Palmityl-CoA (BioDeep_00000004146)

 

Secondary id: BioDeep_00000630343, BioDeep_00001868767

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid

化学式: C37H66N7O17P3S (1005.3448576)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 5.95%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C37H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/t26-,30-,31-,32+,36-/m1/s1



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(1)

PlantCyc(0)

代谢反应

2495 个相关的代谢反应过程信息。

Reactome(37)

BioCyc(3)

WikiPathways(14)

Plant Reactome(243)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2198)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • M Kerr, K M J H Dennis, C A Carr, W Fuller, G Berridge, S Rohling, C L Aitken, C Lopez, R Fischer, J J Miller, K Clarke, D J Tyler, L C Heather. Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 08; 35(8):e21765. doi: 10.1096/fj.202100394r. [PMID: 34318967]
  • Henver S Brunetta, Heather L Petrick, Bayley Vachon, Everson A Nunes, Graham P Holloway. Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. The Biochemical journal. 2021 07; 478(13):2539-2553. doi: 10.1042/bcj20210264. [PMID: 34129667]
  • Lucas M O'Neill, Chang-An Guo, Fang Ding, Yar Xin Phang, Zhaojin Liu, Sohel Shamsuzzaman, James M Ntambi. Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease. International journal of molecular sciences. 2020 Nov; 21(22):. doi: 10.3390/ijms21228619. [PMID: 33207603]
  • Xiaolei Pan, Zheng Fan, Lei Chen, Chang Liu, Fang Bai, Yu Wei, Zhenyang Tian, Yuanyuan Dong, Jing Shi, Hao Chen, Yongxin Jin, Zhihui Cheng, Shouguang Jin, Jianping Lin, Weihui Wu. PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids. Nucleic acids research. 2020 06; 48(11):5967-5985. doi: 10.1093/nar/gkaa377. [PMID: 32406921]
  • Pierre-Emmanuel Tardo-Dino, Julianne Touron, Stéphane Baugé, Stéphanie Bourdon, Nathalie Koulmann, Alexandra Malgoyre. The effect of a physiological increase in temperature on mitochondrial fatty acid oxidation in rat myofibers. Journal of applied physiology (Bethesda, Md. : 1985). 2019 08; 127(2):312-319. doi: 10.1152/japplphysiol.00652.2018. [PMID: 31161881]
  • James John Asciolla, Kalpana Rajanala, Marilyn D Resh. In Vitro Analysis of Hedgehog Acyltransferase and Porcupine Fatty Acyltransferase Activities. Methods in molecular biology (Clifton, N.J.). 2019; 2009(?):243-255. doi: 10.1007/978-1-4939-9532-5_19. [PMID: 31152409]
  • Carine Lindquist, Bodil Bjørndal, Hege G Bakke, Grete Slettom, Marie Karoliussen, Arild C Rustan, G Hege Thoresen, Jon Skorve, Ottar K Nygård, Rolf Kristian Berge. A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats. PloS one. 2019; 14(9):e0222558. doi: 10.1371/journal.pone.0222558. [PMID: 31550253]
  • Sonia Cortassa, Steven J Sollott, Miguel A Aon. Mitochondrial respiration and ROS emission during β-oxidation in the heart: An experimental-computational study. PLoS computational biology. 2017 Jun; 13(6):e1005588. doi: 10.1371/journal.pcbi.1005588. [PMID: 28598967]
  • Paula M Miotto, Gregory R Steinberg, Graham P Holloway. Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise. The Biochemical journal. 2017 02; 474(4):557-569. doi: 10.1042/bcj20160913. [PMID: 27941154]
  • Rongsui Gao, Defeng Li, Yuan Lin, Jingxia Lin, Xiaoyun Xia, Hui Wang, Lijun Bi, Jun Zhu, Bachar Hassan, Shihua Wang, Youjun Feng. Structural and Functional Characterization of the FadR Regulatory Protein from Vibrio alginolyticus. Frontiers in cellular and infection microbiology. 2017; 7(?):513. doi: 10.3389/fcimb.2017.00513. [PMID: 29312893]
  • Melissa K Ritchie, Lynnette C Johnson, Jill E Clodfelter, Charles W Pemble, Brian E Fulp, Cristina M Furdui, Steven J Kridel, W Todd Lowther. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. The Journal of biological chemistry. 2016 Feb; 291(7):3520-30. doi: 10.1074/jbc.m115.702597. [PMID: 26663084]
  • Eric Soupene, Joseph Kao, Daniel H Cheng, Derek Wang, Alexander L Greninger, Giselle M Knudsen, Joseph L DeRisi, Frans A Kuypers. Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA. Journal of lipid research. 2016 Feb; 57(2):288-98. doi: 10.1194/jlr.m065003. [PMID: 26621918]
  • David R Colquhoun, Alexey E Lyashkov, Ceereena Ubaida Mohien, Veronica N Aquino, Brandon T Bullock, Rhoel R Dinglasan, Brian J Agnew, David R M Graham. Bioorthogonal mimetics of palmitoyl-CoA and myristoyl-CoA and their subsequent isolation by click chemistry and characterization by mass spectrometry reveal novel acylated host-proteins modified by HIV-1 infection. Proteomics. 2015 Jun; 15(12):2066-77. doi: 10.1002/pmic.201500063. [PMID: 25914232]
  • Demidmaa Tuvdendorj, Xiao-jun Zhang, David L Chinkes, Lijian Wang, Zhanpin Wu, Noe A Rodriguez, David N Herndon, Robert R Wolfe. Triglycerides produced in the livers of fasting rabbits are predominantly stored as opposed to secreted into the plasma. Metabolism: clinical and experimental. 2015 May; 64(5):580-7. doi: 10.1016/j.metabol.2015.01.002. [PMID: 25682063]
  • Jessica Seeßle, Gerhard Liebisch, Gerd Schmitz, Wolfgang Stremmel, Walee Chamulitrat. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochimica et biophysica acta. 2015 May; 1851(5):549-65. doi: 10.1016/j.bbalip.2015.01.004. [PMID: 25603556]
  • Andrew J Worth, Sankha S Basu, Nathaniel W Snyder, Clementina Mesaros, Ian A Blair. Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels. The Journal of biological chemistry. 2014 Sep; 289(39):26895-26903. doi: 10.1074/jbc.m114.591354. [PMID: 25122772]
  • Franziska Dittrich-Domergue, Jérôme Joubès, Patrick Moreau, René Lessire, Sten Stymne, Frédéric Domergue. The bifunctional protein TtFARAT from Tetrahymena thermophila catalyzes the formation of both precursors required to initiate ether lipid biosynthesis. The Journal of biological chemistry. 2014 Aug; 289(32):21984-94. doi: 10.1074/jbc.m114.579318. [PMID: 24917677]
  • Marie-Soleil Beaudoin, Christopher G R Perry, Alicia M Arkell, Adrian Chabowski, Jeremy A Simpson, David C Wright, Graham P Holloway. Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats. The Journal of physiology. 2014 Jun; 592(12):2519-33. doi: 10.1113/jphysiol.2013.270538. [PMID: 24639481]
  • Madhumitha Balanarasimha, Andrea M Davis, Frances L Soman, S Dean Rider, Heather A Hostetler. Ligand-regulated heterodimerization of peroxisome proliferator-activated receptor α with liver X receptor α. Biochemistry. 2014 Apr; 53(16):2632-43. doi: 10.1021/bi401679y. [PMID: 24713062]
  • Janos Kerner, Paul E Minkler, Edward J Lesnefsky, Charles L Hoppel. Fatty acid chain elongation in palmitate-perfused working rat heart: mitochondrial acetyl-CoA is the source of two-carbon units for chain elongation. The Journal of biological chemistry. 2014 Apr; 289(14):10223-34. doi: 10.1074/jbc.m113.524314. [PMID: 24558043]
  • Yi Yu, Chris R J Carter, Nermeen Youssef, Jason R B Dyck, Peter E Light. Intracellular long-chain acyl CoAs activate TRPV1 channels. PloS one. 2014; 9(5):e96597. doi: 10.1371/journal.pone.0096597. [PMID: 24798548]
  • Sarah Brice Russo, Rotem Tidhar, Anthony H Futerman, L Ashley Cowart. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. The Journal of biological chemistry. 2013 May; 288(19):13397-409. doi: 10.1074/jbc.m112.428185. [PMID: 23530041]
  • E Alefishat, S P H Alexander, V Ralevic. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate. British journal of pharmacology. 2013 Apr; 168(8):1911-22. doi: 10.1111/bph.12086. [PMID: 23215951]
  • Xiao-jun Zhang, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Noe A Rodriguez, David N Herndon, Robert R Wolfe. Acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis. Metabolism: clinical and experimental. 2013 Jan; 62(1):44-51. doi: 10.1016/j.metabol.2012.06.002. [PMID: 22898252]
  • Sung Ho Moon, Christopher M Jenkins, Michael A Kiebish, Harold F Sims, David J Mancuso, Richard W Gross. Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release. The Journal of biological chemistry. 2012 Aug; 287(35):29837-50. doi: 10.1074/jbc.m112.373654. [PMID: 22778252]
  • Benjamin C Jennings, Maurine E Linder. DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities. The Journal of biological chemistry. 2012 Mar; 287(10):7236-45. doi: 10.1074/jbc.m111.337246. [PMID: 22247542]
  • Xiao-Jun Zhang, Noe A Rodriguez, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Alai Tan, David N Herndon, Robert R Wolfe. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. Journal of lipid research. 2012 Jan; 53(1):119-25. doi: 10.1194/jlr.m019901. [PMID: 21934122]
  • Eri Oyanagi, Hiromi Yano, Masataka Uchida, Kozo Utsumi, Junzo Sasaki. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acid stress. Biochemical and biophysical research communications. 2011 Aug; 412(1):61-7. doi: 10.1016/j.bbrc.2011.07.039. [PMID: 21791201]
  • Christopher A Haynes, Jeremy C Allegood, Elaine W Wang, Samuel L Kelly, M Cameron Sullards, Alfred H Merrill. Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry. Journal of lipid research. 2011 Aug; 52(8):1583-94. doi: 10.1194/jlr.d015586. [PMID: 21586681]
  • Sergei A Novgorodov, Bill X Wu, Tatyana I Gudz, Jacek Bielawski, Tatiana V Ovchinnikova, Yusuf A Hannun, Lina M Obeid. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. The Journal of biological chemistry. 2011 Jul; 286(28):25352-62. doi: 10.1074/jbc.m110.214866. [PMID: 21613224]
  • Christopher M Jenkins, Jingyue Yang, Harold F Sims, Richard W Gross. Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism. The Journal of biological chemistry. 2011 Apr; 286(14):11937-50. doi: 10.1074/jbc.m110.203661. [PMID: 21258134]
  • Natasha H Banke, Adam R Wende, Teresa C Leone, J Michael O'Donnell, E Dale Abel, Daniel P Kelly, E Douglas Lewandowski. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circulation research. 2010 Jul; 107(2):233-41. doi: 10.1161/circresaha.110.221713. [PMID: 20522803]
  • Xiao-jun Zhang, David L Chinkes, Zhanpin Wu, David N Herndon, Robert R Wolfe. The synthetic rate of muscle triglyceride but not phospholipid is increased in obese rabbits. Metabolism: clinical and experimental. 2009 Nov; 58(11):1649-56. doi: 10.1016/j.metabol.2009.05.021. [PMID: 19608209]
  • Seigo Korematsu, Yujiro Kosugi, Toshihide Kumamoto, Seiji Yamaguchi, Tatsuro Izumi. Novel mutation of early, perinatal-onset, myopathic-type very-long-chain acyl-CoA dehydrogenase deficiency. Pediatric neurology. 2009 Aug; 41(2):151-3. doi: 10.1016/j.pediatrneurol.2009.02.020. [PMID: 19589468]
  • Markus F Rütti, Stéphane Richard, Anke Penno, Arnold von Eckardstein, Thorsten Hornemann. An improved method to determine serine palmitoyltransferase activity. Journal of lipid research. 2009 Jun; 50(6):1237-44. doi: 10.1194/jlr.d900001-jlr200. [PMID: 19181628]
  • Go Tajima, Nobuo Sakura, Kenichiro Shirao, Satoshi Okada, Miyuki Tsumura, Yutaka Nishimura, Hiroaki Ono, Yuki Hasegawa, Ikue Hata, Etsuo Naito, Seiji Yamaguchi, Yosuke Shigematsu, Masao Kobayashi. Development of a new enzymatic diagnosis method for very-long-chain Acyl-CoA dehydrogenase deficiency by detecting 2-hexadecenoyl-CoA production and its application in tandem mass spectrometry-based selective screening and newborn screening in Japan. Pediatric research. 2008 Dec; 64(6):667-72. doi: 10.1203/pdr.0b013e318187cc44. [PMID: 18670371]
  • Heather A Hostetler, Lindsay R Syler, Lindy N Hall, Guan Zhu, Friedhelm Schroeder, Ann B Kier. A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. Journal of biomolecular screening. 2008 Oct; 13(9):855-61. doi: 10.1177/1087057108323127. [PMID: 18812576]
  • Muhammad A Abdul-Ghani, Florian L Muller, Yuhong Liu, Alberto O Chavez, Bogdan Balas, Pengou Zuo, Zhi Chang, Devjit Tripathy, Rucha Jani, Marjorie Molina-Carrion, Adriana Monroy, Franco Folli, Holly Van Remmen, Ralph A DeFronzo. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. American journal of physiology. Endocrinology and metabolism. 2008 Sep; 295(3):E678-85. doi: 10.1152/ajpendo.90287.2008. [PMID: 18593850]
  • Rob Stierum, Ana Conesa, Wilbert Heijne, Ben van Ommen, Karin Junker, Mary P Scott, Roger J Price, Clive Meredith, Brian G Lake, John Groten. Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Aug; 46(8):2616-28. doi: 10.1016/j.fct.2008.04.019. [PMID: 18539377]
  • Hiromutsu Tominaga, Hideki Katoh, Keiichi Odagiri, Yasuyo Takeuchi, Hirotaka Kawashima, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh, Hideharu Hayashi. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 2008 Jul; 295(1):H105-12. doi: 10.1152/ajpheart.01307.2007. [PMID: 18469143]
  • Sonja Primassin, Frank Ter Veld, Ertan Mayatepek, Ute Spiekerkoetter. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. Pediatric research. 2008 Jun; 63(6):632-7. doi: 10.1203/pdr.0b013e31816ff6f0. [PMID: 18317232]
  • Diego F G Vallejo, J Raúl Grigera, Marcelo D Costabel. A hydrophobic loop in acyl-CoA binding protein is functionally important for binding to palmitoyl-coenzyme A: a molecular dynamics study. International journal of biological macromolecules. 2008 Apr; 42(3):271-7. doi: 10.1016/j.ijbiomac.2007.12.003. [PMID: 18242688]
  • Ellen Aasum, Ahmed Murtaz Khalid, Oddrun Anita Gudbrandsen, Ole-Jakob How, Rolf K Berge, Terje S Larsen. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. Journal of molecular and cellular cardiology. 2008 Jan; 44(1):201-9. doi: 10.1016/j.yjmcc.2007.08.020. [PMID: 17931655]
  • David M Selva, Kevin N Hogeveen, Sheila M Innis, Geoffrey L Hammond. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. The Journal of clinical investigation. 2007 Dec; 117(12):3979-87. doi: 10.1172/jci32249. [PMID: 17992261]
  • Olga Jáuregui, Adriana Y Sierra, Patricia Carrasco, Esther Gratacós, Fausto G Hegardt, Núria Casals. A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells. Analytica chimica acta. 2007 Sep; 599(1):1-6. doi: 10.1016/j.aca.2007.07.066. [PMID: 17765057]
  • C Cowles, A Mally, J K Chipman. Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. Toxicology. 2007 Aug; 238(1):49-59. doi: 10.1016/j.tox.2007.05.027. [PMID: 17624652]
  • Tomoaki Toyama, Naomi Kudo, Yasuhide Hibino, Atsushi Mitsumoto, Masazumi Nishikawa, Yoichi Kawashima. Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats. Journal of pharmacological sciences. 2007 Jun; 104(2):137-45. doi: 10.1254/jphs.fp0060997. [PMID: 17538229]
  • S Wein, J Ukropec, D Gasperíková, I Klimes, E Seböková. Concerted action of leptin in regulation of fatty acid oxidation in skeletal muscle and liver. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2007 Apr; 115(4):244-51. doi: 10.1055/s-2007-956166. [PMID: 17479441]
  • Clinton R Bruce, Camilla Brolin, Nigel Turner, Mark E Cleasby, Feike R van der Leij, Gregory J Cooney, Edward W Kraegen. Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. American journal of physiology. Endocrinology and metabolism. 2007 Apr; 292(4):E1231-7. doi: 10.1152/ajpendo.00561.2006. [PMID: 17179390]
  • Sarah M Turpin, Graeme I Lancaster, Ian Darby, Mark A Febbraio, Matthew J Watt. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. American journal of physiology. Endocrinology and metabolism. 2006 Dec; 291(6):E1341-50. doi: 10.1152/ajpendo.00095.2006. [PMID: 16849630]
  • Michaela Liebig, Ina Schymik, Martina Mueller, Udo Wendel, Ertan Mayatepek, Jos Ruiter, Arnold W Strauss, Ronald J A Wanders, Ute Spiekerkoetter. Neonatal screening for very long-chain acyl-coA dehydrogenase deficiency: enzymatic and molecular evaluation of neonates with elevated C14:1-carnitine levels. Pediatrics. 2006 Sep; 118(3):1065-9. doi: 10.1542/peds.2006-0666. [PMID: 16950999]
  • Bin Zeng, Xiaomin Cai, Guan Zhu. Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum. Microbiology (Reading, England). 2006 Aug; 152(Pt 8):2355-2363. doi: 10.1099/mic.0.28944-0. [PMID: 16849800]
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  • Jingyue Yang, Beverly Gibson, Jacqueline Snider, Christopher M Jenkins, Xianlin Han, Richard W Gross. Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance. Biochemistry. 2005 Sep; 44(35):11903-12. doi: 10.1021/bi0508082. [PMID: 16128592]
  • D S Rubink, W W Winder. Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase. Journal of applied physiology (Bethesda, Md. : 1985). 2005 Apr; 98(4):1221-7. doi: 10.1152/japplphysiol.00621.2004. [PMID: 15579580]
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  • Charlotta S Olofsson, Albert Salehi, Cecilia Holm, Patrik Rorsman. Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. The Journal of physiology. 2004 Jun; 557(Pt 3):935-48. doi: 10.1113/jphysiol.2004.066258. [PMID: 15090611]
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