Fluoroacetic acid (BioDeep_00000006063)

 

Secondary id: BioDeep_00001867939

human metabolite blood metabolite


代谢物信息卡片


Fluoroacetic acid, ammonium salt, 2-(14)C-labeled

化学式: C2H3FO2 (78.0117)
中文名称: 氟乙酸
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(otcml) 45.89%

分子结构信息

SMILES: C(C(=O)O)F
InChI: InChI=1S/C2H3FO2/c3-1-2(4)5/h1H2,(H,4,5)

描述信息

D010575 - Pesticides > D012378 - Rodenticides
D016573 - Agrochemicals

同义名列表

32 个代谢物同义名

Fluoroacetic acid, ammonium salt, 2-(14)C-labeled; Fluoroacetic acid, terbium (+3) salt; Fluoroacetic acid, mercury (2+) salt; Fluoroacetic acid, copper (2+) salt; Fluoroacetic acid, lead (+4) salt; Fluoroacetic acid, potassium salt; Fluoroacetic acid, magnesium salt; Fluoroacetic acid, aluminum salt; Fluoroacetic acid, ammonium salt; Fluoroacetic acid, cadmium salt; Fluoroacetic acid, calcium salt; Fluoroacetic acid, barium salt; Fluoroacetic acid, sodium salt; Fluoroacetic acid, 18F-labeled; Sodium (18F)fluoroacetate; Acide-monofluoracetique; Monofluoroacetic acid; sodium fluoroacetate; Monofluoressigsaure; 2-fluoroacetic acid; FLUOROACETIC ACID; Monofluoroacetate; Gifblaar poison; Fluoroacetate; Compound 1080; Cymonic acid; Cymonate; UN 2642; HFA; Sodium fluoroacetate; Fluoroacetate; Fluoroacetic acid



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACO1, CFAP410, CYP2D6, CYP3A4, ENO2, GSTZ1, KYAT1, OPA1, SLC9A1
Peripheral membrane protein 1 HSD17B6
Endoplasmic reticulum membrane 2 CYP2D6, CYP3A4
Mitochondrion membrane 1 TSPO
Nucleus 2 CS, PLCZ1
cytosol 10 ACO1, ACO2, CFAP410, COMT, ENO2, GSTZ1, KYAT1, OPA1, PLCZ1, TSPO
dendrite 2 COMT, OPA1
mitochondrial membrane 2 OPA1, TSPO
nucleoplasm 3 OPA1, PLCZ1, SLC9A1
Cell membrane 5 COMT, ENO2, GRID1, SLC38A5, SLC9A1
lamellipodium 1 SLC9A1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 GRID1, SLC38A5, SLC9A1, TSPO
Synapse 1 COMT
cell surface 1 SLC9A1
glutamatergic synapse 1 GRID1
Golgi apparatus 1 ACO1
Golgi membrane 1 INS
mitochondrial inner membrane 2 ATP5ME, OPA1
Cytoplasm, cytosol 2 ACO1, KYAT1
plasma membrane 6 CFAP410, COMT, ENO2, GRID1, SLC38A5, SLC9A1
Membrane 9 COMT, CS, CYP2D6, CYP3A4, ENO2, OPA1, SLC38A5, SLC9A1, TSPO
apical plasma membrane 1 SLC9A1
axon 1 COMT
basolateral plasma membrane 1 SLC9A1
extracellular exosome 7 ACO1, COMT, CS, ENO2, GRID1, SLC9A1, TSPO
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 ACO1, CYP2D6, HSD17B6, TSPO
extracellular space 2 ENO2, INS
perinuclear region of cytoplasm 2 PLCZ1, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 11 ACO1, ACO2, ATP5ME, CFAP410, CS, CYP2D6, GSTZ1, KYAT1, OPA1, SLC9A1, TSPO
intracellular membrane-bounded organelle 6 CFAP410, COMT, CYP2D6, CYP3A4, HSD17B6, TSPO
Microsome membrane 3 CYP2D6, CYP3A4, HSD17B6
pronucleus 1 PLCZ1
Secreted 1 INS
extracellular region 1 INS
Single-pass membrane protein 2 CYP2D6, OPA1
mitochondrial outer membrane 2 OPA1, TSPO
Mitochondrion matrix 1 CS
mitochondrial matrix 3 ACO2, CS, GSTZ1
Extracellular side 1 COMT
photoreceptor connecting cilium 1 CFAP410
photoreceptor inner segment 1 ENO2
photoreceptor outer segment 1 CFAP410
T-tubule 1 SLC9A1
perikaryon 1 ENO2
nucleolus 1 PLCZ1
axon cytoplasm 1 OPA1
Single-pass type II membrane protein 1 COMT
postsynaptic membrane 1 GRID1
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 1 OPA1
Membrane raft 1 SLC9A1
focal adhesion 1 SLC9A1
microtubule 1 OPA1
GABA-ergic synapse 1 GRID1
Mitochondrion intermembrane space 1 OPA1
mitochondrial intermembrane space 1 OPA1
Postsynaptic cell membrane 1 GRID1
ciliary basal body 1 CFAP410
Cytoplasm, cytoskeleton, cilium basal body 1 CFAP410
mitochondrial crista 1 OPA1
Cell projection, cilium, photoreceptor outer segment 1 CFAP410
Basolateral cell membrane 1 SLC9A1
endosome lumen 1 INS
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
[Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane 1 OPA1
[Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space 1 OPA1
proton-transporting ATP synthase complex 1 ATP5ME
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
sperm head 1 PLCZ1
phosphopyruvate hydratase complex 1 ENO2
cation-transporting ATPase complex 1 SLC9A1
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • L Liu, F Li, Z Dong, G Dong, J Xu, W Liu, X Wang, X Hai, K Yu. Plasma fluoroacetic acid concentrations: Symptoms, hematological, and biochemical characteristics in patients with fluoroacetic acid poisoning in the emergency department. Human & experimental toxicology. 2020 May; 39(5):634-641. doi: 10.1177/0960327119897743. [PMID: 31957492]
  • Aristóteles G Costa, Antônio Último de Carvalho, Marília M Melo, Benito Soto-Blanco. Sequential administrations of trifluoroacetate induce tolerance to Palicourea maccgravii, a monofluoroacetate-containing plant, in calves. Toxicon : official journal of the International Society on Toxinology. 2019 Mar; 160(?):8-11. doi: 10.1016/j.toxicon.2019.02.005. [PMID: 30772434]
  • Stephanie C Lima, Kelly C S Godoy, Paula V Leal, Stephen T Lee, James A Pfister, Alda I Souza, Claudio S L de Barros, Ricardo A A de Lemos. Toxicity of the different vegetative stages of Amorimia pubiflora to sheep. Toxicon : official journal of the International Society on Toxinology. 2019 Feb; 158(?):47-50. doi: 10.1016/j.toxicon.2018.11.306. [PMID: 30471379]
  • Claudia Lucía Arroyave Hoyos, Maria Alejandra Cañas Galvis, David Ospina Estrada, Maria Camila Henao Solarte, Salomé Lopera Cardona. Intravenous Lipid Emulsion and Ethanol for Sodium Fluoroacetate Poisoning. American journal of therapeutics. 2018 Nov; 25(6):e756-e758. doi: 10.1097/mjt.0000000000000765. [PMID: 29668489]
  • Xiaoyi Zhang, Xiuyao Zhang, Xinxin Cai, Ruifen Li. [Determination of monofluoroacetic acid in plasma and urine by stable isotope dilution ion chromatography-triple quadrupole mass spectrometry]. Se pu = Chinese journal of chromatography. 2018 Oct; 36(10):979-984. doi: 10.3724/sp.j.1123.2018.06011. [PMID: 30378356]
  • Liang Liu, Shuang Hu, Suodi Zhai, Xin Hai. Analysis of monofluoroacetic acid in human plasma by UFLC-MS/MS and its application in patients with sodium monofluoroacetate or monofluoroacetamide poisoning. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 158(?):370-375. doi: 10.1016/j.jpba.2018.06.028. [PMID: 29936376]
  • John M Adaska, Guillermo Rimoldi, Patricia C Blanchard, John Champagne, Robert H Poppenga, Michelle Mostrom. Multiple episodes of 1080 (sodium monofluoroacetate) intoxication in a California calf-raising operation. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2018 Sep; 30(5):747-751. doi: 10.1177/1040638718781435. [PMID: 29973111]
  • Engy Shokry, Fabrício Carrião Dos Santos, Paulo Henrique Jorge da Cunha, Maria Clorinda Soares Fioravanti, Antônio Dionísio Feitosa Noronha Filho, Naiara Zedes Pereira, Nelson Roberto Antoniosi Filho. Earwax: A clue to discover fluoroacetate intoxication in cattle. Toxicon : official journal of the International Society on Toxinology. 2017 Oct; 137(?):54-57. doi: 10.1016/j.toxicon.2017.07.014. [PMID: 28716647]
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  • Xiao-Min Xu, Zeng-Xuan Cai, Jing-Shun Zhang, Yiping Ren, Jian-Long Han. Analysis of monofluoroacetic acid in urine by liquid chromatography-triple quadrupole mass spectrometry and preparation of the positive sample by the bioconversion from monofluoroacetamide to monofluoroacetic acid in vitro. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1027(?):131-8. doi: 10.1016/j.jchromb.2016.05.026. [PMID: 27284971]
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