cyclothiazide (BioDeep_00000408824)

Main id: BioDeep_00000009375

 


代谢物信息卡片


cyclothiazide

化学式: C14H16ClN3O4S2 (389.0270726)
中文名称: 环噻嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl
InChI: InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)

描述信息

C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
Same as: D01256
Cyclothiazide, a positive allosteric modulator of AMPA receptors, is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current[1].

同义名列表

1 个代谢物同义名

cyclothiazide



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19 个数据库交叉引用编号

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jelena Baranovic, Chandra S Ramanujan, Nahoko Kasai, Charles R Midgett, Dean R Madden, Keiichi Torimitsu, John F Ryan. Reconstitution of homomeric GluA2(flop) receptors in supported lipid membranes: functional and structural properties. The Journal of biological chemistry. 2013 Mar; 288(12):8647-8657. doi: 10.1074/jbc.m112.422105. [PMID: 23382380]
  • Xiao-Bing Zhang, Guang-Chun Sun, Lu-Ying Liu, Fang Yu, Tian-Le Xu. Alpha2 subunit specificity of cyclothiazide inhibition on glycine receptors. Molecular pharmacology. 2008 Apr; 73(4):1195-202. doi: 10.1124/mol.107.042655. [PMID: 18162605]
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  • Olivia N Dumitrescu, Dario A Protti, Sriparna Majumdar, Hanns Ulrich Zeilhofer, Heinz Wässle. Ionotropic glutamate receptors of amacrine cells of the mouse retina. Visual neuroscience. 2006 Jan; 23(1):79-90. doi: 10.1017/s0952523806231079. [PMID: 16597352]
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  • Shi-Yong Huang, Yu Liu, Pei-Ji Liang. Role of Ca2+ store in AMPA-triggered Ca2+ dynamics in retinal horizontal cells. Neuroreport. 2004 Oct; 15(15):2311-5. doi: 10.1097/00001756-200410250-00002. [PMID: 15640746]
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  • F F Youssef, J I Addae, A McRae, T W Stone. Long-term potentiation protects rat hippocampal slices from the effects of acute hypoxia. Brain research. 2001 Jul; 907(1-2):144-50. doi: 10.1016/s0006-8993(01)02594-x. [PMID: 11430897]
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  • T H Johansen, A Chaudhary, T A Verdoorn. Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. Molecular pharmacology. 1995 Nov; 48(5):946-55. doi: . [PMID: 7476926]
  • K M Partin, D Bowie, M L Mayer. Structural determinants of allosteric regulation in alternatively spliced AMPA receptors. Neuron. 1995 Apr; 14(4):833-43. doi: 10.1016/0896-6273(95)90227-9. [PMID: 7718245]
  • X Jeunemaitre, A Charru, G Chatellier, P Degoulet, J Julien, P F Plouin, P Corvol, J Ménard. Long-term metabolic effects of spironolactone and thiazides combined with potassium-sparing agents for treatment of essential hypertension. The American journal of cardiology. 1988 Nov; 62(16):1072-7. doi: 10.1016/0002-9149(88)90551-6. [PMID: 3189169]
  • J T Salonen, P Ylitalo. Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement. European journal of clinical pharmacology. 1982; 22(6):495-9. doi: 10.1007/bf00609621. [PMID: 7128662]