Etidocaine (BioDeep_00000408876)
Main id: BioDeep_00000002762
代谢物信息卡片
Etidocaine
化学式: C17H28N2O (276.2201518)
中文名称: 益替多咔因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN(CC)C(CC)C(=O)Nc(c(C)1)c(C)ccc1
InChI: InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:4904
- KEGG: C07530
- KEGGdrug: D04095
- PubChem: 37497
- DrugBank: DB08987
- ChEMBL: CHEMBL492
- MeSH: Etidocaine
- CAS: 36637-18-0
- CAS: 38188-41-9
- CAS: 60108-68-1
- CAS: 38188-42-0
- MoNA: WA001638
- MoNA: WA001637
- MoNA: WA001636
- MoNA: WA001635
- PubChem: 9733
- NIKKAJI: J369.232I
- RefMet: Etidocaine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juliana Damasceno Oliveira, Gustavo Henrique Rodrigues da Silva, Ludmila David de Moura, Gabriela Göethel, Juliana Z B Papini, Bruna Renata Casadei, Ligia Nunes de Morais Ribeiro, Luis Fernando Cabeça, Solange Cristina Garcia, Elizabeth Ferreira Martinez, Giovana Radomille Tofoli, Eneida de Paula. DoE development of ionic gradient liposomes: A successful approach to improve encapsulation, prolong anesthesia and decrease the toxicity of etidocaine.
International journal of pharmaceutics.
2023 Mar; 634(?):122672. doi:
10.1016/j.ijpharm.2023.122672. [PMID: 36738810] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Sarah Ciechanowicz, Vinod Patil. Lipid emulsion for local anesthetic systemic toxicity.
Anesthesiology research and practice.
2012; 2012(?):131784. doi:
10.1155/2012/131784. [PMID: 21969824] - Leelach Rothschild, Sarah Bern, Sarah Oswald, Guy Weinberg. Intravenous lipid emulsion in clinical toxicology.
Scandinavian journal of trauma, resuscitation and emergency medicine.
2010 Oct; 18(?):51. doi:
10.1186/1757-7241-18-51. [PMID: 20923546] - Cynthia A Wong. Advances in labor analgesia.
International journal of women's health.
2010 Aug; 1(?):139-54. doi:
10.2147/ijwh.s4553. [PMID: 21072284] - Eneida de Paula, Shirley Schreier, Harold C Jarrell, Leonardo Fernandes Fraceto. Preferential location of lidocaine and etidocaine in lecithin bilayers as determined by EPR, fluorescence and 2H NMR.
Biophysical chemistry.
2008 Jan; 132(1):47-54. doi:
10.1016/j.bpc.2007.10.004. [PMID: 17976897] - Olivier Mathieu, Dominique Hillaire-Buys, Christophe Dadure, Franck Barnay, Jean Claude Mathieu-Daudé, Françoise Bressolle. Liquid chromatography-electrospray mass spectrometry determination of free and total concentrations of ropivacaine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 831(1-2):91-8. doi:
10.1016/j.jchromb.2005.11.035. [PMID: 16360344] - Guy Weinberg. Lipid rescue resuscitation from local anaesthetic cardiac toxicity.
Toxicological reviews.
2006; 25(3):139-45. doi:
10.2165/00139709-200625030-00001. [PMID: 17192120] - Leonardo Fernandes Fraceto, Alberto Spisni, Shirley Schreier, Eneida de Paula. Differential effects of uncharged aminoamide local anesthetics on phospholipid bilayers, as monitored by 1H-NMR measurements.
Biophysical chemistry.
2005 May; 115(1):11-8. doi:
10.1016/j.bpc.2004.12.003. [PMID: 15848279] - A Dullenkopf, A Borgeat. [Local anesthetics. Differences and similarities in the "-cains"].
Der Anaesthesist.
2003 Apr; 52(4):329-40. doi:
10.1007/s00101-003-0463-5. [PMID: 12715136] - Joel B Gunter. Benefit and risks of local anesthetics in infants and children.
Paediatric drugs.
2002; 4(10):649-72. doi:
10.2165/00128072-200204100-00003. [PMID: 12269841] - G K Wang, C Quan, S Y Wang. Local anesthetic block of batrachotoxin-resistant muscle Na+ channels.
Molecular pharmacology.
1998 Aug; 54(2):389-96. doi:
10.1124/mol.54.2.389. [PMID: 9687581] - G K Wang, C Quan, S Wang. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels.
Pflugers Archiv : European journal of physiology.
1998 Jan; 435(2):293-302. doi:
10.1007/s004240050515. [PMID: 9382945] - J Drewe, S Rufer, J Huwyler, E Küsters. High-performance liquid chromatographic method for an automated determination of local anaesthetics in human plasma.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 691(1):105-10. doi:
10.1016/s0378-4347(96)00381-7. [PMID: 9140763] - F M Ferrante, G J Fanciullo, K P Grichnik, J Vaisman, G M Sacks, M A Concepcion. Regression of sensory anesthesia during continuous epidural infusions of bupivacaine and opioid for total knee replacement.
Anesthesia and analgesia.
1993 Dec; 77(6):1179-84. doi:
10.1213/00000539-199312000-00017. [PMID: 8250310] - K Kawabata, K Sumikawa, T Kamibayashi, K Fukumitsu, Y Hayashi, K Takada, I Yoshiya. Effect of local anaesthetics on the stimulus-secretion coupling in bovine adrenal chromaffin cells.
The Journal of pharmacy and pharmacology.
1993 Jul; 45(7):632-5. doi:
10.1111/j.2042-7158.1993.tb05667.x. [PMID: 8105059] - B Bruguerolle, M Prat. Circadian phase-dependent protein and tissular binding of three local anesthetics (bupivacaine, etidocaine, and mepivacaine) in mice: a possible mechanism of their chronotoxicokinetics?.
Chronobiology international.
1992 Dec; 9(6):448-52. doi:
10.3109/07420529209064558. [PMID: 1473199] - X Sun, K D Garlid. On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes.
The Journal of biological chemistry.
1992 Sep; 267(27):19147-54. doi:
". [PMID: 1382068] - J B Dahl, J Rosenberg, H Kehlet. Effect of thoracic epidural etidocaine 1.5\% on somatosensory evoked potentials, cortisol and glucose during cholecystectomy.
Acta anaesthesiologica Scandinavica.
1992 May; 36(4):378-82. doi:
10.1111/j.1399-6576.1992.tb03484.x. [PMID: 1595345] - O W Lau, Y C Wong, K Chan. The use of a packed column for the determination of bupivacaine in human plasma by gas chromatography: an application in a pharmacokinetic study of bupivacaine.
Forensic science international.
1992 Mar; 53(2):125-9. doi:
10.1016/0379-0738(92)90187-2. [PMID: 1592321] - H C Niesel, H Kaiser. [Dose limits for local anesthetics. Recommendations based on toxicologic and pharmacokinetic data].
Regional-Anaesthesie.
1991 Aug; 14(5):79-82. doi:
NULL. [PMID: 1822598] - M Grouselle, O Tueux, P Dabadie, D Georgescaud, J P Mazat. Effect of local anaesthetics on mitochondrial membrane potential in living cells.
The Biochemical journal.
1990 Oct; 271(1):269-72. doi:
10.1042/bj2710269. [PMID: 2222418] - P A Nydahl, K Axelsson, P G Larsson, L Philipson, P Leissner, U H Sjöstrand. Influence of intravenous local anaesthetics upon quadriceps muscle function.
Acta anaesthesiologica Scandinavica.
1990 Jul; 34(5):393-6. doi:
10.1111/j.1399-6576.1990.tb03109.x. [PMID: 2389655] - B Bruguerolle, M Prat. Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice.
The Journal of pharmacy and pharmacology.
1990 Mar; 42(3):201-2. doi:
10.1111/j.2042-7158.1990.tb05387.x. [PMID: 1974619] - R Schwilick, K Weingärtner, G V Kissler, P Reinhold. [Elimination of the obturator reflex as a specific indication for dilute solutions of etidocaine. A study of the suitability of a local anesthetic for reflex elimination in the 3-in-1 block technic].
Regional-Anaesthesie.
1990 Jan; 13(1):6-10. doi:
NULL. [PMID: 2305117] - M W Kalichman, H C Powell, R R Myers. Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve.
The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):406-13. doi:
". [PMID: 2746508] - H A Adams, J Biscoping, K Ludolf, A Börgmann, B Bachmann-M, G Hempelmann. [The quantitative analysis of amide local anesthetics using high pressure liquid chromatography and ultraviolet detection (HPLC/UV)].
Regional-Anaesthesie.
1989 May; 12(3):53-7. doi:
NULL. [PMID: 2772274] - H C Powell, M W Kalichman, R S Garrett, R R Myers. Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics.
Laboratory investigation; a journal of technical methods and pathology.
1988 Aug; 59(2):271-80. doi:
. [PMID: 3404978] - A Seelig, P R Allegrini, J Seelig. Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group.
Biochimica et biophysica acta.
1988 Apr; 939(2):267-76. doi:
10.1016/0005-2736(88)90070-3. [PMID: 3355817] - J A Wildsmith, A J Gissen, B Takman, B G Covino. Differential nerve blockade: esters v. amides and the influence of pKa.
British journal of anaesthesia.
1987 Mar; 59(3):379-84. doi:
10.1093/bja/59.3.379. [PMID: 3828187] - Y Le Normand, C De Villepoix, A Athouel, M F Kergueris, M Bourin, C Larousse, Y Blanloeil, J C Melchior. Determination of bupivacaine in human plasma by capillary gas chromatography with nitrogen-selective detection.
Journal of chromatography.
1986 Nov; 383(1):232-5. doi:
10.1016/s0378-4347(00)83467-2. [PMID: 3818842] - M Prat, B Bruguerolle. Rapid simultaneous gas-liquid chromatographic determination of five local anesthetic drugs in serum.
Clinical chemistry.
1986 Nov; 32(11):2098. doi:
10.1093/clinchem/32.11.2098b. [PMID: 3779952] - M Wood. Plasma drug binding: implications for anesthesiologists.
Anesthesia and analgesia.
1986 Jul; 65(7):786-804. doi:
NULL. [PMID: 3087239] - D E Coyle, D D Denson. Simultaneous measurement of bupivacaine, etidocaine, lidocaine, meperidine, mepivacaine, and methadone.
Therapeutic drug monitoring.
1986; 8(1):98-101. doi:
10.1097/00007691-198603000-00016. [PMID: 3961898] - N C Hjortsø, P Neumann, F Frøsig, T Andersen, A Lindhard, E Rogon, H Kehlet. A controlled study on the effect of epidural analgesia with local anaesthetics and morphine on morbidity after abdominal surgery.
Acta anaesthesiologica Scandinavica.
1985 Nov; 29(8):790-6. doi:
10.1111/j.1399-6576.1985.tb02302.x. [PMID: 4082879] - D A Dutton, D D Moir, H B Howie, J Thorburn, R Watson. Choice of local anaesthetic drug for extradural caesarean section. Comparison of 0.5\% and 0.75\% bupivacaine and 1.5\% etidocaine.
British journal of anaesthesia.
1984 Dec; 56(12):1361-8. doi:
10.1093/bja/56.12.1361. [PMID: 6498044] - H R Ha, B Funk, H R Gerber, F Follath. Determination of bupivacaine in plasma by high-performance liquid chromatography.
Anesthesia and analgesia.
1984 Apr; 63(4):448-50. doi:
NULL. [PMID: 6703373] - P L Liu, H S Feldman, R Giasi, M K Patterson, B G Covino. Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration.
Anesthesia and analgesia.
1983 Apr; 62(4):375-9. doi:
. [PMID: 6829942] - A J Gissen, B G Covino, J Gregus. Differential sensitivity of fast and slow fibers in mammalian nerve. III. Effect of etidocaine and bupivacaine on fast/slow fibers.
Anesthesia and analgesia.
1982 Jul; 61(7):570-5. doi:
. [PMID: 6283948] - P H Rosenberg, A Alila. Hydrophobic membrane interaction of etidocaine, bupivacaine and 2-chloroprocaine. A spin and fluorescent probe study.
Naunyn-Schmiedeberg's archives of pharmacology.
1982 May; 319(2):95-100. doi:
10.1007/bf00503919. [PMID: 7110378] - H Pedersen, H O Morishima, M Finster, G R Arthur, B G Covino. Pharmacokinetics of etidocaine in fetal and neonatal lambs and adult sheep.
Anesthesia and analgesia.
1982 Feb; 61(2):104-8. doi:
NULL. [PMID: 7198869] - D J Morgan, B B Koay, J D Paull. Plasma protein binding of etidocaine during pregnancy and labour.
European journal of clinical pharmacology.
1982; 22(5):451-7. doi:
10.1007/bf00542552. [PMID: 7117359] - K Strasser, J Abel, M Breulmann, I Schumacher, H P Siepmann, H J Trampisch. [Plasma level of etidocaine within the first two hours after axillary plexus block in healthy adults and patients with renal insufficiency (author's transl)].
Der Anaesthesist.
1981 Jan; 30(1):14-8. doi:
. [PMID: 7468999] - H J Hartung, P M Osswald, J Abel, R Meissner. [Plasma concentrations of etidocaine after supraclavicular plexus block (author's transl)].
Anasthesie, Intensivtherapie, Notfallmedizin.
1980 Oct; 15(5):392-5. doi:
NULL. [PMID: 7457783] - H J Hartung, P M Osswald, J Abel. [The interaction of sedativa with etidocaine in patients with brachial plexus block (author's transl)].
Der Anaesthesist.
1980 Oct; 29(10):52-4. doi:
NULL. [PMID: 7446941] - G B Park, P E Erdtmansky, R R Brown, M P Kullberg, J Edelson. Analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine.
Journal of pharmaceutical sciences.
1980 May; 69(5):603-5. doi:
10.1002/jps.2600690537. [PMID: 7381753] - J C Chapin, L G Kushins, E S Munson, L M Schick. Lidocaine, bupivacaine, etidocaine, and epinephrine-induced arrhythmias during halothane anesthesia in dogs.
Anesthesiology.
1980 Jan; 52(1):23-6. doi:
10.1097/00000542-198001000-00006. [PMID: 7352641] - K Huovinen, P Lehtovirta, M Forss, I Kivalo, K Teramo. Changes in placental intervillous blood flow measured by the 133xenon method during lumbar epidural block for elective caesarean section.
Acta anaesthesiologica Scandinavica.
1979 Dec; 23(6):529-33. doi:
10.1111/j.1399-6576.1979.tb01483.x. [PMID: 545989] - L E Mather, G T Tucker, T M Murphy, M D Stanton-Hicks, J J Bonica. Cardiovascular and subjective central nervous system effects of long-acting local anaesthetics in man.
Anaesthesia and intensive care.
1979 Aug; 7(3):215-21. doi:
10.1177/0310057x7900700302. [PMID: 495929] - G T Tucker, L E Mather. Clinical pharmacokinetics of local anaesthetics.
Clinical pharmacokinetics.
1979 Jul; 4(4):241-78. doi:
10.2165/00003088-197904040-00001. [PMID: 385208] - K R Courtney, J J Kendig, E N Cohen. The rates of interaction of local anesthetics with sodium channels in nerve.
The Journal of pharmacology and experimental therapeutics.
1978 Nov; 207(2):594-604. doi:
". [PMID: 712641] - J Vine, D Morgan, J Thomas. The identification of eight hydroxylated metabolites of etidocaine by chemical ionization mass spectrometry.
Xenobiotica; the fate of foreign compounds in biological systems.
1978 Aug; 8(8):509-13. doi:
10.3109/00498257809056153. [PMID: 695694] - D Morgan, D McQuillan, J Thomas. Pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. 11 Etidocaine.
European journal of clinical pharmacology.
1978 Jul; 13(5):365-71. doi:
10.1007/bf00644610. [PMID: 668795] - G Garstka, H Stoeckel. [Diaplacentar transfer of local anaesthetics (author's transl)].
Praktische Anasthesie, Wiederbelebung und Intensivtherapie.
1978 Feb; 13(1):1-6. doi:
NULL. [PMID: 634894] - D C Moore, L D Bridenbaugh, G E Thompson, R I Balfour, W G Horton. Factors determining dosages of amide-type local anesthetic drugs.
Anesthesiology.
1977 Sep; 47(3):263-8. doi:
10.1097/00000542-197709000-00006. [PMID: 889115] - E Lanz, D Caton, H Schlereth, D H Barron. [The effect of local anaesthetics on uterine blood flow and O2-consumption in pregnant sheep (author's transl)].
Der Anaesthesist.
1977 Aug; 26(8):403-10. doi:
. [PMID: 907074] - D J Morgan, M P Smyth, J Thomas, J Vine. Cyclic metabolites of etidocaine in humans.
Xenobiotica; the fate of foreign compounds in biological systems.
1977 Jun; 7(6):365-75. doi:
10.3109/00498257709035795. [PMID: 610053] - J A Wildsmith, G T Tucker, S Cooper, D B Scott, B G Covino. Plasma concentrations of local anaesthetics after interscalene brachial plexus block.
British journal of anaesthesia.
1977 May; 49(5):461-6. doi:
10.1093/bja/49.5.461. [PMID: 861114] - G T Tucker, S Cooper, D Littlewood, F P Buckley, B G Covino, D B Scott. Observed and predicted accumulation of local anaesthetic agents during continuous extradural analgesia.
British journal of anaesthesia.
1977 Mar; 49(3):237-42. doi:
10.1093/bja/49.3.237. [PMID: 911576] - E S Munson, W L Paul, W J Embro. Central-nervous-system toxicity of local anesthetic mixtures in monkeys.
Anesthesiology.
1977 Mar; 46(3):179-83. doi:
10.1097/00000542-197703000-00004. [PMID: 402868] - M H Malagodi, E S Munson, W J Embro. Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys.
British journal of anaesthesia.
1977 Feb; 49(2):121-5. doi:
10.1093/bja/49.2.121. [PMID: 402143] - L Wiklund. Human hepatic blood flow and its relation to systemic circulation during intravenous infusion of bupivacaine or etidocaine.
Acta anaesthesiologica Scandinavica.
1977; 21(3):189-99. doi:
10.1111/j.1399-6576.1977.tb01209.x. [PMID: 878832] - L E Mather, G T Tucker, T M Murphy, Stanton-Hicks D'A, J J Bonica. The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics.
British journal of anaesthesia.
1976 Oct; 48(10):989-94. doi:
10.1093/bja/48.10.989. [PMID: 791313] - M Stanton-Hicks, T M Murphy, J J Bonica, L E Mather, G T Tucker. Effects of extradural block: comparison of the properties, circulatory effects and pharmacokinetics of etidocaine and bupivacaine.
British journal of anaesthesia.
1976 Jun; 48(6):575-86. doi:
10.1093/bja/48.6.575. [PMID: 952693] - H Renck, H Eström. Thoracic epidural analgesia III--prolongation in the early postoperative period by intermittent injections of etidocaine with adrenaline.
Acta anaesthesiologica Scandinavica.
1976; 20(2):104-10. doi:
10.1111/j.1399-6576.1976.tb05016.x. [PMID: 936966] - J Thomas, D Morgan, J Vine. Metabolism of etidocaine in man.
Xenobiotica; the fate of foreign compounds in biological systems.
1976 Jan; 6(1):39-48. doi:
10.3109/00498257609151610. [PMID: 1274369] - A R Abdel-Salam, J B Vonwiller, D B Scott. Evaluation of etidocaine in extradural block.
British journal of anaesthesia.
1975 Oct; 47(10):1081-6. doi:
10.1093/bja/47.10.1081. [PMID: 1106739] - E S Munson, W K Tucker, B Ausinsch, M H Malagodi. Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.
Anesthesiology.
1975 Apr; 42(4):471-8. doi:
10.1097/00000542-197504000-00018. [PMID: 1119714]