Kukoamine A (BioDeep_00000000058)
Secondary id: BioDeep_00000861244
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C28H42N4O6 (530.3104192000001)
中文名称: 地骨皮甲素, 地骨皮甲素
谱图信息:
最多检出来源 Viridiplantae(otcml) 39.81%
分子结构信息
SMILES: C1=CC(=C(C=C1CCC(=O)NCCCNCCCCNCCCNC(=O)CCC2=CC(=C(C=C2)O)O)O)O
InChI: InChI=1S/C28H42N4O6/c33-23-9-5-21(19-25(23)35)7-11-27(37)31-17-3-15-29-13-1-2-14-30-16-4-18-32-28(38)12-8-22-6-10-24(34)26(36)20-22/h5-6,9-10,19-20,29-30,33-36H,1-4,7-8,11-18H2,(H,31,37)(H,32,38)
描述信息
Kukoamine A is an alkaloid from the root bark of Lycium chinense (Chinese boxthorn
Kukoamine A is an amine.
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
同义名列表
13 个代谢物同义名
(Z)-3-(3,4-dihydroxyphenyl)-N-(3-{[4-({3-[(Z)-[3-(3,4-dihydroxyphenyl)-1-hydroxypropylidene]amino]propyl}amino)butyl]amino}propyl)propimidic acid; 3-(3,4-Bis(oxidanyl)phenyl)-N-(3-(4-(3-(3-(3,4-bis(oxidanyl)phenyl)propanoylamino)propylamino)butylamino)propyl)propanamide; 3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydroxy-phenyl)-propionylamino]-propylamino}-butylamino)-propyl]-propionamide; 3-(3,4-dihydroxyphenyl)-N-[3-[4-[3-[3-(3,4-dihydroxyphenyl)propanoylamino]propylamino]butylamino]propyl]propanamide; Benzenepropanamide, N,N-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-; N,N-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide]; N(1),N(12)-bis(dihydrocaffeoyl)spermine; N1,N12-Bis(dihydrocaffeoyl) spermine; N1,N2-bis(dihydrocaffeoyl)spermine; 1,14-Bis(dihydrocaffeoyl)spermine; Kukoamine A; 9YM64FBW2R; Kukoamine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:81220
- KEGG: C17615
- PubChem: 5318865
- HMDB: HMDB0030392
- Metlin: METLIN71818
- ChEMBL: CHEMBL79129
- Wikipedia: Kukoamine A
- MeSH: kukoamine A
- KNApSAcK: C00028433
- foodb: FDB002245
- chemspider: 4477322
- CAS: 75288-96-9
- medchemexpress: HY-N2392
- PMhub: MS000025943
- PubChem: 96023959
- NIKKAJI: J11.311E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinrong Wei, Aysha Arif Chahel, Yuan Ni, Xiaoyi Wei, Yuling Zhao, Ying Wang, Shaohua Zeng. Lycium RIN negatively modulate the biosynthesis of kukoamine A in hairy roots through decreasing thermospermine synthase expression.
International journal of biological macromolecules.
2023 Aug; ?(?):126246. doi:
10.1016/j.ijbiomac.2023.126246. [PMID: 37567520] - Xiuxiu Liu, Mingjing Wang, Yao Song, Chaoqun Zhang, Yonghong Jiang, Wen Li, Binbin Xu, Zhiyan Jiang. Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
Drug development research.
2022 09; 83(6):1455-1466. doi:
10.1002/ddr.21975. [PMID: 35862278] - David Zaragoza-Huesca, Carlos Martínez-Cortés, Antonio Jesús Banegas-Luna, Alfonso Pérez-Garrido, Josefina María Vegara-Meseguer, Julia Peñas-Martínez, Maria Carmen Rodenas, Salvador Espín, Horacio Pérez-Sánchez, Irene Martínez-Martínez. Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.
International journal of molecular sciences.
2022 Mar; 23(5):. doi:
10.3390/ijms23052796. [PMID: 35269938] - Xiu-Xiu Liu, Ming-Jing Wang, Qian-Na Kan, Cui Li, Zhen Xiao, Yong-Hong Jiang, Wen Li, Xiao Li, Zhi-Yan Jiang. Kukoamine A Improves Mycoplasma pneumoniae Pneumonia by Regulating miR-222-3p/Superoxide Dismutase 2.
BioMed research international.
2022; 2022(?):2064013. doi:
10.1155/2022/2064013. [PMID: 35774277] - Christine A Butts, Duncan I Hedderley, Sheridan Martell, Hannah Dinnan, Susanne Middlemiss-Kraak, Barry J Bunn, Tony K McGhie, Ross E Lill. Influence of oral administration of kukoamine A on blood pressure in a rat hypertension model.
PloS one.
2022; 17(5):e0267567. doi:
10.1371/journal.pone.0267567. [PMID: 35522680] - Yue Yang, Lingyue Gao, Yixuan Niu, Xiang Li, Wenwu Liu, Xiaowen Jiang, Yaqian Liu, Qingchun Zhao. Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons.
Neurochemical research.
2020 Nov; 45(11):2703-2711. doi:
10.1007/s11064-020-03114-y. [PMID: 32892226] - Jia Liu, Xiaowen Jiang, Qiao Zhang, Sen Lin, Jun Zhu, Yajun Zhang, Jiabao Du, Xiaolong Hu, Weihong Meng, Qingchun Zhao. Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway.
Neurochemistry international.
2017 Jul; 107(?):191-197. doi:
10.1016/j.neuint.2016.12.024. [PMID: 28088348] - XiaoLong Hu, Qi Song, Xin Li, DanDan Li, Qiao Zhang, WeiHong Meng, QingChun Zhao. Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement.
Neuropharmacology.
2017 05; 117(?):352-363. doi:
10.1016/j.neuropharm.2017.02.022. [PMID: 28238714] - Guangyun Li, Fang Zhou, Ying Chen, Weiguo Zhang, Ning Wang. Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):536-543. doi:
10.1016/j.biopha.2017.02.024. [PMID: 28254666] - Xiao-Long Hu, Ling-Yue Gao, Yi-Xuan Niu, Xing Tian, Jian Wang, Wei-Hong Meng, Qiao Zhang, Can Cui, Lu Han, Qing-Chun Zhao. Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-D-aspartate receptors.
Biochimica et biophysica acta.
2015 Feb; 1850(2):287-98. doi:
10.1016/j.bbagen.2014.11.006. [PMID: 25445711] - Elena V Piletska, Rosemary Burns, Leon A Terry, Sergey A Piletsky. Application of a molecularly imprinted polymer for the extraction of kukoamine a from potato peels.
Journal of agricultural and food chemistry.
2012 Jan; 60(1):95-9. doi:
10.1021/jf203669b. [PMID: 22142260] - Dimitra Hadjipavlou-Litina, George E Magoulas, Stavros E Bariamis, Denis Drainas, Konstantinos Avgoustakis, Dionissios Papaioannou. Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?.
Bioorganic & medicinal chemistry.
2010 Dec; 18(23):8204-17. doi:
10.1016/j.bmc.2010.10.012. [PMID: 21041094] - Dimitra Hadjipavlou-Litina, Thomas Garnelis, Constantinos M Athanassopoulos, Dionissios Papaioannou. Kukoamine A analogs with lipoxygenase inhibitory activity.
Journal of enzyme inhibition and medicinal chemistry.
2009 Oct; 24(5):1188-93. doi:
10.1080/14756360902779193. [PMID: 19772491] - Adrian J Parr, Fred A Mellon, Ian J Colquhoun, Howard V Davies. Dihydrocaffeoyl polyamines (kukoamine and allies) in potato (Solanum tuberosum) tubers detected during metabolite profiling.
Journal of agricultural and food chemistry.
2005 Jun; 53(13):5461-6. doi:
10.1021/jf050298i. [PMID: 15969534]