pindolol (BioDeep_00000408849)
Main id: BioDeep_00000002354
代谢物信息卡片
pindolol
化学式: C14H20N2O2 (248.15247000000002)
中文名称: 吲哚洛尔, 平多洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:8214
- KEGG: C07445
- KEGG: C90604
- KEGGdrug: D00513
- PubChem: 4828
- DrugBank: DB00960
- ChEMBL: CHEMBL500
- MeSH: Pindolol
- CAS: 13523-86-9
- MoNA: WA001224
- MoNA: WA001223
- MoNA: WA001222
- MoNA: WA001221
- MoNA: WA001220
- MoNA: WA001219
- PubChem: 9648
- NIKKAJI: J3.439H
- medchemexpress: HY-B0982
- KNApSAcK: 8214
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Wang, Chong Li, Peng Li. A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization.
Journal of the American Society for Mass Spectrometry.
2022 Feb; 33(2):304-314. doi:
10.1021/jasms.1c00305. [PMID: 35040644] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry.
Angewandte Chemie (International ed. in English).
2020 12; 59(51):23162-23168. doi:
10.1002/anie.202006481. [PMID: 32869436] - Paulo Vinicius Bernardes Gonçalves, Fernanda de Lima Moreira, Jhohann Richard de Lima Benzi, Ricardo Carvalho Cavalli, Geraldo Duarte, Vera Lucia Lanchote. Nonrelevant Pharmacokinetic Drug-Drug Interaction Between Furosemide and Pindolol Enantiomers in Hypertensive Parturient Women.
Journal of clinical pharmacology.
2020 11; 60(11):1527-1529. doi:
10.1002/jcph.1719. [PMID: 32789919] - Marián Masár, Jasna Hradski, Martin G Schmid, Roman Szucs. Advantages and Pitfalls of Capillary Electrophoresis of Pharmaceutical Compounds and Their Enantiomers in Complex Samples: Comparison of Hydrodynamically Opened and Closed Systems.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
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Molecular pharmacology.
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The Journal of pharmacy and pharmacology.
2019 Oct; 71(10):1576-1583. doi:
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2018 06; 135(?):63-72. doi:
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Bioorganic & medicinal chemistry.
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PloS one.
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Talanta.
2012 Jan; 89(?):149-54. doi:
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2012 Jan; 674(2-3):307-14. doi:
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2011 Dec; 61(4):403-13. doi:
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2010 Nov; 18(21):7486-96. doi:
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2009 Dec; 877(31):4007-14. doi:
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Analytical biochemistry.
2009 Sep; 392(2):103-9. doi:
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PloS one.
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2009 Feb; 27(1):20-30. doi:
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Veterinary anaesthesia and analgesia.
2009 Jan; 36(1):86-94. doi:
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Molecular pharmaceutics.
2009 Jan; 6(1):11-8. doi:
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Chemosphere.
2008 Nov; 73(8):1265-71. doi:
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Physiology & behavior.
2008 Sep; 95(1-2):88-92. doi:
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Journal of chromatography. A.
2008 Jul; 1196-1197(?):23-7. doi:
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Biomedical chromatography : BMC.
2008 Jul; 22(7):702-11. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Psychiatric genetics.
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Journal of clinical psychopharmacology.
2008 Apr; 28(2):249-51. doi:
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Talanta.
2008 Mar; 75(1):222-6. doi:
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European journal of pharmacology.
2008 Jan; 578(1):43-50. doi:
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Vascular health and risk management.
2008; 4(1):23-30. doi:
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Biological psychiatry.
2007 Sep; 62(6):680-6. doi:
10.1016/j.biopsych.2006.11.019. [PMID: 17511969] - Maria Walczak, Malgorzata Szafarz, Joanna Szymura-Oleksiak, Grazyna Groszek, Marek Bednarski, Barbara Filipek. Application of liquid chromatography-tandem mass spectrometry method for the analysis of new nonselective beta-adrenergic blocker 1-(1-H-indol-4-yloxy)-3-{[2-(2-methoxy phenoxy)ethylo]amino}propan-2-ol (2F109) in rat plasma.
Chirality.
2007 Jul; 19(7):536-41. doi:
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2007 Jun; 852(1-2):640-5. doi:
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Pharmacology, biochemistry, and behavior.
2007 May; 87(1):41-7. doi:
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Analytical and bioanalytical chemistry.
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Electrophoresis.
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Electrophoresis.
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Pharmacology, biochemistry, and behavior.
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2005 Jun; 86(2-3):305-11. doi:
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2004 Sep; 24(9):1037-45. doi:
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Pharmacogenetics.
2004 Jun; 14(6):343-9. doi:
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Forensic science international.
2004 Apr; 141(1):23-31. doi:
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Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - René Severijnen, Nazila Bayat, Hans Bakker, Jules Tolboom, Ger Bongaerts. Enteral drug absorption in patients with short small bowel : a review.
Clinical pharmacokinetics.
2004; 43(14):951-62. doi:
10.2165/00003088-200443140-00001. [PMID: 15530127] - Santi Kaewmokul, Varanuj Chatsudthipong, Kristen K Evans, William H Dantzler, Stephen H Wright. Functional mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule.
American journal of physiology. Renal physiology.
2003 Dec; 285(6):F1149-59. doi:
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Human psychopharmacology.
2003 Oct; 18(7):569-74. doi:
10.1002/hup.522. [PMID: 14533141] - Haruyo Sanbe, Jun Haginaka. Restricted access media-molecularly imprinted polymer for propranolol and its application to direct injection analysis of beta-blockers in biological fluids.
The Analyst.
2003 Jun; 128(6):593-7. doi:
10.1039/b301257n. [PMID: 12866873] - Mathew W Bridge, Andrew S Weller, Mark Rayson, David A Jones. Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function.
European journal of applied physiology.
2003 Jun; 89(5):451-9. doi:
10.1007/s00421-003-0800-z. [PMID: 12684806] - Dallas Bednarczyk, Sean Ekins, James H Wikel, Stephen H Wright. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Molecular pharmacology.
2003 Mar; 63(3):489-98. doi:
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Psychopharmacology.
2003 Mar; 166(3):284-93. doi:
10.1007/s00213-002-1339-0. [PMID: 12589521] - Peter S Talbot, Marc Laruelle. The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2002 Dec; 12(6):503-11. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2002 Nov; 34(11-12):703-8. doi:
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Chirality.
2002 Aug; 14(8):683-7. doi:
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Neurochemistry international.
2002 Jul; 41(1):17-27. doi:
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Journal of pharmaceutical and biomedical analysis.
2002 Apr; 28(1):97-106. doi:
10.1016/s0731-7085(01)00631-8. [PMID: 11861113] - Cristina Cusin, Alessandro Serretti, Raffaella Zanardi, Enrico Lattuada, David Rossini, Roberta Lilli, Cristina Lorenzi, Enrico Smeraldi. Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity.
The international journal of neuropsychopharmacology.
2002 Mar; 5(1):27-35. doi:
10.1017/s1461145701002711. [PMID: 12057029] - Johan Sandell, Christer Halldin, Yuan-Hwa Chou, Carl-Gunnar Swahn, Seth-Olov Thorberg, Lars Farde. PET-examination and metabolite evaluation in monkey of [(11)C]NAD-299, a radioligand for visualisation of the 5-HT(1A) receptor.
Nuclear medicine and biology.
2002 Jan; 29(1):39-45. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
2001 Dec; 765(2):167-77. doi:
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European journal of pharmacology.
2001 Dec; 433(2-3):173-6. doi:
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Journal of medicinal chemistry.
2001 Dec; 44(25):4370-8. doi:
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Psychiatry research.
2001 Nov; 104(3):195-203. doi:
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2001 Oct; 11(5):375-80. doi:
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Biological & pharmaceutical bulletin.
2001 Oct; 24(10):1191-4. doi:
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Biological psychiatry.
2001 Sep; 50(5):323-30. doi:
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Molecular psychiatry.
2001 Sep; 6(5):586-92. doi:
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Journal of neurochemistry.
2001 Aug; 78(3):619-30. doi:
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Biological psychiatry.
2001 Jul; 50(1):13-21. doi:
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British journal of clinical pharmacology.
2001 Jun; 51(6):547-55. doi:
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Biological & pharmaceutical bulletin.
2001 Jun; 24(6):671-7. doi:
10.1248/bpb.24.671. [PMID: 11411557] - S J Hemmings. New methods for the isolation of skeletal muscle sarcolemma and sarcoplasmic reticulum allowing a comparison between the mammalian and amphibian beta(2)-adrenergic receptors and calcium pumps.
Cell biochemistry and function.
2001 Jun; 19(2):133-41. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2001 Apr; 280(4):G595-602. doi:
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Therapeutic drug monitoring.
2001 Feb; 23(1):39-46. doi:
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Journal of clinical psychopharmacology.
2001 Feb; 21(1):36-45. doi:
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Autonomic neuroscience : basic & clinical.
2000 Aug; 82(3):123-9. doi:
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Nuclear medicine and biology.
2000 Jul; 27(5):515-21. doi:
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