-14. doi: 10.1007/s00384-011-1367-5. [PMID: 22108905]
  • Nobuo N Noda, Takafumi Kobayashi, Wakana Adachi, Yuko Fujioka, Yoshinori Ohsumi, Fuyuhiko Inagaki. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. The Journal of biological chemistry. 2012 May; 287(20):16256-66. doi: 10.1074/jbc.m112.348250. [PMID: 22437838]
  • Jean Charles Isner, Thomas Nühse, Frans J M Maathuis. The cyclic nucleotide cGMP is involved in plant hormone signalling and alters phosphorylation of Arabidopsis thaliana root proteins. Journal of experimental botany. 2012 May; 63(8):3199-205. doi: 10.1093/jxb/ers045. [PMID: 22345640]
  • Yu Cheng Zhu, Sandy West, Fanny X Liu, Yueping He. Interaction of proteinase inhibitors with Cry1Ac toxicity and the presence of 15 chymotrypsin cDNAs in the midgut of the tobacco budworm, Heliothis virescens (F.) (Lepidoptera: Noctuidae). Pest management science. 2012 May; 68(5):692-701. doi: 10.1002/ps.2315. [PMID: 22228503]
  • Alison H Kingston-Smith, Teri E Davies, Joan Edwards, Alan Gay, Luis A J Mur. Evidence of a role for foliar salicylic acid in regulating the rate of post-ingestive protein breakdown in ruminants and contributing to landscape pollution. Journal of experimental botany. 2012 May; 63(8):3243-55. doi: 10.1093/jxb/ers048. [PMID: 22378947]
  • Sudhakar Pandurangan, Agnieszka Pajak, Stephen J Molnar, Elroy R Cober, Sangeeta Dhaubhadel, Cinta Hernández-Sebastià, Werner M Kaiser, Randall L Nelson, Steven C Huber, Frédéric Marsolais. Relationship between asparagine metabolism and protein concentration in soybean seed. Journal of experimental botany. 2012 May; 63(8):3173-84. doi: 10.1093/jxb/ers039. [PMID: 22357599]
  • Joerg Fettke, Lydia Leifels, Henrike Brust, Karoline Herbst, Martin Steup. Two carbon fluxes to reserve starch in potato (Solanum tuberosum L.) tuber cells are closely interconnected but differently modulated by temperature. Journal of experimental botany. 2012 May; 63(8):3011-29. doi: 10.1093/jxb/ers014. [PMID: 22378944]
  • Azza Al-Tawashi, Sung Yun Jung, Dou Liu, Bing Su, Jun Qin. Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity. The Journal of biological chemistry. 2012 Apr; 287(18):14644-58. doi: 10.1074/jbc.m111.261875. [PMID: 22375002]
  • Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α. Journal of neuroinflammation. 2012 Apr; 9(?):81. doi: 10.1186/1742-2094-9-81. [PMID: 22537532]
  • Mustafa Yavuz Selcuk, Bilge Aygen, Ayhan Dogukan, Zeynep Tuzcu, Fatih Akdemir, James R Komorowski, Mustafa Atalay, Kazim Sahin. Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats. Nutrition & metabolism. 2012 Apr; 9(?):30. doi: 10.1186/1743-7075-9-30. [PMID: 22483164]
  • Gon-Sup Kim, Hyoung Joon Park, Jong-Hwa Woo, Mi-Kyeong Kim, Phil-Ok Koh, Wongi Min, Yeoung-Gyu Ko, Chung-Hei Kim, Chung-Kil Won, Jae-Hyeon Cho. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC complementary and alternative medicine. 2012 Apr; 12(?):31. doi: 10.1186/1472-6882-12-31. [PMID: 22471389]
  • Xuan Yao, Wei Xiong, Tiantian Ye, Yan Wu. Overexpression of the aspartic protease ASPG1 gene confers drought avoidance in Arabidopsis. Journal of experimental botany. 2012 Apr; 63(7):2579-93. doi: 10.1093/jxb/err433. [PMID: 22268147]
  • Eun Young Kim, Joon Seok Choi, Ko Eun Lee, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Suhn Hee Kim, Jong Un Lee, Soo Wan Kim. Altered regulation of renal Acid base transporters in response to ammonium chloride loading in rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2012 Apr; 16(2):91-5. doi: 10.4196/kjpp.2012.16.2.91. [PMID: 22563253]
  • Cheul Ho Park, Jae Woo Kim. Effect of advanced glycation end products on oxidative stress and senescence of trabecular meshwork cells. Korean journal of ophthalmology : KJO. 2012 Apr; 26(2):123-31. doi: 10.3341/kjo.2012.26.2.123. [PMID: 22511839]
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  • Axel Tiessen, Annika Nerlich, Benjamin Faix, Christine Hümmer, Simon Fox, Kay Trafford, Hans Weber, Winfriede Weschke, Peter Geigenberger. Subcellular analysis of starch metabolism in developing barley seeds using a non-aqueous fractionation method. Journal of experimental botany. 2012 Mar; 63(5):2071-87. doi: 10.1093/jxb/err408. [PMID: 22200665]
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