D-myo-Inositol 3,4,5,6-tetrakisphosphate (BioDeep_00000005549)

 

Secondary id: BioDeep_00001869100

human metabolite Endogenous


代谢物信息卡片


{[(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid

化学式: C6H16O18P4 (499.9287)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 19.04%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m0/s1

描述信息

Inositol phosphates are a family of water-soluble intracellular signalling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. D-myo-Inositol 3,4,5,6-tetrakisphosphate, also known as Ins(3,4,5,6)P4, has a direct biphasic (activation/inhibition) effect on an epithelial Ca2+-activated chloride channel. The effect of Ins(3,4,5,6)P4 is not mimicked by other inositol tetrakisphosphate isomers, is dependent on the prevailing calcium concentration, and is influenced when channels are phosphorylated by calmodulin kinase II. The predominant effect of Ins(3,4,5,6)P4 on phosphorylated channels is inhibitory at levels of intracellular calcium observed in stimulated cells. Ins(3,4,5,6)P4 activity acts to inhibit calcium-dependent chloride secretion. The secretion of fluid and electrolytes across intestinal epithelial cells in response to Ca2+-dependent secretagogues is a tightly regulated process that is subject to both positive and negative influences. Agonists of Gq protein-coupled receptor (GqPCRs) appear to have the ability to evoke antisecretory mechanisms. One is mediated by the generation of Ins(3,4,5,6)P4 and serves to chronically downregulate epithelial responsiveness to subsequent challenges with Ca2+-dependent agonists (PMID: 12388102, 11408264).
Inositol phosphates are a family of water-soluble intracellular signaling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. D-Myo-inositol (3,4,5,6) tetrakisphosphate (Ins(3,4,5,6)P4) has a direct biphasic (activation/inhibition) effect on an epithelial Ca2+-activated chloride channel. The effect of Ins(3,4,5,6)P4 is not mimicked by other inositol tetrakisphosphate isomers, is dependent on the prevailing calcium concentration, and is influenced when channels are phosphorylated by calmodulin kinase II. The predominant effect of Ins(3,4,5,6)P4 on phosphorylated channels is inhibitory at levels of intracellular calcium observed in stimulated cells. Ins(3,4,5,6)P4 activity acts to inhibit calcium-dependent chloride secretion. The secretion of fluid and electrolytes across intestinal epithelial cells in response to Ca2+-dependent secretagogues is a tightly regulated process that is subject to both positive and negative influences. Agonists of Gq protein-coupled receptor (GqPCRs) appear to have the ability to evoke antisecretory mechanisms. One is mediated by the generation of Ins(3,4,5,6)P4 and serves to chronically downregulate epithelial responsiveness to subsequent challenge with Ca2+-dependent agonists. (PMID: 12388102, 11408264) [HMDB]

同义名列表

20 个代谢物同义名

{[(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1R,2S,3R,4S,5S,6R)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-myo-Inositol, 3,4,5,6-tetrakis(dihydrogen phosphate); D-Myo-inositol 3,4,5,6-tetrakisphosphoric acid; Myo-inositol-3,4,5,6-tetrakisphosphoric acid; 1D-myo-Inositol 3,4,5,6-tetrakisphosphate; D-myo-Inositol 3,4,5,6-tetrakisphosphate; Inositol 3,4,5,6-tetrakisphosphoric acid; Myo-inositol-3,4,5,6-tetrakisphosphate; Inositol-3,4,5,6-tetraphosphoric acid; D-myo-Inositol 3,4,5,6-tetraphosphate; D-myo-Inositol-1,3,4,6-tetraphosphate; Inositol 3,4,5,6-tetrakis(phosphate); Inositol 3,4,5,6-tetrakisphosphate; Inositol 3,4,5,6-tetraphosphate; Inositol-3,4,5,6-tetraphosphate; Ins(3,4,5,6)P4; Ins(3,4,5,6)P3; Ins-3,4,5,6-P4; SCHEMBL513820



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

315 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(0)

WikiPathways(0)

Plant Reactome(288)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(12)

PharmGKB(0)

2 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 6 AKT1, EGFR, ITPR3, POMC, RAC1, VDR
Peripheral membrane protein 1 CLCA1
Endosome membrane 3 CLCN5, EGFR, TF
Endoplasmic reticulum membrane 3 EGFR, ITPR3, RAC1
Nucleus 5 AKT1, EGFR, PLCZ1, RAC1, VDR
cytosol 7 AKT1, CLCN5, ITPK1, PLCZ1, PRKCQ, RAC1, VDR
dendrite 1 RAC1
trans-Golgi network 1 RAC1
nucleoplasm 5 AKT1, ITPR3, PLCZ1, SCNN1G, VDR
RNA polymerase II transcription regulator complex 1 VDR
Cell membrane 5 AKT1, CLCA1, CLCN5, EGFR, RAC1
Lipid-anchor 1 RAC1
Cytoplasmic side 1 RAC1
lamellipodium 2 AKT1, RAC1
ruffle membrane 2 EGFR, RAC1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 CLCN5, ITPR3, SCNN1G
Golgi apparatus membrane 1 CLCN5
Synapse 1 RAC1
cell cortex 2 AKT1, RAC1
cell junction 1 EGFR
cell surface 2 EGFR, TF
glutamatergic synapse 3 AKT1, EGFR, RAC1
Golgi apparatus 1 CLCN5
Golgi membrane 3 CLCN5, EGFR, INS
lysosomal membrane 2 CLCN5, EGF
neuronal cell body 1 ITPR3
postsynapse 2 AKT1, RAC1
synaptic vesicle 1 CLCN5
endosome 1 EGFR
plasma membrane 12 AKT1, CLCA1, CLCN5, EGF, EGFR, F2, ITPR3, KNG1, PRKCQ, RAC1, SCNN1G, TF
Membrane 6 AKT1, CLCN5, EGF, EGFR, ITPR3, RAC1
apical plasma membrane 4 EGFR, ITPK1, SCNN1G, TF
basolateral plasma membrane 1 EGFR
brush border 1 ITPR3
extracellular exosome 6 EGF, F2, KNG1, RAC1, SCNN1G, TF
endoplasmic reticulum 1 ITPR3
extracellular space 8 EGF, EGFR, F2, IL4, INS, KNG1, POMC, TF
perinuclear region of cytoplasm 3 EGFR, PLCZ1, TF
protein-containing complex 2 AKT1, EGFR
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 EGFR
Secreted 6 F2, IL4, INS, POMC, RAC1, TF
extracellular region 9 CLCA1, EGF, F2, IL4, INS, KNG1, POMC, RAC1, TF
basal part of cell 1 TF
Extracellular side 1 CLCA1
centriolar satellite 1 PRKCQ
nuclear membrane 1 EGFR
external side of plasma membrane 1 SCNN1G
dendritic spine 1 RAC1
cytoplasmic vesicle 2 RAC1, TF
microtubule cytoskeleton 1 AKT1
nucleolus 2 ITPR3, PLCZ1
Early endosome 2 CLCN5, TF
apical part of cell 2 CLCN5, ITPR3
cell-cell junction 1 AKT1
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 2 AKT1, TF
Apical cell membrane 1 SCNN1G
Cell projection, lamellipodium 1 RAC1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 EGFR
focal adhesion 2 EGFR, RAC1
spindle 1 AKT1
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 ITPR3
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 F2, KNG1
secretory granule 1 POMC
nuclear outer membrane 1 ITPR3
Late endosome 1 TF
receptor complex 3 EGFR, ITPR3, VDR
Zymogen granule membrane 1 CLCA1
ciliary basal body 1 AKT1
chromatin 1 VDR
cytoskeleton 1 RAC1
cytoplasmic ribonucleoprotein granule 1 RAC1
Secreted, extracellular space 2 CLCA1, KNG1
blood microparticle 3 F2, KNG1, TF
Recycling endosome membrane 1 RAC1
endosome lumen 1 INS
microvillus 1 CLCA1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 RAC1
Melanosome 1 RAC1
basal plasma membrane 2 EGFR, TF
synaptic membrane 1 EGFR
secretory granule lumen 3 INS, POMC, TF
HFE-transferrin receptor complex 1 TF
secretory granule membrane 2 ITPR3, RAC1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 F2, INS, KNG1, TF
platelet alpha granule lumen 2 EGF, KNG1
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 3 EGF, EGFR, TF
platelet dense tubular network membrane 1 ITPR3
ficolin-1-rich granule membrane 1 RAC1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
vesicle coat 1 TF
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
NADPH oxidase complex 1 RAC1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
dense body 1 TF


文献列表

  • Daniel Bosch, Adolfo Saiardi. Arginine transcriptional response does not require inositol phosphate synthesis. The Journal of biological chemistry. 2012 Nov; 287(45):38347-55. doi: 10.1074/jbc.m112.384255. [PMID: 22992733]
  • J Navarro-Fernández, H Pérez-Sánchez, I Martínez-Martínez, I Meliciani, J A Guerrero, V Vicente, J Corral, W Wenzel. In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. Journal of medicinal chemistry. 2012 Jul; 55(14):6403-12. doi: 10.1021/jm300621j. [PMID: 22742452]
  • Mohammad Alimohammadi, Kanishka de Silva, Clarisse Ballu, Nawab Ali, Mariya V Khodakovskaya. Reduction of inositol (1,4,5)-trisphosphate affects the overall phosphoinositol pathway and leads to modifications in light signalling and secondary metabolism in tomato plants. Journal of experimental botany. 2012 Jan; 63(2):825-35. doi: 10.1093/jxb/err306. [PMID: 21994174]
  • Søren K Rasmussen, Christina Rønn Ingvardsen, Anna Maria Torp. Mutations in genes controlling the biosynthesis and accumulation of inositol phosphates in seeds. Biochemical Society transactions. 2010 Apr; 38(2):689-94. doi: 10.1042/bst0380689. [PMID: 20298244]
  • Jennifer Mitchell, Xueqing Wang, Guangping Zhang, Martina Gentzsch, Deborah J Nelson, Stephen B Shears. An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Current biology : CB. 2008 Oct; 18(20):1600-5. doi: 10.1016/j.cub.2008.08.073. [PMID: 18951024]
  • Amanda R Stiles, Xun Qian, Stephen B Shears, Elizabeth A Grabau. Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS letters. 2008 Jun; 582(13):1853-8. doi: 10.1016/j.febslet.2008.04.054. [PMID: 18474240]
  • Adolfo Saiardi, Shamshad Cockcroft. Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels. Science signaling. 2008 Jan; 1(4):pe5. doi: 10.1126/stke.14pe5. [PMID: 18272466]
  • Elisabetta Tosti. Calcium ion currents mediating oocyte maturation events. Reproductive biology and endocrinology : RB&E. 2006 May; 4(?):26. doi: 10.1186/1477-7827-4-26. [PMID: 16684344]
  • John R Couchman, Susan Vogt, Ssang-Taek Lim, Yangmi Lim, Eok-Soo Oh, Glenn D Prestwich, Anne Theibert, Weontae Lee, Anne Woods. Regulation of inositol phospholipid binding and signaling through syndecan-4. The Journal of biological chemistry. 2002 Dec; 277(51):49296-303. doi: 10.1074/jbc.m209679200. [PMID: 12377772]
  • Laura Zonia, Sofia Cordeiro, Jaroslav Tupý, José A Feijó. Oscillatory chloride efflux at the pollen tube apex has a role in growth and cell volume regulation and is targeted by inositol 3,4,5,6-tetrakisphosphate. The Plant cell. 2002 Sep; 14(9):2233-49. doi: . [PMID: 12215517]