Uridine triphosphate (BioDeep_00000415808)
Main id: BioDeep_00000004350
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Uridine 5_-triphosphate
化学式: C9H15N2O15P3 (483.968531)
中文名称: 尿苷-5-三磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
InChI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
描述信息
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:15713
- KEGG: C00075
- PubChem: 6133
- DrugBank: DB04005
- ChEMBL: CHEMBL336296
- MeSH: Uridine Triphosphate
- CAS: 63-39-8
- MoNA: CCMSLIB00000479750
- MoNA: CCMSLIB00005464495
- MoNA: MoNA024191
- MoNA: MoNA024139
- PubChem: 3375
- PDB-CCD: UTP
- 3DMET: B01149
- NIKKAJI: J4.827E
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 9606 Homo sapiens:
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 4233 Helianthus tuberosus: 10.1080/00021369.1967.10858790
- 9606 Homo sapiens:
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 4233 Helianthus tuberosus: 10.1080/00021369.1967.10858790
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Complementary therapies in medicine.
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10.1016/j.ctim.2022.102831. [PMID: 35398481] - Jintong Pan, Huihui Li, Junhua Shi. Clinical Application of the Classical Theory of Traditional Chinese Medicine in Diabetic Nephropathy.
Computational and mathematical methods in medicine.
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Scientific reports.
2021 08; 11(1):16999. doi:
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Rheumatology (Oxford, England).
2021 07; 60(7):3252-3261. doi:
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American journal of physiology. Renal physiology.
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American journal of physiology. Gastrointestinal and liver physiology.
2009 Dec; 297(6):G1198-205. doi:
10.1152/ajpgi.00168.2009. [PMID: 19779019] - Thuy T B Vo, Eui-Man Jung, Vu Hoang Dang, Yeong-Min Yoo, Kyung-Chul Choi, Frank H Yu, Eui-Bae Jeung. Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats.
Reproductive biology and endocrinology : RB&E.
2009 Sep; 7(?):104. doi:
10.1186/1477-7827-7-104. [PMID: 19781091] - Elvin Odgaard, Helle A Praetorius, Jens Leipziger. AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct.
American journal of physiology. Renal physiology.
2009 Aug; 297(2):F341-9. doi:
10.1152/ajprenal.00190.2009. [PMID: 19515810] - Georg Lamprecht, Chih-Jen Hsieh, Simone Lissner, Lilia Nold, Andreas Heil, Veronika Gaco, Julia Schäfer, Jerrold R Turner, Michael Gregor. Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.
The Journal of biological chemistry.
2009 Jul; 284(29):19744-53. doi:
10.1074/jbc.m109.004127. [PMID: 19447883] - A K Lawrance, L Deng, R Rozen. Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Gut.
2009 Jun; 58(6):805-11. doi:
10.1136/gut.2007.143107. [PMID: 19174418] - Ciara Leydon, Kimberly V Fisher, Danielle Lodewyck-Falciglia. The cystic fibrosis transmembrane conductance regulator and chloride-dependent ion fluxes of ovine vocal fold epithelium.
Journal of speech, language, and hearing research : JSLHR.
2009 Jun; 52(3):745-54. doi:
10.1044/1092-4388(2008/07-0192). [PMID: 18806217] - János Fodor, Csaba Matta, Tamás Juhász, Tamás Oláh, Mónika Gönczi, Zsolt Szíjgyártó, Pál Gergely, László Csernoch, Róza Zákány. Ionotropic purinergic receptor P2X4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures.
Cell calcium.
2009 May; 45(5):421-30. doi:
10.1016/j.ceca.2009.02.004. [PMID: 19297018] - Seung-Ryoung Jung, Mean-Hwan Kim, Bertil Hille, Duk-Su Koh. Control of granule mobility and exocytosis by Ca2+ -dependent formation of F-actin in pancreatic duct epithelial cells.
Traffic (Copenhagen, Denmark).
2009 Apr; 10(4):392-410. doi:
10.1111/j.1600-0854.2009.00884.x. [PMID: 19192247] - Shigeki Kiyonaka, Kenta Kato, Motohiro Nishida, Kazuhiro Mio, Takuro Numaga, Yuichi Sawaguchi, Takashi Yoshida, Minoru Wakamori, Emiko Mori, Tomohiro Numata, Masakazu Ishii, Hiroki Takemoto, Akio Ojida, Kenta Watanabe, Aya Uemura, Hitoshi Kurose, Takashi Morii, Tsutomu Kobayashi, Yoji Sato, Chikara Sato, Itaru Hamachi, Yasuo Mori. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Proceedings of the National Academy of Sciences of the United States of America.
2009 Mar; 106(13):5400-5. doi:
10.1073/pnas.0808793106. [PMID: 19289841] - H T Syyong, H H C Yang, G Trinh, C Cheung, K H Kuo, C van Breemen. Mechanism of asynchronous Ca(2+) waves underlying agonist-induced contraction in the rat basilar artery.
British journal of pharmacology.
2009 Feb; 156(4):587-600. doi:
10.1111/j.1476-5381.2008.00063.x. [PMID: 19154440] - Weihong Ma, Hui Hui, Pablo Pelegrin, Annmarie Surprenant. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):409-18. doi:
10.1124/jpet.108.146365. [PMID: 19023039] - M A Ostuni, P Egido, G Peranzi, G L Alonso, J-J Lacapere, D A Gonzalez. Characterization of a functional NTPDase in the endoplasmic reticulum of rat submandibular salivary gland.
Physiological research.
2009; 58(6):843-854. doi:
10.33549/physiolres.931682. [PMID: 19093741] - Guiling Zhao, Adebowale Adebiyi, Eva Blaskova, Qi Xi, Jonathan H Jaggar. Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries.
American journal of physiology. Cell physiology.
2008 Nov; 295(5):C1376-84. doi:
10.1152/ajpcell.00362.2008. [PMID: 18799650] - V F Sivuk, I M Rusina, A F Makarchikov. Purification and characteristics of functional properties of soluble nucleoside triphosphatase (apyrase) from bovine brain.
Biochemistry. Biokhimiia.
2008 Sep; 73(9):1047-52. doi:
10.1134/s0006297908090137. [PMID: 18976223] - Jan K Hennigs, Nicole Burhenne, Frauke Stähler, Marcel Winnig, Bettina Walter, Wolfgang Meyerhof, Hartwig Schmale. Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo.
Journal of neurochemistry.
2008 Sep; 106(5):2249-62. doi:
10.1111/j.1471-4159.2008.05563.x. [PMID: 18627437] - N Kochanowski, F Blanchard, R Cacan, F Chirat, E Guedon, A Marc, J-L Goergen. Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon-gamma glycosylation during batch and fed-batch cultures of CHO cells.
Biotechnology and bioengineering.
2008 Jul; 100(4):721-33. doi:
10.1002/bit.21816. [PMID: 18496872] - Erin Knock, Liyuan Deng, Qing Wu, Andrea K Lawrance, Xiao-ling Wang, Rima Rozen. Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
The Journal of nutrition.
2008 Apr; 138(4):653-8. doi:
10.1093/jn/138.4.653. [PMID: 18356316] - Miho Oyasu, Mineko Fujimiya, Kaori Kashiwagi, Shiho Ohmori, Hirotsugu Imaeda, Naoaki Saito. Immunogold electron microscopic demonstration of distinct submembranous localization of the activated gammaPKC depending on the stimulation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2008 Mar; 56(3):253-65. doi:
10.1369/jhc.7a7291.2007. [PMID: 18040079] - Joost J B Keurentjes, Ronan Sulpice, Yves Gibon, Marie-Caroline Steinhauser, Jingyuan Fu, Maarten Koornneef, Mark Stitt, Dick Vreugdenhil. Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana.
Genome biology.
2008; 9(8):R129. doi:
10.1186/gb-2008-9-8-r129. [PMID: 18710526] - K Ross, G Parker, M Whitaker, N J Reynolds. Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes.
The British journal of dermatology.
2008 Jan; 158(1):31-7. doi:
10.1111/j.1365-2133.2007.08298.x. [PMID: 18028502] - Agnes B Renner, Kathrin Rieger, Detlef Grunow, Martin Zimmermann-Kordmann, Martin Gohlke, Werner Reutter. Liver-specific increase of UTP and UDP-sugar concentrations in rats induced by dietary vitamin B6-deficiency and its relation to complex N-glycan structures of liver membrane-proteins.
Glycoconjugate journal.
2007 Dec; 24(9):531-41. doi:
10.1007/s10719-007-9048-x. [PMID: 17577663] - Kehinde Ross, Michael Whitaker, Nick J Reynolds. Agonist-induced calcium entry correlates with STIM1 translocation.
Journal of cellular physiology.
2007 Jun; 211(3):569-76. doi:
10.1002/jcp.20993. [PMID: 17299780] - Yo Sugawara, Hiroko Nishii, Tomoko Takahashi, Junji Yamauchi, Norikazu Mizuno, Kenji Tago, Hiroshi Itoh. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase.
Cellular signalling.
2007 Jun; 19(6):1301-8. doi:
10.1016/j.cellsig.2007.01.012. [PMID: 17307333] - Anna Solini, Eleonora Santini, Daniele Chimenti, Paola Chiozzi, Federico Pratesi, Sabina Cuccato, Simonetta Falzoni, Roberto Lupi, Ele Ferrannini, Giuseppe Pugliese, Francesco Di Virgilio. Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1537-47. doi:
10.1152/ajprenal.00440.2006. [PMID: 17264311] - Kohsuke Sekine, Makoto Fujiwara, Masato Nakayama, Toshifumi Takao, Toshiharu Hase, Naoki Sato. DNA binding and partial nucleoid localization of the chloroplast stromal enzyme ferredoxin:sulfite reductase.
The FEBS journal.
2007 Apr; 274(8):2054-69. doi:
10.1111/j.1742-4658.2007.05748.x. [PMID: 17371503] - Andrei A Ivanov, Hyojin Ko, Liesbet Cosyn, Savitri Maddileti, Pedro Besada, Ingrid Fricks, Stefano Costanzi, T Kendall Harden, Serge Van Calenbergh, Kenneth A Jacobson. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
Journal of medicinal chemistry.
2007 Mar; 50(6):1166-76. doi:
10.1021/jm060903o. [PMID: 17302398] - Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, Xu Gang Xia. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.
International journal of biological sciences.
2007 Mar; 3(4):242-50. doi:
10.7150/ijbs.3.242. [PMID: 17389931] - S Klawitter, L P Hofmann, J Pfeilschifter, A Huwiler. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity.
British journal of pharmacology.
2007 Feb; 150(3):271-80. doi:
10.1038/sj.bjp.0706983. [PMID: 17200676] - Yuanyuan Zhang, Wei Li, Mary Vore. Translational regulation of rat multidrug resistance-associated protein 2 expression is mediated by upstream open reading frames in the 5' untranslated region.
Molecular pharmacology.
2007 Jan; 71(1):377-83. doi:
10.1124/mol.106.029793. [PMID: 17065236] - Srdjan M Vlajkovic, Carol J H Wang, Christian Soeller, Herbert Zimmermann, Peter R Thorne, Gary D Housley. Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells.
The international journal of biochemistry & cell biology.
2007; 39(4):810-7. doi:
10.1016/j.biocel.2007.01.003. [PMID: 17307380] - Jyothi Bhat, Rajendra Rane, Suresh M Solapure, Dhiman Sarkar, Umender Sharma, M N Harish, Sarah Lamb, Darren Plant, Peter Alcock, Steve Peters, Shubhada Barde, Raman K Roy. High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog.
Journal of biomolecular screening.
2006 Dec; 11(8):968-76. doi:
10.1177/1087057106291978. [PMID: 17021309] - Seung-Ryoung Jung, Kyungjin Kim, Bertil Hille, Toan D Nguyen, Duk-Su Koh. Pattern of Ca2+ increase determines the type of secretory mechanism activated in dog pancreatic duct epithelial cells.
The Journal of physiology.
2006 Oct; 576(Pt 1):163-78. doi:
10.1113/jphysiol.2006.114876. [PMID: 16857709] - Luca Ulianich, Maria Giovanna Elia, Antonella Sonia Treglia, Antonella Muscella, Bruno Di Jeso, Carlo Storelli, Santo Marsigliante. The sarcoplasmic-endoplasmic reticulum Ca2+ ATPase 2b regulates the Ca2+ transients elicited by P2Y2 activation in PC Cl3 thyroid cells.
The Journal of endocrinology.
2006 Sep; 190(3):641-9. doi:
10.1677/joe.1.06455. [PMID: 17003265] - I M Rusina, A F Makarchikov, E A Makar, V L Kubyshin. [Nucleoside-5'-triphosphate hydrolysis in the liver and kidney of rats with chronic alloxan diabetes].
Biomeditsinskaia khimiia.
2006 Jul; 52(4):364-9. doi:
NULL. [PMID: 17044594] - Hideki Aizaki, Keum S Choi, Minyi Liu, Yi-jia Li, Michael M C Lai. Polypyrimidine-tract-binding protein is a component of the HCV RNA replication complex and necessary for RNA synthesis.
Journal of biomedical science.
2006 Jul; 13(4):469-80. doi:
10.1007/s11373-006-9088-4. [PMID: 16691359] - Yuting Tang, Lubing Zhou, Joseph W Gunnet, Pamela G Wines, Ellen V Cryan, Keith T Demarest. Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A.
Biochemical and biophysical research communications.
2006 Jun; 345(1):29-37. doi:
10.1016/j.bbrc.2006.04.051. [PMID: 16674924] - Sonia Dorion, Daniel P Matton, Jean Rivoal. Characterization of a cytosolic nucleoside diphosphate kinase associated with cell division and growth in potato.
Planta.
2006 Jun; 224(1):108-24. doi:
10.1007/s00425-005-0199-3. [PMID: 16395585] - Anna-Karin Wihlborg, Johanna Balogh, Lingwei Wang, Catharina Borna, Ying Dou, Bhalchandra V Joshi, Eduardo Lazarowski, Kenneth A Jacobson, Anders Arner, David Erlinge. Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.
Circulation research.
2006 Apr; 98(7):970-6. doi:
10.1161/01.res.0000217402.73402.cd. [PMID: 16543499] - Kenneth A Jacobson, Stefano Costanzi, Andrei A Ivanov, Susanna Tchilibon, Pedro Besada, Zhan-Guo Gao, Savitri Maddileti, T Kendall Harden. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.
Biochemical pharmacology.
2006 Feb; 71(4):540-9. doi:
10.1016/j.bcp.2005.11.010. [PMID: 16359641] - You-Tzung Chen, Akio Kobayashi, Kin Ming Kwan, Randy L Johnson, Richard R Behringer. Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice.
BMC nephrology.
2006 Feb; 7(?):1. doi:
10.1186/1471-2369-7-1. [PMID: 16464245] - Mercedes Montiel, Enrique Pérez de la Blanca, Eugenio Jiménez. P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2006; 18(1-3):123-34. doi:
10.1159/000095180. [PMID: 16914897] - Liaman Mamedova, Valérie Capra, Maria Rosa Accomazzo, Zhan-Guo Gao, Silvia Ferrario, Marta Fumagalli, Maria P Abbracchio, G Enrico Rovati, Kenneth A Jacobson. CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Biochemical pharmacology.
2005 Dec; 71(1-2):115-25. doi:
10.1016/j.bcp.2005.10.003. [PMID: 16280122]