FA 18:2;O (BioDeep_00000629169)

 

Secondary id: BioDeep_00000003308


代谢物信息卡片


(S)-9-Hydroxy-trans,trans-10,12-octadecadienoic acid

化学式: C18H32O3 (296.2351)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 15.29%

分子结构信息

SMILES: C(/C=C/C(=O)CCCCCCCCCCCCCC)(=O)O
InChI: InChI=1S/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)15-16-18(20)21/h15-16H,2-14H2,1H3,(H,20,21)/b16-15+

描述信息

同义名列表

97 个代谢物同义名

(9R,10S)-(12Z)-9,10-Epoxyoctadecenoic acid; 9R,10S-epoxy-12Z-octadecenoic acid; 9R,10S-EpOME; 9(10)-EpOME; FA 18:2;O; (1S,2S)-3-oxo-2-pentyl-cyclopentaneoctanoic acid; (1R,2R)-3-oxo-2-pentyl-cyclopentaneoctanoic acid; 4-oxo-2E-octadecenoic acid; 13-hydroxy-9Z,12Z-octadecadienoic acid; 13-hydroxyoctadeca-9Z,12Z-dienoic acid; 10-hydroxy-9Z,12Z-octadecadienoic acid; 10-hydroxyoctadeca-9Z,12Z-dienoic acid; 11-Octadecenoic acid, 9-oxo-, (Z)-; 9-keto-11Z-octadecenoic acid; 9-oxo-11Z-octadecenoic acid; 10,12-Octadecadienoic acid, 9-hydroxy-; 9-Hydroxyoctadeca-10,12-dienoic acid; 9-hydroxy-10,12-Octadecadienoic acid; 9,12-Octadecadienoic acid, 15-hydroxy-, (9Z,12Z)-; 9,12-Octadecadienoic acid, 15-hydroxy-, (Z,Z)-; cis-15-Hydroxy-9,12-octadecadienoic acid; 15-hydroxy-9Z,12Z-Octadecadienoic acid; 15-Hydroxy-Z,Z-9,15-octadecadienoic acid; 15-Hydroxy-9Z,15Z-octadecadienoic acid; 15-Hydroxyoctadeca-9c,15c-dienoic acid; 9-Octadecenoic acid, 13-oxo-, (E); 13-keto-trans-9-octadecenoic acid; 13-Oxo-trans-9-octadecenoic acid; 13-Keto-E-9-octadecenoic acid; 13-Oxo-E-9-octadecenoic acid; 13-oxo-9E-Octadecenoic acid; 13-Oxo-E-9-octadecensaeure; 11,14-Octadecadienoic acid, 8-hydroxy-, (Z,Z)-; 8-Hydroxy-Z,Z-11,14-octadecadienoic acid; 8-hydroxy-11Z,14Z-Octadecadienoic acid; 12-Octadecenoic acid, 9-oxo-, (12Z)-; 9-Keto-Z-12-Octadecenoic acid; 9-Keto-Z-12-Octadecensaeure; 9-oxo-12Z-Octadecenoic acid; 9-Oxo-12c-Octadecenoic acid; 9-Oxo-12c-Octadecensaeure; 9,10-epoxy-12-octadecenoic acid; 9,10-EpOME(12); 12,13-epoxy-9-octadecenoic acid; 12,13-EpOME(9); 12-oxo-9Z-octadecenoic acid; 12-OxoOME(9Z); 12-oxo-9E-octadecenoic acid; 12-OxoOME(9E); 12-oxo-10Z-octadecenoic acid; 12-OxoOME(10Z); 12-oxo-10E-octadecenoic acid; 12-OxoOME(10E); 10-Octadecynoic acid, 12-hydroxy-; 12-hydroxy-10-octadecynoic acid; 9-Octadecynoic acid, 12-hydroxy-, (S)-; 12S-hydroxy-9-octadecynoic acid; 9-Octadecynoic acid, 12-hydroxy-; 12-hydroxy-9-octadecynoic acid; Stearolic acid, 12-hydroxy-; Ricinstearolic acid; (S)-9-Hydroxy-trans,trans-10,12-octadecadienoic acid; (S)-9-Hydroxy-10-trans,12-trans-octadecadienoic acid; 10,12-Octadecadienoic acid, 9-hydroxy-, [S-(E,E)]-; (S)-9-Hydroxy-trans,trans-octadecadienoic acid; (S)-9-Hydroxy-10E,12E-octadecadienoic acid; 9S-hydroxy-10E,12E-octadecadienoic acid; beta-Dimorphecolic acid; (S)-; 13-hydroxy-trans-9,trans-11-octadecadienoic acid; 13-hydroxy-9E,11E-octadecadienoic acid; alpha-artemisic acid; 12-hydroxy-cis-9,cis-15-octadecadienoic acid; 12-hydroxy-9Z,15Z-octadecadienoic acid; Densipolic acid; 9-hydroxy-trans-10,trans-12-octadecadienoic acid; 9-hydroxy-10E,12E-octadecadienoic acid; Dimorphecolic acid; 2R-hydroxy-9Z,12Z-octadecadienoic acid; 2R-hydroxy-linoleic acid; 2-hydroxy-linoleic acid; 10-oxo-12-cis-octadecenoic acid; 10-keto-12Z-octadecenoic acid; 10-oxo-12Z-octadecenoic acid; 12(Z)-10KOME; 7-Methoxy-9-methyl-4E,8E-hexadecadienoic acid; 6-oxo-4E-octadecenoic acid; 10-oxo-11E-octadecenoic acid; 11(E)-10-KOME; 11-Octadecenoic acid, 7-oxo-, (Z)-; 7-Keto-11c-octadecenoic acid; 7-Oxo-11c-octadecenoic acid; 7-keto-11-Octadecenoic acid; 7-oxo-11-Octadecenoic acid; (Z)-13-Oxo-9-octadecenoic acid; 13-keto-9Z-octadecenoic acid; 13-Oxo-9Z-octadecenoic acid



数据库引用编号

88 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, CASP3, EGFR, PPARG, STAT3, TP53, VEGFA
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 7 AKT1, CASP3, EGFR, PPARG, STAT3, TP53, VEGFA
cytosol 6 AKT1, CASP3, IL1B, PPARG, STAT3, TP53
centrosome 1 TP53
nucleoplasm 5 AKT1, CASP3, PPARG, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 3 AKT1, EGFR, TNF
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 3 EGFR, TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, EGFR
Golgi apparatus 1 VEGFA
Golgi membrane 1 EGFR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
endosome 1 EGFR
plasma membrane 4 AKT1, EGFR, STAT3, TNF
Membrane 4 AKT1, EGFR, TP53, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 1 MMP9
endoplasmic reticulum 2 TP53, VEGFA
extracellular space 5 EGFR, IL1B, MMP9, TNF, VEGFA
perinuclear region of cytoplasm 2 EGFR, PPARG
adherens junction 1 VEGFA
mitochondrion 1 TP53
protein-containing complex 3 AKT1, EGFR, TP53
intracellular membrane-bounded organelle 1 PPARG
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 2 IL1B, VEGFA
extracellular region 4 IL1B, MMP9, TNF, VEGFA
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 2 MMP9, VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 EGFR, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 MMP9
secretory granule 2 IL1B, VEGFA
receptor complex 2 EGFR, PPARG
ciliary basal body 1 AKT1
chromatin 3 PPARG, STAT3, TP53
phagocytic cup 1 TNF
site of double-strand break 1 TP53
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MMP9
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
tertiary granule lumen 1 MMP9
Secreted, extracellular exosome 1 IL1B
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
death-inducing signaling complex 1 CASP3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Veronika Paluchova, Anders Vik, Tomas Cajka, Marie Brezinova, Kristyna Brejchova, Viktor Bugajev, Lubica Draberova, Petr Draber, Jana Buresova, Petra Kroupova, Kristina Bardova, Martin Rossmeisl, Jan Kopecky, Trond Vidar Hansen, Ondrej Kuda. Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice. Molecular nutrition & food research. 2020 06; 64(11):e1901238. doi: 10.1002/mnfr.201901238. [PMID: 32277573]
  • So Yeon Kwon, Karen Massey, Mark A Watson, Tayab Hussain, Giacomo Volpe, Christopher D Buckley, Anna Nicolaou, Paul Badenhorst. Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO. Life science alliance. 2020 02; 3(2):. doi: 10.26508/lsa.201900356. [PMID: 31992650]
  • Huan Bian, Jingjing Ma, Zhiming Geng, Ting Liu, Chong Sun, Daoying Wang, Muhan Zhang, Weimin Xu. Changes of hydroxyl-linoleic acids during Chinese-style sausage processing and their relationships with lipids oxidation. Food chemistry. 2019 Oct; 296(?):63-68. doi: 10.1016/j.foodchem.2019.05.183. [PMID: 31202307]
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  • David C Nieman, Mary Pat Meaney, Casey S John, Kevin J Knagge, Huiyuan Chen. 9- and 13-Hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2h running. Brain, behavior, and immunity. 2016 Aug; 56(?):246-52. doi: 10.1016/j.bbi.2016.03.020. [PMID: 27018002]
  • Ting Zhao, Hong Du, Janice S Blum, Cong Yan. Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis. Oncotarget. 2016 Jan; 7(2):1529-43. doi: 10.18632/oncotarget.6414. [PMID: 26625314]
  • Kexi Zha, Changting Zuo, Aihong Wang, Bingchang Zhang, Yan Zhang, Bei Wang, Yunjia Wang, Jiajun Zhao, Ling Gao, Chao Xu. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. Lipids in health and disease. 2015 Aug; 14(?):95. doi: 10.1186/s12944-015-0092-4. [PMID: 26302822]
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  • Vamsi J Nalam, Jantana Keereetaweep, Jyoti Shah. The green peach aphid, Myzus persicae, acquires a LIPOXYGENASE5-derived oxylipin from Arabidopsis thaliana, which promotes colonization of the host plant. Plant signaling & behavior. 2013 Jan; 8(1):e22735. doi: 10.4161/psb.22735. [PMID: 23221749]
  • Christopher E Ramsden, Amit Ringel, Ariel E Feldstein, Ameer Y Taha, Beth A MacIntosh, Joseph R Hibbeln, Sharon F Majchrzak-Hong, Keturah R Faurot, Stanley I Rapoport, Yewon Cheon, Yoon-Mi Chung, Michael Berk, J Douglas Mann. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins, leukotrienes, and essential fatty acids. 2012 Oct; 87(4-5):135-41. doi: 10.1016/j.plefa.2012.08.004. [PMID: 22959954]
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  • Satoru Tamura, Masafumi Kaneko, Atsushi Shiomi, Guang-Ming Yang, Toshiaki Yamaura, Nobutoshi Murakami. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia. Bioorganic & medicinal chemistry letters. 2010 Mar; 20(6):1837-9. doi: 10.1016/j.bmcl.2010.01.165. [PMID: 20176483]
  • Hideru Obinata, Takashi Izumi. G2A as a receptor for oxidized free fatty acids. Prostaglandins & other lipid mediators. 2009 Sep; 89(3-4):66-72. doi: 10.1016/j.prostaglandins.2008.11.002. [PMID: 19063986]
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  • Yuki Kawakami, Tomomi Nakamura, Tomoko Hosokawa, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Hideaki Tsuji, Hideki Yoshida, Takahiko Hada, Yoshitaka Takahashi. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. Prostaglandins, leukotrienes, and essential fatty acids. 2009 May; 80(5-6):239-45. doi: 10.1016/j.plefa.2009.04.006. [PMID: 19457650]
  • Hiroshi Yokoi, Hajime Mizukami, Akito Nagatsu, Takamasa Ohno, Hiroki Tanabe, Makoto Inoue. Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.). Biological & pharmaceutical bulletin. 2009 Apr; 32(4):735-40. doi: 10.1248/bpb.32.735. [PMID: 19336916]
  • Anna Leonardini, Luigi Laviola, Sebastio Perrini, Annalisa Natalicchio, Francesco Giorgino. Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity. PPAR research. 2009; 2009(?):818945. doi: 10.1155/2009/818945. [PMID: 20182551]
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