2'-Hydroxygenistein (BioDeep_00000004134)

 

Secondary id: BioDeep_00000270323, BioDeep_00000396351

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, 9CI

化学式: C15H10O6 (286.0477)
中文名称: 2-羟基金雀异黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 19.04%

Reviewed

Last reviewed on 2024-08-06.

Cite this Page

2'-Hydroxygenistein. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2_-hydroxygenistein (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000004134). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(cc(c2c(c1)occ(c2=O)c1c(cc(cc1)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-7-1-2-9(11(18)3-7)10-6-21-13-5-8(17)4-12(19)14(13)15(10)20/h1-6,16-19H

描述信息

Isolated from Cajanus cajan (pigeon pea), Dolichos biflorus (papadi), Lablab niger (hyacinth bean), Phaseolus vulgaris (kidney bean) and Phaseolus coccineus (scarlet runner bean). 2-Hydroxygenistein is found in many foods, some of which are pulses, walnut, saskatoon berry, and garden tomato (variety).
2-Hydroxygenistein is found in adzuki bean. 2-Hydroxygenistein is isolated from Cajanus cajan (pigeon pea), Dolichos biflorus (papadi), Lablab niger (hyacinth bean), Phaseolus vulgaris (kidney bean) and Phaseolus coccineus (scarlet runner bean).

同义名列表

8 个代谢物同义名

3-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, 9CI; 3-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; 3-(2,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one; 5,7,2,4-Tetrahydroxy-isoflavone; 2,4,5,7-Tetrahydroxy-Isoflavone; 2,4,5,7-Tetrahydroxyisoflavone; 2-Hydroxygenistein; 2'-Hydroxygenistein



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

101 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AHR, AIMP2, AR, ESR1, FDPS, FPR1, MAPK8, TUBB4B
Peripheral membrane protein 3 ESR1, GORASP1, HSD17B6
Nucleus 6 AHR, AIMP2, AR, ESR1, MAPK8, TUBB4B
cytosol 7 AHR, AIMP2, AR, ESR1, FDPS, MAPK8, TUBB4B
nucleoplasm 5 AHR, AR, ESR1, FDPS, MAPK8
Cell membrane 3 ESR1, FPR1, TNF
Cytoplasmic side 2 ESR1, GORASP1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 FPR1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 1 TNF
Golgi apparatus 2 ESR1, GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 GAA
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 AIMP2
Lysosome 1 GAA
plasma membrane 6 AR, ESR1, FPR1, GAA, IFNLR1, TNF
Membrane 7 AIMP2, AR, ESR1, FDPS, FPR1, GAA, IFNLR1
axon 1 MAPK8
extracellular exosome 4 BMP3, GAA, LYZ, TUBB4B
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 3 BMP3, LYZ, TNF
lysosomal lumen 1 GAA
protein-containing complex 3 AHR, AR, ESR1
intracellular membrane-bounded organelle 2 GAA, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 IFNLR1
Secreted 2 BMP3, GAA
extracellular region 5 BMP3, GAA, LYZ, TNF, TUBB4B
mitochondrial matrix 1 FDPS
transcription regulator complex 2 AHR, ESR1
external side of plasma membrane 1 TNF
Extracellular vesicle 1 TUBB4B
microtubule cytoskeleton 1 TUBB4B
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
cis-Golgi network 1 GORASP1
Peroxisome 1 FDPS
nuclear speck 1 AR
chromatin 3 AHR, AR, ESR1
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
aryl hydrocarbon receptor complex 1 AHR
tertiary granule membrane 1 GAA
euchromatin 1 ESR1
secretory granule membrane 1 FPR1
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule membrane 2 FPR1, GAA
azurophil granule lumen 2 LYZ, TUBB4B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 1]: Nucleus 1 ESR1
ficolin-1-rich granule membrane 2 FPR1, GAA
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Young Hye Seo, Ju-Hyun Jeon, Miran Jeong, Seung Mok Ryu, Won Kyung Jeon, Dae Sik Jang, Sang Hee Shim, Dongho Lee, Jung-Hye Choi, Jun Lee. Chemical Constituents of Apios americana Tubers and Their Inhibitory Activities on Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Journal of natural products. 2018 07; 81(7):1598-1603. doi: 10.1021/acs.jnatprod.8b00182. [PMID: 29932657]
  • Guoan Shen, David Huhman, Zhentian Lei, John Snyder, Lloyd W Sumner, Richard A Dixon. Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus. Plant physiology. 2012 May; 159(1):70-80. doi: 10.1104/pp.112.195271. [PMID: 22430842]
  • Maurice Ducret Awouafack, Peter Spiteller, Marc Lamshöft, Souvik Kusari, Bojidarka Ivanova, Pierre Tane, Michael Spiteller. Antimicrobial isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora. Journal of natural products. 2011 Feb; 74(2):272-8. doi: 10.1021/np1005218. [PMID: 21265557]
  • Sylwia Pawlak-Sprada, Maciej Stobiecki, Joanna Deckert. Activation of phenylpropanoid pathway in legume plants exposed to heavy metals. Part II. Profiling of isoflavonoids and their glycoconjugates induced in roots of lupine (Lupinus luteus) seedlings treated with cadmium and lead. Acta biochimica Polonica. 2011; 58(2):217-23. doi: . [PMID: 21503277]
  • Maciej Stobiecki, Anna Staszków, Anna Piasecka, Pedro M Garcia-Lopez, Francisco Zamora-Natera, Piotr Kachlicki. LC-MSMS profiling of flavonoid conjugates in wild Mexican lupine, Lupinus reflexus. Journal of natural products. 2010 Jul; 73(7):1254-60. doi: 10.1021/np100139d. [PMID: 20568784]
  • Li-Wen Chen, Ming-Jen Cheng, Chien-Fang Peng, Ih-Sheng Chen. Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. Chemistry & biodiversity. 2010 Jul; 7(7):1814-21. doi: 10.1002/cbdv.200900227. [PMID: 20658670]
  • Swati Madan, Gyanendra Nath Singh, Kanchan Kohli, Mohammed Ali, Yatendra Kumar, Raman Mohan Singh, Om Prakash. Isoflavonoids from Flemingia strobilifera (L) R. Br. roots. Acta poloniae pharmaceutica. 2009 May; 66(3):297-303. doi: ". [PMID: 19645330]
  • Li Tian, Gregory J Peel, Zhentian Lei, Naveed Aziz, Xinbin Dai, Ji He, Bonnie Watson, Patrick X Zhao, Lloyd W Sumner, Richard A Dixon. Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. BMC plant biology. 2009 Jan; 9(?):1. doi: 10.1186/1471-2229-9-1. [PMID: 19123941]
  • Ting Yin, Hua Liu, Bin Wang, Guang-Zhong Tu, Hong Liang, Yu-Ying Zhao. [Chemical constituents from Spatholobus sinensis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Jan; 43(1):67-70. doi: . [PMID: 18357735]
  • Cheryl Lans. Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. Journal of ethnobiology and ethnomedicine. 2007 Jan; 3(?):3. doi: 10.1186/1746-4269-3-3. [PMID: 17207273]
  • P M García-López, P Kachlicki, F Zamora-Natera, J Ruiz-Moreno, M Stobiecki. Profiling isoflavone conjugates in different organs of Lupinus exaltatus Zucc. Phytochemical analysis : PCA. 2006 May; 17(3):184-91. doi: 10.1002/pca.904. [PMID: 16749426]
  • Piotr Kachlicki, Lukasz Marczak, Lucien Kerhoas, Jacques Einhorn, Maciej Stobiecki. Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. Journal of mass spectrometry : JMS. 2005 Aug; 40(8):1088-103. doi: 10.1002/jms.884. [PMID: 15971291]
  • Hun Sung Yoo, Ji Suk Lee, Chul Young Kim, Jinwoong Kim. Flavonoids of Crotalaria sessiliflora. Archives of pharmacal research. 2004 May; 27(5):544-6. doi: 10.1007/bf02980129. [PMID: 15202561]
  • Horng-Huey Ko, Jing-Ru Weng, Lo-Ti Tsao, Ming-Hong Yen, Jih-Pyang Wang, Chun-Nan Lin. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. Bioorganic & medicinal chemistry letters. 2004 Feb; 14(4):1011-4. doi: 10.1016/j.bmcl.2003.11.074. [PMID: 15013012]
  • George Duker-Eshun, Jerzy W Jaroszewski, William A Asomaning, Francis Oppong-Boachie, S Brøgger Christensen. Antiplasmodial constituents of Cajanus cajan. Phytotherapy research : PTR. 2004 Feb; 18(2):128-30. doi: 10.1002/ptr.1375. [PMID: 15022164]
  • P Bednarek, L Kerhoas, J Einhorn, R Frański, P Wojtaszek, M Rybus-Zajac, M Stobiecki. Profiling of flavonoid conjugates in Lupinus albus and Lupinus angustifolius responding to biotic and abiotic stimuli. Journal of chemical ecology. 2003 May; 29(5):1127-42. doi: 10.1023/a:1023877422403. [PMID: 12857026]