Pindolol (BioDeep_00000002354)

 

Secondary id: BioDeep_00000408849

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-(1H-indol-4-Yloxy)-3-[(1-methylethyl)amino]propan-2-ol

化学式: C14H20N2O2 (248.15247000000002)
中文名称: 吲哚洛尔, 平多洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 0.67%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

描述信息

Pindolol is only found in individuals that have used or taken this drug. It is a moderately lipophilic beta blocker (adrenergic beta-antagonists). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Pindolol non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
CONFIDENCE standard compound; INTERNAL_ID 4098
CONFIDENCE standard compound; INTERNAL_ID 2663
Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

同义名列表

28 个代谢物同义名

1-(1H-indol-4-Yloxy)-3-[(1-methylethyl)amino]propan-2-ol; 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; 1-(1H-indol-4-Yloxy)-3-(propan-2-ylamino)-propan-2-ol; 1-(1H-indol-4-Yloxy)-3-(isopropylamino)propan-2-ol; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; Glauco-visken; Cardilic acid; Blocklin L; Prinodolol; Betapindol; Durapindol; Pindololum; Blocklin-L; Pectobloc; Prindolol; Cardilate; Blockin L; Carvisken; Calvisken; Pynastin; pindolol; Decreten; Pinbetol; Visken; LB-46; LB 46; Pindolol; Pindolol



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Wang, Chong Li, Peng Li. A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization. Journal of the American Society for Mass Spectrometry. 2022 Feb; 33(2):304-314. doi: 10.1021/jasms.1c00305. [PMID: 35040644]
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  • Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry. Angewandte Chemie (International ed. in English). 2020 12; 59(51):23162-23168. doi: 10.1002/anie.202006481. [PMID: 32869436]
  • Paulo Vinicius Bernardes Gonçalves, Fernanda de Lima Moreira, Jhohann Richard de Lima Benzi, Ricardo Carvalho Cavalli, Geraldo Duarte, Vera Lucia Lanchote. Nonrelevant Pharmacokinetic Drug-Drug Interaction Between Furosemide and Pindolol Enantiomers in Hypertensive Parturient Women. Journal of clinical pharmacology. 2020 11; 60(11):1527-1529. doi: 10.1002/jcph.1719. [PMID: 32789919]
  • Marián Masár, Jasna Hradski, Martin G Schmid, Roman Szucs. Advantages and Pitfalls of Capillary Electrophoresis of Pharmaceutical Compounds and Their Enantiomers in Complex Samples: Comparison of Hydrodynamically Opened and Closed Systems. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186852. [PMID: 32961980]
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  • Yeliz Demir. The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis. The Journal of pharmacy and pharmacology. 2019 Oct; 71(10):1576-1583. doi: 10.1111/jphp.13144. [PMID: 31347707]
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