FA 20:4;O (BioDeep_00000628861)
Secondary id: BioDeep_00000001718, BioDeep_00000004023, BioDeep_00000019035, BioDeep_00000397598, BioDeep_00000594395, BioDeep_00000608000, BioDeep_00000608004
代谢物信息卡片
(5E,8E)-10-{3-[(2E)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoic acid
化学式: C20H32O3 (320.23513219999995)
中文名称: 14(S),15(R)-环氧-(5Z,8Z,11Z)-二十碳三烯酸
谱图信息:
最多检出来源 Macaca mulatta(otcml) 0.91%
分子结构信息
SMILES: C(/C=C\C/C=C\CCCC(=O)O)/C=C\CC1OC1CCCCC
InChI: InChI=1S/C20H32O3/c1-4-5-6-12-15-18(2)16-13-10-8-7-9-11-14-17-19(23-3)20(21)22/h4,7-8,18-19H,1,5-6,10,12-17H2,2-3H3,(H,21,22)/b8-7+/t18?,19-/m0/s1
描述信息
An EET obtained by formal epoxidation of the 14,15-double bond of arachidonic acid.
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
62 个代谢物同义名
(5Z,8Z,11Z)-14,15-Epoxyeicosa-5.8.11-trienoic acid; (5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid; 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid; (+/-)14,15-EpETrE; FA 20:4;O; 14,15-EET; (5E,8E)-10-{3-[(2E)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoic acid; 11,12-Epoxyeicosatrienoic acid; (5E,8Z)-10-{3-[(2E)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoic acid; 11,12-EpETrE; 8S,9R-epoxy-5Z,11Z,14Z-eicosatrienoic acid; 8S,9R-EpETrE; 8S,9R-EET; 8R,9S-epoxy-5Z,11Z,14Z-eicosatrienoic acid; 8R,9S-EpETrE; 8R,9S-EET; 5S,6R-epoxy-8Z,11Z,14Z-eicosatrienoic acid; 5S,6R-EpETrE; 5S,6R-EET; 5R,6S-epoxy-8Z,11Z,14Z-eicosatrienoic acid; 5R,6S-EpETrE; 5R,6S-EET; 11R,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acid; 11R,12S-EpETrE; 11R,12S-EET; 11S,12R-epoxy-5Z,8Z,14Z-eicosatrienoic acid; 11S,12R-EpETrE; 11S,12R-EET; 14(S),15(R)-Epoxy-(5Z,8Z,11Z)-eicosatrienoic acid; 14S,15R-epoxy-5Z,8Z,11Z-eicosatrienoic acid; 14S,15R-EpETrE; 14S,15R-EET; 11,12-epoxy-5Z,8Z,14Z-eicosatrienoic acid; (+/-)11,12-EpETrE; 11,12-EET; 14R,15S-epoxy-5Z,8Z,11Z-eicosatrienoic acid; 14R,15S-EpETrE; 10S-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; 10S-Hydroxy-arachidonic acid; 20-hydroxy-2E,4E,6E,8E-eicosatetraenoic acid; 20-hydroxy-eicosatetraenoic acid; 18R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; 18-hydroxy-arachidonic acid; 5,8,11,13-Eicosatetraenoic acid, 15-hydroxy-, [R-(E,Z,Z,Z)]-; D-(R)-15-Hydroxy-5,8,11,13-eicosatetraenoic acid; 15R-hydroxy-5E,8Z,11Z,13Z-eicosatetraenoic acid; 15(R)-Hydroxyeicosatetraenoic acid; 15(R)-HETE; 5,8,11,15-Eicosatetraenoic acid, 14-hydroxy-, (E,Z,Z,Z)-; 14-hydroxy-5E,8Z,11Z,15Z-eicosatetraenoic acid; 11R-hydroxy-5E,8Z,12Z,14Z-eicosatetraenoic acid; [9R-(5Z,7E,11Z,14Z)]-9-Hydroxy-5,7,11,14-eicosatetraenoic acid; 5,7,11,14-Eicosatetraenoic acid, 9-hydroxy-, [R-(E,Z,Z,Z)]-; 9R-hydroxy-5E,7Z,11Z,14Z-eicosatetraenoic acid; 4,8,11,14-Eicosatetraenoic acid, 6-hydroxy-, (E,Z,Z,Z)-; 6-hydroxy-4E,8Z,11Z,14Z-eicosatetraenoic acid; 2S-methoxy-12-methyloctadeca-7E,17-dien-5-ynoic acid; (E)-Stellettic acid B; 2S-methoxy-12-methyloctadeca-7Z,17-dien-5-ynoic acid; (Z)-Stellettic acid B; 5R,6R-epoxy-9E-eicosen-7-ynoic acid; 12-hydroxy-5Z,8Z,10Z,14Z-Eicosatetraenoic acid
数据库引用编号
77 个数据库交叉引用编号
- ChEBI: CHEBI:34157
- ChEBI: CHEBI:132302
- ChEBI: CHEBI:132303
- ChEBI: CHEBI:165260
- ChEBI: CHEBI:165259
- ChEBI: CHEBI:132277
- ChEBI: CHEBI:132276
- ChEBI: CHEBI:132274
- ChEBI: CHEBI:132275
- ChEBI: CHEBI:88823
- ChEBI: CHEBI:91132
- KEGG: C14771
- PubChem: 53480479
- PubChem: 40490656
- PubChem: 40490662
- PubChem: 40490652
- PubChem: 25320407
- PubChem: 6440793
- PubChem: 40490664
- PubChem: 6440524
- PubChem: 5283201
- PubChem: 10829545
- PubChem: 6440419
- PubChem: 11141754
- PubChem: 5312987
- PubChem: 5312985
- PubChem: 5312981
- PubChem: 5312979
- PubChem: 5312974
- PubChem: 11088509
- PubChem: 10914199
- PubChem: 137323810
- PubChem: 9543626
- ChEMBL: CHEMBL132343
- ChEMBL: CHEMBL128117
- ChEMBL: CHEMBL564452
- LipidMAPS: LMFA03080005
- LipidMAPS: LMFA03090011
- LipidMAPS: LMFA03090010
- LipidMAPS: LMFA03080019
- LipidMAPS: LMFA03080018
- LipidMAPS: LMFA03080017
- LipidMAPS: LMFA03080016
- LipidMAPS: LMFA03080015
- LipidMAPS: LMFA03080014
- LipidMAPS: LMFA03080013
- LipidMAPS: LMFA03080004
- LipidMAPS: LMFA03080001
- LipidMAPS: LMFA03060110
- LipidMAPS: LMFA03060094
- LipidMAPS: LMFA03060093
- LipidMAPS: LMFA03060067
- LipidMAPS: LMFA03060065
- LipidMAPS: LMFA03060061
- LipidMAPS: LMFA03060059
- LipidMAPS: LMFA03060054
- LipidMAPS: LMFA02000378
- LipidMAPS: LMFA02000377
- LipidMAPS: LMFA01070046
- LipidMAPS: LMFA01030719
- CAS: 87173-80-6
- CAS: 87173-81-7
- CAS: 123931-40-8
- CAS: 105304-92-5
- CAS: 98103-48-1
- CAS: 74868-37-4
- CAS: 81276-03-1
- CAS: 69845-60-9
- CAS: 124411-81-0
- MetaboLights: MTBLC34157
- PubChem: 17395769
- NIKKAJI: J185.460G
- RefMet: 11,12-EpETrE
- PubChem: 5283204
- RefMet: 11S,12R-EpETrE
- RefMet: 14S,15R-EpETrE
- RefMet: 8R,9S-EpETrE
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liman Luo, Yan Yang, Menglu Fu, Jinlan Luo, Wenhua Li, Ling Tu, Ruolan Dong. 11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106740. doi:
10.1016/j.prostaglandins.2023.106740. [PMID: 37119935] - Yiwei Fang, Zheng Zhang, Yun Zhao, Guoqiang Sun, Meilin Peng, Chunyan Liu, Guilin Yi, Kai Zhao, Hui Yang. The value of lipid metabolites 9,10-DOA and 11,12-EET in prenatal diagnosis of fetal heart defects.
Clinica chimica acta; international journal of clinical chemistry.
2023 Apr; 544(?):117330. doi:
10.1016/j.cca.2023.117330. [PMID: 37037297] - Jie Zhang, Chuang Yang, Hongmei Qiu, Junxia Yang, Ke Wu, Shumei Ding, Chengyan Jiang, Qingsong Jiang. 14,15-EET involved in the development of diabetic cardiac hypertrophy mediated by PPARs.
Prostaglandins & other lipid mediators.
2022 04; 159(?):106620. doi:
10.1016/j.prostaglandins.2022.106620. [PMID: 35091081] - Shuiqing Hu, Jinlan Luo, Menglu Fu, Liman Luo, Yueting Cai, Wenhua Li, Yuanyuan Li, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu. Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1.
American journal of physiology. Heart and circulatory physiology.
2021 08; 321(2):H353-H368. doi:
10.1152/ajpheart.00979.2020. [PMID: 34142887] - Shanthi Nagarajan, Zu Yuan Qian, Parthiban Marimuthu, Nabil J Alkayed, Sanjiv Kaul, Anthony P Barnes. Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors.
Journal of chemical information and modeling.
2021 07; 61(7):3442-3452. doi:
10.1021/acs.jcim.1c00335. [PMID: 34242503] - John D Imig, Md Abdul Hye Khan, Anna Burkhan, Guan Chen, Adeniyi Michael Adebesin, John R Falck. Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062793. [PMID: 33801911] - Menglu Fu, Jing Yu, Zhihui Chen, Ying Tang, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Ling Tu, Xizhen Xu. Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells.
Molecular and cellular endocrinology.
2021 03; 523(?):111149. doi:
10.1016/j.mce.2020.111149. [PMID: 33387601] - John D Imig, Wojciech K Jankiewicz, Abdul H Khan. Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Hypertension (Dallas, Tex. : 1979).
2020 07; 76(1):3-15. doi:
10.1161/hypertensionaha.120.13898. [PMID: 32475311] - Cuiping Zhang, Zuojian Hu, Ke Wang, Lujie Yang, Yue Li, Hartmut Schlüter, Pengyuan Yang, Jiaxu Hong, Hongxiu Yu. Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions.
The Analyst.
2020 Jun; 145(11):3967-3976. doi:
10.1039/d0an00263a. [PMID: 32319474] - Ming-Xiao Wang, Li-Jun Wang, Yu Xiao, Dan-Dan Zhang, Xin-Peng Duan, Wen-Hui Wang. Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule.
American journal of physiology. Renal physiology.
2020 06; 318(6):F1369-F1376. doi:
10.1152/ajprenal.00018.2020. [PMID: 32308018] - Mercè Pallàs, Santiago Vázquez, Coral Sanfeliu, Carles Galdeano, Christian Griñán-Ferré. Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy.
Biomolecules.
2020 05; 10(5):. doi:
10.3390/biom10050703. [PMID: 32369955] - Marco Rahm, Juliane Merl-Pham, Jerzy Adamski, Stefanie M Hauck. Time-resolved phosphoproteomic analysis elucidates hepatic 11,12-Epoxyeicosatrienoic acid signaling pathways.
Prostaglandins & other lipid mediators.
2020 02; 146(?):106387. doi:
10.1016/j.prostaglandins.2019.106387. [PMID: 31669255] - Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Molecular neurobiology.
2019 Dec; 56(12):8451-8474. doi:
10.1007/s12035-019-01669-8. [PMID: 31257558] - Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu, Andreas Pohlmann, Jan Hentschel, Karen Arakelyan, Erdmann Seeliger, Bert Flemming, Dennis Gürgen, Michael Rothe, Thoralf Niendorf, Vijaya L Manthati, John R Falck, Michael Haase, Wolf-Hagen Schunck, Duska Dragun. A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Acta physiologica (Oxford, England).
2019 10; 227(2):e13297. doi:
10.1111/apha.13297. [PMID: 31077555] - Marco Raffaele, Lars Bellner, Shailendra P Singh, Gaia Favero, Rita Rezzani, Luigi Fabrizio Rodella, John R Falck, Nader G Abraham, Luca Vanella. Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling.
Experimental cell research.
2019 07; 380(2):180-187. doi:
10.1016/j.yexcr.2019.04.029. [PMID: 31039348] - Maxwell Zeigler, Dale Whittington, Nona Sotoodehnia, Rozenn N Lemaitre, Rheem A Totah. A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.
Chemistry and physics of lipids.
2018 11; 216(?):162-170. doi:
10.1016/j.chemphyslip.2018.09.004. [PMID: 30201384] - Lu Liu, Nitin Puri, Marco Raffaele, Joseph Schragenheim, Shailendra P Singh, J Alyce Bradbury, Lars Bellner, Luca Vanella, Darryl C Zeldin, Jian Cao, Nader G Abraham. Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.
Prostaglandins & other lipid mediators.
2018 09; 138(?):1-8. doi:
10.1016/j.prostaglandins.2018.07.004. [PMID: 30041041] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Pinming Liu, Shaoling Zhang, Jingwei Gao, Ying Lin, Guangzi Shi, Wanbing He, Rhian M Touyz, Li Yan, Hui Huang. Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary Aldosteronism.
Hypertension (Dallas, Tex. : 1979).
2018 04; 71(4):592-598. doi:
10.1161/hypertensionaha.117.10644. [PMID: 29440332] - Yuan Guo, Fei Luo, Xv Zhang, Jingyuan Chen, Li Shen, Yi Zhu, Danyan Xu. TPPU enhanced exercise-induced epoxyeicosatrienoic acid concentrations to exert cardioprotection in mice after myocardial infarction.
Journal of cellular and molecular medicine.
2018 03; 22(3):1489-1500. doi:
10.1111/jcmm.13412. [PMID: 29265525] - Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu. 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.
Journal of experimental & clinical cancer research : CR.
2018 Feb; 37(1):23. doi:
10.1186/s13046-018-0694-6. [PMID: 29426357] - Xiaoyan Huang, Yuguang Wang, Yi Wang, Liang Yang, Jia Wang, Yue Gao. Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(4):1646-1658. doi:
10.1159/000493500. [PMID: 30227401] - Qi Zhang, Xiang Wang, Guifang Yan, Juan Lei, Yu Zhou, Lei Wu, Ting Wang, Xiao Zhang, Duyun Ye, Yongsheng Li. Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(4):1377-1389. doi:
10.1159/000487563. [PMID: 29462800] - Bing-Qing Deng, Ying Luo, Xin Kang, Chang-Bin Li, Christophe Morisseau, Jun Yang, Kin Sing Stephen Lee, Jian Huang, Da-Yong Hu, Ming-Yu Wu, Ai Peng, Bruce D Hammock, Jun-Yan Liu. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2017 11; 114(47):12608-12613. doi:
10.1073/pnas.1705615114. [PMID: 29109264] - Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand. Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids.
Archives of toxicology.
2017 Nov; 91(11):3571-3585. doi:
10.1007/s00204-017-2060-4. [PMID: 28975360] - Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah. Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
Free radical biology & medicine.
2017 11; 112(?):131-140. doi:
10.1016/j.freeradbiomed.2017.07.015. [PMID: 28734877] - William B Campbell, John D Imig, James M Schmitz, John R Falck. Orally Active Epoxyeicosatrienoic Acid Analogs.
Journal of cardiovascular pharmacology.
2017 Oct; 70(4):211-224. doi:
10.1097/fjc.0000000000000523. [PMID: 28937442] - Julia M Santos, Jung-A Park, Aby Joiakim, David A Putt, Robert N Taylor, Hyesook Kim. The role of soluble epoxide hydrolase in preeclampsia.
Medical hypotheses.
2017 Oct; 108(?):81-85. doi:
10.1016/j.mehy.2017.07.033. [PMID: 29055406] - Xuehong Liu, Zu-Yuan Qian, Fuchun Xie, Wei Fan, Jonathan W Nelson, Xiangshu Xiao, Sanjiv Kaul, Anthony P Barnes, Nabil J Alkayed. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid.
Prostaglandins & other lipid mediators.
2017 09; 132(?):31-40. doi:
10.1016/j.prostaglandins.2016.09.002. [PMID: 27649858] - Yong Zhou, Tian Liu, Jia-Xi Duan, Ping Li, Guo-Ying Sun, Yong-Ping Liu, Jun Zhang, Liang Dong, Kin Sing Stephen Lee, Bruce D Hammock, Jian-Xin Jiang, Cha-Xiang Guan. Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice.
Shock (Augusta, Ga.).
2017 05; 47(5):638-645. doi:
10.1097/shk.0000000000000767. [PMID: 27753791] - Charles Austin Pickens, Lorraine M Sordillo, Chen Zhang, Jenifer I Fenton. Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE).
Metabolism: clinical and experimental.
2017 05; 70(?):177-191. doi:
10.1016/j.metabol.2017.01.034. [PMID: 28403941] - Amy A Rand, Bogdan Barnych, Christophe Morisseau, Tomas Cajka, Kin Sing Stephen Lee, Dipak Panigrahy, Bruce D Hammock. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
Proceedings of the National Academy of Sciences of the United States of America.
2017 04; 114(17):4370-4375. doi:
10.1073/pnas.1616893114. [PMID: 28396419] - A Sporková, Z Husková, P Škaroupková, N Rami Reddy, J R Falck, J Sadowski, L Červenka. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure.
Physiological research.
2017 03; 66(1):29-39. doi:
10.33549/physiolres.933350. [PMID: 27782740] - Becca A Flitter, Kelli L Hvorecny, Emiko Ono, Taylor Eddens, Jun Yang, Daniel H Kwak, Christopher D Bahl, Thomas H Hampton, Christophe Morisseau, Bruce D Hammock, Xinyu Liu, Janet S Lee, Jay K Kolls, Bruce D Levy, Dean R Madden, Jennifer M Bomberger. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Proceedings of the National Academy of Sciences of the United States of America.
2017 01; 114(1):136-141. doi:
10.1073/pnas.1610242114. [PMID: 27980032] - Ingrid Fleming. The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling.
Vascular pharmacology.
2016 11; 86(?):31-40. doi:
10.1016/j.vph.2016.03.001. [PMID: 26975734] - Bei Wang, Hesong Zeng, Zheng Wen, Chen Chen, Dao Wen Wang. CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1.
Aging cell.
2016 10; 15(5):940-52. doi:
10.1111/acel.12507. [PMID: 27416746] - Marco Di Pascoli, Francesca Zampieri, Alberto Verardo, Paola Pesce, Cristian Turato, Paolo Angeli, David Sacerdoti, Massimo Bolognesi. Inhibition of epoxyeicosatrienoic acid production in rats with cirrhosis has beneficial effects on portal hypertension by reducing splanchnic vasodilation.
Hepatology (Baltimore, Md.).
2016 09; 64(3):923-30. doi:
10.1002/hep.28686. [PMID: 27312119] - Alexandra Sporková, Rami N Reddy, John R Falck, John D Imig, Libor Kopkan, Janusz Sadowski, Luděk Červenka. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids.
The American journal of the medical sciences.
2016 05; 351(5):513-9. doi:
10.1016/j.amjms.2016.02.030. [PMID: 27140711] - Dorothee J Funk, Bernd L Sorg, Klaus Kopka, Heinz H Schmeiser. Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.
Prostaglandins & other lipid mediators.
2016 03; 123(?):63-7. doi:
10.1016/j.prostaglandins.2016.04.006. [PMID: 27166927] - Haitham E El-Sikhry, Nasser Alsaleh, Rambabu Dakarapu, John R Falck, John M Seubert. Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
PloS one.
2016; 11(8):e0160380. doi:
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American journal of physiology. Renal physiology.
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Prostaglandins & other lipid mediators.
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Prostaglandins & other lipid mediators.
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Prostaglandins & other lipid mediators.
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Prostaglandins & other lipid mediators.
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Prostaglandins & other lipid mediators.
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American journal of physiology. Heart and circulatory physiology.
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Prostaglandins & other lipid mediators.
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Prostaglandins & other lipid mediators.
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Experimental cell research.
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Prostaglandins & other lipid mediators.
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Basic & clinical pharmacology & toxicology.
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American journal of physiology. Renal physiology.
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