3,3,5-triiodothyronine (BioDeep_00000415895)

Main id: BioDeep_00000006558

 

BioNovoGene_Lab2019


代谢物信息卡片


3,3,5-Triiodo-L-thyronine

化学式: C15H12I3NO4 (650.7901)
中文名称: 3,3,5-三碘- L -甲状腺氨酸
谱图信息: 最多检出来源 Homo sapiens(not specific) 25.24%

分子结构信息

SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
InChI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

3 个代谢物同义名

3,3,5-triiodothyronine; 3,3,5-Triiodo-L-thyronine; 3,3',5'-Triiodo-L-thyronine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, PRL, TSHB
Endosome membrane 2 DIO3, TF
Nucleus 4 ALB, PRL, THRA, THRB
cytosol 3 ALB, SST, THRA
nuclear body 1 THRB
centrosome 1 ALB
nucleoplasm 4 ATP2B1, PRL, THRA, THRB
RNA polymerase II transcription regulator complex 3 PRL, THRA, THRB
Cell membrane 4 ATP2B1, DIO3, ITGAM, SLC16A2
Multi-pass membrane protein 2 ATP2B1, SLC16A2
Synapse 1 ATP2B1
cell surface 3 ITGAM, TF, TPO
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuronal cell body 1 SST
presynaptic membrane 1 ATP2B1
plasma membrane 8 ATP2B1, DIO2, DIO3, GCG, ITGAM, SLC16A2, TF, TPO
synaptic vesicle membrane 1 ATP2B1
Membrane 5 ATP2B1, DIO2, ITGAM, SLC16A2, TPO
apical plasma membrane 2 SLC16A2, TF
basolateral plasma membrane 1 ATP2B1
extracellular exosome 6 ALB, ATP2B1, ITGAM, SERPINA7, TF, TTR
endoplasmic reticulum 1 ALB
extracellular space 13 ALB, GCG, IGF1, INS, ITGAM, PRL, SERPINA7, SST, TF, TG, TPO, TSHB, TTR
perinuclear region of cytoplasm 1 TF
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 ATP2B1, DIO3
Single-pass type I membrane protein 2 ITGAM, TPO
Secreted 11 ALB, GCG, IGF1, INS, PRL, SST, TF, TG, TRH, TSHB, TTR
extracellular region 12 ALB, GCG, IGF1, INS, PRL, SERPINA7, SST, TF, TG, TRH, TSHB, TTR
Single-pass membrane protein 1 DIO2
basal part of cell 1 TF
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ITGAM
cytoplasmic vesicle 1 TF
Early endosome 1 TF
clathrin-coated pit 1 TF
recycling endosome 1 TF
Single-pass type II membrane protein 1 DIO3
vesicle 1 TF
Apical cell membrane 1 SLC16A2
Membrane raft 1 ITGAM
GABA-ergic synapse 1 SST
secretory granule 1 TRH
lateral plasma membrane 1 ATP2B1
Late endosome 1 TF
ciliary basal body 1 ALB
chromatin 3 PRL, THRA, THRB
cell projection 1 ATP2B1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, TF
Basolateral cell membrane 1 ATP2B1
endosome lumen 2 INS, PRL
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 TF
exocytic vesicle 1 IGF1
plasma membrane raft 1 ITGAM
secretory granule lumen 3 GCG, INS, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, GCG, INS, TF
platelet alpha granule lumen 2 ALB, IGF1
endocytic vesicle 1 TF
transport vesicle 1 INS
azurophil granule lumen 1 TTR
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 SST
clathrin-coated endocytic vesicle membrane 1 TF
integrin complex 1 ITGAM
vesicle coat 1 TF
[Glucagon-like peptide 1]: Secreted 1 GCG
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
integrin alphaM-beta2 complex 1 ITGAM
[Isoform Alpha-2]: Cytoplasm 1 THRA
photoreceptor ribbon synapse 1 ATP2B1
ciliary transition fiber 1 ALB
dense body 1 TF


文献列表

  • Davide Corinti, Barbara Chiavarino, Mattia Spano, Aura Tintaru, Simonetta Fornarini, Maria Elisa Crestoni. Molecular Basis for the Remarkably Different Gas-Phase Behavior of Deprotonated Thyroid Hormones Triiodothyronine (T3) and Reverse Triiodothyronine (rT3): A Clue for Their Discrimination?. Analytical chemistry. 2021 11; 93(44):14869-14877. doi: 10.1021/acs.analchem.1c03892. [PMID: 34714056]
  • David J Halsall, Susan Oddy. Clinical and laboratory aspects of 3,3',5'-triiodothyronine (reverse T3). Annals of clinical biochemistry. 2021 01; 58(1):29-37. doi: 10.1177/0004563220969150. [PMID: 33040575]
  • Eleonore Fröhlich, Richard Wahl. Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients. Frontiers in endocrinology. 2021; 12(?):587518. doi: 10.3389/fendo.2021.587518. [PMID: 33981284]
  • Liam McKeever, Sarah J Peterson, Omar Lateef, Sally Freels, Tatiana L Fonseca, Barbara M L C Bocco, Gustavo W Fernandes, Kelly Roehl, Kristen Nowak, Marisa Mozer, Antonio C Bianco, Carol A Braunschweig. Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation. The Journal of clinical endocrinology and metabolism. 2020 02; 105(2):. doi: 10.1210/clinem/dgz077. [PMID: 31581295]
  • Hung-Yun Lin, Heng-Yuan Tang, Matthew Leinung, Shaker A Mousa, Aleck Hercbergs, Paul J Davis. Action of Reverse T3 on Cancer Cells. Endocrine research. 2019 Nov; 44(4):148-152. doi: 10.1080/07435800.2019.1600536. [PMID: 30943372]
  • Giuseppe Bello, Giorgia Spinazzola, Valentina Giammatteo, Luca Montini, Gennaro De Pascale, Alessandra Bisanti, Maria G Annetta, Eliana Troiani, Antonio Bianchi, Alfredo Pontecorvi, Mariano A Pennisi, Giorgio Conti, Massimo Antonelli. Effects of Thyroid Hormone Treatment on Diaphragmatic Efficiency in Mechanically Ventilated Subjects With Nonthyroidal Illness Syndrome. Respiratory care. 2019 Oct; 64(10):1199-1207. doi: 10.4187/respcare.06770. [PMID: 31015389]
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  • Qing Chang, Yue'e Peng, Lifen Yun, Qingxin Zhu, Shenghong Hu, Qin Shuai. Rapid Identification of Unknown Organic Iodine in Small-Volume Complex Biological Samples Based on Nanospray Mass Spectrometry Coupled with in-Tube Solid Phase Microextraction. Analytical chemistry. 2017 04; 89(7):4147-4152. doi: 10.1021/acs.analchem.7b00037. [PMID: 28287711]
  • Simon H S Pearce, Salman Razvi, Mohammad E Yadegarfar, Carmen Martin-Ruiz, Andrew Kingston, Joanna Collerton, Theo J Visser, Tom B Kirkwood, Carol Jagger. Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study. The Journal of clinical endocrinology and metabolism. 2016 11; 101(11):4385-4394. doi: 10.1210/jc.2016-1935. [PMID: 27552542]
  • Arnaldo Moura Neto, Maria Candida Ribeiro Parisi, Sarah Monte Alegre, Elizabeth Joao Pavin, Marcos Antonio Tambascia, Denise Engelbrecht Zantut-Wittmann. Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus. Endocrine. 2016 Jan; 51(1):63-71. doi: 10.1007/s12020-015-0651-5. [PMID: 26049370]
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  • Andreas Jurik, Barbara Zdrazil, Marion Holy, Thomas Stockner, Harald H Sitte, Gerhard F Ecker. A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1). Journal of medicinal chemistry. 2015 Mar; 58(5):2149-58. doi: 10.1021/jm5015428. [PMID: 25679268]
  • Hiroyuki Sakai, Hidenori Nagao, Mamoru Sakurai, Takako Okumura, Yoshiyuki Nagai, Junpei Shikuma, Rokuro Ito, Tetsuya Imazu, Takashi Miwa, Masato Odawara. Correlation between Serum Levels of 3,3',5'-Triiodothyronine and Thyroid Hormones Measured by Liquid Chromatography-Tandem Mass Spectrometry and Immunoassay. PloS one. 2015; 10(10):e0138864. doi: 10.1371/journal.pone.0138864. [PMID: 26426328]
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  • Solomon Maximo Greenberg, Alfonso Massimiliano Ferrara, Everton S Nicholas, Alexandra M Dumitrescu, Vivian Cody, Roy E Weiss, Samuel Refetoff. A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. Thyroid : official journal of the American Thyroid Association. 2014 Jun; 24(6):945-50. doi: 10.1089/thy.2013.0540. [PMID: 24494774]
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  • Davide Gnocchi, Silvia Leoni, Sandra Incerpi, Giovannella Bruscalupi. 3,5,3'-triiodothyronine (T3) stimulates cell proliferation through the activation of the PI3K/Akt pathway and reactive oxygen species (ROS) production in chick embryo hepatocytes. Steroids. 2012 May; 77(6):589-95. doi: 10.1016/j.steroids.2012.01.022. [PMID: 22366194]
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  • Tatsuya Kunisue, Akifumi Eguchi, Hisato Iwata, Shinsuke Tanabe, Kurunthachalam Kannan. Analysis of thyroid hormones in serum of Baikal seals and humans by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay methods: application of the LC-MS/MS method to wildlife tissues. Environmental science & technology. 2011 Dec; 45(23):10140-7. doi: 10.1021/es203002a. [PMID: 22035339]
  • Alessandro Marsili, Dan Tang, John W Harney, Prabhat Singh, Ann Marie Zavacki, Monica Dentice, Domenico Salvatore, P Reed Larsen. Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle. American journal of physiology. Endocrinology and metabolism. 2011 Nov; 301(5):E818-24. doi: 10.1152/ajpendo.00292.2011. [PMID: 21771965]
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  • Bernt Rønning, Anne S Mortensen, Børge Moe, Olivier Chastel, Augustine Arukwe, Claus Bech. Food restriction in young Japanese quails: effects on growth, metabolism, plasma thyroid hormones and mRNA species in the thyroid hormone signalling pathway. The Journal of experimental biology. 2009 Oct; 212(19):3060-7. doi: 10.1242/jeb.029835. [PMID: 19749098]
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  • Yves Debaveye, Björn Ellger, Liese Mebis, Theo J Visser, Veerle M Darras, Greet Van den Berghe. Effects of substitution and high-dose thyroid hormone therapy on deiodination, sulfoconjugation, and tissue thyroid hormone levels in prolonged critically ill rabbits. Endocrinology. 2008 Aug; 149(8):4218-28. doi: 10.1210/en.2007-1566. [PMID: 18450965]
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  • María Clemente, Pilar Ruiz-Cuevas, Antonio Carrascosa, Neus Potau, Jordi Almar, Salvador Salcedo, Diego Yeste. Thyroid function in preterm infants 27-29 weeks of gestational age during the first four months of life: results from a prospective study comprising 80 preterm infants. Journal of pediatric endocrinology & metabolism : JPEM. 2007 Dec; 20(12):1269-80. doi: 10.1515/jpem.2007.20.12.1269. [PMID: 18341087]
  • I Cassar-Malek, B Picard, S Kahl, J F Hocquette. Relationships between thyroid status, tissue oxidative metabolism, and muscle differentiation in bovine fetuses. Domestic animal endocrinology. 2007 Jul; 33(1):91-106. doi: 10.1016/j.domaniend.2006.04.011. [PMID: 16797912]
  • Robin P Peeters, Wendy M van der Deure, Annewieke W van den Beld, Hans van Toor, Steven W J Lamberts, Joop A M J L Janssen, André G Uitterlinden, Theo J Visser. The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clinical endocrinology. 2007 Jun; 66(6):808-15. doi: 10.1111/j.1365-2265.2007.02817.x. [PMID: 17408423]
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