Prostaglandin D2 (BioDeep_00000629490)
Main id: BioDeep_00000003317
Chemicals and Drugs
代谢物信息卡片
(5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
化学式: C20H32O5 (352.2249622)
中文名称: 前列腺素 D2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C(C(CC1=O)O)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
描述信息
A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:15555
- KEGG: C00696
- PubChem: 448457
- DrugBank: DB02056
- ChEMBL: CHEMBL1235252
- LipidMAPS: LMFA03010004
- MeSH: Prostaglandin D2
- CAS: 41598-07-6
- MetaboLights: MTBLC15555
- PubChem: 3964
- PDB-CCD: PG2
- 3DMET: B01315
- NIKKAJI: J16.416J
- RefMet: PGD2
分类词条
相关代谢途径
Reactome(12)
- Metabolism
- Metabolism of lipids
- Developmental Biology
- Signaling Pathways
- Fatty acid metabolism
- Arachidonic acid metabolism
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
- Signaling by GPCR
- GPCR ligand binding
- Class A/1 (Rhodopsin-like receptors)
- GPCR downstream signalling
- G alpha (i) signalling events
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 62751 Larix sibirica: 10.1007/BF00598571
- 134440 Gersemia fruticosa: 10.1016/S0040-4039(00)73658-6
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 62751 Larix sibirica: 10.1007/BF00598571
- 134440 Gersemia fruticosa: 10.1016/S0040-4039(00)73658-6
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi-Fan Kang, Jin-Xin Liu, Kai Xu, Xue-Li Li, Xiang Lu. sPLA2GIB Promotes PGD2 and IL-13 Production in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps.
The Laryngoscope.
2023 Aug; ?(?):. doi:
10.1002/lary.30977. [PMID: 37594194] - Yuya Miyamoto, Masatoshi Nakatsuji, Takuya Yoshida, Tadayasu Ohkubo, Takashi Inui. Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX.
The FEBS journal.
2023 08; 290(16):3983-3996. doi:
10.1111/febs.16791. [PMID: 37021622] - Akane Hayashi, Naoaki Sakamoto, Koji Kobayashi, Takahisa Murata. Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion.
Frontiers in immunology.
2023; 14(?):1276852. doi:
10.3389/fimmu.2023.1276852. [PMID: 37942331] - Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, Daniel Merk, Fredrik Wermeling, Jesper Z Haeggström, Gunnar Nilsson, Dieter Steinhilber, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson. Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.
Journal of lipid research.
2022 12; 63(12):100310. doi:
10.1016/j.jlr.2022.100310. [PMID: 36370807] - Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Peng. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4574-4582. doi:
10.19540/j.cnki.cjcmm.20220217.701. [PMID: 36164862] - Junxia Feng, Meizhi Lu, Wenhao Li, Jingchun Li, Ping Meng, Zukai Li, Xuejuan Gao, Yunfang Zhang. PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
Molecular and cellular biochemistry.
2022 Jul; 477(7):1959-1971. doi:
10.1007/s11010-022-04419-y. [PMID: 35380292] - Nadia Elshareif, Chaitanya K Gavini, Virginie Mansuy-Aubert. LXR agonist modifies neuronal lipid homeostasis and decreases PGD2 in the dorsal root ganglia in western diet-fed mice.
Scientific reports.
2022 06; 12(1):10754. doi:
10.1038/s41598-022-14604-0. [PMID: 35750708] - Deping Kong, Ying Yu. Prostaglandin D2 signaling and cardiovascular homeostasis.
Journal of molecular and cellular cardiology.
2022 06; 167(?):97-105. doi:
10.1016/j.yjmcc.2022.03.011. [PMID: 35367459] - Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan P Jastrzębski, Karol G Makowczenko, Monika Golubska, Iwona Bogacka. PPARγ regulates the expression of genes involved in the DNA damage response in an inflamed endometrium.
Scientific reports.
2022 03; 12(1):4026. doi:
10.1038/s41598-022-07986-8. [PMID: 35256739] - Carlos Antonio Trindade da Silva, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Rosanna Tarkany Basting, Marcelo Henrique Napimoga. Peroxisome proliferator-activated receptor-gamma (PPARγ) and its immunomodulation function: current understanding and future therapeutic implications.
Expert review of clinical pharmacology.
2022 Mar; 15(3):295-303. doi:
10.1080/17512433.2022.2071697. [PMID: 35481412] - Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang. Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes.
Neurotoxicity research.
2022 Feb; 40(1):154-172. doi:
10.1007/s12640-020-00318-6. [PMID: 34997457] - Ko Fujimori. Prostaglandin D2 and F2α as Regulators of Adipogenesis and Obesity.
Biological & pharmaceutical bulletin.
2022; 45(8):985-991. doi:
10.1248/bpb.b22-00210. [PMID: 35908908] - Xin Hu, Ye-An Zhang, Ben Chen, Zi Jin, Mei-Lin Lin, Ming Li, Hong-Xia Mei, Jia-Chao Lu, Yu-Qiang Gong, Sheng-Wei Jin, Sheng-Xing Zheng. Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome.
International immunopharmacology.
2022 Jan; 102(?):108348. doi:
10.1016/j.intimp.2021.108348. [PMID: 34920958] - Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-Kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa, Keisuke Yoshikawa. A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus.
Journal of neuroinflammation.
2021 Dec; 18(1):304. doi:
10.1186/s12974-021-02361-2. [PMID: 34961526] - Sonja Rittchen, Katharina Jandl, Ilse Lanz, Bernhard Reiter, Nerea Ferreirós, Daniel Kratz, Jörg Lindenmann, Luka Brcic, Thomas Bärnthaler, Reham Atallah, Horst Olschewski, Eva M Sturm, Akos Heinemann. Monocytes and Macrophages Serve as Potent Prostaglandin D2 Sources during Acute, Non-Allergic Pulmonary Inflammation.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111697. [PMID: 34769126] - Nagisa Ito, Tatsuro Nakamura, Naoaki Sakamoto, Akane Hayashi, Takahisa Murata. Extraction and measurement of urinary tetranor-PGDM in disposable diapers.
Journal of pharmacological sciences.
2021 Oct; 147(2):208-210. doi:
10.1016/j.jphs.2021.06.011. [PMID: 34384569] - Carl Eguez, Michelle A Clark, Ann Tenneil O'Connor. 15-Deoxy-Δ-12,14-prostaglandin J2 effects in vascular smooth muscle cells: Implications in vascular smooth muscle cell proliferation and contractility.
Prostaglandins & other lipid mediators.
2021 10; 156(?):106583. doi:
10.1016/j.prostaglandins.2021.106583. [PMID: 34332056] - Tatsuro Nakamura. The roles of lipid mediators in type I hypersensitivity.
Journal of pharmacological sciences.
2021 Sep; 147(1):126-131. doi:
10.1016/j.jphs.2021.06.001. [PMID: 34294363] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - Heng Liu, R N V Krishna Deepak, Anna Shiriaeva, Cornelius Gati, Alexander Batyuk, Hao Hu, Uwe Weierstall, Wei Liu, Lei Wang, Vadim Cherezov, Hao Fan, Cheng Zhang. Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.
Proceedings of the National Academy of Sciences of the United States of America.
2021 08; 118(32):. doi:
10.1073/pnas.2102813118. [PMID: 34341104] - Misato Kida, Tatsuro Nakamura, Yuki Fujiwara, Masataka Nakamura, Takahisa Murata. PGD2 /CRTH2 signaling promotes acquired immunity against bee venom by enhancing IgE production.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 06; 35(6):e21616. doi:
10.1096/fj.202002748rr. [PMID: 33978990] - Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney.
Clinical and experimental nephrology.
2021 May; 25(5):445-455. doi:
10.1007/s10157-021-02021-y. [PMID: 33595729] - Christoph Schmöcker, Heike Gottschall, Katharina M Rund, Laura Kutzner, Fabian Nolte, Annika I Ostermann, Dirk Hartmann, Nils Helge Schebb, Karsten H Weylandt. Oxylipin patterns in human colon adenomas.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 04; 167(?):102269. doi:
10.1016/j.plefa.2021.102269. [PMID: 33812217] - Salma Mani, Xavier Norel, Mathilde Varret, Sarra Bchir, Amel Ben Anes, Abdelahamid Garrouch, Zouhair Tabka, Dan Longrois, Karim Chahed. Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 03; 166(?):102252. doi:
10.1016/j.plefa.2021.102252. [PMID: 33545665] - Meng Yuan, Yue Zhang, Tong Hua, Xiang-Li Liu, Tong Liu, Ru-Yu Yuan, Guang-Ping Li, Yi Zhu, Xu Zhang. Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a beneficial eicosanoid-pattern in patients with acute myocardial infarction: A randomized, controlled trial.
Clinical nutrition (Edinburgh, Scotland).
2021 02; 40(2):445-459. doi:
10.1016/j.clnu.2020.05.034. [PMID: 33041091] - Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan Paweł Jastrzębski, Iwona Bogacka. Transcriptome analysis of porcine endometrium after LPS-induced inflammation: effects of the PPAR-gamma ligands in vitro†.
Biology of reproduction.
2021 01; 104(1):130-143. doi:
10.1093/biolre/ioaa200. [PMID: 33112378] - Christine L Hammond, Elisa Roztocil, Mithra O Gonzalez, Steven E Feldon, Collynn F Woeller. MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK.
Investigative ophthalmology & visual science.
2021 01; 62(1):29. doi:
10.1167/iovs.62.1.29. [PMID: 33507228] - S Inagaki, T Nakamura, Y Hamasaki, K Yamamoto-Hanada, T Fukuie, M Narita, T Shimosawa, T Murata, Y Ohya. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis.
Clinical and experimental dermatology.
2021 Jan; 46(1):130-134. doi:
10.1111/ced.14393. [PMID: 32705704] - R Stokes Peebles. Urine: A Lens for Asthma Pathogenesis and Treatment?.
American journal of respiratory and critical care medicine.
2021 01; 203(1):1-3. doi:
10.1164/rccm.202007-2899ed. [PMID: 32791002] - Nanae Nagata, Sakura Masuko, Rikako Inoue, Tatsuro Nakamura, Kosuke Aritake, Takahisa Murata. Development of Monoclonal Antibody-Based EIA for Tetranor-PGDM which Reflects PGD2 Production in the Body.
Journal of immunology research.
2021; 2021(?):5591115. doi:
10.1155/2021/5591115. [PMID: 33997056] - Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh. 15-Deoxy-△12,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis.
Frontiers in immunology.
2021; 12(?):615803. doi:
10.3389/fimmu.2021.615803. [PMID: 33633749] - Hiromi Koma, Yasuhiro Yamamoto, Noboru Okamura, Tatsurou Yagami. A plausible involvement of plasmalemmal voltage-dependent anion channel 1 in the neurotoxicity of 15-deoxy-Δ12,14 -prostaglandin J2.
Brain and behavior.
2020 12; 10(12):e01866. doi:
10.1002/brb3.1866. [PMID: 33200588] - Sonja Rittchen, Kathrin Rohrer, Wolfgang Platzer, Eva Knuplez, Thomas Bärnthaler, Leigh M Marsh, Reham Atallah, Katharina Sinn, Walter Klepetko, Neha Sharma, Chandran Nagaraj, Akos Heinemann. Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4.
Biochemical pharmacology.
2020 12; 182(?):114277. doi:
10.1016/j.bcp.2020.114277. [PMID: 33038299] - Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu, Jian Zhang, Yujun Shen. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages.
Circulation research.
2020 10; 127(10):1323-1336. doi:
10.1161/circresaha.120.316784. [PMID: 32912104] - Ajay Gupta, Kate Chander Chiang. Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease.
Medical hypotheses.
2020 Oct; 143(?):110122. doi:
10.1016/j.mehy.2020.110122. [PMID: 32759007] - L Li, E Y Lai, X Cao, W J Welch, C S Wilcox. Endothelial prostaglandin D2 opposes angiotensin II contractions in mouse isolated perfused intracerebral microarterioles.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2020 Oct; 21(4):1470320320966177. doi:
10.1177/1470320320966177. [PMID: 33094663] - Shakeel Shahzad, Mark Willcox. Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J2) for effective treatment and reduction in the death toll.
Medical hypotheses.
2020 Oct; 143(?):110080. doi:
10.1016/j.mehy.2020.110080. [PMID: 32683221] - Mengwen Li, Xinsheng Fan, Qinfei Yue, Fangyuan Hu, Yiming Zhang, Chan Zhu. The neuro-immune interaction in airway inflammation through TRPA1 expression in CD4+ T cells of asthmatic mice.
International immunopharmacology.
2020 Sep; 86(?):106696. doi:
10.1016/j.intimp.2020.106696. [PMID: 32570040] - Yuanting Chen, Jie Xiang, Fenghua Qian, Bastihalli T Diwakar, Baiye Ruan, Siyang Hao, K Sandeep Prabhu, Robert F Paulson. Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation.
Blood.
2020 07; 136(2):235-246. doi:
10.1182/blood.2019003480. [PMID: 32350523] - Zhe Peng, Miaomiao Li, Xiaodan Tan, Pu Xiang, Hong Wang, Ying Luo, Yang Yang, Haifeng Huang, Zhihao Chen, Hui Xia, Yuke Li, Jiahua Zhang, Chao Gu, Maozhu Liu, Qiong Wang, Mengyuan Chen, Junqing Yang. miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2.
Biochemical pharmacology.
2020 07; 177(?):113983. doi:
10.1016/j.bcp.2020.113983. [PMID: 32311346] - Shadab Abadpour, Björn Tyrberg, Simen W Schive, Charlotte Wennberg Huldt, Peter Gennemark, Erik Ryberg, Tina Rydén-Bergsten, David M Smith, Olle Korsgren, Stanko Skrtic, Hanne Scholz, Maria Sörhede Winzell. Inhibition of the prostaglandin D2-GPR44/DP2 axis improves human islet survival and function.
Diabetologia.
2020 07; 63(7):1355-1367. doi:
10.1007/s00125-020-05138-z. [PMID: 32350565] - Hiroaki Hayashi, Yuma Fukutomi, Chihiro Mitsui, Keiichi Kajiwara, Kentaro Watai, Yosuke Kamide, Yuto Nakamura, Yuto Hamada, Yasuhiro Tomita, Kiyoshi Sekiya, Takahiro Tsuburai, Kenji Izuhara, Keiko Wakahara, Naozumi Hashimoto, Yoshinori Hasegawa, Masami Taniguchi. Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial.
American journal of respiratory and critical care medicine.
2020 06; 201(12):1488-1498. doi:
10.1164/rccm.201906-1215oc. [PMID: 32142372] - Tianming Wang, Xueyan Zhang, Yiwen Ye, Rong Shi, Yueming Ma. Quantification of prostaglandins E2 and D2 using liquid chromatography-tandem mass spectrometry in a mouse ear edema model.
Analytical methods : advancing methods and applications.
2020 06; 12(22):2865-2871. doi:
10.1039/d0ay00506a. [PMID: 32930210] - Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami. The Anti-Neuron-Specific Enolase Antibody Induced Neuronal Cell Death in a Novel Fashion.
Molecular neurobiology.
2020 May; 57(5):2265-2278. doi:
10.1007/s12035-020-01876-8. [PMID: 32006234] - Keisuke Suzuki, Shiho Suzuki, Yuko Ishii, Madoka Okamura, Takeo Matsubara, Hiroaki Fujita, Narihiro Nozawa, Saro Kobayashi, Koichi Hirata. Plasma prostaglandin D2 synthase levels in sleep and neurological diseases.
Journal of the neurological sciences.
2020 Apr; 411(?):116692. doi:
10.1016/j.jns.2020.116692. [PMID: 31981928] - Hiroshi Nango, Yasuhiro Kosuge, Nana Yoshimura, Hiroko Miyagishi, Takanori Kanazawa, Kaname Hashizaki, Toyofumi Suzuki, Kumiko Ishige. The Molecular Mechanisms Underlying Prostaglandin D2-Induced Neuritogenesis in Motor Neuron-Like NSC-34 Cells.
Cells.
2020 04; 9(4):. doi:
10.3390/cells9040934. [PMID: 32290308] - Jonathan Muri, Qian Feng, Helene Wolleb, Abdijapar Shamshiev, Christian Ebner, Luigi Tortola, Petr Broz, Erick M Carreira, Manfred Kopf. Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.
Cell reports.
2020 03; 30(13):4399-4417.e7. doi:
10.1016/j.celrep.2020.03.019. [PMID: 32234476] - Shuang Zhang, Miao Yu, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han, Yajun Duan. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo.
British journal of pharmacology.
2020 03; 177(5):1041-1060. doi:
10.1111/bph.14886. [PMID: 31658492] - Zhi-Hao Zhang, Jun-Qiu He, Ying-Yong Zhao, Hua-Chao Chen, Ning-Hua Tan. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Acta pharmacologica Sinica.
2020 Mar; 41(3):373-382. doi:
10.1038/s41401-019-0319-4. [PMID: 31705123] - Abdul Rashid Issahaku, Clement Agoni, Ransford O Kumi, Fisayo A Olotu, Mahmoud E S Soliman. Lipid-Embedded Molecular Dynamics Simulation Model for Exploring the Reverse Prostaglandin D2 Agonism of CT-133 towards CRTH2 in the Treatment of Type-2 Inflammation Dependent Diseases.
Chemistry & biodiversity.
2020 Mar; 17(3):e1900548. doi:
10.1002/cbdv.201900548. [PMID: 32034875] - Oyebola O Oyesola, Carolina Duque, Linda C Huang, Elisabeth M Larson, Simon P Früh, Lauren M Webb, Seth A Peng, Elia D Tait Wojno. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.
Journal of immunology (Baltimore, Md. : 1950).
2020 02; 204(4):1001-1011. doi:
10.4049/jimmunol.1900745. [PMID: 31900341] - S Rangarajan, G Rezonzew, P Chumley, H Fatima, M Y Golovko, W Feng, P Hua, E A Jaimes. COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease.
American journal of physiology. Renal physiology.
2020 02; 318(2):F475-F485. doi:
10.1152/ajprenal.00407.2019. [PMID: 31841390] - Ramona C Dolscheid-Pommerich, Juliane Weikert, Madlen Reinicke, Rolf Fimmers, Birgit Stoffel-Wagner, Felix Erdfelder, Uta Ceglarek, Lars Eichhorn. Changes in PUFA and eicosanoid metabolism during/after apnea diving: a prospective single-center study.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2020 Fou; 47(4):539-549. doi:
. [PMID: 33227829] - Shin-Ichi Akanuma, Kahori Hashimoto, Yukiko Yoshida, Yoshiyuki Kubo, Ken-Ichi Hosoya. Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
Biological & pharmaceutical bulletin.
2020; 43(11):1669-1677. doi:
10.1248/bpb.b20-00388. [PMID: 33132311] - Vikas Kumar, A Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T R Santhosh Kumar, Chandrasekharan C Kartha. Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana.
Molecular and cellular biochemistry.
2020 Jan; 463(1-2):147-160. doi:
10.1007/s11010-019-03637-1. [PMID: 31595424] - Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami. 15-Deoxy-Δ12,14-prostaglandin J2 Inhibits Cell Migration on Renal Cell Carcinoma via Down-Regulation of Focal Adhesion Kinase Signaling.
Biological & pharmaceutical bulletin.
2020; 43(1):153-157. doi:
10.1248/bpb.b19-00748. [PMID: 31902920] - Shima Rezaee, Naser Kakavandi, Mohammad Shabani, Mohsen Khosravi, Seyed R Hosseini-Fard, Mohammad Najafi. COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis.
Endocrine, metabolic & immune disorders drug targets.
2020; 20(9):1514-1522. doi:
10.2174/1871530320666200511012142. [PMID: 32389118] - Qi-Shan Wang, Bing-Xin Xu, Kai-Jian Fan, Yun-Wu Li, Jing Wu, Ting-Yu Wang. Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats.
Drug design, development and therapy.
2020; 14(?):4101-4113. doi:
10.2147/dddt.s256850. [PMID: 33116399] - Gregorio Peron, Stefania Sut, Simone Dal Ben, Dario Voinovich, Stefano Dall'Acqua. Untargeted UPLC-MS metabolomics reveals multiple changes of urine composition in healthy adult volunteers after consumption of curcuma longa L. extract.
Food research international (Ottawa, Ont.).
2020 01; 127(?):108730. doi:
10.1016/j.foodres.2019.108730. [PMID: 31882111] - Natália R T Amorim, Glaucia Souza-Almeida, Tatiana Luna-Gomes, Patricia T Bozza, Claudio Canetti, Bruno L Diaz, Clarissa M Maya-Monteiro, Christianne Bandeira-Melo. Leptin Elicits In Vivo Eosinophil Migration and Activation: Key Role of Mast Cell-Derived PGD2.
Frontiers in endocrinology.
2020; 11(?):572113. doi:
10.3389/fendo.2020.572113. [PMID: 33117286] - Manuella Verdinelli de Paula Reis, Gabriela Leite de Souza, Priscilla Barbosa Ferreira Soares, Maria Aparecida de Souza, Carlos José Soares, Camilla Christian Gomes Moura. Effect of ScLL and 15d-PGJ2 on viability and cytokine release in LPS-stimulated fibroblasts: an in vitro study.
Brazilian oral research.
2020; 34(?):e013. doi:
10.1590/1807-3107bor-2020.vol34.0013. [PMID: 32074213] - Jennifer R Kimbrough, Zachary Austin, Ginger L Milne, Gary A Sulikowski. Synthesis of a Human Urinary Metabolite of Prostaglandin D2.
Organic letters.
2019 12; 21(24):10048-10051. doi:
10.1021/acs.orglett.9b03983. [PMID: 31799855] - A Sikora-Wiorkowska, A Smolen, G Czechowska, K Wiorkowski, A Korolczuk. The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2019 Dec; 70(6):. doi:
10.26402/jpp.2019.6.07. [PMID: 32084649] - Sven-Christian Pawelzik, Antoine Avignon, Helena Idborg, Catherine Boegner, Françoise Stanke-Labesque, Per-Johan Jakobsson, Ariane Sultan, Magnus Bäck. Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects.
Prostaglandins & other lipid mediators.
2019 12; 145(?):106361. doi:
10.1016/j.prostaglandins.2019.106361. [PMID: 31419481] - Rabia Nazik Yüksel, Ayşe Pınar Titiz, Elif Tatlıdil Yaylacı, Kübranur Ünal, Turan Turhan, Gamze Erzin, Cevdet Züngün, Makbule Çiğdem Aydemir, Erol Göka. Serum PGE2, 15d-PGJ, PPARγ and CRP levels in patients with schizophrenia.
Asian journal of psychiatry.
2019 Dec; 46(?):24-28. doi:
10.1016/j.ajp.2019.09.026. [PMID: 31590005] - Akane Hayashi, Shota Fujii, Tatsuro Nakamura, Koji Kobayashi, Miki Sakatani, Maiko Endo, Tomotsugu Takahashi, Takahisa Murata. Production of lipid mediators in mastitic milk of cow.
Animal science journal = Nihon chikusan Gakkaiho.
2019 Aug; 90(8):999-1007. doi:
10.1111/asj.13222. [PMID: 31148331] - Woo Kim, Haruhiko Tokuda, Tetsu Kawabata, Kazuhiko Fujita, Go Sakai, Daiki Nakashima, Junko Tachi, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa. Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.
Prostaglandins & other lipid mediators.
2019 08; 143(?):106327. doi:
10.1016/j.prostaglandins.2019.03.002. [PMID: 30946899] - Ivelina Urban, Martin Turinsky, Sviatlana Gehrmann, Jakob Morgenstern, Maik Brune, Moritz R Milewski, Andreas H Wagner, Cordula Rumig, Thomas Fleming, Florian Leuschner, Christian A Gleissner, Markus Hecker. 15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells With a Genetically Determined NO Deficit.
Circulation research.
2019 07; 125(3):282-294. doi:
10.1161/circresaha.118.313820. [PMID: 31213138] - Daiki Horikami, Naoki Toya, Koji Kobayashi, Keisuke Omori, Nanae Nagata, Takahisa Murata. L-PGDS-derived PGD2 attenuates acute lung injury by enhancing endothelial barrier formation.
The Journal of pathology.
2019 07; 248(3):280-290. doi:
10.1002/path.5253. [PMID: 30734298] - Sonja Rittchen, Akos Heinemann. Therapeutic Potential of Hematopoietic Prostaglandin D2 Synthase in Allergic Inflammation.
Cells.
2019 06; 8(6):. doi:
10.3390/cells8060619. [PMID: 31226822] - Jovana Maric, Avinash Ravindran, Luca Mazzurana, Aline Van Acker, Anna Rao, Efthymia Kokkinou, Maria Ekoff, Dominique Thomas, Alexander Fauland, Gunnar Nilsson, Craig E Wheelock, Sven-Erik Dahlén, Nerea Ferreirós, Gerd Geisslinger, Danielle Friberg, Akos Heinemann, Viktoria Konya, Jenny Mjösberg. Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation.
The Journal of allergy and clinical immunology.
2019 06; 143(6):2202-2214.e5. doi:
10.1016/j.jaci.2018.10.069. [PMID: 30578872] - Hu Wang, Fanny Cheung, Anna C Stoll, Patricia Rockwell, Maria E Figueiredo-Pereira. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1436-1450. doi:
10.1016/j.bbadis.2019.02.016. [PMID: 30796971] - Ahmed E M Elhassanny, Daniel A Ladin, Eman Soliman, Hussam Albassam, Andrew Morris, Robert Kobet, Kathleen Thayne, Colin Burns, Allison S Danell, Rukiyah Van Dross. Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants.
Prostaglandins & other lipid mediators.
2019 06; 142(?):9-23. doi:
10.1016/j.prostaglandins.2019.03.001. [PMID: 30858059] - Baptiste Buisseret, Owein Guillemot-Legris, Giulio G Muccioli, Mireille Alhouayek. Prostaglandin D2-glycerol ester decreases carrageenan-induced inflammation and hyperalgesia in mice.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 05; 1864(5):609-618. doi:
10.1016/j.bbalip.2019.01.009. [PMID: 30684679] - Frederik Desmarais, Karl-F Bergeron, Eric Rassart, Catherine Mounier. Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 04; 1864(4):522-531. doi:
10.1016/j.bbalip.2019.01.001. [PMID: 30630053] - Shujue Li, Yu Lan, Wenzheng Wu, Xiaolu Duan, Zhenzhen Kong, Wenqi Wu, Guohua Zeng. Peroxisome proliferator-activated receptor γ modulates renal crystal retention associated with high oxalate concentration by regulating tubular epithelial cellular transdifferentiation.
Journal of cellular physiology.
2019 03; 234(3):2837-2850. doi:
10.1002/jcp.27102. [PMID: 30317563] - Ko Fujimori, Kosuke Aritake, Yo Oishi, Nanae Nagata, Toko Maehara, Michael Lazarus, Yoshihiro Urade. L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance.
Scientific reports.
2019 02; 9(1):1931. doi:
10.1038/s41598-018-38453-y. [PMID: 30760783] - Hiromi Koma, Yasuhiro Yamamoto, Hiroaki Kumagai, Tatsurou Yagami. 4,4-Diisothiocyanatostilbene Disulfonic Acid Enhanced 15-Deoxy-Δ12,14-prostaglandin J2-Induced Neuronal Apoptosis.
Biological & pharmaceutical bulletin.
2019; 42(11):1913-1920. doi:
10.1248/bpb.b19-00536. [PMID: 31685774] - Wataru Suto, Hiroyasu Sakai, Yoshihiko Chiba. Sustained exposure to prostaglandin D2 augments the contraction induced by acetylcholine via a DP1 receptor-mediated activation of p38 in bronchial smooth muscle of naive mice.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2019; 55(0):1-13. doi:
10.1540/jsmr.55.1. [PMID: 30918168] - Zhencheng Xiong, Pan Luo, Jun Zhou, Mingsheng Tan. 15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review.
Drug design, development and therapy.
2019; 13(?):1879-1888. doi:
10.2147/dddt.s206695. [PMID: 31213775] - Eri Takeshita, Hirofumi Komaki, Hisateru Tachimori, Kazuhisa Miyoshi, Ikuo Yamamiya, Yuko Shimizu-Motohashi, Akihiko Ishiyama, Takashi Saito, Eiji Nakagawa, Kenji Sugai, Masayuki Sasaki. Urinary prostaglandin metabolites as Duchenne muscular dystrophy progression markers.
Brain & development.
2018 Nov; 40(10):918-925. doi:
10.1016/j.braindev.2018.06.012. [PMID: 30006121] - Mohammad Shahidur Rahman, Pinky Karim Syeda, Michael N N Nartey, Md Mazharul Islam Chowdhury, Hidehisa Shimizu, Kohji Nishimura, Mitsuo Jisaka, Fumiaki Shono, Kazushige Yokota. Comparison of pro-adipogenic effects between prostaglandin (PG) D2 and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD2, during the maturation phase of cultured adipocytes.
Prostaglandins & other lipid mediators.
2018 11; 139(?):71-79. doi:
10.1016/j.prostaglandins.2018.10.006. [PMID: 30393164] - Shinichiro Inagaki, Shingo Maeda, Masami Narita, Tatsuro Nakamura, Tatsuo Shimosawa, Takahisa Murata, Yukihiro Ohya. Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy.
The Journal of allergy and clinical immunology.
2018 11; 142(5):1634-1636.e10. doi:
10.1016/j.jaci.2018.06.032. [PMID: 29981807] - Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba. Prostaglandin D₂ Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle.
International journal of molecular sciences.
2018 Oct; 19(10):. doi:
10.3390/ijms19103036. [PMID: 30301147] - Lei Wang, Dandan Yao, R N V Krishna Deepak, Heng Liu, Qingpin Xiao, Hao Fan, Weimin Gong, Zhiyi Wei, Cheng Zhang. Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Molecular cell.
2018 10; 72(1):48-59.e4. doi:
10.1016/j.molcel.2018.08.009. [PMID: 30220562] - Sachin Kumar, Akanksha Sharma, Rinkesh Kumar Gupta, Ajay Kumar Verma, Premendra D Dwivedi. Allergenicity assessment of Buchanania lanzan protein extract in Balb/c mice.
International immunopharmacology.
2018 Oct; 63(?):170-182. doi:
10.1016/j.intimp.2018.07.039. [PMID: 30096600] - Mireille Alhouayek, Baptiste Buisseret, Adrien Paquot, Owein Guillemot-Legris, Giulio G Muccioli. The endogenous bioactive lipid prostaglandin D2-glycerol ester reduces murine colitis via DP1 and PPARγ receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 09; 32(9):5000-5011. doi:
10.1096/fj.201701205r. [PMID: 29630407] - Brian M Ross. Methylnicotinate stimulated prostaglandin synthesis in patients with schizophrenia: A preliminary investigation.
Prostaglandins, leukotrienes, and essential fatty acids.
2018 09; 136(?):99-102. doi:
10.1016/j.plefa.2017.05.002. [PMID: 28552466] - Bart Hilvering, Timothy S C Hinks, Linda Stöger, Emanuele Marchi, Maryam Salimi, Rahul Shrimanker, Wei Liu, Wentao Chen, Jian Luo, Simei Go, Timothy Powell, Jennifer Cane, Samantha Thulborn, Ayako Kurioka, Tianqi Leng, Jamie Matthews, Clare Connolly, Catherine Borg, Mona Bafadhel, Christian B Willberg, Adaikalavan Ramasamy, Ratko Djukanović, Graham Ogg, Ian D Pavord, Paul Klenerman, Luzheng Xue. Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.
Mucosal immunology.
2018 09; 11(5):1408-1419. doi:
10.1038/s41385-018-0049-9. [PMID: 29907870] - Tetsuya Tachibana, Yasua Nakai, Ryosuke Makino, Md Sakirul Islam Khan, Mark A Cline. Physiological response to central and peripheral injection of prostaglandin D2 in chicks.
Prostaglandins & other lipid mediators.
2018 07; 137(?):46-51. doi:
10.1016/j.prostaglandins.2018.06.002. [PMID: 29936041] - Bin Zhang, Qingli Bie, Peipei Wu, Jie Zhang, Benshuai You, Hui Shi, Hui Qian, Wenrong Xu. PGD2/PTGDR2 Signaling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer.
Stem cells (Dayton, Ohio).
2018 07; 36(7):990-1003. doi:
10.1002/stem.2821. [PMID: 29604141] - Marianne Frieri. Mast Cell Activation Syndrome.
Clinical reviews in allergy & immunology.
2018 Jun; 54(3):353-365. doi:
10.1007/s12016-015-8487-6. [PMID: 25944644] - Sarah McGarrity, Ósk Anuforo, Haraldur Halldórsson, Andreas Bergmann, Skarphéðinn Halldórsson, Sirus Palsson, Hanne H Henriksen, Pär Ingemar Johansson, Óttar Rolfsson. Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification.
Scientific reports.
2018 05; 8(1):6811. doi:
10.1038/s41598-018-25015-5. [PMID: 29717213] - Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma. Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases.
Molecular neurobiology.
2018 03; 55(3):2227-2248. doi:
10.1007/s12035-017-0435-4. [PMID: 28299574] - Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles. Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs.
Nature communications.
2018 02; 9(1):725. doi:
10.1038/s41467-018-03129-8. [PMID: 29463843] - Priscilla A T Pereira, Patrícia A Assis, Morgana K B Prado, Simone G Ramos, David M Aronoff, Francisco W G de Paula-Silva, Carlos A Sorgi, Lúcia H Faccioli. Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum.
Journal of lipid research.
2018 02; 59(2):195-206. doi:
10.1194/jlr.m078162. [PMID: 29217623] - Matthew Thomas Ferreira, Renata Nascimento Gomes, Alexandros Theodoros Panagopoulos, Fernando Gonçalves de Almeida, José Carlos Esteves Veiga, Alison Colquhoun. Opposing roles of PGD2 in GBM.
Prostaglandins & other lipid mediators.
2018 01; 134(?):66-76. doi:
10.1016/j.prostaglandins.2017.10.002. [PMID: 29042181] - Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li, Marianna Kulka. Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor γ activator-mediated inhibition of dendritic cells.
International journal of immunopathology and pharmacology.
2018 Jan; 32(?):2058738418787739. doi:
10.1177/2058738418787739. [PMID: 30014756] - Natália R T Amorim, Tatiana Luna-Gomes, Marcos Gama-Almeida, Glaucia Souza-Almeida, Claudio Canetti, Bruno L Diaz, Peter F Weller, Patricia Torres Bozza, Clarissa M Maya-Monteiro, Christianne Bandeira-Melo. Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors.
Frontiers in immunology.
2018; 9(?):2139. doi:
10.3389/fimmu.2018.02139. [PMID: 30298073]