glyburide (BioDeep_00000408870)
Main id: BioDeep_00000001992
代谢物信息卡片
Glibenclamide
化学式: C23H28ClN3O5S (493.1438108000001)
中文名称: 格列苯脲
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: ClC1=CC(C(NCCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)=O)=C(OC)C=C1
InChI: InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
描述信息
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
同义名列表
2 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:5441
- KEGG: C07022
- KEGGdrug: D00336
- KEGGdrug: D81733
- PubChem: 3488
- DrugBank: DB01016
- ChEMBL: CHEMBL472
- MeSH: Glyburide
- CAS: 10238-21-8
- MoNA: WA001548
- MoNA: WA001547
- MoNA: WA001546
- MoNA: WA001545
- MoNA: WA001544
- MoNA: WA001543
- PubChem: 9234
- PDB-CCD: GBM
- NIKKAJI: J3.430D
- RefMet: Glyburide
- medchemexpress: HY-15206
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hai Trieu Ly, Khuong Duy Pham, Phung Hien Le, Thi Hong Tuoi Do, Thi Thu Huong Nguyen, Van Minh Le. Pharmacological properties of Ensete glaucum seed extract: Novel insights for antidiabetic effects via modulation of oxidative stress, inflammation, apoptosis and MAPK signaling pathways.
Journal of ethnopharmacology.
2024 Feb; 320(?):117427. doi:
10.1016/j.jep.2023.117427. [PMID: 37992883] - Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad. Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies.
Frontiers in bioscience (Landmark edition).
2024 Jan; 29(1):43. doi:
10.31083/j.fbl2901043. [PMID: 38287835] - Waqar Ahmed Siddiqui, Muniza Qayyum, Aamina Quddus Qureshi, Momina Khalid, Sehrish Zaffar, Rabiea Bilal. The Bronchodilator Potential of Astragalus sarcocolla: An in vitro Experiment.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2024 Jan; 34(1):58-62. doi:
10.29271/jcpsp.2024.01.58. [PMID: 38185962] - Ahad Yamchi, Maryam Rahimi, Bita Javan, Dorsa Abdollahi, Mojgan Salmanian, Majid Shahbazi. Evaluation of the impact of polypeptide-p on diabetic rats upon its cloning, expression, and secretion in Saccharomyces boulardii.
Archives of microbiology.
2023 Dec; 206(1):37. doi:
10.1007/s00203-023-03773-9. [PMID: 38142245] - Shahrokh Bagheri, Reza Mohammadrezaei Khorramabadi, Vahideh Assadollahi, Peyman Khosravi, Ahmad Cheraghi Venol, Saeed Veiskerami, Hassan Ahmadvand. The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes.
Archives of physiology and biochemistry.
2023 Dec; 129(4):870-878. doi:
10.1080/13813455.2021.1877308. [PMID: 33524274] - Mehmet Salih Bakaç, Abdulahad Dogan, Mustafa Abdullah Yılmaz, Fikret Altındag, Fatih Donmez, Abdulhamit Battal. Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation.
BMC complementary medicine and therapies.
2023 Nov; 23(1):410. doi:
10.1186/s12906-023-04252-w. [PMID: 37964249] - Shanmugam Devi Bala, Ramalingam Saravanan, Gurumoorthy Mahalakshmi, Raju Murali, Natarajan Ashokkumar. Bacoside-A Improves Antioxidant Enzymes and Alleviates Oxidative Stress Coexist with Markers of Renal Function in a Rat Model of Type 2 Diabetes Mellitus.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2023 Nov; 34(6):537-547. doi:
10.4103/sjkdt.sjkdt_163_21. [PMID: 38725204] - Muhammad Idrees, Inayat U Rahman, Hamza A Khan, Yasar M Yousufzai, Ejaz H Khan, Mohammad I Khan, Saima Gul. Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1451-1456. doi:
. [PMID: 37869921] - Nesrein S Salim, Mohamed Abdel-Alim, Huda E M Said, Mohamed F Foda. Phenolic Profiles, Antihyperglycemic, Anti-Diabetic, and Antioxidant Properties of Egyptian Sonchus oleraceus Leaves Extract: An In Vivo Study.
Molecules (Basel, Switzerland).
2023 Sep; 28(17):. doi:
10.3390/molecules28176389. [PMID: 37687218] - Asser F Bedair, Ahmed Wahid, Nesrine S El-Mezayen, Amira F El-Yazbi, Hadeel A Khalil, Nayera W Hassan, Elham A Afify. Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 165(?):115068. doi:
10.1016/j.biopha.2023.115068. [PMID: 37392650] - Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol.
Alcohol (Fayetteville, N.Y.).
2023 Jun; ?(?):. doi:
10.1016/j.alcohol.2023.05.008. [PMID: 37295565] - Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.
General physiology and biophysics.
2023 May; 42(3):297-306. doi:
10.4149/gpb_2023008. [PMID: 37098743] - Serdar Sahinturk. Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106735. doi:
10.1016/j.prostaglandins.2023.106735. [PMID: 37059294] - Milad Rahemi, Shokooh Mohtadi, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. The role of L-arginine/NO/cGMP/KATP channel pathway in the local antinociceptive effect of berberine in the rat formalin test.
Behavioural pharmacology.
2023 Mar; ?(?):. doi:
10.1097/fbp.0000000000000721. [PMID: 36939560] - Nesreen M I M Elkomy, Amina El-Shaibany, Gehad M Elnagar, Ahmed S Abdelkhalek, Hassan Al-Mahbashi, Mahmoud M Elaasser, Salwa M Raweh, Maha A Aldiyarbi, Ali E Raslan. Evaluation of acute oral toxicity, anti-diabetic and antioxidant effects of Aloe vera flowers extract.
Journal of ethnopharmacology.
2023 Feb; ?(?):116310. doi:
10.1016/j.jep.2023.116310. [PMID: 36863642] - Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica.
Journal of natural products.
2023 01; 86(1):138-148. doi:
10.1021/acs.jnatprod.2c00844. [PMID: 36529937] - Mohammad Parvez, Farrukh Hussain, Murad Khan. Crude extract from Euphorbia prostrata extended curative period of glibenclemide in alloxan-induced diabetic rats.
Journal of complementary & integrative medicine.
2023 Jan; ?(?):. doi:
10.1515/jcim-2022-0315. [PMID: 36662647] - Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Lucila Herrera-Ruiz, Jaqueline Molina-Cabrera, María Cruz Juárez-Aragón, Francisco Javier Flores-Murrieta. Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception.
Journal of ethnopharmacology.
2023 Jan; 300(?):115756. doi:
10.1016/j.jep.2022.115756. [PMID: 36170958] - Christian Omonzokpea Ehikioya, Aishat Mary Osagie, Sylvia Oghogho Omage, Kingsley Omage, Marshall Arebojie Azeke. Carbohydrate digestive enzyme inhibition, hepatoprotective, antioxidant and antidiabetic benefits of Persea americana.
Scientific reports.
2023 01; 13(1):284. doi:
10.1038/s41598-022-26801-y. [PMID: 36609426] - Omayma A R Abozaid, Sawsan M El-Sonbaty, Neama M A Hamam, Moustafa A Farrag, Ahmad S Kodous. Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats.
Biological trace element research.
2023 Jan; 201(1):306-323. doi:
10.1007/s12011-022-03140-7. [PMID: 35237941] - Hassan N Althurwi, Gamal A Soliman, Rehab F Abdel-Rahman, Reham M Abd-Elsalam, Hanan A Ogaly, Mohammed H Alqarni, Faisal F Albaqami, Maged S Abdel-Kader. Vulgarin, a Sesquiterpene Lactone from Artemisia judaica, Improves the Antidiabetic Effectiveness of Glibenclamide in Streptozotocin-Induced Diabetic Rats via Modulation of PEPCK and G6Pase Genes Expression.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232415856. [PMID: 36555498] - Sadettin Demirel. Rosa damascena Miller essential oil relaxes rat trachea via KV channels, KATP channels, and BKCa channels.
Prostaglandins & other lipid mediators.
2022 12; 163(?):106673. doi:
10.1016/j.prostaglandins.2022.106673. [PMID: 36115499] - Davis Kibirige, Ronald Olum, Andrew Peter Kyazze, Felix Bongomin, Richard E Sanya. Availability and affordability of essential medicines and diagnostic tests for diabetes mellitus in Africa.
Tropical medicine & international health : TM & IH.
2022 11; 27(11):942-960. doi:
10.1111/tmi.13819. [PMID: 36121433] - Abdulaziz K Al Mouslem, Hany Ezzat Khalil, Promise Madu Emeka, Ghallab Alotaibi. Investigation of the Chemical Composition, Antihyperglycemic and Antilipidemic Effects of Bassia eriophora and Its Derived Constituent, Umbelliferone on High-Fat Diet and Streptozotocin-Induced Diabetic Rats.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27206941. [PMID: 36296534] - Kendal Erdem Duman, Abdulahad Dogan, Burak Kaptaner. Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats.
Journal of food biochemistry.
2022 10; 46(10):e14314. doi:
10.1111/jfbc.14314. [PMID: 35802765] - Armenia Armenia, Fatma Sri Wahyuni, Almahdy Almahdy, Rahmad Abdillah, Popy Genca Aquista, Diana Puspita Putri, Murhamah Zikra. Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats.
Journal of complementary & integrative medicine.
2022 Sep; 19(3):627-636. doi:
10.1515/jcim-2022-0054. [PMID: 35446514] - Darshan Mehta, Miao Li, Noriko Nakamura, Mani Chidambaram, Xiaobo He, Matthew S Bryant, Ralph Patton, Kelly Davis, Jeffrey Fisher. In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):194-203. doi:
10.1016/j.reprotox.2022.06.007. [PMID: 35714934] - Hongling Chen, Li Zhao, Yuting Meng, Xixi Qian, Ya Fan, Quanli Zhang, Chao Wang, Fan Lin, Baoan Chen, Lin Xu, Wenbin Huang, Jing Chen, Xuerong Wang. Sulfonylurea receptor 1-expressing cancer cells induce cancer-associated fibroblasts to promote non-small cell lung cancer progression.
Cancer letters.
2022 06; 536(?):215611. doi:
10.1016/j.canlet.2022.215611. [PMID: 35240233] - Hannah J Irvine, Animesh Acharjee, Zoe Wolcott, Zsuzsanna Ament, H E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth, W Taylor Kimberly. Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide.
Cell reports. Medicine.
2022 06; 3(6):100654. doi:
10.1016/j.xcrm.2022.100654. [PMID: 35700741] - Hamid Heidari, Azam Khalaj, Sima Khani, Maasoume Abdollahi, Hamid Farahani, Samira Khani. Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats.
Hormone molecular biology and clinical investigation.
2022 May; ?(?):. doi:
10.1515/hmbci-2021-0050. [PMID: 35488439] - Azra Bozcaarmutlu, Canan Sapmaz, Ömer Bozdoğan, Aysel Kükner, Leyla Kılınç, Salih Tunç Kaya, Oğulcan Talat Özarslan, Didem Ekşioğlu. The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver.
Drug and chemical toxicology.
2022 May; 45(3):990-998. doi:
10.1080/01480545.2020.1802475. [PMID: 32762264] - Omoaghe Adams O, Oyesola O, Ezike Tony, Omizu Blessing, Boone I Kukoyi. Effects of combined Garcinia kola and Kigelia africana on Insulin and Paraoxonase 1 (PON1) levels in type 2 diabetic rats.
Current drug discovery technologies.
2022 Apr; ?(?):. doi:
10.2174/1570163819666220408100011. [PMID: 35400345] - Olajumoke A Oyebode, Ochuko L Erukainure, Anil A Chuturgoon, Terisha Ghazi, Pragalathan Naidoo, Chika I Chukwuma, Md Shahidul Islam. Bridelia ferruginea Benth. (Euphorbiaceae) mitigates oxidative imbalance and lipotoxicity, with concomitant modulation of insulin signaling pathways via GLUT4 upregulation in hepatic tissues of diabetic rats.
Journal of ethnopharmacology.
2022 Feb; 284(?):114816. doi:
10.1016/j.jep.2021.114816. [PMID: 34763044] - Laiza S Biano, Alan S Oliveira, David N Palmeira, Luis André Silva, Ricardo L C de Albuquerque-Junior, Marcelo C Duarte, Cristiane B Correa, Renata Grespan, Josemar S Batista, Enilton A Camargo. Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice.
Journal of ethnopharmacology.
2022 Feb; 284(?):114792. doi:
10.1016/j.jep.2021.114792. [PMID: 34737011] - Dmitry I Maltsev, Kennelia A Mellanson, Vsevolod V Belousov, Grigori N Enikolopov, Oleg V Podgorny. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum.
Histochemistry and cell biology.
2022 Feb; 157(2):239-250. doi:
10.1007/s00418-021-02048-y. [PMID: 34757474] - M Granado, D González-Hedström, S Amor, A Fajardo-Vidal, M Villalva, M de la Fuente-Fernández, A Tejera-Muñoz, L Jaime, S Santoyo, A L García-Villalón. Marjoram extract prevents ischemia reperfusion-induced myocardial damage and exerts anti-contractile effects in aorta segments of male wistar rats.
Journal of ethnopharmacology.
2022 Jan; 282(?):114660. doi:
10.1016/j.jep.2021.114660. [PMID: 34547419] - Neha Sharma, Anand Kar, Sunanda Panda, Dhananjay Yadav. Co-administration of Pterocarpus marsupium Extract and Glibenclamide Exhibits Better Effects in Regulating Hyperglycemia and Associated Changes in Alloxan-induced Diabetic Mice.
Current topics in medicinal chemistry.
2022; 22(32):2617-2628. doi:
10.2174/1568026623666221108125036. [PMID: 36366849] - Shatw Khalid Ali, Rojgar H Ali. Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
PloS one.
2022; 17(7):e0271138. doi:
10.1371/journal.pone.0271138. [PMID: 35802659] - Nithiyaa Perumal, Meenakshii Nallappan, Shamarina Shohaimi, Nur Kartinee Kassim, Thiam Tsui Tee, Yew Hoong Cheah. Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jan; 145(?):112401. doi:
10.1016/j.biopha.2021.112401. [PMID: 34785415] - S Rahman, Gul Jan, F Gul Jan, H Ur Rahim. Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice.
Brazilian journal of biology = Revista brasleira de biologia.
2022; 84(?):e261518. doi:
10.1590/1519-6984.261518. [PMID: 36228225] - Ziyuan Wu, Muthukumaran Jayachandran, Wai San Cheang, Baojun Xu. Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation.
Oxidative medicine and cellular longevity.
2022; 2022(?):6099872. doi:
10.1155/2022/6099872. [PMID: 35251478] - Rebecca Nakaziba, Aloysius Lubega, Jasper Ogwal-Okeng, Paul E Alele. Phytochemical Analysis, Acute Toxicity, as well as Antihyperglycemic and Antidiabetic Activities of Corchorus olitorius L. Leaf Extracts.
TheScientificWorldJournal.
2022; 2022(?):1376817. doi:
10.1155/2022/1376817. [PMID: 35898284] - Tarek Atia, Mohammad Zahidul Iqbal, Hassan Fathy Ahmed, Hader I Sakr, M H Abdelzaher, Deaa Fekri Morsi, Mostafa E Metawee. Vitamin D Supplementation Could Enhance the Effectiveness of Glibenclamide in Treating Diabetes and Preventing Diabetic Nephropathy: A Biochemical, Histological and Immunohistochemical Study.
Journal of evidence-based integrative medicine.
2022 Jan; 27(?):2515690X221116403. doi:
10.1177/2515690x221116403. [PMID: 35942573] - R C Douho Djimeli, M L Nchouwet, S L Poualeu Kamani, L M Tchoumba Tchoumi, A Kamanyi, S L Wansi Ngnokam. Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts of Nauclea diderrichii in Wistar Rats.
BioMed research international.
2022; 2022(?):7569848. doi:
10.1155/2022/7569848. [PMID: 35769665] - M Oliur Rahman, Ali S Alqahtani, Sayma Binte Huda, Shah Alam Siddiqui, Omar M Noman, Fahd Nasr, Md Abul Hassan, Sheikh Nazrul Islam. Streblus asper attenuates alloxan-induced diabetes in rats and demonstrates antioxidant and cytotoxic effects.
Pharmaceutical biology.
2021 Dec; 59(1):1058-1064. doi:
10.1080/13880209.2021.1954668. [PMID: 34365913] - Chuan Wang, Dan Ma, Yimin Hua, Hongyu Duan. Modulation of Placental Breast Cancer Resistance Protein by HDAC1 in Mice: Implications for Optimization of Pharmacotherapy During Pregnancy.
Reproductive sciences (Thousand Oaks, Calif.).
2021 12; 28(12):3540-3546. doi:
10.1007/s43032-021-00773-2. [PMID: 34668144] - Hong-Mei Yin, Qiong He, Jia Chen, Zhen Li, Wanli Yang, Xiaobo Hu. Drug metabolism-related eight-gene signature can predict the prognosis of gastric adenocarcinoma.
Journal of clinical laboratory analysis.
2021 Dec; 35(12):e24085. doi:
10.1002/jcla.24085. [PMID: 34773716] - Bradley K Schniers, Devaraja Rajasekaran, Ksenija Korac, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D Bhutia. PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target.
The Biochemical journal.
2021 10; 478(20):3757-3774. doi:
10.1042/bcj20210377. [PMID: 34569600] - Yao Lu, Yajing Jia, Jing Lu, Juan Liu, Yuxin Xu, Yong Liu, Keyang Chen. Progenies of gestational diabetes mellitus exhibit sex disparity in metabolism after respective therapies of insulin, glibenclamide, and metformin in dams during pregnancy.
Archives of physiology and biochemistry.
2021 Oct; ?(?):1-13. doi:
10.1080/13813455.2021.1991957. [PMID: 34689672] - Mona F Mahmoud, Shimaa Abdelaal, Heba Osama Mohammed, Assem M El-Shazly, Rachid Daoud, Mohamed A El Raey, Mansour Sobeh. Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):112085. doi:
10.1016/j.biopha.2021.112085. [PMID: 34463263] - Xiaofei Qiu, Qinghui Wang, Liyan Hou, Cuili Zhang, Qingshan Wang, Xiulan Zhao. Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model.
Toxicology letters.
2021 Oct; 349(?):1-11. doi:
10.1016/j.toxlet.2021.05.008. [PMID: 34052309] - Miao Ma, Kexia Chai, Rui Deng. Study of the correlation between the noncanonical pathway of pyroptosis and idiopathic inflammatory myopathy.
International immunopharmacology.
2021 Sep; 98(?):107810. doi:
10.1016/j.intimp.2021.107810. [PMID: 34116285] - Camila Pires Mendes, Bárbara Graziela Postal, Marisa Jádna Silva Frederico, Rui Gonçalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patrícia Devantier Neuenfeldt, Ricardo José Nunes, Fátima Regina Mena Barreto Silva. Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats.
Bioorganic chemistry.
2021 09; 114(?):105157. doi:
10.1016/j.bioorg.2021.105157. [PMID: 34328855] - Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard, Elham Bahreini. Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.
Reproductive biology and endocrinology : RB&E.
2021 Jul; 19(1):104. doi:
10.1186/s12958-021-00794-1. [PMID: 34233693] - Chao Tan, Hui Chen, Zan Lin. Detection of glibenclamide adulterated in antidiabetic Chinese patent medicine by attenuated total reflectance -infrared spectroscopy and chemometrics.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Jul; 255(?):119723. doi:
10.1016/j.saa.2021.119723. [PMID: 33780893] - Arun Sudaramoorthy, Gobinath Shanmugam, Narkunaraja Shanmugam. Inhibitory effect of Salvia coccinea on inflammatory responses through NF-κB signaling pathways in THP-1 cells and acute rat diabetes mellitus.
Acta histochemica.
2021 Jul; 123(5):151735. doi:
10.1016/j.acthis.2021.151735. [PMID: 34052674] - Dr Ghandi Ibrahim Kasimu, Murtala Bello Abubakar, Bello Bashir Audu, Abdullahi Suleiman Mainasara. Effect of Co-administration of Glibenclamide and Aqueous Calyx Extract of Hibiscus Sabdariffa on Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2021 Jun; 36(1):77-84. doi:
. [PMID: 34987253] - Ping Xu, Juan Xiao, Shuixia Chi. Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Journal of biochemical and molecular toxicology.
2021 Jun; 35(6):1-12. doi:
10.1002/jbt.22763. [PMID: 33724628] - Lihong Wen, Bin Huang, Rong Tu, Kunzhen Wan, Hong Zhang, Xiaoyun Zhang. Effectiveness and safety of glibenclamide for stroke: protocol for a systematic review and meta-analysis.
BMJ open.
2021 05; 11(5):e043585. doi:
10.1136/bmjopen-2020-043585. [PMID: 33972335] - Benjamin Kingsley Harley, Isaac Kingsley Amponsah, Inemesit Okon Ben, Donatus Wewura Adongo, Nana Ama Mireku-Gyimah, Michael Kwesi Baah, Abraham Yeboah Mensah, Theophilus Christian Fleischer. Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111379. doi:
10.1016/j.biopha.2021.111379. [PMID: 33761602] - Hui-Li Lin, Pei-Wen Cheng, Yi-Chen Tu, Bor-Chun Yeh, Bin-Nan Wu, Kuo-Ping Shen. The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR.
The Journal of pharmacy and pharmacology.
2021 Apr; 73(6):835-845. doi:
10.1093/jpp/rgab029. [PMID: 33779726] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Andrei C Sposito, Ikaro Breder, Alexandre A S Soares, Sheila T Kimura-Medorima, Daniel B Munhoz, Riobaldo M R Cintra, Isabella Bonilha, Daniela C Oliveira, Jessica Cunha Breder, Pamela Cavalcante, Camila Moreira, Filipe A Moura, Jose Carlos de Lima-Junior, Helison R P do Carmo, Joaquim Barreto, Wilson Nadruz, Luiz Sergio F Carvalho, Thiago Quinaglia. Dapagliflozin effect on endothelial dysfunction in diabetic patients with atherosclerotic disease: a randomized active-controlled trial.
Cardiovascular diabetology.
2021 03; 20(1):74. doi:
10.1186/s12933-021-01264-z. [PMID: 33771149] - Michael J Armahizer, Amy Kruger Howard, Hyunuk Seung, Lakshman Kalasapudi, Charles Sansur, Nicholas A Morris. Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients.
World neurosurgery.
2021 03; 147(?):e63-e68. doi:
10.1016/j.wneu.2020.11.107. [PMID: 33253952] - Elliott L Rodriguez, Pingyang Tao, Ashley G Woolfork, Zhao Li, Ryan Matsuda, Zuchen Sun, David S Hage. Studies of binding by sulfonylureas with glyoxal- and methylglyoxal-modified albumin by immunoextraction using affinity microcolumns.
Journal of chromatography. A.
2021 Feb; 1638(?):461683. doi:
10.1016/j.chroma.2020.461683. [PMID: 33223150] - Faizan Abul Qais, Tarique Sarwar, Iqbal Ahmad, Rais Ahmad Khan, Syed Ali Shahzad, Fohad Mabood Husain. Glyburide inhibits non-enzymatic glycation of HSA: An approach for the management of AGEs associated diabetic complications.
International journal of biological macromolecules.
2021 Feb; 169(?):143-152. doi:
10.1016/j.ijbiomac.2020.12.096. [PMID: 33338529] - Bagher Pourheydar, Mahrokh Samadi, Parisa Habibi, Ahmad Ali Nikibakhsh, Roya Naderi. Renoprotective effects of tropisetron through regulation of the TGF-β1, p53 and matrix metalloproteinases in streptozotocin-induced diabetic rats.
Chemico-biological interactions.
2021 Feb; 335(?):109332. doi:
10.1016/j.cbi.2020.109332. [PMID: 33387473] - Liwei Gao, Wenzhi Zhang, Leiyan Yang, Hong Fan, Opeyemi Joshua Olatunji. Stink bean (Parkia speciosa) empty pod: a potent natural antidiabetic agent for the prevention of pancreatic and hepatorenal dysfunction in high fat diet/streptozotocin-induced type 2 diabetes in rats.
Archives of physiology and biochemistry.
2021 Jan; ?(?):1-7. doi:
10.1080/13813455.2021.1876733. [PMID: 33522287] - Samuel Maritim, Pierre Boulas, Yiqing Lin. Comprehensive analysis of liposome formulation parameters and their influence on encapsulation, stability and drug release in glibenclamide liposomes.
International journal of pharmaceutics.
2021 Jan; 592(?):120051. doi:
10.1016/j.ijpharm.2020.120051. [PMID: 33161039] - Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jan; 43(1):49-55. doi:
10.1080/10641963.2020.1797087. [PMID: 32706597] - Vasile-Ion Iancu, Roxana-Elena Scutariu, Florentina-Laura Chiriac, Gabriel-Lucian Radu. Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2021; 56(3):310-323. doi:
10.1080/10934529.2021.1873671. [PMID: 33471573] - Mazhar Hussain, Asim Elahi, Abid Hussain, Javed Iqbal, Lubna Akhtar, Abdul Majid. Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes.
Journal of diabetes research.
2021; 2021(?):9973862. doi:
10.1155/2021/9973862. [PMID: 34239940] - Xian Wang, Wanting Liu, Huizhen Chen, Qiu Chen. Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Gynecologic and obstetric investigation.
2021; 86(3):218-230. doi:
10.1159/000515893. [PMID: 33979807] - Yunfeng Zhu, Sushma Devi, Manish Kumar, Randhir Singh Dahiya, Tarkeshwer. Evaluation of Gamma Amino Butyric Acid (GABA) and Glibenclamide Combination Therapy in Streptozotocin Induced Diabetes.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(11):2005-2016. doi:
10.2174/1871530320666201208110945. [PMID: 33292127] - Nausheen Nazir, Muhammad Zahoor, Riaz Ullah, Essan Ezzeldin, Gamal A E Mostafa. Curative Effect of Catechin Isolated from Elaeagnus Umbellata Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model.
Molecules (Basel, Switzerland).
2020 Dec; 26(1):. doi:
10.3390/molecules26010137. [PMID: 33396845] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Suresh Khadke, Pallavi Mandave, Aniket Kuvalekar, Vijaya Pandit, Manjiri Karandikar, Nitin Mantri. Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats.
Nutrients.
2020 Nov; 12(12):. doi:
10.3390/nu12123652. [PMID: 33261004] - Judith Nkechiyere Uwazie, Musa Toyin Yakubu, Anofi Omotayo Tom Ashafa, Taofeek Olakunle Ajiboye. Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats.
Journal of ethnopharmacology.
2020 Oct; 261(?):112997. doi:
10.1016/j.jep.2020.112997. [PMID: 32534114] - Xiaohan Wu, Yang Liu, Daimiao Tu, Xianjian Liu, Shulin Niu, Ya Suo, Tong Liu, Guangping Li, Changle Liu. Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits.
Journal of cardiovascular translational research.
2020 10; 13(5):731-740. doi:
10.1007/s12265-020-09965-8. [PMID: 32048199] - Witor Ribeiro Ferraz, Renan Augusto Gomes, Andre Luis S Novaes, Gustavo Henrique Goulart Trossini. Ligand and structure-based virtual screening applied to the SARS-CoV-2 main protease: an in silico repurposing study.
Future medicinal chemistry.
2020 10; 12(20):1815-1828. doi:
10.4155/fmc-2020-0165. [PMID: 32787684] - Tao Li, Dirong Wu, Yang Yang, Tao Xiao, Yilin Han, Jing Li, Ting Liu, Li Li, Zeqin Dai, Yongjun Li, Xiaozhong Fu. Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4'-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups.
Bioorganic chemistry.
2020 08; 101(?):103980. doi:
10.1016/j.bioorg.2020.103980. [PMID: 32540782] - Lukas Klumpp, Jennifer Dressman. Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: Case examples glibenclamide and dipyridamole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Aug; 151(?):105380. doi:
10.1016/j.ejps.2020.105380. [PMID: 32442630] - Trenton D Colburn, Clark T Holdsworth, Jesse C Craig, Daniel M Hirai, Shawnee Montgomery, David C Poole, Timothy I Musch, Michael J Kenney. ATP-sensitive K+ channel inhibition in rats decreases kidney and skeletal muscle blood flow without increasing sympathetic nerve discharge.
Respiratory physiology & neurobiology.
2020 07; 278(?):103444. doi:
10.1016/j.resp.2020.103444. [PMID: 32330600] - Didem Yilmaz-Oral, Alev Onder, Serap Gur, Ángel A Carbonell-Barrachina, Ecem Kaya-Sezginer, Cetin Volkan Oztekin, Murat Zor. The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats.
Andrologia.
2020 Jul; 52(6):e13606. doi:
10.1111/and.13606. [PMID: 32352181] - Kaibin Huang, Zhong Ji, Yongming Wu, Yunqiang Huang, Guangning Li, Saijun Zhou, Zhi Yang, Wenguo Huang, Guoshuai Yang, Guohu Weng, Pingyan Chen, Suyue Pan. Safety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): study protocol for a randomized controlled trial.
BMC neurology.
2020 Jun; 20(1):239. doi:
10.1186/s12883-020-01823-z. [PMID: 32527232] - Eman A Elbassuoni, Neven M Аziz, Wagdу N Habeeb. The role of activation of KАTP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy.
Journal of cellular physiology.
2020 06; 235(6):5223-5228. doi:
10.1002/jcp.29403. [PMID: 31774182] - Margarita-Maria Panou, Michelle Antoni, Ethan L Morgan, Eleni-Anna Loundras, Christopher W Wasson, Matthew Welberry-Smith, Jamel Mankouri, Andrew Macdonald. Glibenclamide inhibits BK polyomavirus infection in kidney cells through CFTR blockade.
Antiviral research.
2020 06; 178(?):104778. doi:
10.1016/j.antiviral.2020.104778. [PMID: 32229236] - Michelle Carey, Eric Lontchi-Yimagou, William Mitchell, Sarah Reda, Kehao Zhang, Sylvia Kehlenbrink, Sudha Koppaka, Sylvan Roger Maginley, Sandra Aleksic, Shobhit Bhansali, Derek M Huffman, Meredith Hawkins. Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents.
Diabetes.
2020 06; 69(6):1140-1148. doi:
10.2337/db19-1256. [PMID: 32217610] - Roya Naderi, Bagher Pourheydar, Rafigheh Ghiasi, Fardin Shafiei. Modulatory effect of tropisetron in the liver of streptozotocin-induced diabetes in rats: biochemical and histological evidence.
Hormone molecular biology and clinical investigation.
2020 May; 41(3):. doi:
10.1515/hmbci-2020-0002. [PMID: 32364517] - C T Chang, J Y Ang, J M Wong, S S Tan, S K Chin, A B Lim, W H Tan, K H Yuen. Bioequivalence and pharmacokinetic comparison of two fixed dose combination of Metformin/ Glibenclamide formulations in healthy subjects under fed condition.
The Medical journal of Malaysia.
2020 05; 75(3):286-291. doi:
NULL. [PMID: 32467546] - Francesca Schinzari, Manfredi Tesauro, Umberto Campia, Carmine Cardillo. Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
Vascular pharmacology.
2020 May; 128-129(?):106676. doi:
10.1016/j.vph.2020.106676. [PMID: 32224233] - Alok Jha, Vinod Kumar, Shabirul Haque, Kamesh Ayasolla, Shourav Saha, Xiqian Lan, Ashwani Malhotra, Moin A Saleem, Karl Skorecki, Pravin C Singhal. Alterations in plasma membrane ion channel structures stimulate NLRP3 inflammasome activation in APOL1 risk milieu.
The FEBS journal.
2020 05; 287(10):2000-2022. doi:
10.1111/febs.15133. [PMID: 31714001] - Durgesh Kumar Dwivedi, G B Jena. NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 04; 393(4):705-716. doi:
10.1007/s00210-019-01773-5. [PMID: 31834465] - Qing Wu, Xi He, Shaojun Zhou, Fuguo Shi, Yuanfu Lu. Role of PEPT1in the transport of cinnabar in Caco-2 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Mar; 63(?):104747. doi:
10.1016/j.tiv.2019.104747. [PMID: 31838184] - Shahin Alizadeh-Fanalou, Mohammad Babaei, Asieh Hosseini, Namamali Azadi, Ali Nazarizadeh, Asie Shojaii, Mohammad Borji, Hassan Malekinejad, Elham Bahreini. Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats.
Journal of ethnopharmacology.
2020 Feb; 248(?):112331. doi:
10.1016/j.jep.2019.112331. [PMID: 31655149] - Peivasteh Safarpour, Milad Daneshi-Maskooni, Mohammadreza Vafa, Mitra Nourbakhsh, Leila Janani, Mohsen Maddah, Fatemeh-Sadat Amiri, Fereshteh Mohammadi, Homa Sadeghi. Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial.
BMC family practice.
2020 02; 21(1):26. doi:
10.1186/s12875-020-1096-3. [PMID: 32033527] - Durgesh Kumar Dwivedi, G B Jena. Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Biochemical and biophysical research communications.
2020 02; 522(2):381-387. doi:
10.1016/j.bbrc.2019.11.100. [PMID: 31761320] - Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purves. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
American journal of physiology. Renal physiology.
2020 02; 318(2):F354-F362. doi:
10.1152/ajprenal.00408.2019. [PMID: 31869244] - Ke Ning, Li Jiang, Ting Hu, Xingyu Wang, Aihua Liu, Yimin Bao. ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia-Reperfusion Injury and Inflammatory Reaction.
BioMed research international.
2020; 2020(?):3039184. doi:
10.1155/2020/3039184. [PMID: 33134375]