FENARIMOL (BioDeep_00000419491)

   

natural product


代谢物信息卡片


Pesticide6_Fenarimol_C17H12Cl2N2O_(2-Chlorophenyl)(4-chlorophenyl)5-pyrimidinylmethanol

化学式: C17H12Cl2N2O (330.0326642)
中文名称: 哑菌灵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)(C3=CN=CN=C3)O)Cl
InChI: InChI=1S/C17H12Cl2N2O/c18-14-7-5-12(6-8-14)17(22,13-9-20-11-21-10-13)15-3-1-2-4-16(15)19/h1-11,22H

描述信息

D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

2 个代谢物同义名

FENARIMOL; Pesticide6_Fenarimol_C17H12Cl2N2O_(2-Chlorophenyl)(4-chlorophenyl)5-pyrimidinylmethanol



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna Janeczko, Jana Oklestkova, Danuše Tarkowská, Barbara Drygaś. Naturally Occurring Ecdysteroids in Triticum aestivum L. and Evaluation of Fenarimol as a Potential Inhibitor of Their Biosynthesis in Plants. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062855. [PMID: 33799719]
  • Kajal Karsauliya, Ashish Kumar Sonker, Manisha Bhateria, Isha Taneja, Anshuman Srivastava, Manu Sharma, Sheelendra Pratap Singh. Plasma protein binding, metabolism, reaction phenotyping and toxicokinetic studies of fenarimol after oral and intravenous administration in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jan; 51(1):72-81. doi: 10.1080/00498254.2020.1796170. [PMID: 32660295]
  • Keimei Oh, Tadashi Matsumoto, Ayumi Yamagami, Tomoki Hoshi, Takeshi Nakano, Yuko Yoshizawa. Fenarimol, a Pyrimidine-Type Fungicide, Inhibits Brassinosteroid Biosynthesis. International journal of molecular sciences. 2015 Jul; 16(8):17273-88. doi: 10.3390/ijms160817273. [PMID: 26230686]
  • Aránzazu Peña, Ma Dolores Mingorance, Ignacio Guzmán, Lourdes Sánchez, Antonio J Fernández-Espinosa, Benito Valdés, Sabina Rossini-Oliva. Protecting effect of recycled urban wastes (sewage sludge and wastewater) on ryegrass against the toxicity of pesticides at high concentrations. Journal of environmental management. 2014 Sep; 142(?):23-9. doi: 10.1016/j.jenvman.2014.04.002. [PMID: 24797639]
  • Hu Zhang, Xinquan Wang, Shulin Zhuang, Mingrong Qian, Kezhi Jiang, Xiangyun Wang, Hao Xu, Peipei Qi, Qiang Wang. Enantioselective separation and simultaneous determination of fenarimol and nuarimol in fruits, vegetables, and soil by liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2012 Oct; 404(6-7):1983-91. doi: 10.1007/s00216-012-6325-8. [PMID: 22955670]
  • Nicholas T Amponsah, Eirian Jones, Hayley J Ridgway, Marlene V Jaspers. Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines. Pest management science. 2012 May; 68(5):676-83. doi: 10.1002/ps.2309. [PMID: 22290833]
  • Eveline Snelders, Simone M T Camps, Anna Karawajczyk, Gijs Schaftenaar, Gert H J Kema, Henrich A van der Lee, Corné H Klaassen, Willem J G Melchers, Paul E Verweij. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PloS one. 2012; 7(3):e31801. doi: 10.1371/journal.pone.0031801. [PMID: 22396740]
  • Hiroshi Sakugawa, Nahed Hasan, Ilemobayo Oguntimehin, Elsayed Belal. Protective and curative effects of foliar-spray Fenton solutions against cucumber (Cucumis sativus, L.) powdery mildew. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2012; 47(12):1909-18. doi: 10.1080/03601234.2012.676448. [PMID: 22755538]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Francisco Javier Fernández Acero, María Carbú, Mohamed Rabie El-Akhal, Carlos Garrido, Victoria E González-Rodríguez, Jesús M Cantoral. Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases. International journal of molecular sciences. 2011 Jan; 12(1):795-816. doi: 10.3390/ijms12010795. [PMID: 21340014]
  • D Ramoutar, R S Cowles, E Requintina, S R Alm. Synergism between demethylation inhibitor fungicides or gibberellin inhibitor plant growth regulators and bifenthrin in a pyrethroid-resistant population of Listronotus maculicollis (Coleoptera: Curculionidae). Journal of economic entomology. 2010 Oct; 103(5):1810-4. doi: 10.1603/ec09374. [PMID: 21061984]
  • Francisco J López-Ruiz, Alejandro Pérez-García, Dolores Fernández-Ortuño, Diego Romero, Emilio García, Antonio de Vicente, James K M Brown, Juan A Torés. Sensitivities to DMI fungicides in populations of Podosphaera fusca in south central Spain. Pest management science. 2010 Jul; 66(7):801-8. doi: 10.1002/ps.1948. [PMID: 20533378]
  • Giovanni Del Sorbo, Michelina Ruocco, Henk-Jan Schoonbeek, Felice Scala, Catello Pane, Francesco Vinale, Marteen A De Waard. Cloning and functional characterization of BcatrA, a gene encoding an ABC transporter of the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea). Mycological research. 2008 Jun; 112(Pt 6):737-46. doi: 10.1016/j.mycres.2008.01.005. [PMID: 18515055]
  • Polina Gadeva, Boyan Dimitrov. Genotoxic effects of the pesticides Rubigan, Omite and Rovral in root-meristem cells of Crepis capillaris L. Mutation research. 2008 Apr; 652(2):191-7. doi: 10.1016/j.mrgentox.2008.02.007. [PMID: 18420449]
  • Helle R Andersen, Ida M Schmidt, Philippe Grandjean, Tina K Jensen, Esben Budtz-Jørgensen, Mia B Kjaerstad, Jesper Baelum, Jesper B Nielsen, Niels E Skakkebaek, Katharina M Main. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environmental health perspectives. 2008 Apr; 116(4):566-72. doi: 10.1289/ehp.10790. [PMID: 18414644]
  • Einat Zeiman, Charles L Greenblatt, Sharona Elgavish, Ina Khozin-Goldberg, Jacob Golenser. Mode of action of fenarimol against Leishmania spp. The Journal of parasitology. 2008 Feb; 94(1):280-6. doi: 10.1645/ge-1259.1. [PMID: 18372651]
  • Karen L Thorpe, Rachel Benstead, Thomas H Hutchinson, Charles R Tyler. Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas). Aquatic toxicology (Amsterdam, Netherlands). 2007 Dec; 85(3):176-83. doi: 10.1016/j.aquatox.2007.08.012. [PMID: 17942165]
  • Yun Sung Kim, Hyeong Min Kim, Cheol Chang, In Cheon Hwang, Hyuncheol Oh, Jong Seog Ahn, Ki Deok Kim, Byung Kook Hwang, Beom Seok Kim. Biological evaluation of neopeptins isolated from a Streptomyces strain. Pest management science. 2007 Dec; 63(12):1208-14. doi: 10.1002/ps.1450. [PMID: 17912683]
  • Tanja Krüger, Philip S Hjelmborg, Bo A G Jönsson, Lars Hagmar, Aleksander Giwercman, Gian-Carlo Manicardi, Davide Bizzaro, Marcello Spanò, Anna Rignell-Hydbom, Henning S Pedersen, Gunnar Toft, Jens Peter Bonde, Eva C Bonefeld-Jørgensen. Xenoandrogenic activity in serum differs across European and Inuit populations. Environmental health perspectives. 2007 Dec; 115 Suppl 1(?):21-7. doi: 10.1289/ehp.9353. [PMID: 18174946]
  • David H Miller, Kathleen M Jensen, Daniel L Villeneuve, Michael D Kahl, Elizabeth A Makynen, Elizabeth J Durhan, Gerald T Ankley. Linkage of biochemical responses to population-level effects: a case study with vitellogenin in the fathead minnow (Pimephales promelas). Environmental toxicology and chemistry. 2007 Mar; 26(3):521-7. doi: 10.1897/06-318r.1. [PMID: 17373517]
  • Anneleen Soetaert, Karlijn van der Ven, Lotte N Moens, Tine Vandenbrouck, Piet van Remortel, Wim M De Coen. Daphnia magna and ecotoxicogenomics: gene expression profiles of the anti-ecdysteroidal fungicide fenarimol using energy-, molting- and life stage-related cDNA libraries. Chemosphere. 2007 Feb; 67(1):60-71. doi: 10.1016/j.chemosphere.2006.09.076. [PMID: 17112564]
  • Helle Raun Andersen, Eva C Bonefeld-Jørgensen, Flemming Nielsen, Kirsten Jarfeldt, Magdalena Niepsuj Jayatissa, Anne Marie Vinggaard. Estrogenic effects in vitro and in vivo of the fungicide fenarimol. Toxicology letters. 2006 May; 163(2):142-52. doi: 10.1016/j.toxlet.2005.10.004. [PMID: 16324804]
  • J Falandysz, T Albanis, J Bachmann, R Bettinetti, I Bochentin, V Boti, S Bristeau, B Daehne, T Dagnac, S Galassi, R Jeannot, J Oehlmann, A Orlikowska, V Sakkas, R Szczerski, V Valsamaki, U Schulte-Oehlmann. Some chemical contaminant of surface sediments at the Baltic Sea coastal region with special emphasis on androgenic and anti-androgenic compounds. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2006; 41(10):2127-62. doi: 10.1080/10934520600872433. [PMID: 17018405]
  • Gerald T Ankley, Kathleen M Jensen, Elizabeth J Durhan, Elizabeth A Makynen, Brian C Butterworth, Michael D Kahl, Daniel L Villeneuve, Ann Linnum, L Earl Gray, Mary Cardon, Vickie S Wilson. Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas). Toxicological sciences : an official journal of the Society of Toxicology. 2005 Aug; 86(2):300-8. doi: 10.1093/toxsci/kfi202. [PMID: 15901916]
  • Anne Marie Vinggaard, Helene Jacobsen, Stine Broeng Metzdorff, Helle Raun Andersen, Christine Nellemann. Antiandrogenic effects in short-term in vivo studies of the fungicide fenarimol. Toxicology. 2005 Feb; 207(1):21-34. doi: 10.1016/j.tox.2004.08.009. [PMID: 15590119]
  • Jin-Cheol Kim, Gyung Ja Choi, Seon-Woo Lee, Jin-Seog Kim, Kyu Young Chung, Kwang Yun Cho. Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildew. Pest management science. 2004 Aug; 60(8):803-8. doi: 10.1002/ps.811. [PMID: 15307672]
  • Ramón Lavado, Rémi Thibaut, Demetrio Raldúa, Rebeca Martín, Cinta Porte. First evidence of endocrine disruption in feral carp from the Ebro River. Toxicology and applied pharmacology. 2004 Apr; 196(2):247-57. doi: 10.1016/j.taap.2003.12.012. [PMID: 15081271]
  • P Poli, M A de Mello, A Buschini, V L S S de Castro, F M Restivo, C Rossi, T M A D Zucchi. Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay. Mutation research. 2003 Sep; 540(1):57-66. doi: 10.1016/s1383-5718(03)00165-7. [PMID: 12972058]
  • P Proença, E Pinho Marques, H Teixeira, F Castanheira, M Barroso, S Avila, D N Vieira. A fatal forensic intoxication with fenarimol: analysis by HPLC/DAD/MSD. Forensic science international. 2003 Apr; 133(1-2):95-100. doi: 10.1016/s0379-0738(03)00054-9. [PMID: 12742694]
  • S Gielen, R Aerts, B Seels. Development of a selective medium for the determination of the spore concentrations of Botrytis cinerea in the air. Communications in agricultural and applied biological sciences. 2003; 68(4 Pt B):685-93. doi: ". [PMID: 15151304]
  • Alan C Andrade, Giovanni Del Sorbo, Johannes G M Van Nistelrooy, Maarten A De Waard. The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds. Microbiology (Reading, England). 2000 Aug; 146 ( Pt 8)(?):1987-1997. doi: 10.1099/00221287-146-8-1987. [PMID: 10931903]
  • R Nakaune, K Adachi, O Nawata, M Tomiyama, K Akutsu, T Hibi. A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Applied and environmental microbiology. 1998 Oct; 64(10):3983-8. doi: 10.1128/aem.64.10.3983-3988.1998. [PMID: 9758830]
  • M Paolini, R Mesirca, L Pozzetti, F Maffei, F Vigagni, P Hrelia, G Cantelli-Forti. Genetic and non-genetic biomarkers related to carcinogenesis in evaluating toxicological risk from Fenarimol. Mutation research. 1996 May; 368(1):27-39. doi: 10.1016/s0165-1218(96)90037-3. [PMID: 8637508]
  • J G van Nistelrooy, J M van den Brink, J A van Kan, R F van Gorcom, M A de Waard. Isolation and molecular characterisation of the gene encoding eburicol 14 alpha-demethylase (cYP51) from Penicillium italicum. Molecular & general genetics : MGG. 1996 Apr; 250(6):725-33. doi: 10.1007/bf02172984. [PMID: 8628233]
  • M Paolini, R Mesirca, L Pozzetti, A Sapone, G Cantelli-Forti. Molecular non-genetic biomarkers related to Fenarimol cocarcinogenesis: organ- and sex-specific CYP induction in rat. Cancer letters. 1996 Mar; 101(2):171-8. doi: 10.1016/0304-3835(96)04130-4. [PMID: 8620466]
  • M Paolini, L Pozzetti, R Mesirca, A Sapone, G Cantelli-Forti. Testosterone hydroxylase in evaluating induction and suppression of murine CYP isoenzymes by fenarimol. Archives of toxicology. 1996; 70(7):451-6. doi: 10.1007/s002040050298. [PMID: 8740540]
  • P Hrelia, F Maffei, F Vigagni, C Fimognari, P Flori, R Stanzani, G Cantelli Forti. Interactive effects between trichloroethylene and pesticides at metabolic and genetic level in mice. Environmental health perspectives. 1994 Nov; 102 Suppl 9(?):31-4. doi: 10.1289/ehp.94102s931. [PMID: 7698080]
  • J Woźniak, J Kopeć-Szlezak. [Changes in serum calcium level in rats as the effect of administration of fenarimol]. Acta haematologica Polonica. 1991; 22(1):145-8. doi: NULL. [PMID: 1823956]
  • M Grabarczyk, U Podstawka, J Kopeć-Szlezak. [Protection of human peripheral blood leukocytes with vitamin E and C from toxic effects of fenarimol in vitro]. Acta haematologica Polonica. 1991; 22(1):136-44. doi: ". [PMID: 1823955]
  • M Grabarczyk, J Kopeć-Szlezak, I Szczepańska, J Woźniak, D Palut. [Cytotoxic effect of fenarimol on peripheral blood cells and organs]. Acta haematologica Polonica. 1989 Jan; 20(1):21-8. doi: NULL. [PMID: 2618563]
  • K S Hirsch, E R Adams, D G Hoffman, J K Markham, N V Owen. Studies to elucidate the mechanism of fenarimol-induced infertility in male rats. Toxicology and applied pharmacology. 1986 Dec; 86(3):391-9. doi: 10.1016/0041-008x(86)90366-2. [PMID: 3787632]