N-hydroxy-4-aminobiphenyl (BioDeep_00000005260)

 

Secondary id: BioDeep_00001028699, BioDeep_00001869170

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


N-Hydroxy-4-aminobiphenyl

化学式: C12H11NO (185.0840596)
中文名称: 4-氨基-4-羟基联苯, 4'-氨基-4-联苯酚
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.4%

分子结构信息

SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)NO
InChI: InChI=1S/C12H11NO/c14-13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13-14H

描述信息

同义名列表

2 个代谢物同义名

N-Hydroxy-4-aminobiphenyl; 4-Amino-4-biphenylol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

77 个相关的代谢反应过程信息。

Reactome(77)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mohamadi A Sarkar, Unyime O Nseyo, Bao-Zhen Zhong. Mutagenic outcome of the urinary carcinogen 4-aminobiphenyl is increased in acidic pH. Environmental toxicology and pharmacology. 2002 Jan; 11(1):23-6. doi: 10.1016/s1382-6689(01)00098-9. [PMID: 21782583]
  • F Y Bois, G Krowech, L Zeise. Modeling human interindividual variability in metabolism and risk: the example of 4-aminobiphenyl. Risk analysis : an official publication of the Society for Risk Analysis. 1995 Apr; 15(2):205-13. doi: 10.1111/j.1539-6924.1995.tb00314.x. [PMID: 7597257]
  • S Karreth, W Lenk. The metabolism of 4-aminobiphenyl in rat. I. Reaction of N-hydroxy-4-aminobiphenyl with rat blood in vivo. Xenobiotica; the fate of foreign compounds in biological systems. 1991 Mar; 21(3):417-28. doi: 10.3109/00498259109039481. [PMID: 1862663]
  • D W Hein, T J Flammang, W G Kirlin, A Trinidad, F Ogolla. Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase. Carcinogenesis. 1987 Dec; 8(12):1767-74. doi: 10.1093/carcin/8.12.1767. [PMID: 3677303]
  • T J Flammang, F F Kadlubar. Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases. Carcinogenesis. 1986 Jun; 7(6):919-26. doi: 10.1093/carcin/7.6.919. [PMID: 3708755]
  • Y Hirao, Y Miyata, W L Hearn, J L Radomski, R Oyasu. Development of sarcomas in heterotopically transplanted rat urinary bladder unit exposed to glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl. Cancer letters. 1981 Feb; 11(4):309-13. doi: 10.1016/0304-3835(81)90096-3. [PMID: 7296524]
  • J L Radomski, W L Hearn, T Radomski, H Moreno, W E Scott. Isolation of the glucuronic acid conjugate of n-hydroxy-4-aminobiphenyl from dog urine and its mutagenic activity. Cancer research. 1977 Jun; 37(6):1757-62. doi: . [PMID: 322861]