Dihydroxyfumaric acid (BioDeep_00000004530)

 

Secondary id: BioDeep_00001869165

human metabolite Endogenous BioNovoGene_Lab2019


代谢物信息卡片


2-Butenedioic acid,2,3-dihydroxy-, (2E)-

化学式: C4H4O6 (148.0007884)
中文名称: 二羟基富马酸, 二羟基富马酸 水合物
谱图信息: 最多检出来源 Homo sapiens(blood) 0.18%

分子结构信息

SMILES: C(=C(C(=O)O)O)(C(=O)O)O
InChI: InChI=1S/C4H4O6/c5-1(3(7)8)2(6)4(9)10/h5,7-8H,(H,9,10)

描述信息

Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxaloglycolate. [HMDB]
Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxaloglycolate.

同义名列表

11 个代谢物同义名

2-Butenedioic acid,2,3-dihydroxy-, (2E)-; 3,4,4-trihydroxy-2-oxobut-3-enoic acid; (2E)-2,3-Dihydroxybut-2-enedioic acid; 3,4,4-Trihydroxy-2-oxobut-3-enoate; (2E)-2,3-Dihydroxybut-2-enedioate; dihydroxy-fumaric acid; Dihydroxyfumaric acid; (2-)Dihydroxyfumarate; Dihydroxy-fumarate; Dihydroxyfumarate; DHF



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J A Gerrard, M J Prince, A D Abell. Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase. Bioorganic & medicinal chemistry letters. 2000 Jul; 10(14):1575-6. doi: 10.1016/s0960-894x(00)00288-2. [PMID: 10915054]
  • H Sugawara, K Tobise, K Kikuchi. Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation. Hypertension research : official journal of the Japanese Society of Hypertension. 1996 Dec; 19(4):223-8. doi: 10.1291/hypres.19.223. [PMID: 8986452]
  • J P Wang, S L Raung, M F Hsu, C C Chen. Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils. British journal of pharmacology. 1994 Nov; 113(3):945-53. doi: 10.1111/j.1476-5381.1994.tb17084.x. [PMID: 7858890]
  • H Sugawara, K Tobise, S Onodera. Absence of antioxidant effects of nifedipine and diltiazem on myocardial membrane lipid peroxidation in contrast with those of nisoldipine and propranolol. Biochemical pharmacology. 1994 Mar; 47(5):887-92. doi: 10.1016/0006-2952(94)90489-8. [PMID: 8135864]
  • T L Yue, P J Mckenna, P G Lysko, J L Gu, K A Lysko, R R Ruffolo, G Z Feuerstein. SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant. European journal of pharmacology. 1994 Jan; 251(2-3):237-43. doi: 10.1016/0014-2999(94)90405-7. [PMID: 8149979]
  • B F Dickens, W B Weglicki, Y S Li, I T Mak. Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS letters. 1992 Oct; 311(3):187-91. doi: 10.1016/0014-5793(92)81098-7. [PMID: 1397313]
  • A M Freedman, I T Mak, R E Stafford, B F Dickens, M M Cassidy, R A Muesing, W B Weglicki. Erythrocytes from magnesium-deficient hamsters display an enhanced susceptibility to oxidative stress. The American journal of physiology. 1992 Jun; 262(6 Pt 1):C1371-5. doi: 10.1152/ajpcell.1992.262.6.c1371. [PMID: 1319674]
  • T L Yue, P J McKenna, R R Ruffolo, G Feuerstein. Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils. European journal of pharmacology. 1992 Apr; 214(2-3):277-80. doi: 10.1016/0014-2999(92)90130-v. [PMID: 1355437]
  • K Todoki, E Okabe, T Kiyose, T Sekishita, H Ito. Oxygen free radical-mediated selective endothelial dysfunction in isolated coronary artery. The American journal of physiology. 1992 Mar; 262(3 Pt 2):H806-12. doi: 10.1152/ajpheart.1992.262.3.h806. [PMID: 1313648]
  • T C Pellmar, D L Lepinski. Electrophysiological consequences of exposure of hippocampal slices to dihydroxyfumarate, a generator of superoxide radicals. Brain research. 1992 Jan; 569(2):189-98. doi: 10.1016/0006-8993(92)90630-r. [PMID: 1311616]
  • R L Thies, A P Autor. Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Archives of biochemistry and biophysics. 1991 May; 286(2):353-63. doi: 10.1016/0003-9861(91)90051-j. [PMID: 1654786]
  • R C Kukreja, E Okabe, G M Schrier, M L Hess. Oxygen radical-mediated lipid peroxidation and inhibition of Ca2+-ATPase activity of cardiac sarcoplasmic reticulum. Archives of biochemistry and biophysics. 1988 Mar; 261(2):447-57. doi: 10.1016/0003-9861(88)90361-x. [PMID: 2833166]
  • I T Mak, J H Kramer, W B Weglicki. Potentiation of free radical-induced lipid peroxidative injury to sarcolemmal membranes by lipid amphiphiles. The Journal of biological chemistry. 1986 Jan; 261(3):1153-7. doi: . [PMID: 3003057]
  • K Nakano, F Obo. Purification of the agent inducing lipid peroxidation with dihydroxyfumaric acid in rat liver mitochondria. Biochemical and biophysical research communications. 1980 Apr; 93(4):1127-31. doi: 10.1016/0006-291x(80)90606-3. [PMID: 7396901]
  • K Nakano, F Obo. Dihydroxyfumaric acid induced lipid peroxidation in rat liver microsomes. Biochemical and biophysical research communications. 1979 Aug; 89(4):1239-44. doi: 10.1016/0006-291x(79)92141-7. [PMID: 496954]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]