beta-tocotrienol (BioDeep_00000004130)

Main id: BioDeep_00000019372

 

human metabolite natural product


代谢物信息卡片


(2R)-2,5,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol

化学式: C28H42O2 (410.3185)
中文名称: 生育三烯酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=CCC/C(C)=C/CC/C(C)=C/CC[C@]1(C)CCc2c(C)c(O)cc(C)c2O1
InChI: InChI=1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-24(6)26(29)19-23(5)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1

描述信息

同义名列表

11 个代谢物同义名

(2R)-2,5,8-Trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol; (2R)-3,4-dihydro-2,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2R,5,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol; epsilon-tocopherol; Tocotrienol, beta; beta-tocotrienol; β tocotrienol; b-Tocotrienol; Β-tocotrienol; e-Tokoferol; beta-Tocotrienol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

78 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(76)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABI3, APOE, BCL2, CASP3, CASP8, CDKN2A, CFLAR, GSK3A, GSK3B, JAK2, PIK3CA, SGCA, SIRT1, STAT3
Peripheral membrane protein 1 JAK2
Endoplasmic reticulum membrane 2 BCL2, RAB18
Nucleus 10 APOE, BCL2, CASP3, CASP8, CDKN2A, GSK3A, GSK3B, JAK2, SIRT1, STAT3
cytosol 12 BCL2, CASP3, CASP8, CDKN2A, CFLAR, GSK3A, GSK3B, JAK2, PIK3CA, RAB18, SIRT1, STAT3
dendrite 2 APOE, GSK3B
centrosome 1 GSK3B
nucleoplasm 7 CASP3, CASP8, CDKN2A, GSK3B, JAK2, SIRT1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 1 GSK3B
Lipid-anchor 1 RAB18
Cytoplasmic side 1 RAB18
lamellipodium 3 ABI3, CASP8, PIK3CA
Golgi apparatus membrane 1 RAB18
dendritic shaft 1 ABI3
glutamatergic synapse 5 ABI3, APOE, CASP3, GSK3B, JAK2
Golgi apparatus 2 APOE, RAB18
Golgi membrane 2 INS, RAB18
neuronal cell body 3 APOE, CASP3, GSK3A
postsynapse 3 GSK3A, GSK3B, JAK2
sarcolemma 1 SGCA
Presynapse 1 GSK3B
plasma membrane 6 APOE, GSK3B, JAK2, PIK3CA, RAB18, STAT3
Membrane 5 ABI3, APOE, BCL2, JAK2, SGCA
apical plasma membrane 1 RAB18
axon 2 GSK3A, GSK3B
caveola 1 JAK2
extracellular exosome 1 APOE
endoplasmic reticulum 2 APOE, BCL2
extracellular space 2 APOE, INS
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 6 BCL2, CASP8, CDKN2A, GSK3A, GSK3B, SIRT1
protein-containing complex 3 BCL2, CASP8, CDKN2A
postsynaptic density 2 ABI3, CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 SGCA
Secreted 2 APOE, INS
extracellular region 2 APOE, INS
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, SGCA
mitochondrial outer membrane 2 BCL2, CASP8
mitochondrial matrix 1 CDKN2A
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 ABI3
beta-catenin destruction complex 2 GSK3A, GSK3B
nucleolus 2 CDKN2A, SIRT1
Wnt signalosome 1 GSK3B
Early endosome 1 APOE
cell-cell junction 1 SGCA
Apical cell membrane 1 RAB18
Cell membrane, sarcolemma 1 SGCA
Cell projection, lamellipodium 1 CASP8
heterochromatin 1 SIRT1
Membrane raft 2 JAK2, SGCA
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 SGCA
focal adhesion 1 JAK2
extracellular matrix 1 APOE
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 1 APOE
nuclear inner membrane 1 SIRT1
chromatin 2 SIRT1, STAT3
Cytoplasmic vesicle, autophagosome membrane 1 RAB18
autophagosome membrane 1 RAB18
cytoskeleton 3 CASP8, JAK2, SGCA
Secreted, extracellular space 1 APOE
Nucleus, nucleolus 1 CDKN2A
blood microparticle 1 APOE
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 2 JAK2, RAB18
endosome lumen 2 INS, JAK2
Lipid droplet 1 RAB18
Nucleus, nucleoplasm 1 CDKN2A
Melanosome 1 APOE
euchromatin 2 JAK2, SIRT1
cell body 1 CASP8
myelin sheath 1 BCL2
secretory granule lumen 1 INS
secretory granule membrane 1 RAB18
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 APOE, INS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 INS, RAB18
clathrin-coated endocytic vesicle membrane 1 APOE
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 APOE
apical dendrite 1 GSK3A
CD95 death-inducing signaling complex 2 CASP8, CFLAR
death-inducing signaling complex 3 CASP3, CASP8, CFLAR
ripoptosome 2 CASP8, CFLAR
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
dystrophin-associated glycoprotein complex 1 SGCA
sarcoglycan complex 1 SGCA
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
BAD-BCL-2 complex 1 BCL2
proximal dendrite 1 GSK3A
senescence-associated heterochromatin focus 1 CDKN2A
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
SCAR complex 1 ABI3
endoplasmic reticulum tubular network 1 RAB18
actin-based cell projection 1 ABI3
[Isoform smARF]: Mitochondrion 1 CDKN2A
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Emily J Watts, Yu Shen, Ephraim P Lansky, Eviatar Nevo, Gerd Bobe, Maret G Traber. High environmental stress yields greater tocotrienol content while changing vitamin e profiles of wild emmer wheat seeds. Journal of medicinal food. 2015 Feb; 18(2):216-23. doi: 10.1089/jmf.2014.0017. [PMID: 25105230]
  • Kazuo Mukai, Eri Ishikawa, Aya Ouchi, Shin-Ichi Nagaoka, Tomomi Suzuki, Katsuhiro Izumisawa, Taisuke Koike. Kinetic study of the quenching reaction of singlet oxygen by α-, β-, γ-, δ-tocotrienols, and palm oil and soybean extracts in solution. Bioscience, biotechnology, and biochemistry. 2014; 78(12):2089-101. doi: 10.1080/09168451.2014.943653. [PMID: 25093256]
  • Chisato Abe, Saiko Ikeda, Tomono Uchida, Kanae Yamashita, Tomio Ichikawa. Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. The Journal of nutrition. 2007 Feb; 137(2):345-50. doi: 10.1093/jn/137.2.345. [PMID: 17237309]
  • H Nakamura, F Furukawa, A Nishikawa, M Miyauchi, H Y Son, T Imazawa, M Hirose. Oral toxicity of a tocotrienol preparation in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2001 Aug; 39(8):799-805. doi: 10.1016/s0278-6915(01)00025-4. [PMID: 11434987]
  • T M Black, P Wang, N Maeda, R A Coleman. Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. The Journal of nutrition. 2000 Oct; 130(10):2420-6. doi: 10.1093/jn/130.10.2420. [PMID: 11015467]
  • E Katsanidis, P B Addis. Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. Free radical biology & medicine. 1999 Dec; 27(11-12):1137-40. doi: 10.1016/s0891-5849(99)00205-1. [PMID: 10641704]
  • V Piironen, P Varo, E L Syväoja, K Salminen, P Koivistoinen. High-performance liquid chromatographic determination of tocopherols and tocotrienols and its application to diets and plasma of Finnish men. I. Analytical method. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1984; 54(1):35-40. doi: . [PMID: 6735614]