Coenzyme Q9 (BioDeep_00000004809)

 

Secondary id: BioDeep_00000639385, BioDeep_00000872491

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]cyclohexa-2,5-diene-1,4-dione

化学式: C54H82O4 (794.6212772)
中文名称: 辅酶Q9
谱图信息: 最多检出来源 Homo sapiens(blood) 0.36%

分子结构信息

SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC1=C(C)C(=O)C(=C(C1=O)OC)OC)/C)/C)/C)/C)/C)/C)/C)/C)C
InChI: InChI=1S/C54H82O4/c1-40(2)22-14-23-41(3)24-15-25-42(4)26-16-27-43(5)28-17-29-44(6)30-18-31-45(7)32-19-33-46(8)34-20-35-47(9)36-21-37-48(10)38-39-50-49(11)51(55)53(57-12)54(58-13)52(50)56/h22,24,26,28,30,32,34,36,38H,14-21,23,25,27,29,31,33,35,37,39H2,1-13H3/b41-24+,42-26+,43-28+,44-30+,45-32+,46-34+,47-36+,48-38+

描述信息

Coenzyme Q9 (CoQ9) is a normal constituent of human plasma. CoQ9 in human plasma may originate as a product of incomplete CoQ10 biosynthesis or from the diet. The estimated dietary CoQ9 intake is 0 to 1.3 umol/day, primarily from cereals and fats, but this is unreliable because many food items contain levels below the detection limit. Plasma CoQ9 increases after supplementation with CoQ10, and CoQ9 and CoQ10 are significantly correlated. (PMID: 17405953).
D020011 - Protective Agents > D000975 - Antioxidants
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2].
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2].

同义名列表

21 个代谢物同义名

2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]cyclohexa-2,5-diene-1,4-dione; 2,3-dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaenyl]cyclohexa-2,5-diene-1,4-dione; 2,3-Dimethoxy-5-methyl-6-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]-1,4-benzoquinone; (all-e)-2,3-Dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-2,5-cyclohexadiene-1,4-dione; 2-Methyl-3-nonaprenyl-5,6-dimethoxy-1,4-benzoquinone; Ubiquinone 9, (Z,Z,Z,Z,Z,e,e,e)-isomer; Ubiquinone Q9;CoQ9;Ubiquinone 9; Coenzyme Q9 from Candida utilis; Ubiquinone Q(sub 9); Coenzyme Q(sub 9); Ubiquinone Q-9; Coenzyme Q(9); Ubiquinone-45; Ubiquinone 45; Ubiquinone Q9; ubiquinone-9; Ubiquinone 9; Coenzyme Q9; CoQ(sub 9); CoQ9; Ubiquinone-9



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mateusz Manicki, Halil Aydin, Luciano A Abriata, Katherine A Overmyer, Rachel M Guerra, Joshua J Coon, Matteo Dal Peraro, Adam Frost, David J Pagliarini. Structure and functionality of a multimeric human COQ7:COQ9 complex. Molecular cell. 2022 11; 82(22):4307-4323.e10. doi: 10.1016/j.molcel.2022.10.003. [PMID: 36306796]
  • J Kucharská, S Poništ, O Vančová, A Gvozdjáková, O Uličná, L Slovák, M Taghdisiesfejir, K Bauerová. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiological research. 2021 11; 70(5):723-733. doi: 10.33549/physiolres.934664. [PMID: 34505525]
  • Yong Li, Shengkun Wang, Danran Bian, Shang Sun, Tengfei Ma. Pseudomonas quercus sp. nov, associated with leaf spot disease of Quercus mongolica. International journal of systematic and evolutionary microbiology. 2021 May; 71(5):. doi: 10.1099/ijsem.0.004800. [PMID: 33999789]
  • Peter Kämpfer, S P Glaeser, John A McInroy, Dominique Clermont, Alexis Criscuolo, Hans-Jürgen Busse. Pseudomonas carbonaria sp. nov., isolated from charcoal. International journal of systematic and evolutionary microbiology. 2021 Apr; 71(4):. doi: 10.1099/ijsem.0.004750. [PMID: 33835910]
  • Wentao Zhu, Kui Dong, Jing Yang, Shan Lu, Xin-He Lai, Ji Pu, Dong Jin, Yuyuan Huang, Sihui Zhang, Juan Zhou, Ying Huang, Jianguo Xu. Acinetobacter lanii sp. nov., Acinetobacter shaoyimingii sp. nov. and Acinetobacter wanghuae sp. nov., isolated from faeces of Equus kiang. International journal of systematic and evolutionary microbiology. 2021 Jan; 71(1):. doi: 10.1099/ijsem.0.004567. [PMID: 33196408]
  • Mohaddaseh Ramezani, Mohammad Pourmohyadini, Mahdi Moshtaghi Nikou, Somaye Makzum, Peter Schumann, Dominique Clermont, Alexis Criscuolo, Mohammad Ali Amoozegar, Peter Kämpfer, Cathrin Spröer. Halomonas lysinitropha sp. nov., a novel halophilic bacterium isolated from a hypersaline wetland. International journal of systematic and evolutionary microbiology. 2020 Dec; 70(12):6098-6105. doi: 10.1099/ijsem.0.004504. [PMID: 33052803]
  • Shunsuke Nashimoto, Yuto Takekawa, Yoh Takekuma, Mitsuru Sugawara, Yuki Sato. Transport via Niemann-Pick C1 Like 1 contributes to the intestinal absorption of ubiquinone. Drug metabolism and pharmacokinetics. 2020 Dec; 35(6):527-533. doi: 10.1016/j.dmpk.2020.08.002. [PMID: 33036883]
  • Phiwayinkosi V Dludla, Sonia Silvestri, Patrick Orlando, Sithandiwe E Mazibuko-Mbeje, Rabia Johnson, Fabio Marcheggiani, Ilenia Cirilli, Christo J F Muller, Johan Louw, Nireshni Chellan, Nnini Obonye, Bongani B Nkambule, Luca Tiano. Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Oct; 68(?):104948. doi: 10.1016/j.tiv.2020.104948. [PMID: 32683093]
  • Jiayuan Jia, Xiaoqiang Wang, Peng Deng, Lin Ma, Sonya M Baird, Xiangdong Li, Shi-En Lu. Pseudomonas glycinae sp. nov. isolated from the soybean rhizosphere. MicrobiologyOpen. 2020 09; 9(9):e1101. doi: 10.1002/mbo3.1101. [PMID: 32657018]
  • Hui Zhao, Yinan Ma, Xiaogang Wu, Liqun Zhang. Pseudomonas viciae sp. nov., isolated from rhizosphere of broad bean. International journal of systematic and evolutionary microbiology. 2020 Sep; 70(9):5012-5018. doi: 10.1099/ijsem.0.004373. [PMID: 32776868]
  • Shehzad Abid Khan, Sepideh Zununi Vahed, Haleh Forouhandeh, Vahideh Tarhriz, Nader Chaparzadeh, Mohammad Amin Hejazi, Che Ok Jeon, Mohammad Saeid Hejazi. Halomonas urmiana sp. nov., a moderately halophilic bacterium isolated from Urmia Lake in Iran. International journal of systematic and evolutionary microbiology. 2020 Apr; 70(4):2254-2260. doi: 10.1099/ijsem.0.004005. [PMID: 32039745]
  • Jing Li, Lin-Hui Wang, Fan-Gqin Xiang, Wen-Long Ding, Li-Jun Xi, Ming-Qing Wang, Zi-Jun Xiao, Jian-Guo Liu. Pseudomonas phragmitis sp. nov., isolated from petroleum polluted river sediment. International journal of systematic and evolutionary microbiology. 2020 Jan; 70(1):364-372. doi: 10.1099/ijsem.0.003763. [PMID: 31661054]
  • Woo Taek Oh, Jin Woo Jun, Sib Sankar Giri, Saekil Yun, Hyoun Joong Kim, Sang Guen Kim, Sang Wha Kim, Jeong Woo Kang, Se Jin Han, Jun Kwon, Ji Hyung Kim, Theo H M Smits, Se Chang Park. Pseudomonas tructae sp. nov., novel species isolated from rainbow trout kidney. International journal of systematic and evolutionary microbiology. 2019 Dec; 69(12):3851-3856. doi: 10.1099/ijsem.0.003696. [PMID: 31483752]
  • Panjaporn Anurat, Kannika Duangmal, Nantana Srisuk. Pseudomonas mangiferae sp. nov., isolated from bark of mango tree in Thailand. International journal of systematic and evolutionary microbiology. 2019 Nov; 69(11):3537-3543. doi: 10.1099/ijsem.0.003657. [PMID: 31429815]
  • Lihui Liu, Tao Yuan, Qianli An, Meiyan Yang, Xiaoyun Mao, Cehui Mo, Zhiyuan Tan, Guixiang Peng. Azotobacter bryophylli sp. nov., isolated from the succulent plant Bryophyllum pinnatum. International journal of systematic and evolutionary microbiology. 2019 Jul; 69(7):1986-1992. doi: 10.1099/ijsem.0.003412. [PMID: 31046894]
  • Kelly Subramanian, Adam Jochem, Maxence Le Vasseur, Samantha Lewis, Brett R Paulson, Thiruchelvi R Reddy, Jason D Russell, Joshua J Coon, David J Pagliarini, Jodi Nunnari. Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts. The Journal of cell biology. 2019 04; 218(4):1353-1369. doi: 10.1083/jcb.201808044. [PMID: 30674579]
  • Hironaga Akita, Zen-Ichiro Kimura, Tamotsu Hoshino. Pseudomonas humi sp. nov., isolated from leaf soil. Archives of microbiology. 2019 Mar; 201(2):245-251. doi: 10.1007/s00203-018-1588-x. [PMID: 30478729]
  • J Christopher Ellis, Michelle Suhan Thomas, Paul A Lawson, Nisha B Patel, Whitney Faircloth, Stephen E Hayes, Emily E Linton, Diana M Norden, Irina S Severenchuk, Caitlin H West, James W Brown, Rebecca G Plante, Craig J Plante. Kistimonas alittae sp. nov., a gammaproteobacterium isolated from the marine annelid Alitta succinea. International journal of systematic and evolutionary microbiology. 2019 Jan; 69(1):235-240. doi: 10.1099/ijsem.0.003137. [PMID: 30484761]
  • Cátia Fidalgo, Diogo Neves Proença, Paula V Morais, Isabel Henriques, Artur Alves. The endosphere of the salt marsh plant Halimione portulacoides is a diversity hotspot for the genus Salinicola: description of five novel species Salinicola halimionae sp. nov., Salinicola aestuarinus sp. nov., Salinicola endophyticus sp. nov., Salinicola halophyticus sp. nov. and Salinicola lusitanus sp. nov. International journal of systematic and evolutionary microbiology. 2019 Jan; 69(1):46-62. doi: 10.1099/ijsem.0.003061. [PMID: 30418109]
  • Ming Xue, Chong-Qing Wen, Lan Liu, Bao-Zhu Fang, Nimaichand Salam, Xue-Min Huang, Yang-Feng Liu, Min Xiao, Wen-Jun Li. Halomonas litopenaei sp. nov., a moderately halophilic, exopolysaccharide-producing bacterium isolated from a shrimp hatchery. International journal of systematic and evolutionary microbiology. 2018 Dec; 68(12):3914-3921. doi: 10.1099/ijsem.0.003090. [PMID: 30372409]
  • Salvadora Navarro-Torre, Lorena Carro, Ignacio D Rodríguez-Llorente, Eloísa Pajuelo, Miguel Ángel Caviedes, José Mariano Igual, Susana Redondo-Gómez, Maria Camacho, Hans-Peter Klenk, Maria Del Carmen Montero-Calasanz. Kushneria phyllosphaerae sp. nov. and Kushneria endophytica sp. nov., plant growth promoting endophytes isolated from the halophyte plant Arthrocnemum macrostachyum. International journal of systematic and evolutionary microbiology. 2018 Sep; 68(9):2800-2806. doi: 10.1099/ijsem.0.002897. [PMID: 30010522]
  • Peter Kämpfer, P D Rekha, Hans-Jürgen Busse, A B Arun, P Priyanka, Stefanie P Glaeser. Halomonas malpeensis sp. nov., isolated from rhizosphere sand of a coastal sand dune plant. International journal of systematic and evolutionary microbiology. 2018 Apr; 68(4):1037-1046. doi: 10.1099/ijsem.0.002616. [PMID: 29458496]
  • Heyon-Woo Koh, Sundas Rani, So-Jeong Kim, Eunyoung Moon, Seung Won Nam, Sung-Keun Rhee, Soo-Je Park. Halomonas aestuarii sp. nov., a moderately halophilic bacterium isolated from a tidal flat. International journal of systematic and evolutionary microbiology. 2017 Nov; 67(11):4298-4303. doi: 10.1099/ijsem.0.001824. [PMID: 28126041]
  • Nusratgul Anwar, Manziram Rozahon, Bolatkhan Zayadan, Hormathan Mamtimin, Mehfuzem Abdurahman, Marygul Kurban, Mihribangul Abdurusul, Tursunay Mamtimin, Muhtar Abdukerim, Erkin Rahman. Pseudomonas tarimensis sp. nov., an endophytic bacteria isolated from Populus euphratica. International journal of systematic and evolutionary microbiology. 2017 Nov; 67(11):4372-4378. doi: 10.1099/ijsem.0.002295. [PMID: 28984556]
  • David Frasson, Michael Opoku, Tara Picozzi, Tanja Torossi, Stefanie Balada, Theo H M Smits, Urs Hilber. Pseudomonas wadenswilerensis sp. nov. and Pseudomonas reidholzensis sp. nov., two novel species within the Pseudomonas putida group isolated from forest soil. International journal of systematic and evolutionary microbiology. 2017 Aug; 67(8):2853-2861. doi: 10.1099/ijsem.0.002035. [PMID: 28820109]
  • Jerome Morel, Iain Hargreaves, David Brealey, Viruna Neergheen, Janne T Backman, Sandro Lindig, Marcus Bläss, Michael Bauer, Daniel F McAuley, Mervyn Singer. Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clinical science (London, England : 1979). 2017 Apr; 131(8):747-758. doi: 10.1042/cs20160802. [PMID: 28202686]
  • Wen Liu, Guojing Zhang, Wendong Xian, Jian Yang, Lingling Yang, Min Xiao, Hongchen Jiang, Wen-Jun Li. Halomonas xiaochaidanensis sp. nov., isolated from a salt lake sediment. Archives of microbiology. 2016 Oct; 198(8):761-6. doi: 10.1007/s00203-016-1235-3. [PMID: 27177899]
  • Adam M Drobish, Brian D Emery, Anne M Whitney, Ana C Lauer, Maureen G Metcalfe, John R McQuiston. Oblitimonas alkaliphila gen. nov., sp. nov., in the family Pseudomonadaceae, recovered from a historical collection of previously unidentified clinical strains. International journal of systematic and evolutionary microbiology. 2016 Aug; 66(8):3063-3070. doi: 10.1099/ijsem.0.001147. [PMID: 27169721]
  • Juan Du, Hina Singh, Hongshan Yu, Feng-Xie Jin, Tae-Hoo Yi. Acinetobacter plantarum sp. nov. isolated from wheat seedlings plant. Archives of microbiology. 2016 Jul; 198(5):393-8. doi: 10.1007/s00203-016-1199-3. [PMID: 26869166]
  • E V V Ramaprasad, Dave Bharti, Ch Sasikala, Ch V Ramana. Zooshikella marina sp. nov. a cycloprodigiosin- and prodigiosin-producing marine bacterium isolated from beach sand. International journal of systematic and evolutionary microbiology. 2015 Dec; 65(12):4669-4673. doi: 10.1099/ijsem.0.000630. [PMID: 26409875]
  • Radka Tušková, Boris Lipták, Pavol Szomolányi, Oľga Vančová, Oľga Uličná, Zuzana Sumbalová, Jarmila Kucharská, Michal Dubovický, Siegfried Trattnig, Tibor Liptaj, Svatava Kašparová. Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study. Behavioural brain research. 2015 May; 284(?):257-64. doi: 10.1016/j.bbr.2015.02.016. [PMID: 25698600]
  • Lei Zhang, Yuanyuan Pan, Kaibiao Wang, Xiaoxia Zhang, Cheng Zhang, Shuang Zhang, Xiaowei Fu, Juquan Jiang. Pseudomonas zhaodongensis sp. nov., isolated from saline and alkaline soils. International journal of systematic and evolutionary microbiology. 2015 Mar; 65(Pt 3):1022-1030. doi: 10.1099/ijs.0.000057. [PMID: 25574037]
  • Víctor Gonzalo Arnau, Leandro Arturo Sánchez, Osvaldo Daniel Delgado. Pseudomonas yamanorum sp. nov., a psychrotolerant bacterium isolated from a subantarctic environment. International journal of systematic and evolutionary microbiology. 2015 Feb; 65(Pt 2):424-431. doi: 10.1099/ijs.0.065201-0. [PMID: 25385990]
  • Yoshiji Ohta, Koji Yashiro, Koji Ohashi, Yosuke Horikoshi, Chiaki Kusumoto, Tatsuya Matsura, Kenji Fukuzawa. Effect of Dietary Vitamin E Supplementation on Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress. Journal of nutritional science and vitaminology. 2015; 61(2):113-22. doi: 10.3177/jnsv.61.113. [PMID: 26052141]
  • Sung-Hyun Yang, Hyun-Seok Seo, Jung-Hyun Lee, Sang-Jin Kim, Kae Kyoung Kwon. Kiloniella spongiae sp. nov., isolated from a marine sponge and emended description of the genus Kiloniella Wiese et al. 2009 and Kiloniella laminariae. International journal of systematic and evolutionary microbiology. 2015 Jan; 65(Pt 1):230-234. doi: 10.1099/ijs.0.069773-0. [PMID: 25326444]
  • Mohammad Ali Amoozegar, Azadeh Shahinpei, Abbas Akhavan Sepahy, Ali Makhdoumi-Kakhki, Shima Sadat Seyedmahdi, Peter Schumann, Antonio Ventosa. Pseudomonas salegens sp. nov., a halophilic member of the genus Pseudomonas isolated from a wetland. International journal of systematic and evolutionary microbiology. 2014 Oct; 64(Pt 10):3565-3570. doi: 10.1099/ijs.0.062935-0. [PMID: 25062699]
  • Asif Hameed, Mariyam Shahina, Shih-Yao Lin, You-Cheng Liu, Chiu-Chung Young. Pseudomonas hussainii sp. nov., isolated from droppings of a seashore bird, and emended descriptions of Pseudomonas pohangensis, Pseudomonas benzenivorans and Pseudomonas segetis. International journal of systematic and evolutionary microbiology. 2014 Jul; 64(Pt 7):2330-2337. doi: 10.1099/ijs.0.060319-0. [PMID: 24744016]
  • Dong-Wook Hyun, Na-Ri Shin, Min-Soo Kim, Sei Joon Oh, Pil Soo Kim, Tae Woong Whon, Jin-Woo Bae. Endozoicomonas atrinae sp. nov., isolated from the intestine of a comb pen shell Atrina pectinata. International journal of systematic and evolutionary microbiology. 2014 Jul; 64(Pt 7):2312-2318. doi: 10.1099/ijs.0.060780-0. [PMID: 24733175]
  • Lin Xu, Xue-Wei Xu, Fan-Xu Meng, Ying-Yi Huo, Aharon Oren, Jun-Yi Yang, Chun-Sheng Wang. Halomonas zincidurans sp. nov., a heavy-metal-tolerant bacterium isolated from the deep-sea environment. International journal of systematic and evolutionary microbiology. 2013 Nov; 63(Pt 11):4230-4236. doi: 10.1099/ijs.0.051656-0. [PMID: 23811134]
  • Irina G Stavrovskaya, Susan S Bird, Vasant R Marur, Matthew J Sniatynski, Sergei V Baranov, Heather K Greenberg, Caryn L Porter, Bruce S Kristal. Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins. Journal of lipid research. 2013 Oct; 54(10):2623-35. doi: 10.1194/jlr.m036285. [PMID: 23690505]
  • Mariona Jové, Victòria Ayala, Omar Ramírez-Núñez, Alba Naudí, Rosanna Cabré, Corinne M Spickett, Manuel Portero-Otín, Reinald Pamplona. Specific lipidome signatures in central nervous system from methionine-restricted mice. Journal of proteome research. 2013 Jun; 12(6):2679-89. doi: 10.1021/pr400064a. [PMID: 23590626]
  • M Madhaiyan, C J Hu, J Jegan Roy, S-J Kim, H-Y Weon, S-W Kwon, L Ji. Aureimonas jatrophae sp. nov. and Aureimonas phyllosphaerae sp. nov., leaf-associated bacteria isolated from Jatropha curcas L. International journal of systematic and evolutionary microbiology. 2013 May; 63(Pt 5):1702-1708. doi: 10.1099/ijs.0.041020-0. [PMID: 22922534]
  • Catarina M Quinzii, Caterina Garone, Valentina Emmanuele, Saba Tadesse, Sindu Krishna, Beatriz Dorado, Michio Hirano. Tissue-specific oxidative stress and loss of mitochondria in CoQ-deficient Pdss2 mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Feb; 27(2):612-21. doi: 10.1096/fj.12-209361. [PMID: 23150520]
  • Yoshiji Ohta, Koji Yashiro, Koji Ohashi, Yoichiro Imai, Chiaki Kusumoto, Tatsuya Matsura, Mayumi Hidaka, Kenji Fukuzawa. Vitamin E depletion enhances liver oxidative damage in rats with water-immersion restraint stress. Journal of nutritional science and vitaminology. 2013; 59(2):79-86. doi: 10.3177/jnsv.59.79. [PMID: 23727636]
  • Jaya Malhotra, Shailly Anand, Swati Jindal, Raman Rajagopal, Rup Lal. Acinetobacter indicus sp. nov., isolated from a hexachlorocyclohexane dump site. International journal of systematic and evolutionary microbiology. 2012 Dec; 62(Pt 12):2883-2890. doi: 10.1099/ijs.0.037721-0. [PMID: 22247213]
  • Fernando Gomez, Ryoichi Saiki, Randall Chin, Chandra Srinivasan, Catherine F Clarke. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation. Gene. 2012 Sep; 506(1):106-16. doi: 10.1016/j.gene.2012.06.023. [PMID: 22735617]
  • Qi-Ming Wang, Teun Boekhout, Feng-Yan Bai. Bensingtonia rectispora sp. nov. and Bensingtonia bomiensis sp. nov., ballistoconidium-forming yeast species from Tibetan plant leaves. International journal of systematic and evolutionary microbiology. 2012 Aug; 62(Pt 8):2039-2044. doi: 10.1099/ijs.0.038117-0. [PMID: 22081720]
  • Anne-Lise Ducluzeau, Yashitola Wamboldt, Christian G Elowsky, Sally A Mackenzie, Robert C Schuurink, Gilles J C Basset. Gene network reconstruction identifies the authentic trans-prenyl diphosphate synthase that makes the solanesyl moiety of ubiquinone-9 in Arabidopsis. The Plant journal : for cell and molecular biology. 2012 Jan; 69(2):366-75. doi: 10.1111/j.1365-313x.2011.04796.x. [PMID: 21950843]
  • Elena Bravo, Simonetta Palleschi, Barbara Rossi, Mariarosaria Napolitano, Luca Tiano, Emanuela D'Amore, Kathleen M Botham. Coenzyme Q metabolism is disturbed in high fat diet-induced non-alcoholic fatty liver disease in rats. International journal of molecular sciences. 2012; 13(2):1644-57. doi: 10.3390/ijms13021644. [PMID: 22408414]
  • Kouichirou Nishi, Akira Takasu, Minori Shibata, Shinya Uchino, Yorihiro Yamamoto, Toshihisa Sakamoto. Hypothermia reduces resuscitation fluid volumes required to maintain blood pressure in a rat hemorrhagic shock model. The journal of trauma and acute care surgery. 2012 Jan; 72(1):130-5. doi: 10.1097/ta.0b013e31821e61d8. [PMID: 21768895]
  • Si Houn Hahn, Sandra Kerfoot, Valeria Vasta. Assay to measure oxidized and reduced forms of CoQ by LC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2012; 837(?):169-79. doi: 10.1007/978-1-61779-504-6_11. [PMID: 22215547]
  • Carmen Venegas, Carmen Cabrera-Vique, Laura García-Corzo, Germaine Escames, Darío Acuña-Castroviejo, Luis Carlos López. Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. Journal of agricultural and food chemistry. 2011 Nov; 59(22):12102-8. doi: 10.1021/jf203428t. [PMID: 22007968]
  • Jacopo Martinis, Felix Kessler, Gaetan Glauser. A novel method for prenylquinone profiling in plant tissues by ultra-high pressure liquid chromatography-mass spectrometry. Plant methods. 2011 Jul; 7(1):23. doi: 10.1186/1746-4811-7-23. [PMID: 21777468]
  • Alexandra Fischer, Constance Schmelzer, Gerald Rimbach, Petra Niklowitz, Thomas Menke, Frank Döring. Association between genetic variants in the Coenzyme Q10 metabolism and Coenzyme Q10 status in humans. BMC research notes. 2011 Jul; 4(?):245. doi: 10.1186/1756-0500-4-245. [PMID: 21774831]
  • Cristina Parrado-Fernández, Guillermo López-Lluch, Elisabet Rodríguez-Bies, Sara Santa-Cruz, Plácido Navas, Jon J Ramsey, José M Villalba. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues. Free radical biology & medicine. 2011 Jun; 50(12):1728-36. doi: 10.1016/j.freeradbiomed.2011.03.024. [PMID: 21447381]
  • Rohit Kohli, Michelle Kirby, Stavra A Xanthakos, Samir Softic, Ariel E Feldstein, Vijay Saxena, Peter H Tang, Lili Miles, Michael V Miles, William F Balistreri, Stephen C Woods, Randy J Seeley. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 2010 Sep; 52(3):934-44. doi: 10.1002/hep.23797. [PMID: 20607689]
  • Kazuaki Ohara, Kanako Sasaki, Kazufumi Yazaki. Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. Journal of experimental botany. 2010 Jun; 61(10):2683-92. doi: 10.1093/jxb/erq103. [PMID: 20421194]
  • Lidiya Bebrevska, Kenne Foubert, Nina Hermans, Shyama Chatterjee, Eric Van Marck, Guido De Meyer, Arnold Vlietinck, Luc Pieters, Sandra Apers. In vivo antioxidative activity of a quantified Pueraria lobata root extract. Journal of ethnopharmacology. 2010 Jan; 127(1):112-7. doi: 10.1016/j.jep.2009.09.039. [PMID: 19799984]
  • Yasukazu Yoshida, Nanako Itoh, Mieko Hayakawa, Yoko Habuchi, Yoshiro Saito, Yoshitane Tsukamoto, Osamu Cynshi, Kou-ichi Jishage, Hiroyuki Arai, Etsuo Niki. The role of alpha-tocopherol in motor hypofunction with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers. The Journal of nutritional biochemistry. 2010 Jan; 21(1):66-76. doi: 10.1016/j.jnutbio.2008.10.006. [PMID: 19157826]
  • Katarina Bauerova, Ema Paulovicova, Danica Mihalova, Frantisek Drafi, Miriam Strosova, Cinzia Mascia, Fiorella Biasi, Jozef Rovensky, Jarmila Kucharska, Anna Gvozdjakova, Silvester Ponist. Combined methotrexate and coenzyme Q₁₀ therapy in adjuvant-induced arthritis evaluated using parameters of inflammation and oxidative stress. Acta biochimica Polonica. 2010; 57(3):347-54. doi: 10.18388/abp.2010_2415. [PMID: 20827446]
  • Ainara Cano, Fiorella Ciaffoni, Ghada M Safwat, Patricia Aspichueta, Begoña Ochoa, Elena Bravo, Kathleen M Botham. Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q?. Journal of applied physiology (Bethesda, Md. : 1985). 2009 Sep; 107(3):707-17. doi: 10.1152/japplphysiol.00297.2009. [PMID: 19608932]
  • Ryoichi Saiki, Adam L Lunceford, Yuchen Shi, Beth Marbois, Rhonda King, Justin Pachuski, Makoto Kawamukai, David L Gasser, Catherine F Clarke. Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. American journal of physiology. Renal physiology. 2008 Nov; 295(5):F1535-44. doi: 10.1152/ajprenal.90445.2008. [PMID: 18784258]
  • Rafael Rodríguez-Acuña, Evelyne Brenne, Florence Lacoste. Determination of coenzyme Q10 and Q9 in vegetable oils. Journal of agricultural and food chemistry. 2008 Aug; 56(15):6241-5. doi: 10.1021/jf800103e. [PMID: 18616270]
  • Mei Zhang, Jun Luo, Yuki Ogiyama, Ryoichi Saiki, Makoto Kawamukai. Heteromer formation of a long-chain prenyl diphosphate synthase from fission yeast Dps1 and budding yeast Coq1. The FEBS journal. 2008 Jul; 275(14):3653-68. doi: 10.1111/j.1742-4658.2008.06510.x. [PMID: 18540885]
  • Michael A Kiebish, Xianlin Han, Hua Cheng, Adam Lunceford, Catherine F Clarke, Hwi Moon, Jeffrey H Chuang, Thomas N Seyfried. Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. Journal of neurochemistry. 2008 Jul; 106(1):299-312. doi: 10.1111/j.1471-4159.2008.05383.x. [PMID: 18373617]
  • Patrick M Hutchins, Robert M Barkley, Robert C Murphy. Separation of cellular nonpolar neutral lipids by normal-phase chromatography and analysis by electrospray ionization mass spectrometry. Journal of lipid research. 2008 Apr; 49(4):804-13. doi: 10.1194/jlr.m700521-jlr200. [PMID: 18223242]
  • Matthew Cooke, Mike Iosia, Thomas Buford, Brian Shelmadine, Geoffrey Hudson, Chad Kerksick, Christopher Rasmussen, Mike Greenwood, Brian Leutholtz, Darryn Willoughby, Richard Kreider. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the International Society of Sports Nutrition. 2008 Mar; 5(?):8. doi: 10.1186/1550-2783-5-8. [PMID: 18318910]
  • Shibendu Biswas, Rabiul Haque, Nihar R Bhuyan, Tanmoy Bera. Participation of chlorobiumquinone in the transplasma membrane electron transport system of Leishmania donovani promastigote: effect of near-ultraviolet light on the redox reaction of plasma membrane. Biochimica et biophysica acta. 2008 Feb; 1780(2):116-27. doi: 10.1016/j.bbagen.2007.09.006. [PMID: 17976919]
  • Lie Li, Deepthi Pabbisetty, Paulo Carvalho, Mitchell A Avery, Bonnie A Avery. Analysis of CoQ10 in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. Journal of pharmaceutical and biomedical analysis. 2008 Jan; 46(1):137-42. doi: 10.1016/j.jpba.2007.10.019. [PMID: 18054195]
  • Ian N Acworth, Paul A Ullucci, Paul H Gamache. Determination of oxidized and reduced CoQ10 and CoQ9 in human plasma/serum using HPLC-ECD. Methods in molecular biology (Clifton, N.J.). 2008; 477(?):245-58. doi: 10.1007/978-1-60327-517-0_19. [PMID: 19082952]
  • Isuke Imada, Eisuke F Sato, Yukimi Kira, Masayasu Inoue. Effect of CoQ homologues on reactive oxygen generation by mitochondria. BioFactors (Oxford, England). 2008; 32(1-4):41-8. doi: 10.1002/biof.5520320106. [PMID: 19096099]
  • Piran Shelley, Jane Tarry-Adkins, Malgorzata Martin-Gronert, Lucilla Poston, Simon Heales, John Clark, Susan Ozanne, Josie McConnell. Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death. Mechanisms of ageing and development. 2007 Nov; 128(11-12):681-7. doi: 10.1016/j.mad.2007.10.002. [PMID: 18035399]
  • Mónica Santos-González, Consuelo Gómez Díaz, Plácido Navas, José Manuel Villalba. Modifications of plasma proteome in long-lived rats fed on a coenzyme Q10-supplemented diet. Experimental gerontology. 2007 Aug; 42(8):798-806. doi: 10.1016/j.exger.2007.04.013. [PMID: 17587521]
  • Edward J Hsieh, Peter Gin, Melissa Gulmezian, UyenPhuong C Tran, Ryoichi Saiki, Beth N Marbois, Catherine F Clarke. Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Archives of biochemistry and biophysics. 2007 Jul; 463(1):19-26. doi: 10.1016/j.abb.2007.02.016. [PMID: 17391640]
  • Sergio F Martin, Isabel Burón, Juan C Espinosa, Joaquín Castilla, José M Villalba, Juan M Torres. Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model. Free radical biology & medicine. 2007 Jun; 42(11):1723-9. doi: 10.1016/j.freeradbiomed.2007.03.005. [PMID: 17462540]
  • L L Gudkov, K B Shumaev, E I Kalenikova, S A Gubkina, A F Vanin, E K Ruuge. [Antioxidant and prooxidant action of nitric oxide donors and metabolites]. Biofizika. 2007 May; 52(3):503-9. doi: . [PMID: 17633540]
  • Sarah Molyneux, Michael Lever, Christopher Florkowski, Peter George. Plasma total coenzyme Q9 (CoQ9) in the New Zealand population: reference interval and biological variation. Clinical chemistry. 2007 Apr; 53(4):802-3. doi: 10.1373/clinchem.2006.083568. [PMID: 17405953]
  • Nina Hermans, Paul Cos, Guido R Y De Meyer, Louis Maes, Luc Pieters, Dirk Vanden Berghe, Arnold J Vlietinck, Tess De Bruyne. Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidants. The Journal of pharmacy and pharmacology. 2007 Jan; 59(1):131-6. doi: 10.1211/jpp.59.1.0017. [PMID: 17227630]
  • Yasukazu Yoshida, Mieko Hayakawa, Yoko Habuchi, Etsuo Niki. Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio. Biochimica et biophysica acta. 2006 Oct; 1760(10):1558-68. doi: 10.1016/j.bbagen.2006.06.007. [PMID: 16908102]
  • Karen M Smith, Samantha Matson, Wayne R Matson, Kerry Cormier, Steven J Del Signore, Sean W Hagerty, Edward C Stack, Hoon Ryu, Robert J Ferrante. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochimica et biophysica acta. 2006 Jun; 1762(6):616-26. doi: 10.1016/j.bbadis.2006.03.004. [PMID: 16647250]
  • Antonio Arroyo, Carlos Santos-Ocaña, Macarena Ruiz-Ferrer, Sergio Padilla, Angela Gavilán, Juan C Rodríguez-Aguilera, Plácido Navas. Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans. FEBS letters. 2006 Mar; 580(7):1740-6. doi: 10.1016/j.febslet.2006.02.025. [PMID: 16504181]
  • Sakiko Takahashi, Yuki Ogiyama, Hiroaki Kusano, Hiroaki Shimada, Makoto Kawamukai, Koh-ichi Kadowaki. Metabolic engineering of coenzyme Q by modification of isoprenoid side chain in plant. FEBS letters. 2006 Feb; 580(3):955-9. doi: 10.1016/j.febslet.2006.01.023. [PMID: 16442107]
  • Jingmin Yan, Kenji Fujii, Junjie Yao, Hideyuki Kishida, Kazunori Hosoe, Jinko Sawashita, Toshio Takeda, Masayuki Mori, Keiichi Higuchi. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Experimental gerontology. 2006 Feb; 41(2):130-40. doi: 10.1016/j.exger.2005.11.007. [PMID: 16387461]
  • Nina Hermans, Paul Cos, Dirk Vanden Berghe, Arnold J Vlietinck, Tess de Bruyne. Method development and validation for monitoring in vivo oxidative stress: evaluation of lipid peroxidation and fat-soluble vitamin status by HPLC in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Aug; 822(1-2):33-9. doi: 10.1016/j.jchromb.2005.05.040. [PMID: 15990367]
  • Julio J Ochoa, José L Quiles, Jesús R Huertas, José Mataix. Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet. The journals of gerontology. Series A, Biological sciences and medical sciences. 2005 Aug; 60(8):970-5. doi: 10.1093/gerona/60.8.970. [PMID: 16127098]
  • Rosario I Bello, Consuelo Gómez-Díaz, María I Burón, Francisco J Alcaín, Plácido Navas, José M Villalba. Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Experimental gerontology. 2005 Aug; 40(8-9):694-706. doi: 10.1016/j.exger.2005.07.003. [PMID: 16125350]
  • Seher Akhtar Khan. Effects of dehydroepiandrosterone (DHEA) on ubiquinone and catalase in the livers of male F-344 rats. Biological & pharmaceutical bulletin. 2005 Jul; 28(7):1301-3. doi: 10.1248/bpb.28.1301. [PMID: 15997119]
  • José L Quiles, Julio J Ochoa, Maurizio Battino, Purificación Gutierrez-Rios, Eduardo A Nepomuceno, Magdalena López Frías, Jesús R Huertas, José Mataix. Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damage. BioFactors (Oxford, England). 2005; 25(1-4):73-86. doi: 10.1002/biof.5520250109. [PMID: 16873932]
  • M Afzal, A Majeed Safer, Shaima Al-Bloushi. CoQ9 potentiates green tea antioxidant activities in Wistar rats. BioFactors (Oxford, England). 2005; 25(1-4):255-9. doi: 10.1002/biof.5520250131. [PMID: 16873954]
  • Luo Jun, Ryoichi Saiki, Kei Tatsumi, Tsuyoshi Nakagawa, Makoto Kawamukai. Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana. Plant & cell physiology. 2004 Dec; 45(12):1882-8. doi: 10.1093/pcp/pch211. [PMID: 15653808]
  • Peter H Tang, Ton deGrauw. Redox cycling of coenzyme Q9 as a new measure of plasma reducing power. Clinical chemistry. 2004 Oct; 50(10):1930-2. doi: 10.1373/clinchem.2004.037010. [PMID: 15484328]
  • Paulo J Oliveira, Telma C Esteves, Raquel Seiça, António J M Moreno, Maria S Santos. Calcium-dependent mitochondrial permeability transition is augmented in the kidney of Goto-Kakizaki diabetic rat. Diabetes/metabolism research and reviews. 2004 Mar; 20(2):131-6. doi: 10.1002/dmrr.423. [PMID: 15037988]
  • Paola Venditti, Raffaella De Rosa, Sergio Di Meo. Effect of cold-induced hyperthyroidism on H2O2 production and susceptibility to stress conditions of rat liver mitochondria. Free radical biology & medicine. 2004 Feb; 36(3):348-58. doi: 10.1016/j.freeradbiomed.2003.11.012. [PMID: 15036354]
  • Fedor Simko, Jana Matuskova, Ivan Luptak, Kristina Krajcirovicova, Jarmila Kucharska, Anna Gvozdjakova, Pavel Babal, Olga Pechanova. Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension. Life sciences. 2004 Jan; 74(10):1211-24. doi: 10.1016/j.lfs.2003.07.032. [PMID: 14697405]
  • J Kucharská, O Ulicná, A Gvozdjáková, Z Sumbalová, O Vancová, P Bozek, M Nakano, M Greksák. Regeneration of coenzyme Q9 redox state and inhibition of oxidative stress by Rooibos tea (Aspalathus linearis) administration in carbon tetrachloride liver damage. Physiological research. 2004; 53(5):515-21. doi: . [PMID: 15479130]
  • Paola Venditti, Raffaella De Rosa, Sergio Di Meo. Effect of thyroid state on susceptibility to oxidants and swelling of mitochondria from rat tissues. Free radical biology & medicine. 2003 Sep; 35(5):485-94. doi: 10.1016/s0891-5849(03)00331-9. [PMID: 12927598]
  • L E Wold, D Muralikrishnan, C B Albano, F L Norby, M Ebadi, J Ren. Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q9 and Q10. Acta diabetologica. 2003 Jun; 40(2):85-90. doi: 10.1007/s005920300010. [PMID: 12861406]
  • Zhi-Zhong Guan, Wen-Feng Yu, Ke-Ren Shan, Tomas Nordman, Jerker Olsson, Agneta Nordberg. Loss of nicotinic receptors induced by beta-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation. Journal of neuroscience research. 2003 Feb; 71(3):397-406. doi: 10.1002/jnr.10496. [PMID: 12526028]
  • Juan C Rodríguez-Aguilera, Claudio Asencio, Macarena Ruiz-Ferrer, Jordana Vela, Plácido Navas. Caenorhabditis elegans ubiquinone biosynthesis genes. BioFactors (Oxford, England). 2003; 18(1-4):237-44. doi: 10.1002/biof.5520180226. [PMID: 14695939]