L-Aspartyl-4-phosphate (BioDeep_00000005091)

 

Secondary id: BioDeep_00001869289

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S)-2-Amino-4-oxo-4-(phosphonooxy)butanoic acid

化学式: C4H8NO7P (213.0038388)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(urine) 0.22%

分子结构信息

SMILES: C(C(C(=O)O)N)C(=O)OP(=O)(O)O
InChI: InChI=1S/C4H8NO7P/c5-2(4(7)8)1-3(6)12-13(9,10)11/h2H,1,5H2,(H,7,8)(H2,9,10,11)/t2-/m0/s1

描述信息

L-Aspartyl-4-phosphate belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from a reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-Aspartyl-4-phosphate is a very strong basic compound (based on its pKa). L-Aspartyl-4-phosphate is involved in both the lysine biosynthesis I and homoserine biosynthesis pathways. L-Aspartyl-4-phosphate is produced from a reaction between L-aspartate and ATP, with ADP as a byproduct. The reaction is catalyzed by aspartate kinase. L-Aspartyl-4-phosphate reacts with NADPH to produce phosphate, L-aspartate-semialdehyde, and NADP+. Aspartate-semialdehyde dehydrogenase catalyzes this reaction.
L-Aspartyl-4-phosphate is involved in both the lysine biosynthesis I and homoserine biosynthesis pathways.
D018377 - Neurotransmitter Agents > D018846 - Excitatory Amino Acids

同义名列表

26 个代谢物同义名

(2S)-2-Amino-4-oxo-4-(phosphonooxy)butanoic acid; 2-amino-4-oxo-4-phosphonooxybutanoic acid; L-Aspart-4-yl phosphoric acid; L-Aspartyl-4-phosphoric acid; L-4-Aspartyl phosphoric acid; beta-L-Aspartyl phosphate; L-Aspartyl beta-phosphate; L-beta-Aspartyl-phosphate; 4-Phosphonato-L-aspartate; 4-Phospho-L-aspartic acid; L-Aspartyl-beta-phosphate; L-Aspart-4-yl phosphate; beta-Aspartyl phosphate; L-Β-aspartyl-phosphate; L-Aspartyl-β-phosphate; L-Aspartyl β-phosphate; L-Aspartyl-4-phosphate; L-4-Aspartyl phosphate; Β-L-aspartyl phosphate; 4-Phospho-L-aspartate; Β-aspartyl phosphate; Phosphoaspartic acid; Aspartyl phosphate; L-beta-Aspartyl-p; L-Aspartyl-4-p; L-Β-aspartyl-p



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

598 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(10)

WikiPathways(1)

Plant Reactome(574)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(13)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Gérald Larrouy-Maumus, Geoff Kelly, Luiz Pedro Sório de Carvalho. Chemical mechanism of glycerol 3-phosphate phosphatase: pH-dependent changes in the rate-limiting step. Biochemistry. 2014 Jan; 53(1):143-51. doi: 10.1021/bi400856y. [PMID: 24359335]
  • Patrice Catty, Sylvain Boutigny, Roger Miras, Jacques Joyard, Norbert Rolland, Daphné Seigneurin-Berny. Biochemical characterization of AtHMA6/PAA1, a chloroplast envelope Cu(I)-ATPase. The Journal of biological chemistry. 2011 Oct; 286(42):36188-97. doi: 10.1074/jbc.m111.241034. [PMID: 21878617]
  • Anna Zorina, Natalia Stepanchenko, Galina V Novikova, Maria Sinetova, Vladimir B Panichkin, Igor E Moshkov, Vladislav V Zinchenko, Sergey V Shestakov, Iwane Suzuki, Norio Murata, Dmitry A Los. Eukaryotic-like Ser/Thr protein kinases SpkC/F/K are involved in phosphorylation of GroES in the Cyanobacterium synechocystis. DNA research : an international journal for rapid publication of reports on genes and genomes. 2011 Jun; 18(3):137-51. doi: 10.1093/dnares/dsr006. [PMID: 21551175]
  • Stephane Paris, Peter M Wessel, Renaud Dumas. Overproduction, purification, and characterization of recombinant bifunctional threonine-sensitive aspartate kinase-homoserine dehydrogenase from Arabidopsis thaliana. Protein expression and purification. 2002 Feb; 24(1):105-10. doi: 10.1006/prep.2001.1539. [PMID: 11812230]
  • Stephane Paris, Peter M Wessel, Renaud Dumas. Overproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana. Protein expression and purification. 2002 Feb; 24(1):99-104. doi: 10.1006/prep.2001.1538. [PMID: 11812229]
  • J R Tuckerman, G Gonzalez, M A Gilles-Gonzalez. Complexation precedes phosphorylation for two-component regulatory system FixL/FixJ of Sinorhizobium meliloti. Journal of molecular biology. 2001 May; 308(3):449-55. doi: 10.1006/jmbi.2001.4591. [PMID: 11327779]
  • E E Strehler, D A Zacharias. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiological reviews. 2001 Jan; 81(1):21-50. doi: 10.1152/physrev.2001.81.1.21. [PMID: 11152753]
  • D Yan, H S Cho, C A Hastings, M M Igo, S Y Lee, J G Pelton, V Stewart, D E Wemmer, S Kustu. Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators. Proceedings of the National Academy of Sciences of the United States of America. 1999 Dec; 96(26):14789-94. doi: 10.1073/pnas.96.26.14789. [PMID: 10611291]
  • S A Anderson, S Jiang, A J Mukkada. The beta-aspartyl phosphate intermediate in a Leishmania donovani promastigote plasma membrane P-type ATPase. Biochimica et biophysica acta. 1994 Oct; 1195(1):81-8. doi: 10.1016/0005-2736(94)90012-4. [PMID: 7918569]
  • P L Jørgensen. Conformational changes in the alpha-subunit and cation transport by pure Na, K-ATPase. The Tokai journal of experimental and clinical medicine. 1982; 7 Suppl(?):51-60. doi: . [PMID: 6310826]
  • J B Dame, G A Scarborough. Identification of the phosphorylated intermediate of the Neurospora plasma membrane H+-ATPase as beta-aspartyl phosphate. The Journal of biological chemistry. 1981 Oct; 256(20):10724-30. doi: . [PMID: 6457042]