3-Hydroxypropanal (BioDeep_00000004528)

 

Secondary id: BioDeep_00001868711

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


beta-Hydroxypropionaldehyde

化学式: C3H6O2 (74.0367776)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 1.75%

分子结构信息

SMILES: C(C=O)CO
InChI: InChI=1S/C3H6O2/c4-2-1-3-5/h2,5H,1,3H2

描述信息

3-Hydroxypropanal is a broad-spectrum antimicrobial substance termed reuterin produced by Lactobacillus reuteri. L. reuteri resides in the gastrointestinal tract of healthy humans and animals, and is believed to. function as a symbiont in the enteric ecosystem. Synthesis of such an antimicrobial substance by an enteric resident raises a number of interesting questions and possibilities as to the role these residents may play in the health of the host. (PMID 3245697). In vivo, glycerol is converted in one enzymatic step into 3-Hydroxypropanal. The 3-Hydroxypropanal -producing Lactobacillus reuteri is used as a probiotic in the health care of humans and animals. 3-Hydroxypropanal forms, together with Hydroxypropanal-hydrate and Hydroxypropanal-dimer, a dynamic, multi-component system (Hydroxypropanal system) used in food preservation, as a precursor for many modern chemicals such as acrolein, acrylic acid, and 1,3-propanediol (1,3-PDO), and for polymer production. 3-Hydroxypropanal can be obtained both through traditional chemistry and bacterial fermentation. To date, 3-HPA has been produced from petrochemical resources as an intermediate in 1,3-PDO production. The biotechnological production of 3-Hydroxypropanal from renewable resources is desirable both for use of 3-Hydroxypropanal in foods and for the production of bulk chemicals. The main challenge will be the efficient production and recovery of pure 3-Hydroxypropanal. (PMID 14669058).
3-Hydroxypropanal is a broad-spectrum antimicrobial substance termed reuterin produced by Lactobacillus reuteri. L. reuteri resides in the gastrointestinal tract of healthy humans and animals, and is believed to
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates[1][2].

同义名列表

11 个代谢物同义名

beta-Hydroxypropionaldehyde; β-hydroxypropionaldehyde; 3-Hydroxypropionaldehyde; b-Hydroxypropionaldehyde; beta-Hydroxypropanal; b-Hydroxypropanal; 3-Hydroxypropanal; 3-oxo-1-Propanol; Hydracrolein; Reuterin; 3-HPA



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nupur K Das, Andrew J Schwartz, Gabrielle Barthel, Naohiro Inohara, Qing Liu, Amanda Sankar, David R Hill, Xiaoya Ma, Olivia Lamberg, Matthew K Schnizlein, Juan L Arqués, Jason R Spence, Gabriel Nunez, Andrew D Patterson, Duxin Sun, Vincent B Young, Yatrik M Shah. Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Cell metabolism. 2020 01; 31(1):115-130.e6. doi: 10.1016/j.cmet.2019.10.005. [PMID: 31708445]
  • Falco Beer, Felix Urbat, Charles M A P Franz, Melanie Huch, Sabine E Kulling, Mirko Bunzel, Diana Bunzel. The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations. Molecular nutrition & food research. 2019 05; 63(10):e1801177. doi: 10.1002/mnfr.201801177. [PMID: 30815965]
  • Jennifer K Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche, Sara M Dann, Robert A Britton, Anthony Haag, Tor C Savidge. Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infection and immunity. 2017 10; 85(10):. doi: 10.1128/iai.00303-17. [PMID: 28760934]
  • Juntana Chimchang, Talent Theparee, Boonyarut Ladda, Somboon Tanasupawat, Benjamas Thanomsub Wongsatayanon, Malai Taweechotipatr. Antimicrobial Properties of a Potential Probiotic Lactobacillus from Thai Newborn Feces. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2015 Oct; 98 Suppl 9(?):S116-22. doi: . [PMID: 26817219]
  • Laura R Jarboe. YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals. Applied microbiology and biotechnology. 2011 Jan; 89(2):249-57. doi: 10.1007/s00253-010-2912-9. [PMID: 20924577]
  • Le-Le Hu, Chen Chen, Tao Huang, Yu-Dong Cai, Kuo-Chen Chou. Predicting biological functions of compounds based on chemical-chemical interactions. PloS one. 2011; 6(12):e29491. doi: 10.1371/journal.pone.0029491. [PMID: 22220213]
  • Rosemarie De Weirdt, Sam Possemiers, Griet Vermeulen, Tanja C W Moerdijk-Poortvliet, Henricus T S Boschker, Willy Verstraete, Tom Van de Wiele. Human faecal microbiota display variable patterns of glycerol metabolism. FEMS microbiology ecology. 2010 Dec; 74(3):601-11. doi: 10.1111/j.1574-6941.2010.00974.x. [PMID: 20946352]
  • Rolene Bauer, Maret du Toit, Jens Kossmann. Influence of environmental parameters on production of the acrolein precursor 3-hydroxypropionaldehyde by Lactobacillus reuteri DSMZ 20016 and its accumulation by wine lactobacilli. International journal of food microbiology. 2010 Jan; 137(1):28-31. doi: 10.1016/j.ijfoodmicro.2009.10.012. [PMID: 19897270]
  • Ronit Reich-Slotky, Christina A Kabbash, Phyllis Della-Latta, John S Blanchard, Steven J Feinmark, Sherry Freeman, Gilla Kaplan, Howard A Shuman, Samuel C Silverstein. Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages. Journal of bacteriology. 2009 Aug; 191(16):5262-71. doi: 10.1128/jb.00175-09. [PMID: 19429621]
  • Hidetoshi Morita, Hidehiro Toh, Shinji Fukuda, Hiroshi Horikawa, Kenshiro Oshima, Takehito Suzuki, Masaru Murakami, Shin Hisamatsu, Yukio Kato, Tatsuya Takizawa, Hideo Fukuoka, Tetsuhiko Yoshimura, Kikuji Itoh, Daniel J O'Sullivan, Larry L McKay, Hiroshi Ohno, Jun Kikuchi, Toshio Masaoka, Masahira Hattori. Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production. DNA research : an international journal for rapid publication of reports on genes and genomes. 2008 Jun; 15(3):151-61. doi: 10.1093/dnares/dsn009. [PMID: 18487258]
  • Valentine Cleusix, Christophe Lacroix, Sabine Vollenweider, Gwenaëlle Le Blay. Glycerol induces reuterin production and decreases Escherichia coli population in an in vitro model of colonic fermentation with immobilized human feces. FEMS microbiology ecology. 2008 Jan; 63(1):56-64. doi: 10.1111/j.1574-6941.2007.00412.x. [PMID: 18028400]
  • S McCoy, S E Gilliland. Isolation and characterization of Lactobacillus species having potential for use as probiotic cultures for dogs. Journal of food science. 2007 Apr; 72(3):M94-7. doi: 10.1111/j.1750-3841.2007.00310.x. [PMID: 17995807]
  • E Rodríguez, J L Arqués, R Rodríguez, M Nuñez, M Medina. Reuterin production by lactobacilli isolated from pig faeces and evaluation of probiotic traits. Letters in applied microbiology. 2003; 37(3):259-63. doi: 10.1046/j.1472-765x.2003.01390.x. [PMID: 12904230]