D-myo-Inositol 3,4,5,6-tetrakisphosphate (BioDeep_00000005549)

 

Secondary id: BioDeep_00001869100

human metabolite Endogenous


代谢物信息卡片


{[(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid

化学式: C6H16O18P4 (499.92871560000003)
中文名称:
谱图信息: 最多检出来源 Ailuropoda melanoleuca(viridiplantae) 14.29%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m0/s1

描述信息

Inositol phosphates are a family of water-soluble intracellular signalling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. D-myo-Inositol 3,4,5,6-tetrakisphosphate, also known as Ins(3,4,5,6)P4, has a direct biphasic (activation/inhibition) effect on an epithelial Ca2+-activated chloride channel. The effect of Ins(3,4,5,6)P4 is not mimicked by other inositol tetrakisphosphate isomers, is dependent on the prevailing calcium concentration, and is influenced when channels are phosphorylated by calmodulin kinase II. The predominant effect of Ins(3,4,5,6)P4 on phosphorylated channels is inhibitory at levels of intracellular calcium observed in stimulated cells. Ins(3,4,5,6)P4 activity acts to inhibit calcium-dependent chloride secretion. The secretion of fluid and electrolytes across intestinal epithelial cells in response to Ca2+-dependent secretagogues is a tightly regulated process that is subject to both positive and negative influences. Agonists of Gq protein-coupled receptor (GqPCRs) appear to have the ability to evoke antisecretory mechanisms. One is mediated by the generation of Ins(3,4,5,6)P4 and serves to chronically downregulate epithelial responsiveness to subsequent challenges with Ca2+-dependent agonists (PMID: 12388102, 11408264).
Inositol phosphates are a family of water-soluble intracellular signaling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. D-Myo-inositol (3,4,5,6) tetrakisphosphate (Ins(3,4,5,6)P4) has a direct biphasic (activation/inhibition) effect on an epithelial Ca2+-activated chloride channel. The effect of Ins(3,4,5,6)P4 is not mimicked by other inositol tetrakisphosphate isomers, is dependent on the prevailing calcium concentration, and is influenced when channels are phosphorylated by calmodulin kinase II. The predominant effect of Ins(3,4,5,6)P4 on phosphorylated channels is inhibitory at levels of intracellular calcium observed in stimulated cells. Ins(3,4,5,6)P4 activity acts to inhibit calcium-dependent chloride secretion. The secretion of fluid and electrolytes across intestinal epithelial cells in response to Ca2+-dependent secretagogues is a tightly regulated process that is subject to both positive and negative influences. Agonists of Gq protein-coupled receptor (GqPCRs) appear to have the ability to evoke antisecretory mechanisms. One is mediated by the generation of Ins(3,4,5,6)P4 and serves to chronically downregulate epithelial responsiveness to subsequent challenge with Ca2+-dependent agonists. (PMID: 12388102, 11408264) [HMDB]

同义名列表

20 个代谢物同义名

{[(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-myo-Inositol, 3,4,5,6-tetrakis(dihydrogen phosphate); D-Myo-inositol 3,4,5,6-tetrakisphosphoric acid; Myo-inositol-3,4,5,6-tetrakisphosphoric acid; 1D-myo-Inositol 3,4,5,6-tetrakisphosphate; D-myo-Inositol 3,4,5,6-tetrakisphosphate; Inositol 3,4,5,6-tetrakisphosphoric acid; Myo-inositol-3,4,5,6-tetrakisphosphate; Inositol-3,4,5,6-tetraphosphoric acid; D-myo-Inositol 3,4,5,6-tetraphosphate; D-myo-Inositol-1,3,4,6-tetraphosphate; Inositol 3,4,5,6-tetrakis(phosphate); Inositol 3,4,5,6-tetrakisphosphate; Inositol 3,4,5,6-tetraphosphate; Inositol-3,4,5,6-tetraphosphate; Ins(3,4,5,6)P4; Ins(3,4,5,6)P3; Ins-3,4,5,6-P4; SCHEMBL513820



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

315 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(0)

WikiPathways(0)

Plant Reactome(288)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(12)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel Bosch, Adolfo Saiardi. Arginine transcriptional response does not require inositol phosphate synthesis. The Journal of biological chemistry. 2012 Nov; 287(45):38347-55. doi: 10.1074/jbc.m112.384255. [PMID: 22992733]
  • J Navarro-Fernández, H Pérez-Sánchez, I Martínez-Martínez, I Meliciani, J A Guerrero, V Vicente, J Corral, W Wenzel. In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. Journal of medicinal chemistry. 2012 Jul; 55(14):6403-12. doi: 10.1021/jm300621j. [PMID: 22742452]
  • Mohammad Alimohammadi, Kanishka de Silva, Clarisse Ballu, Nawab Ali, Mariya V Khodakovskaya. Reduction of inositol (1,4,5)-trisphosphate affects the overall phosphoinositol pathway and leads to modifications in light signalling and secondary metabolism in tomato plants. Journal of experimental botany. 2012 Jan; 63(2):825-35. doi: 10.1093/jxb/err306. [PMID: 21994174]
  • Søren K Rasmussen, Christina Rønn Ingvardsen, Anna Maria Torp. Mutations in genes controlling the biosynthesis and accumulation of inositol phosphates in seeds. Biochemical Society transactions. 2010 Apr; 38(2):689-94. doi: 10.1042/bst0380689. [PMID: 20298244]
  • Jennifer Mitchell, Xueqing Wang, Guangping Zhang, Martina Gentzsch, Deborah J Nelson, Stephen B Shears. An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Current biology : CB. 2008 Oct; 18(20):1600-5. doi: 10.1016/j.cub.2008.08.073. [PMID: 18951024]
  • Amanda R Stiles, Xun Qian, Stephen B Shears, Elizabeth A Grabau. Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS letters. 2008 Jun; 582(13):1853-8. doi: 10.1016/j.febslet.2008.04.054. [PMID: 18474240]
  • Adolfo Saiardi, Shamshad Cockcroft. Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels. Science signaling. 2008 Jan; 1(4):pe5. doi: 10.1126/stke.14pe5. [PMID: 18272466]
  • Elisabetta Tosti. Calcium ion currents mediating oocyte maturation events. Reproductive biology and endocrinology : RB&E. 2006 May; 4(?):26. doi: 10.1186/1477-7827-4-26. [PMID: 16684344]
  • John R Couchman, Susan Vogt, Ssang-Taek Lim, Yangmi Lim, Eok-Soo Oh, Glenn D Prestwich, Anne Theibert, Weontae Lee, Anne Woods. Regulation of inositol phospholipid binding and signaling through syndecan-4. The Journal of biological chemistry. 2002 Dec; 277(51):49296-303. doi: 10.1074/jbc.m209679200. [PMID: 12377772]
  • Laura Zonia, Sofia Cordeiro, Jaroslav Tupý, José A Feijó. Oscillatory chloride efflux at the pollen tube apex has a role in growth and cell volume regulation and is targeted by inositol 3,4,5,6-tetrakisphosphate. The Plant cell. 2002 Sep; 14(9):2233-49. doi: . [PMID: 12215517]