3-Methyldioxyindole (BioDeep_00000005977)

 

Secondary id: BioDeep_00001868814

human metabolite Endogenous natural product


代谢物信息卡片


1,3-Dihydro-3-hydroxy-3-methyl-2H-indol-2-one

化学式: C9H9NO2 (163.0633)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 26.59%

分子结构信息

SMILES: CC1(C2=CC=CC=C2NC1=O)O
InChI: InChI=1S/C9H9NO2/c1-9(12)6-4-2-3-5-7(6)10-8(9)11/h2-5,12H,1H3,(H,10,11)

描述信息

3-Methyldioxyindole is a metabolite of aldehyde dehydrogenase (NAD+) (K00128)(EC 1.2.1.3) formed during 3-methylindole metabolism (PMID: 88251990). It is the major urinary metabolite of 3-methylindole. (PMID: 2519781). It is thought that 3-Methyldioxyindole is an in vivo oxidation product of 3-methylindole which is a metabolic product of tryptophan, produced by bacteria in the colon (PMID: 2796599).
3-Methyldioxyindole is a metabolite of aldehyde dehydrogenase (NAD+) (K00128)(EC 1.2.1.3) formed during 3-methylindole metabolism (PMID: 88251990). It is the major urinary metabolite of 3-methylindole. (PMID: 2519781).

同义名列表

6 个代谢物同义名

1,3-Dihydro-3-hydroxy-3-methyl-2H-indol-2-one; 3-hydroxy-3-methyl-2,3-dihydro-1H-indol-2-one; 3-Hydroxy-3-methyl-2-indolinone; 3-Hydroxy-3-methyl-oxindole; 3-Hydroxy-3-methyloxindole; 3-Methyldioxyindole



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ASS1, CYP1A1, CYP2E1, NR1I3
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP2E1, HSD17B6
Endoplasmic reticulum membrane 5 CYB5A, CYP1A1, CYP1B1, CYP2E1, CYP7A1
Nucleus 3 NR1H4, NR1I2, NR1I3
cytosol 3 ASS1, CYB5A, NR1I3
nuclear body 1 NR1I2
nucleoplasm 4 ASS1, NR1H4, NR1I2, NR1I3
RNA polymerase II transcription regulator complex 1 NR1H4
Cell membrane 1 TNF
Early endosome membrane 1 HSD17B6
cell surface 1 TNF
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 ASS1
plasma membrane 1 TNF
Membrane 2 CYB5A, CYP1B1
extracellular exosome 1 ASS1
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 2 IL10, TNF
mitochondrion 2 CYP1A1, CYP1B1
intracellular membrane-bounded organelle 6 CYB5A, CYP1A1, CYP1B1, CYP2E1, CYP7A1, HSD17B6
Microsome membrane 5 CYP1A1, CYP1B1, CYP2E1, CYP7A1, HSD17B6
Secreted 1 IL10
extracellular region 2 IL10, TNF
Single-pass membrane protein 1 CYP7A1
mitochondrial outer membrane 2 ASS1, CYB5A
transcription regulator complex 1 NR1I2
external side of plasma membrane 1 TNF
perikaryon 1 ASS1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 NR1I3
receptor complex 1 NR1H4
chromatin 3 NR1H4, NR1I2, NR1I3
phagocytic cup 1 TNF
cytoskeleton 1 NR1I3
[Isoform 3]: Nucleus 1 NR1H4
cell body fiber 1 ASS1
euchromatin 1 NR1H4
intermediate filament cytoskeleton 1 NR1I2
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
[Isoform 4]: Nucleus 1 NR1H4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • C Brunius, J K Vidanarachchi, J Tomankova, K Lundström, K Andersson, G Zamaratskaia. Skatole metabolites in urine as a biological marker of pigs with enhanced hepatic metabolism. Animal : an international journal of animal bioscience. 2016 Oct; 10(10):1734-40. doi: 10.1017/s1751731116000574. [PMID: 27080076]
  • P Wiercinska, Y Lou, E J Squires. The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism. Animal : an international journal of animal bioscience. 2012 May; 6(5):834-45. doi: 10.1017/s1751731111002175. [PMID: 22558931]
  • Maren Moe, Sigbjørn Lien, Christian Bendixen, Jakob Hedegaard, Henrik Hornshøj, Ingunn Berget, Theo H E Meuwissen, Eli Grindflek. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone. BMC veterinary research. 2008 Aug; 4(?):29. doi: 10.1186/1746-6148-4-29. [PMID: 18684314]
  • D J Smith, M L Appleton, J R Carlson, G S Yost. Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats. Drug metabolism and disposition: the biological fate of chemicals. 1996 Jan; 24(1):119-25. doi: . [PMID: 8825199]
  • G L Skiles, J D Adams, G S Yost. Isolation and identification of 3-hydroxy-3-methyloxindole, the major murine metabolite of 3-methylindole. Chemical research in toxicology. 1989 Jul; 2(4):254-9. doi: 10.1021/tx00010a007. [PMID: 2519781]
  • C F Albrecht, D J Chorn, P L Wessels. Detection of 3-hydroxy-3-methyloxindole in human urine. Life sciences. 1989; 45(12):1119-26. doi: 10.1016/0024-3205(89)90169-0. [PMID: 2796599]