Chlorsulfuron (BioDeep_00000005710)

 

Secondary id: BioDeep_00001868063

human metabolite blood metabolite


代谢物信息卡片


1-(2-chlorobenzenesulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea

化学式: C12H12ClN5O4S (357.02985020000006)
中文名称: 氯磺隆
谱图信息: 最多检出来源 Homo sapiens(blood) 83.33%

分子结构信息

SMILES: CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2Cl
InChI: InChI=1S/C12H12ClN5O4S/c1-7-14-10(17-12(15-7)22-2)16-11(19)18-23(20,21)9-6-4-3-5-8(9)13/h3-6H,1-2H3,(H2,14,15,16,17,18,19)

描述信息

D010575 - Pesticides > D006540 - Herbicides
D016573 - Agrochemicals

同义名列表

4 个代谢物同义名

1-(2-chlorobenzenesulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea; Chlorsulfuron, monoammonium salt; Chlorsulphuron; CHLORSULFURON



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Rustem Ustun, Gordon Chalmers, Daniel Tehrani, Bulent Uzun. Computational molecular explanation of Soybean AHAS resistance from P197S mutation. Plant physiology and biochemistry : PPB. 2023 May; 201(?):107782. doi: 10.1016/j.plaphy.2023.107782. [PMID: 37315349]
  • Fan-Fei Meng, Xue-Wen Sun, Ming-Hao Shang, Jia-Shuang Zhang, Cong-Wei Niu, Yong-Hong Li, Zhong-Wen Wang, Jian-Guo Wang, Zheng-Ming Li. Chemical preparation, degradation analysis, computational docking and biological activities of novel sulfonylureas with 2,5-disubstituted groups. Pesticide biochemistry and physiology. 2022 Nov; 188(?):105261. doi: 10.1016/j.pestbp.2022.105261. [PMID: 36464366]
  • Yali Zheng, Lili Gu, Junli Shi, Mengxiao Zhang, Guanghui Kong, Zhijun Li, Yi Han, Jian Peng. [Determination of sulfonylurea herbicide residues in tobacco leaves by molecularly imprinted-solid phase extraction-high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2018 Jul; 36(7):659-664. doi: 10.3724/sp.j.1123.2018.01010. [PMID: 30136538]
  • B Rainbird, R H Bentham, K L Soole. Rhizoremediation of residual sulfonylurea herbicides in agricultural soils using Lens culinaris and a commercial supplement. International journal of phytoremediation. 2018 Jan; 20(2):104-113. doi: 10.1080/15226514.2017.1337070. [PMID: 28613079]
  • Philippa J Barrell, Julie M Latimer, Samantha J Baldwin, Michelle L Thompson, Jeanne M E Jacobs, Anthony J Conner. Somatic cell selection for chlorsulfuron-resistant mutants in potato: identification of point mutations in the acetohydroxyacid synthase gene. BMC biotechnology. 2017 06; 17(1):49. doi: 10.1186/s12896-017-0371-4. [PMID: 28587679]
  • Roberto Busi, Stephen B Powles. Inheritance of 2,4-D resistance traits in multiple herbicide- resistant Raphanus raphanistrum populations. Plant science : an international journal of experimental plant biology. 2017 Apr; 257(?):1-8. doi: 10.1016/j.plantsci.2017.01.003. [PMID: 28224914]
  • Linjuan Wang, Houhua Li, Chunzhao Zhao, Shengfei Li, Lingyao Kong, Wenwu Wu, Weisheng Kong, Yan Liu, Yuanyuan Wei, Jian-Kang Zhu, Hairong Zhang. The inhibition of protein translation mediated by AtGCN1 is essential for cold tolerance in Arabidopsis thaliana. Plant, cell & environment. 2017 01; 40(1):56-68. doi: 10.1111/pce.12826. [PMID: 27577186]
  • Magdalena Alesso, Luis A Escudero, María Carolina Talio, Liliana P Fernández. Monitoring of chlorsulfuron in biological fluids and water samples by molecular fluorescence using rhodamine B as fluorophore. Talanta. 2016 Nov; 160(?):431-436. doi: 10.1016/j.talanta.2016.07.053. [PMID: 27591634]
  • Christopher Preston, Jenna M Malone. Inheritance of resistance to 2,4-D and chlorsulfuron in a multiple-resistant population of Sisymbrium orientale. Pest management science. 2015 Nov; 71(11):1523-8. doi: 10.1002/ps.3956. [PMID: 25476820]
  • Zhongsen Li, Zhan-Bin Liu, Aiqiu Xing, Bryan P Moon, Jessica P Koellhoffer, Lingxia Huang, R Timothy Ward, Elizabeth Clifton, S Carl Falco, A Mark Cigan. Cas9-Guide RNA Directed Genome Editing in Soybean. Plant physiology. 2015 Oct; 169(2):960-70. doi: 10.1104/pp.15.00783. [PMID: 26294043]
  • Vijay K Varanasi, Amar S Godar, Randall S Currie, Anita J Dille, Curtis R Thompson, Phillip W Stahlman, Mithila Jugulam. Field-evolved resistance to four modes of action of herbicides in a single kochia (Kochia scoparia L. Schrad.) population. Pest management science. 2015 Sep; 71(9):1207-12. doi: 10.1002/ps.4034. [PMID: 25950428]
  • Kimitsune Ishizaki, Ryuichi Nishihama, Minoru Ueda, Keisuke Inoue, Sakiko Ishida, Yoshiki Nishimura, Toshiharu Shikanai, Takayuki Kohchi. Development of Gateway Binary Vector Series with Four Different Selection Markers for the Liverwort Marchantia polymorpha. PloS one. 2015; 10(9):e0138876. doi: 10.1371/journal.pone.0138876. [PMID: 26406247]
  • Kateřina Hamouzová, Pavlína Košnarová, Jaroslav Salava, Josef Soukup, Pavel Hamouz. Mechanisms of resistance to acetolactate synthase-inhibiting herbicides in populations of Apera spica-venti from the Czech Republic. Pest management science. 2014 Apr; 70(4):541-8. doi: 10.1002/ps.3563. [PMID: 23893862]
  • Jia-Long Yao, Sumathi Tomes, Andrew P Gleave. Transformation of apple (Malus × domestica) using mutants of apple acetolactate synthase as a selectable marker and analysis of the T-DNA integration sites. Plant cell reports. 2013 May; 32(5):703-14. doi: 10.1007/s00299-013-1404-7. [PMID: 23494389]
  • Yu-Ting Lee, Chang-Jun Cui, Eve W L Chow, Nason Pue, Thierry Lonhienne, Jian-Guo Wang, James A Fraser, Luke W Guddat. Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of medicinal chemistry. 2013 Jan; 56(1):210-9. doi: 10.1021/jm301501k. [PMID: 23237384]
  • Heping Han, Qin Yu, Edison Purba, Mei Li, Michael Walsh, Shane Friesen, Stephen B Powles. A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides. Pest management science. 2012 Aug; 68(8):1164-70. doi: 10.1002/ps.3278. [PMID: 22431132]
  • Xu Wei Fu, Yan Jiao Wu, Jin Rong Qu, Hong Yang. Preparation and utilization of molecularly imprinted polymer for chlorsulfuron extraction from water, soil, and wheat plant. Environmental monitoring and assessment. 2012 Jul; 184(7):4161-70. doi: 10.1007/s10661-011-2252-y. [PMID: 21805075]
  • José Fenoll, Pilar Hellín, Pilar Flores, Carmen María Martínez, Simón Navarro. Photocatalytic degradation of five sulfonylurea herbicides in aqueous semiconductor suspensions under natural sunlight. Chemosphere. 2012 May; 87(8):954-61. doi: 10.1016/j.chemosphere.2012.01.056. [PMID: 22356857]
  • John E Casida. The greening of pesticide-environment interactions: some personal observations. Environmental health perspectives. 2012 Apr; 120(4):487-93. doi: 10.1289/ehp.1104405. [PMID: 22472325]
  • Husrev Mennan, Jens C Streibig, Mathieu Ngouajio, Emine Kaya. Tolerance of two Bifora radians Bieb populations to ALS inhibitors in winter wheat. Pest management science. 2012 Jan; 68(1):116-22. doi: 10.1002/ps.2231. [PMID: 21717566]
  • Luis Orcaray, María Igal, Ana Zabalza, Mercedes Royuela. Role of exogenously supplied ferulic and p-coumaric acids in mimicking the mode of action of acetolactate synthase inhibiting herbicides. Journal of agricultural and food chemistry. 2011 Sep; 59(18):10162-8. doi: 10.1021/jf2025538. [PMID: 21870840]
  • Nikolaos S Kaloumenos, Vasiliki N Adamouli, Christos A Dordas, Ilias G Eleftherohorinos. Corn poppy (Papaver rhoeas) cross-resistance to ALS-inhibiting herbicides. Pest management science. 2011 May; 67(5):574-85. doi: 10.1002/ps.2104. [PMID: 21308964]
  • R Busi, M M Vila-Aiub, S B Powles. Genetic control of a cytochrome P450 metabolism-based herbicide resistance mechanism in Lolium rigidum. Heredity. 2011 May; 106(5):817-24. doi: 10.1038/hdy.2010.124. [PMID: 20877397]
  • T Z Hu, S He, X Y Huang, L Deng, G X Wang. Cloning, molecular characterization and heterologous expression of a glutathione S-transferase gene in rice. Bioorganicheskaia khimiia. 2011 May; 37(3):386-92. doi: 10.1134/s1068162011030174. [PMID: 21899054]
  • Tingzhang Hu, Shuai He, Guojun Yang, Hua Zeng, Guixue Wang, Zaigang Chen, Xiaoyun Huang. Isolation and characterization of a rice glutathione S-transferase gene promoter regulated by herbicides and hormones. Plant cell reports. 2011 Apr; 30(4):539-49. doi: 10.1007/s00299-010-0964-z. [PMID: 21153026]
  • David M G Anderson, Vikki A Carolan, Susan Crosland, Kate R Sharples, Malcolm R Clench. Examination of the translocation of sulfonylurea herbicides in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid communications in mass spectrometry : RCM. 2010 Nov; 24(22):3309-19. doi: 10.1002/rcm.4767. [PMID: 20973006]
  • Zhongsen Li, Bryan P Moon, Aiqiu Xing, Zhan-Bin Liu, Richard P McCardell, Howard G Damude, S Carl Falco. Stacking multiple transgenes at a selected genomic site via repeated recombinase-mediated DNA cassette exchanges. Plant physiology. 2010 Oct; 154(2):622-31. doi: 10.1104/pp.110.160093. [PMID: 20720171]
  • Luis Orcaray, María Igal, Daniel Marino, Ana Zabalza, Mercedes Royuela. The possible role of quinate in the mode of action of glyphosate and acetolactate synthase inhibitors. Pest management science. 2010 Mar; 66(3):262-9. doi: 10.1002/ps.1868. [PMID: 19918955]
  • Qin Yu, Ibrahim Abdallah, Heping Han, Mechelle Owen, Stephen Powles. Distinct non-target site mechanisms endow resistance to glyphosate, ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep; 230(4):713-23. doi: 10.1007/s00425-009-0981-8. [PMID: 19603180]
  • Jonathan Gressel. Crops with target-site herbicide resistance for Orobanche and Striga control. Pest management science. 2009 May; 65(5):560-5. doi: 10.1002/ps.1738. [PMID: 19280593]
  • K Adamczewski, R Kierzek, K Matysiak. Influence of long-term used herbicides on resistance development in Apera spica-venti L. to sulfonylureas. Communications in agricultural and applied biological sciences. 2009; 74(2):491-6. doi: ". [PMID: 20222609]
  • Sébastien Lageix, Elodie Lanet, Marie-Noëlle Pouch-Pélissier, Marie-Claude Espagnol, Christophe Robaglia, Jean-Marc Deragon, Thierry Pélissier. Arabidopsis eIF2alpha kinase GCN2 is essential for growth in stress conditions and is activated by wounding. BMC plant biology. 2008 Dec; 8(?):134. doi: 10.1186/1471-2229-8-134. [PMID: 19108716]
  • Carlos A Sala, Mariano Bulos, Mariel Echarte, Sherry R Whitt, Robert Ascenzi. Molecular and biochemical characterization of an induced mutation conferring imidazolinone resistance in sunflower. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2008 Dec; 118(1):105-12. doi: 10.1007/s00122-008-0880-6. [PMID: 18784913]
  • Xiaofei Sun, Xing Huang, Bo Chen, Shunpeng Li, Jian He. [Isolation of a metsulfuron-methyl-resistant bacteria and cloning and expression of the acetohydroxyacid synthase genes ilvlH]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2008 Nov; 48(11):1493-8. doi: . [PMID: 19149165]
  • Yuhua Zhang, Yifei Wang, Kostya Kanyuka, Martin A J Parry, Stephen J Powers, Nigel G Halford. GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis. Journal of experimental botany. 2008; 59(11):3131-41. doi: 10.1093/jxb/ern169. [PMID: 18603615]
  • Y-Q Lu, J Baker, C Preston. The spread of resistance to acetolactate synthase inhibiting herbicides in a wind borne, self-pollinated weed species, Lactuca serriola L. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2007 Aug; 115(4):443-50. doi: 10.1007/s00122-007-0576-3. [PMID: 17628783]
  • Laura Delgado-Moreno, Aranzazu Peña. Organic amendments from olive cake as a strategy to modify the degradation of sulfonylurea herbicides in soil. Journal of agricultural and food chemistry. 2007 Jul; 55(15):6213-8. doi: 10.1021/jf0708342. [PMID: 17608500]
  • Ting-Zhang Hu, Wei-Ping Wang, Kai-Ming Cao, Mian Xia, Xi-Ping Wang. Isolation and characterization of OsGSTL1 promoter from rice. Yi chuan xue bao = Acta genetica Sinica. 2006 Jun; 33(6):525-31. doi: 10.1016/s0379-4172(06)60081-4. [PMID: 16800383]
  • Fabrice Roux, Christine Camilleri, Aurélie Bérard, Xavier Reboud. Multigenerational versus single generation studies to estimate herbicide resistance fitness cost in Arabidopsis thaliana. Evolution; international journal of organic evolution. 2005 Oct; 59(10):2264-9. doi: ". [PMID: 16405169]
  • Ana Zabalza, Esther M González, Cesar Arrese-Igor, Mercedes Royuela. Fermentative metabolism is induced by inhibiting different enzymes of the branched-chain amino acid biosynthesis pathway in pea plants. Journal of agricultural and food chemistry. 2005 Sep; 53(19):7486-93. doi: 10.1021/jf050654x. [PMID: 16159177]
  • S Slavov, V Valkov, R Batchvarova, S Atanassova, M Alexandrova, A Atanassov. Chlorsulfuron resistant transgenic tobacco as a tool for broomrape control. Transgenic research. 2005 Jun; 14(3):273-8. doi: 10.1007/s11248-004-8081-9. [PMID: 16145835]
  • Wen-Sheng Xiang, Xiang-Jing Wang, Tian-Rui Ren, Xiu-Lian Ju. Expression of a wheat cytochrome P450 monooxygenase in yeast and its inhibition by glyphosate. Pest management science. 2005 Apr; 61(4):402-6. doi: 10.1002/ps.969. [PMID: 15627243]
  • Jennifer A McCourt, Siew Siew Pang, Luke W Guddat, Ronald G Duggleby. Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry. 2005 Feb; 44(7):2330-8. doi: 10.1021/bi047980a. [PMID: 15709745]
  • Ana Zabalza, Luis Orcaray, Susana Gaston, Mercedes Royuela. Carbohydrate accumulation in leaves of plants treated with the herbicide chlorsulfuron or imazethapyr is due to a decrease in sink strength. Journal of agricultural and food chemistry. 2004 Dec; 52(25):7601-6. doi: 10.1021/jf0486996. [PMID: 15675810]
  • Judith M Kolkman, Mary B Slabaugh, Jose M Bruniard, Simon Berry, B Shaun Bushman, Christine Olungu, Nele Maes, Gustavo Abratti, Andres Zambelli, Jerry F Miller, Alberto Leon, Steven J Knapp. Acetohydroxyacid synthase mutations conferring resistance to imidazolinone or sulfonylurea herbicides in sunflower. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2004 Oct; 109(6):1147-59. doi: 10.1007/s00122-004-1716-7. [PMID: 15309298]
  • Krishna Ray, Arun Jagannath, Suveena Arora Gangwani, Pradeep Kumar Burma, Deepak Pental. Mutant acetolactate synthase gene is an efficient in vitro selectable marker for the genetic transformation of Brassica juncea (oilseed mustard). Journal of plant physiology. 2004 Sep; 161(9):1079-83. doi: 10.1016/j.jplph.2004.02.001. [PMID: 15499910]
  • Y Ito, M Eiguchi, N Kurata. Establishment of an enhancer trap system with Ds and GUS for functional genomics in rice. Molecular genetics and genomics : MGG. 2004 Jul; 271(6):639-50. doi: 10.1007/s00438-004-1023-7. [PMID: 15221455]
  • René Ruiter, Ilse van den Brande, Ellen Stals, Stijn Delauré, Marc Cornelissen, Kathleen D'Halluin. Spontaneous mutation frequency in plants obscures the effect of chimeraplasty. Plant molecular biology. 2003 Nov; 53(5):675-89. doi: 10.1023/b:plan.0000019111.96107.01. [PMID: 15010606]
  • Susana Gaston, Miquel Ribas-Carbo, Silvia Busquets, Joseph A Berry, Ana Zabalza, Mercedes Royuela. Changes in mitochondrial electron partitioning in response to herbicides inhibiting branched-chain amino acid biosynthesis in soybean. Plant physiology. 2003 Nov; 133(3):1351-9. doi: 10.1104/pp.103.027805. [PMID: 14576285]
  • Andrej Kochevenko, Lothar Willmitzer. Chimeric RNA/DNA oligonucleotide-based site-specific modification of the tobacco acetolactate syntase gene. Plant physiology. 2003 May; 132(1):174-84. doi: 10.1104/pp.102.016857. [PMID: 12746523]
  • Georg Jander, Scott R Baerson, Jebecka A Hudak, Kathleen A Gonzalez, Kenneth J Gruys, Robert L Last. Ethylmethanesulfonate saturation mutagenesis in Arabidopsis to determine frequency of herbicide resistance. Plant physiology. 2003 Jan; 131(1):139-46. doi: 10.1104/pp.102.010397. [PMID: 12529522]
  • J H Ahtiainen, P Vanhala, A Myllymäki. Effects of different plant protection programs on soil microbes. Ecotoxicology and environmental safety. 2003 Jan; 54(1):56-64. doi: 10.1016/s0147-6513(02)00020-9. [PMID: 12547636]
  • Dolores M Bartholomew, Drew E Van Dyk, Sze-Mei Cindy Lau, Daniel P O'Keefe, Philip A Rea, Paul V Viitanen. Alternate energy-dependent pathways for the vacuolar uptake of glucose and glutathione conjugates. Plant physiology. 2002 Nov; 130(3):1562-72. doi: 10.1104/pp.008334. [PMID: 12428021]
  • C Kjaer, U Heimbach. Relationships between sulfonylurea herbicide treatment of host plants and the performance of herbivorous insects. Pest management science. 2001 Dec; 57(12):1161-6. doi: 10.1002/ps.407. [PMID: 11802605]
  • A Coyner, G Gupta, T Jones. Effect of chlorsulfuron on growth of submerged aquatic macrophyte Potamogeton pectinatus (sago pondweed). Environmental pollution (Barking, Essex : 1987). 2001; 111(3):453-5. doi: 10.1016/s0269-7491(00)00084-1. [PMID: 11202750]
  • P R Beetham, P B Kipp, X L Sawycky, C J Arntzen, G D May. A tool for functional plant genomics: chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations. Proceedings of the National Academy of Sciences of the United States of America. 1999 Jul; 96(15):8774-8. doi: 10.1073/pnas.96.15.8774. [PMID: 10411951]
  • J A Grandoni, P T Marta, J V Schloss. Inhibitors of branched-chain amino acid biosynthesis as potential antituberculosis agents. The Journal of antimicrobial chemotherapy. 1998 Oct; 42(4):475-82. doi: 10.1093/jac/42.4.475. [PMID: 9818746]
  • L De Veylder, M Van Montagu, D Inzé. Herbicide safener-inducible gene expression in Arabidopsis thaliana. Plant & cell physiology. 1997 May; 38(5):568-77. doi: 10.1093/oxfordjournals.pcp.a029206. [PMID: 9210333]
  • J Bergelson, C B Purrington, C J Palm, J C López-Gutiérrez. Costs of resistance: a test using transgenic Arabidopsis thaliana. Proceedings. Biological sciences. 1996 Dec; 263(1377):1659-63. doi: 10.1098/rspb.1996.0242. [PMID: 9025313]
  • D J Morré, J Fleurimont, M Sweeting. Chlorsulfuron blocks 2,4-D-induced cell enlargement and NADH oxidase in excised sections of soybean hypocotyls. Biochimica et biophysica acta. 1995 Nov; 1240(1):5-9. doi: 10.1016/0005-2736(95)00177-5. [PMID: 7495848]
  • G Mourad, G Haughn, J King. Intragenic recombination in the CSR1 locus of Arabidopsis. Molecular & general genetics : MGG. 1994 Apr; 243(2):178-84. doi: 10.1007/bf00280315. [PMID: 8177214]
  • M A Honma, B J Baker, C S Waddell. High-frequency germinal transposition of DsALS in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 1993 Jul; 90(13):6242-6. doi: 10.1073/pnas.90.13.6242. [PMID: 8392193]
  • K Y Lee, P Lund, K Lowe, P Dunsmuir. Homologous recombination in plant cells after Agrobacterium-mediated transformation. The Plant cell. 1990 May; 2(5):415-25. doi: 10.1105/tpc.2.5.415. [PMID: 2152167]
  • N E Olszewski, F B Martin, F M Ausubel. Specialized binary vector for plant transformation: expression of the Arabidopsis thaliana AHAS gene in Nicotiana tabacum. Nucleic acids research. 1988 Nov; 16(22):10765-82. doi: 10.1093/nar/16.22.10765. [PMID: 3060849]