3-(3,4-Dihydroxyphenyl)lactic acid (BioDeep_00000000626)

   

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


3-(3,4-DIHYDROXYPHENYL)LACTIC ACID DL-.BETA.-(3,4-DIHYDROXYPHENYL)LACTIC ACID

化学式: C9H10O5 (198.052821)
中文名称: (Rac)-丹参素
谱图信息: 最多检出来源 Homo sapiens(blood) 30.39%

分子结构信息

SMILES: c1(c(ccc(c1)C[C@@H](C(=O)O)O)O)O
InChI: InChI=1S/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)

描述信息

3-(3,4-dihydroxyphenyl)lactic acid is a 2-hydroxy monocarboxylic acid and a member of catechols. It is functionally related to a rac-lactic acid. It is a conjugate acid of a 3-(3,4-dihydroxyphenyl)lactate.
3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid is a natural product found in Salvia miltiorrhiza, Salvia sonchifolia, and other organisms with data available.
3-(3,4-Dihydroxyphenyl)lactic acid is a natural catecholamine metabolite present in normal newborns plasma (PMID 1391254) and in normal urine (PMID 7460271) [HMDB]. 3-(3,4-Dihydroxyphenyl)lactic acid is found in rosemary.
3-(3,4-Dihydroxyphenyl)lactic acid is a natural catecholamine metabolite present in normal newborns plasma (PMID 1391254) and in normal urine (PMID 7460271).

同义名列表

33 个代谢物同义名

3-(3,4-DIHYDROXYPHENYL)LACTIC ACID DL-.BETA.-(3,4-DIHYDROXYPHENYL)LACTIC ACID; 3,4-dihydroxyphenyllactic acid, monosodium salt, (+-)-isomer; 3,4-dihydroxyphenyllactic acid, monosodium salt, (R)-isomer; beta-(3,4-dihydroxylphenyl)-alpha-hydroxylpropionic acid; 2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid; 3,4-dihydroxyphenyllactic acid, monosodium salt; 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid; Benzenepropanoic acid, alpha,3,4-trihydroxy-; 3,4-dihydroxyphenyllactic acid, (+-)-isomer; 2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoate; 3,4-dihydroxyphenyllactic acid, (R)-isomer; DL-beta-(3,4-Dihydroxyphenyl)lactic acid; Benzenepropanoic acid, a,3,4-trihydroxy-; DL-b-(3,4-Dihydroxyphenyl)lactic acid; 3-(3,4-dihydroxyphenyl)lactic acid; 3-Ethoxy-5-fluorophenylboronicacid; .ALPHA.-HYDROXYDIHYDROCAFFEIC ACID; Dan shen suan A;Salvianic acid A; (3,4-dihydroxyphenyl)lactic acid; alpha-Hydroxyhydrocaffeic acid; 3,4-dihydroxyphenyllactic acid; 3-(3,4-Dihydroxyphenyl)lactate; a-Hydroxyhydrocaffeic acid; 3,4-Dihydroxyphenyllactate; alpha-Hydroxyhydrocaffeate; salvianic acid A sodium; (Rac)-Salvianic acid A; (+/-)-DAN SHEN SU; DANSHENSU, (+/-)-; UNII-NA8H56YM3K; Danshensuan A; NA8H56YM3K; Danshensu



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Bai, Qiufeng Qin, Shuying Li, Xulan Cui, Yixuan Zhong, Lei Yang, Lin An, Di Deng, Jinlan Zhao, Rong Zhang, Shasha Bai. Salvia miltiorrhiza inhibited lung cancer through aerobic glycolysis suppression. Journal of ethnopharmacology. 2024 Sep; 331(?):118281. doi: 10.1016/j.jep.2024.118281. [PMID: 38701934]
  • Yingqiu Shi, Haoran Li, Yugang Lin, Shufang Wang, Guofang Shen. Effective constituents and protective effect of Mudan granules against Schwann cell injury. Journal of ethnopharmacology. 2024 Apr; 323(?):117692. doi: 10.1016/j.jep.2023.117692. [PMID: 38176668]
  • Ruyu Wang, Xuwen Chen, Hongtao Li, Xixiang Chen, Donghui Sun, Danmei Yu, Jiani Lu, Yuanyuan Xie, Qian Zhang, Jianrong Xu, Weidong Zhang, Hongzhuan Chen, Shunying Liu, Lili Chen. Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity. International journal of biological macromolecules. 2024 Feb; 257(Pt 2):128623. doi: 10.1016/j.ijbiomac.2023.128623. [PMID: 38070810]
  • Min Bai, Na Cui, Yucheng Liao, Chao Guo, Liang Li, Ying Yin, Aidong Wen, Jingwen Wang, Weiliang Ye, Yi Ding. Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury. Journal of controlled release : official journal of the Controlled Release Society. 2023 Nov; 364(?):473-489. doi: 10.1016/j.jconrel.2023.11.002. [PMID: 37939854]
  • Miao Zeng, Xiaolu Zhang, Nuan Lv, Luming Wang, Yanrong Suo, Jiali Gan, Lin Yang, Bin Yu, Xijuan Jiang, Wenyun Zeng. Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKKβ mediated inflammation in macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 165(?):115153. doi: 10.1016/j.biopha.2023.115153. [PMID: 37437377]
  • Xiaolu Zhang, Qiuyue Yang, Ruifeng Zhang, Yilin Zhang, Wenyun Zeng, Qun Yu, Miao Zeng, Jiali Gan, Huhu Li, Lin Yang, Qing Gao, Xijuan Jiang. Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis. BioFactors (Oxford, England). 2023 Jul; ?(?):. doi: 10.1002/biof.1991. [PMID: 37458329]
  • Yueting Yu, Jia Wang, Qingze Liu, Fangyong Wei, Xuejun Xie, Mei Zhang. Integrated serum pharmacochemistry and serum pharmacology to investigate the active components and mechanism of Bushen Huoxue Prescription in the treatment of diabetic retinopathy. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 235(?):115586. doi: 10.1016/j.jpba.2023.115586. [PMID: 37494766]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Ya-Chao Wang, Huan Wang, Chang-le Shao, Xiu-Ya Li, Ji Cui, Hai-Dong Guo. Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage. In vitro cellular & developmental biology. Animal. 2023 Jun; ?(?):. doi: 10.1007/s11626-023-00773-3. [PMID: 37294373]
  • Ruizhi Han, Ke Gao, Yulin Jiang, Jieyu Zhou, Guochao Xu, Jinjun Dong, Ulrich Schwaneberg, Yu Ji, Ye Ni. Self-Sufficient In Vitro Multi-Enzyme Cascade for Efficient Synthesis of Danshensu from l-DOPA. ACS synthetic biology. 2023 01; 12(1):277-286. doi: 10.1021/acssynbio.2c00552. [PMID: 36412006]
  • Rui-Xin Li, Cai-Lian Fan, Wan-Yi Xu, Wen Wei, Xiao-Xing Wang, Zi-Ting Li, Peng-Cheng Zhao, Zhi-Jian Su, Xi-Yang Tang, Zhi-Hong Yao, Yi Dai. Simultaneous determination of multiple constituents of Qi-Lin pill by UPLC-MS/MS: Applications to pharmacokinetics and testicular tissue distribution in rats. Journal of pharmaceutical and biomedical analysis. 2023 Jan; 223(?):115157. doi: 10.1016/j.jpba.2022.115157. [PMID: 36379101]
  • Peng Zhou, Baisong An, Xiaolei Zhang, Jiming Lv, Baisong Lin. Therapeutic effect and mechanism of danshensu on coronary heart disease using liquid chromatography combined with mass spectrometry metabolomics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Oct; 1208(?):123400. doi: 10.1016/j.jchromb.2022.123400. [PMID: 35917776]
  • Yuejin Xue, Liyuan Zhang, Lusha Zhang, Wei Sun, Zhirui Fang, Yuze Leng, Mengyao Li, Xiuyun Ren, Rui Zhang, Yingxue Zhang, Lu Chen, Hong Wang. Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154271. doi: 10.1016/j.phymed.2022.154271. [PMID: 35777120]
  • Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao. Danshensu Attenuated Epithelial-Mesenchymal Transformation and Chemoresistance of Colon Cancer Cells Induced by Platelets. Frontiers in bioscience (Landmark edition). 2022 05; 27(5):160. doi: 10.31083/j.fbl2705160. [PMID: 35638427]
  • Wei Wang, Sha-Sha Li, Xin-Feng Xu, Chan Yang, Xiao-Ge Niu, Shu-Xian Yin, Xiao-Yan Pan, Wei Xu, Guo-Dong Hu, Chan Wang, Shu-Wen Liu. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta pharmacologica Sinica. 2022 Apr; 43(4):771-780. doi: 10.1038/s41401-021-00714-4. [PMID: 34267343]
  • Guangxu Xiao, Jiaxu Liu, Huanyi Wang, Shuang He, Jianwei Liu, Guanwei Fan, Ming Lyu, Yan Zhu. CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury. Frontiers in immunology. 2022; 13(?):1007341. doi: 10.3389/fimmu.2022.1007341. [PMID: 36325326]
  • Huaman Liu, Xinyue Zhang, Yumeng Shao, Xuehong Lin, Feng Dong, Xue Liu. Danshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway. Bioengineered. 2021 12; 12(1):3113-3124. doi: 10.1080/21655979.2021.1944020. [PMID: 34187349]
  • Chen Yu, Hua Dong, Qingchen Wang, Junzhe Bai, Yan-Ni Li, Juan-Juan Zhao, Jia-Zhu Li. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111995. doi: 10.1016/j.biopha.2021.111995. [PMID: 34435595]
  • Qiongtao Song, Fuwen Zhang, Xue Han, Yanrong Yang, Ying Zhao, Junguo Duan. Ameliorative effects and mechanisms of salvianic acid A on retinal iron overload in vivo and in vitro. Experimental eye research. 2021 08; 209(?):108642. doi: 10.1016/j.exer.2021.108642. [PMID: 34058232]
  • Qiong-Zhi Zhang, Ting-Ting Fu, Jia-Ning Dai, Zhi-Nan Zhou, Cui-Zhen Shen. Sodium Danshensu promotes the healing of stage 2 pressure injury wounds in ischemia/reperfusion injury rat models: possible regulation of apoptosis and inflammatory response. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2021 08; 41(4):571-580. doi: 10.19852/j.cnki.jtcm.2021.03.009. [PMID: 34392650]
  • Yanhua Guan, Xu Wang. Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2021 Mar; 27(?):e928153. doi: 10.12659/msm.928153. [PMID: 33770068]
  • Yun-Wen Chen, Yun-Ping Huang, Pei-Chang Wu, Wei-Yu Chiang, Ping-Hsun Wang, Bo-Yie Chen. The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13030978. [PMID: 33803057]
  • Justyna Krzyżanowska-Kowalczyk, Mariusz Kowalczyk, Michał B Ponczek, Łukasz Pecio, Paweł Nowak, Joanna Kolodziejczyk-Czepas. Pulmonaria obscura and Pulmonaria officinalis Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors-In Vitro and In Silico Studies. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030631. [PMID: 33530389]
  • Honglei Xu, Kun He, Yi Li, Yulong Tao, Chunfang Xu, Zhenlin Hu, Tingfang Wang, Chuan Zhang. Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs. Biological & pharmaceutical bulletin. 2020 May; 43(5):801-809. doi: 10.1248/bpb.b19-00878. [PMID: 32132313]
  • Guang Liu, Qianqian Zhang, Jinli Zhang, Ning Zhang. Preventive but nontherapeutic effect of danshensu on hypoxic pulmonary hypertension. The Journal of international medical research. 2020 May; 48(5):300060520914218. doi: 10.1177/0300060520914218. [PMID: 32419546]
  • Da-Wei Sun, Qing Gao, Xin Qi. Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal Pathway. Chinese journal of integrative medicine. 2020 Apr; 26(4):283-291. doi: 10.1007/s11655-019-3165-9. [PMID: 31254156]
  • Yujia Li, Hui Chen, Yating Yang, Menglan Niu, Jiaxin Wang, Yuanyuan Wu, Linhui Niu, Hongliang Liu, Dengke Bao. Danshen formula granule and salvianic acid A alleviate ethanol-induced neurotoxicity. Journal of natural medicines. 2020 Mar; 74(2):399-408. doi: 10.1007/s11418-019-01379-4. [PMID: 31828593]
  • Jinjing Jia, Xiumei Mo, Junfeng Liu, Fenggen Yan, Ning Wang, Ying Lin, Hongyi Li, Yan Zheng, Dancan Chen. Mechanism of danshensu-induced inhibition of abnormal epidermal proliferation in psoriasis. European journal of pharmacology. 2020 Feb; 868(?):172881. doi: 10.1016/j.ejphar.2019.172881. [PMID: 31866405]
  • Tian Wang, Cuiting Li, Bing Han, Zhenhua Wang, Xiaoyu Meng, Leiming Zhang, Jie He, Fenghua Fu. Neuroprotective effects of Danshensu on rotenone-induced Parkinson's disease models in vitro and in vivo. BMC complementary medicine and therapies. 2020 Jan; 20(1):20. doi: 10.1186/s12906-019-2738-7. [PMID: 32020857]
  • Yuanyuan Zhang, Gaohua Zhang, Yingran Liang, Hongfang Wang, Qian Wang, Ying Zhang, Xuan Zhang, Jianping Zhang, Li Chu. Potential Mechanisms Underlying the Hepatic-Protective Effects of Danshensu on Iron Overload Mice. Biological & pharmaceutical bulletin. 2020; 43(6):968-975. doi: 10.1248/bpb.b19-01084. [PMID: 32475919]
  • Jinli Zhang, Qianqian Zhang, Guang Liu, Ning Zhang. Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu. European journal of pharmacology. 2019 Dec; 864(?):172710. doi: 10.1016/j.ejphar.2019.172710. [PMID: 31586468]
  • Ho Jung Bae, Kandhasamy Sowndhararajan, Hyeon-Bae Park, So-Yeon Kim, Songmun Kim, Dong Hyun Kim, Ji Woong Choi, Dae Sik Jang, Jong Hoon Ryu, Se Jin Park. Danshensu attenuates scopolamine and amyloid-β-induced cognitive impairments through the activation of PKA-CREB signaling in mice. Neurochemistry international. 2019 12; 131(?):104537. doi: 10.1016/j.neuint.2019.104537. [PMID: 31425745]
  • Dan Jia, Cheng-Zhong Zhang, Yan Qiu, Xiao-Fei Chen, Lin Jia, Alex F Chen, Yi-Feng Chai, Zhen-Yu Zhu, Jin Huang, Chuan Zhang. Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis. Acta pharmacologica Sinica. 2019 Dec; 40(12):1513-1522. doi: 10.1038/s41401-019-0265-1. [PMID: 31253938]
  • Gang Cao, Ruyi Zhu, Ting Jiang, Dongxin Tang, Hiu Yee Kwan, Tao Su. Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Oct; 63(?):153055. doi: 10.1016/j.phymed.2019.153055. [PMID: 31377585]
  • Shuai Ji, Xian Shao, Zhen-Yu Su, Lei Ji, Yu-Jie Wang, Yun-Su Ma, Lu Zhao, Yan Du, Meng-Zhe Guo, Dao-Quan Tang. Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):367-375. doi: 10.1016/j.jpba.2019.05.055. [PMID: 31202879]
  • Xuekai Tian, Dong Li, Yulin He, Wenyu Zhang, Hongmei He, Renrang Du, Weijun Pang, Gongshe Yang, Taiyong Yu. Supplementation of salvianic acid A to boar semen extender to improve seminal quality and antioxidant capacity. Animal science journal = Nihon chikusan Gakkaiho. 2019 Sep; 90(9):1142-1148. doi: 10.1111/asj.13263. [PMID: 31321871]
  • Tianzhen Xiong, Jing Jiang, Yajun Bai, Tai-Ping Fan, Ye Zhao, Xiaohui Zheng, Yujie Cai. Biosynthesis of D-danshensu from L-DOPA using engineered Escherichia coli whole cells. Applied microbiology and biotechnology. 2019 Aug; 103(15):6097-6105. doi: 10.1007/s00253-019-09947-0. [PMID: 31187210]
  • Peng Lu, Yue Xing, Zhifeng Xue, Zhe Ma, Bing Zhang, Hui Peng, Qi Tony Zhou, Hongfei Liu, Zhidong Liu, Jiawei Li. Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4561. doi: 10.1002/bmc.4561. [PMID: 31017297]
  • Dan Jia, Liyan Xiong, Xuhong Yu, Xiaofei Chen, Tingfang Wang, Alex F Chen, Yifeng Chai, Zhenyu Zhu, Chuan Zhang. Cardioprotective mechanism study of salvianic acid A sodium based on a proteome microarray approach and metabolomic profiling of rat serum after myocardial infarction. Molecular omics. 2019 08; 15(4):271-279. doi: 10.1039/c9mo00005d. [PMID: 31099812]
  • Tianzhen Xiong, Pu Jia, Jing Jiang, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. Journal of biotechnology. 2019 Jul; 300(?):48-54. doi: 10.1016/j.jbiotec.2019.05.008. [PMID: 31125578]
  • Dan-Dan Huang, Xiao-Hong Wei, Hong-Na Mu, Chun-Shui Pan, Quan Li, Bai-He Hu, Xin Chang, Li Yan, Jing-Yu Fan, Yu-Ying Liu, Jian-Yuan Luo, Jing-Yan Han. Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury Via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3. Shock (Augusta, Ga.). 2019 06; 51(6):745-756. doi: 10.1097/shk.0000000000001185. [PMID: 29863652]
  • Francesca Nicolì, Marzia Vergine, Carmine Negro, Andrea Luvisi, Eliana Nutricati, Alessio Aprile, Patrizia Rampino, Erika Sabella, Luigi De Bellis, Antonio Miceli. Salvia clandestina L.: unexploited source of danshensu. Natural product research. 2019 Feb; 33(3):439-442. doi: 10.1080/14786419.2018.1452015. [PMID: 29553808]
  • Qiongtao Song, Yuanyuan Zhang, Xue Han, Ying Zhang, Xuan Zhang, Yonggang Gao, Jianping Zhang, Li Chu, Senming Zhao. Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):945-956. doi: 10.1016/j.biopha.2018.10.147. [PMID: 30551549]
  • Xiao-Dan Mei, Yu-Qi Wang, Zi-Jian Wang, Wen-Jing Zhao, Zhan-Peng Shang, Yan-Jiang Qiao, Jia-Yu Zhang. [Identification of metabolites of Danshensu in vivo in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Oct; 43(19):3933-3939. doi: 10.19540/j.cnki.cjcmm.20180709.010. [PMID: 30453721]
  • Ailing Hui, Huayang Yin, Zheng Zhang, An Zhou, Jingchao Chen, Li Yang, Zeyu Wu, Wencheng Zhang. Enhancement of brain-targeting delivery of danshensu in rat through conjugation with pyrazine moiety to form danshensu-pyrazine ester. Drug delivery and translational research. 2018 06; 8(3):787-796. doi: 10.1007/s13346-018-0501-0. [PMID: 29524164]
  • Zheng Zachory Wei, Dongdong Chen, Li-Ping Liu, Xiaohuan Gu, Weiwei Zhong, Yong-Bo Zhang, Yongjun Wang, Shan Ping Yu, Ling Wei. Enhanced Neurogenesis and Collaterogenesis by Sodium Danshensu Treatment After Focal Cerebral Ischemia in Mice. Cell transplantation. 2018 04; 27(4):622-636. doi: 10.1177/0963689718771889. [PMID: 29984620]
  • Zheng Zhou, Hexin Tan, Qing Li, Junfeng Chen, Shouhong Gao, Yun Wang, Wansheng Chen, Lei Zhang. CRISPR/Cas9-mediated efficient targeted mutagenesis of RAS in Salvia miltiorrhiza. Phytochemistry. 2018 Apr; 148(?):63-70. doi: 10.1016/j.phytochem.2018.01.015. [PMID: 29421512]
  • Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan, Yuqiang Wang. A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway. Current pharmaceutical design. 2018 02; 23(39):6062-6070. doi: 10.2174/1381612823666170817125925. [PMID: 28820076]
  • Ning Zhang, Mingqing Dong, Ying Luo, Feng Zhao, Yongjun Li. Danshensu prevents hypoxic pulmonary hypertension in rats by inhibiting the proliferation of pulmonary artery smooth muscle cells via TGF-β-smad3-associated pathway. European journal of pharmacology. 2018 Feb; 820(?):1-7. doi: 10.1016/j.ejphar.2017.12.010. [PMID: 29221952]
  • Xinyi Yuan, Fuhuan Fei, Huanmei Sun, Chaoni Xiao, Xinfeng Zhao, Yajun Zhang, Xiaohui Zheng. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. International journal of nanomedicine. 2018; 13(?):2265-2274. doi: 10.2147/ijn.s159789. [PMID: 29695905]
  • Lei Gao, Yiu-Wa Kwan, Andrew C Bulmer, Christopher W K Lai. Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment. Oxidative medicine and cellular longevity. 2018; 2018(?):8267560. doi: 10.1155/2018/8267560. [PMID: 29670682]
  • Mei-Ching Teng, Pei Chang Wu, Si-Ping Lin, Chien-Yun Wu, Ping-Hsun Wang, Chueh-Tan Chen, Bo-Yie Chen. Danshensu Decreases UVB-Induced Corneal Inflammation in an Experimental Mouse Model via Oral Administration. Current eye research. 2018 01; 43(1):27-34. doi: 10.1080/02713683.2017.1379543. [PMID: 29111819]
  • Ying Yin, Jialin Duan, Chao Guo, Guo Wei, Yanhua Wang, Yue Guan, Fei Mu, Minna Yao, Miaomiao Xi, Aidong Wen. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis. European journal of pharmacology. 2017 Nov; 814(?):274-282. doi: 10.1016/j.ejphar.2017.08.035. [PMID: 28864209]
  • Wei Li, Hongjie Zhou, Yang Chu, Xiangyang Wang, Ruizhi Luo, Liu Yang, Navaneethakrishnan Polachi, Xiao Li, Min Chen, Luqi Huang, Xueying Yan, Zhixin Guo, He Sun. Simultaneous determination and pharmacokinetics of danshensu, protocatechuic aldehyde, 4-hydroxy-3-methyloxyphenyl lactic acid and protocatechuic acid in human plasma by LC-MS/MS after oral administration of Compound Danshen Dripping Pills. Journal of pharmaceutical and biomedical analysis. 2017 Oct; 145(?):860-864. doi: 10.1016/j.jpba.2017.06.014. [PMID: 28830061]
  • Xiaojing Zhang, Huihui Hu, Jingxiong Luo, Huixing Deng, Pei Yu, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Yuqiang Wang. A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway. Biological & pharmaceutical bulletin. 2017 Sep; 40(9):1490-1498. doi: 10.1248/bpb.b17-00313. [PMID: 28637941]
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