6-Methoxymellein (BioDeep_00000004911)

 

Secondary id: BioDeep_00001868774

human metabolite natural product


代谢物信息卡片


6-Methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin, (R)-(-)-isomer

化学式: C11H12O4 (208.0736)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 19.07%

分子结构信息

SMILES: c1c(cc2c(c1O)C(=O)O[C@@H](C2)C)OC
InChI: InChI=1S/C11H12O4/c1-6-3-7-4-8(14-2)5-9(12)10(7)11(13)15-6/h4-6,12H,3H2,1-2H3

描述信息

Isolated from Aspergillus caespitosus, Aspergillus variecolor and Sporormia bipartis. Reaches fungitoxic levels in stored infected carrot. Shows broad antimicrobial action. 6-Methoxymellein is found in wild carrot, root vegetables, and carrot.
6-Methoxymellein is found in carrot. 6-Methoxymellein is isolated from Aspergillus caespitosus, Aspergillus variecolor and Sporormia bipartis. Reaches fungitoxic levels in stored infected carrot. Shows broad antimicrobial action.

同义名列表

13 个代谢物同义名

6-Methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin, (R)-(-)-isomer; 3,4-dihydro-8-Hydroxy-6-methoxy-3-methyl-1H-2-benzopyran-1-one; 8-hydroxy-6-methoxy-3-methyl-3,4-dihydro-1H-2-benzopyran-1-one; 2,4-Dihydro-8-hydroxy-6-methoxy-3-methyl-1H-2-benzopyran-1-one; 3,4-Dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin; 3-Methyl-6-methoxy-8-hydroxy-3,4-dihydroisocoumarin; 6-Methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin; Antibiotic LL-N313a; 6-Mhmd-isocoumarin; 6-Methoxymellein; Isocoumarin; LL-N313a; 6-Methoxymellein



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

74 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 GTPBP4, MYC, PRKX
Peripheral membrane protein 3 AOC1, CYP27A1, GORASP1
Mitochondrion membrane 1 CYP27A1
Nucleus 3 GTPBP4, MYC, PRKX
cytosol 2 CD44, GTPBP4
nucleoplasm 3 GTPBP4, MYC, PRKX
Cell membrane 2 AOC1, CD44
Cytoplasmic side 1 GORASP1
Golgi apparatus membrane 1 GORASP1
cell surface 3 CD24, CD44, EPCAM
Golgi apparatus 2 CD44, GORASP1
Golgi membrane 1 GORASP1
mitochondrial inner membrane 1 CYP27A1
plasma membrane 3 AOC1, CD44, EPCAM
Membrane 4 CD24, CD44, GTPBP4, MYC
apical plasma membrane 2 CD44, EPCAM
basolateral plasma membrane 2 CD44, EPCAM
extracellular exosome 3 AOC1, CD44, EPCAM
extracellular space 5 AOC1, CXCL8, IL10, IL4, IL6
perinuclear region of cytoplasm 1 GTPBP4
Cell junction, tight junction 1 EPCAM
bicellular tight junction 2 AOC1, EPCAM
mitochondrion 1 CYP27A1
protein-containing complex 1 MYC
intracellular membrane-bounded organelle 1 CD24
Single-pass type I membrane protein 2 CD44, EPCAM
Secreted 5 CD44, CXCL8, IL10, IL4, IL6
extracellular region 6 AOC1, CD44, CXCL8, IL10, IL4, IL6
Single-pass membrane protein 1 CD44
mitochondrial matrix 1 CYP27A1
Extracellular side 1 AOC1
nuclear membrane 1 GTPBP4
external side of plasma membrane 1 CD24
nucleolus 2 GTPBP4, MYC
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 CD24
focal adhesion 1 CD44
cis-Golgi network 1 GORASP1
Peroxisome 1 AOC1
lateral plasma membrane 1 EPCAM
chromatin 1 MYC
cell projection 1 CD44
Secreted, extracellular space 1 AOC1
Nucleus, nucleolus 2 GTPBP4, MYC
nuclear envelope 1 MYC
microvillus 1 CD44
Cell projection, microvillus 1 CD44
Nucleus, nucleoplasm 1 MYC
secretory granule membrane 1 CD44
endoplasmic reticulum lumen 1 IL6
specific granule lumen 1 AOC1
RNA polymerase II transcription repressor complex 1 MYC
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Lateral cell membrane 1 EPCAM
Rough endoplasmic reticulum 1 MYC
lamellipodium membrane 1 CD44
Myc-Max complex 1 MYC
macrophage migration inhibitory factor receptor complex 1 CD44
interleukin-6 receptor complex 1 IL6
nucleoplasmic reticulum 1 MYC


文献列表

  • Alì Snene, Carmina Sirignano, Daniela Rigano, Carmen Formisano, Ridha El Mokni, Giuseppe Ercolano, Hatem Dhaouadi, Angela Ianaro, Saoussen Hammami, Orazio Taglialatela-Scafati. Antiproliferative metabolites from the Northern African endemic plant Daucus virgatus (Apiaceae). Phytochemistry. 2017 Nov; 143(?):194-198. doi: 10.1016/j.phytochem.2017.08.010. [PMID: 28843162]
  • Randi Seljåsen, Gjermund Vogt, Elisabeth Olsen, Per Lea, Lars Arne Høgetveit, Torgeir Tajet, Richard Meadow, Gunnar B Bengtsson. Influence of field attack by carrot psyllid (Trioza apicalis Förster) on sensory quality, antioxidant capacity and content of terpenes, falcarindiol and 6-methoxymellein of carrots (Daucus carota L.). Journal of agricultural and food chemistry. 2013 Mar; 61(11):2831-8. doi: 10.1021/jf303979y. [PMID: 23414489]
  • Sébastien Louarn, Arkadiusz Nawrocki, Merete Edelenbos, Dan F Jensen, Ole N Jensen, David B Collinge, Birgit Jensen. The influence of the fungal pathogen Mycocentrospora acerina on the proteome and polyacetylenes and 6-methoxymellein in organic and conventionally cultivated carrots (Daucus carota) during post harvest storage. Journal of proteomics. 2012 Jan; 75(3):962-77. doi: 10.1016/j.jprot.2011.10.014. [PMID: 22075166]
  • Ludger Schmiech, Daisuke Uemura, Thomas Hofmann. Reinvestigation of the bitter compounds in carrots (Daucus carota L.) by using a molecular sensory science approach. Journal of agricultural and food chemistry. 2008 Nov; 56(21):10252-60. doi: 10.1021/jf8023358. [PMID: 18922011]
  • Andreas Czepa, Thomas Hofmann. Quantitative studies and sensory analyses on the influence of cultivar, spatial tissue distribution, and industrial processing on the bitter off-taste of carrots (Daucus carota l.) and carrot products. Journal of agricultural and food chemistry. 2004 Jul; 52(14):4508-14. doi: 10.1021/jf0496393. [PMID: 15237959]
  • D Engelmeier, F Hadacek, O Hofer, G Lutz-Kutschera, M Nagl, G Wurz, H Greger. Antifungal 3-butylisocoumarins from Asteraceae-Anthemideae. Journal of natural products. 2004 Jan; 67(1):19-25. doi: 10.1021/np0301339. [PMID: 14738379]
  • Andreas Czepa, Thomas Hofmann. Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree. Journal of agricultural and food chemistry. 2003 Jun; 51(13):3865-73. doi: 10.1021/jf034085+. [PMID: 12797757]
  • F Kurosaki, A Nishi. Stimulation of calcium influx and calcium cascade by cyclic AMP in cultured carrot cells. Archives of biochemistry and biophysics. 1993 Apr; 302(1):144-51. doi: 10.1006/abbi.1993.1192. [PMID: 8385897]