PHENCYCLIDINE (BioDeep_00000408341)
Main id: BioDeep_00000002816
natural product
代谢物信息卡片
PHENCYCLIDINE
化学式: C17H25N (243.198689)
中文名称: 苯环利定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(CC1)(C2=CC=CC=C2)N3CCCCC3
InChI: InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:8058
- KEGG: C07575
- PubChem: 6468
- DrugBank: DB03575
- ChEMBL: CHEMBL275528
- MeSH: Phencyclidine
- CAS: 101887-87-0
- CAS: 77-10-1
- MoNA: CCMSLIB00004721851
- MoNA: CCMSLIB00004679320
- PubChem: 9778
- PDB-CCD: 1PC
- NIKKAJI: J4.441E
- RefMet: Phencyclidine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hafseh Fanaei, Seyyed Ali Mard, Alireza Sarkaki, Gholamreza Goudarzi, Layasadat Khorsandi. Gallic acid protects the liver against NAFLD induced by dust exposure and high-fat diet through inhibiting oxidative stress and repressing the inflammatory signaling pathways NF-kβ/TNF-α/IL-6 in Wistar rats.
Avicenna journal of phytomedicine.
2021 Sep; 11(5):527-540. doi:
10.22038/ajp.2021.17835. [PMID: 34745924] - Anders Bork Davidsen, Marie Mardal, Sys Stybe Johansen, Petur Weihe Dalsgaard, Kristian Linnet. In vitro and in vivo metabolism and detection of 3-HO-PCP, a synthetic phencyclidine, in human samples and pooled human hepatocytes using high resolution mass spectrometry.
Drug testing and analysis.
2020 Jul; 12(7):987-993. doi:
10.1002/dta.2807. [PMID: 32311838] - In Soo Ryu, Oc-Hee Kim, Young Eun Lee, Ji Sun Kim, Zhan-Hui Li, Tae Wan Kim, Ri-Na Lim, Young Ju Lee, Jae Hoon Cheong, Hee Jin Kim, Yong Sup Lee, Scott C Steffensen, Bong Hyo Lee, Joung-Wook Seo, Eun Young Jang. The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents.
International journal of molecular sciences.
2020 Jun; 21(13):. doi:
10.3390/ijms21134631. [PMID: 32610694] - Lisa Christine Dunlop, David Wood, John Archer, Simon Hudson, Paul Dargan. Severe Toxicity to the New Psychoactive Substances 3-Hydroxyphencyclidine and N-Ethylhexedrone: an Analytically Confirmed Case Report.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2020 01; 16(1):67-70. doi:
10.1007/s13181-019-00734-x. [PMID: 31482320] - Antoine Berar, Jean-Sébastien Allain, Sophie Allard, Charles Lefevre, Alain Baert, Isabelle Morel, Renaud Bouvet, Thomas Gicquel. Intoxication with 3-MeO-PCP alone: A case report and literature review.
Medicine.
2019 Dec; 98(52):e18295. doi:
10.1097/md.0000000000018295. [PMID: 31876705] - Panpan Wang, Ting Cao, Jiaojiao Chen, Yiguo Jiang, Cheng Wang, John L Waddington, Xuechu Zhen. D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
Neuropharmacology.
2019 10; 157(?):107675. doi:
10.1016/j.neuropharm.2019.107675. [PMID: 31233824] - Corinne Murphy, Rebekah Dyer, Matthew W McAllister. Phencyclidine False Positive Result Induced by LamoTRIgine on the PROFILE-V MEDTOXScan Drugs of Abuse Test System.
Journal of emergency nursing.
2019 Sep; 45(5):582-583. doi:
10.1016/j.jen.2019.01.015. [PMID: 30827576] - Isabel Gomila, Maria Ángeles Leciñena, Miguel Ángel Elorza, Yolanda Pastor, Laura Sahuquillo, Miguel Servera, Jordi Puiguriguer, Bernardino Barcelo. Detectability of Dissociative Psychoactive Substances in Urine by Five Commercial Phencyclidine Immunoassays.
Journal of analytical toxicology.
2019 Jul; 43(6):497-503. doi:
10.1093/jat/bkz026. [PMID: 31329888] - Alice Ameline, Hugues Greney, Laurent Monassier, Jean-Sébastien Raul, Pascal Kintz. Metabolites to parent 3-MeO-PCP ratio in human urine collected in two fatal cases.
Journal of analytical toxicology.
2019 May; 43(4):321-324. doi:
10.1093/jat/bky097. [PMID: 30476158] - Sophie Allard, Pierre-Marie Allard, Isabelle Morel, Thomas Gicquel. Application of a molecular networking approach for clinical and forensic toxicology exemplified in three cases involving 3-MeO-PCP, doxylamine, and chlormequat.
Drug testing and analysis.
2019 May; 11(5):669-677. doi:
10.1002/dta.2550. [PMID: 30468699] - Pascal Kintz, Alice Ameline, Alexis Walch, Audrey Farrugia, Jean-Sébastien Raul. Murdered while under the influence of 3-MeO-PCP.
International journal of legal medicine.
2019 Mar; 133(2):475-478. doi:
10.1007/s00414-018-1901-x. [PMID: 30039274] - Nicolás Fernández, Florencia Falguera, Laura M Cabanillas, Patricia N Quiroga. False-positive phencyclidine immunoassay results caused by metronidazole.
Clinical toxicology (Philadelphia, Pa.).
2018 12; 56(12):1211-1212. doi:
10.1080/15563650.2018.1483026. [PMID: 29893585] - Thilina U Jayawardena, K K Asanka Sanjeewa, I P Shanura Fernando, Bo Mi Ryu, Min-Cheol Kang, Youngheun Jee, Won Woo Lee, You-Jin Jeon. Sargassum horneri (Turner) C. Agardh ethanol extract inhibits the fine dust inflammation response via activating Nrf2/HO-1 signaling in RAW 264.7 cells.
BMC complementary and alternative medicine.
2018 Sep; 18(1):249. doi:
10.1186/s12906-018-2314-6. [PMID: 30200963] - Christopher F McCain, Leah B Namey, Oliver Freudenreich. Lamotrigine Cross-Reactivity With Phencyclidine in Rapid Urine Toxicology in a Research Study.
The primary care companion for CNS disorders.
2018 Jul; 20(4):. doi:
10.4088/pcc.17l02192. [PMID: 30084548] - Alex J Krotulski, Donna M Papsun, Melissa Friscia, Jennifer L Swartz, Brian D Holsey, Barry K Logan. Fatality Following Ingestion of Tetrahydrofuranylfentanyl, U-49900 and Methoxy-Phencyclidine.
Journal of analytical toxicology.
2018 Apr; 42(3):e27-e32. doi:
10.1093/jat/bkx092. [PMID: 29186585] - Hagar Tadmor, Idit Golani, Ravid Doron, Ilana Kremer, Alon Shamir. ErbB signaling antagonist ameliorates behavioral deficit induced by phencyclidine (PCP) in mice, without affecting metabolic syndrome markers.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 03; 82(?):322-331. doi:
10.1016/j.pnpbp.2017.08.010. [PMID: 28818421] - The-Vinh Tran, Se Jin Park, Eun-Joo Shin, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Yu Jeung Lee, Seung-Yeol Nah, Toshitaka Nabeshima, Hyoung-Chun Kim. Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.
Brain research bulletin.
2018 03; 137(?):71-78. doi:
10.1016/j.brainresbull.2017.11.004. [PMID: 29122692] - T Michael Farley, Emily N Anderson, Jade N Feller. False-positive phencyclidine (PCP) on urine drug screen attributed to desvenlafaxine (Pristiq) use.
BMJ case reports.
2017 Nov; 2017(?):. doi:
10.1136/bcr-2017-222106. [PMID: 29170178] - The-Vinh Tran, Eun-Joo Shin, Ji Hoon Jeong, Ji Won Lee, Youngho Lee, Choon-Gon Jang, Seung-Yeol Nah, Xin Gen Lei, Kazuya Toriumi, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim. Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice.
Molecular neurobiology.
2017 11; 54(9):7042-7062. doi:
10.1007/s12035-016-0239-y. [PMID: 27796745] - Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V Radonjić, Nataša Petronijević. Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.
BMC pharmacology & toxicology.
2017 10; 18(1):65. doi:
10.1186/s40360-017-0171-4. [PMID: 29020988] - Stephen Thornton, David Lisbon, Thomas Lin, Roy Gerona. Beyond Ketamine and Phencyclidine: Analytically Confirmed Use of Multiple Novel Arylcyclohexylamines.
Journal of psychoactive drugs.
2017 Sep; 49(4):289-293. doi:
10.1080/02791072.2017.1333660. [PMID: 28590798] - Brian N Chang, Michael P Smith. A Case of Unusual Drug Screening Results.
Clinical chemistry.
2017 05; 63(5):958-961. doi:
10.1373/clinchem.2016.264507. [PMID: 28455300] - Elisabetta Bertol, Jennifer Pascali, Diego Palumbo, Valeria Catalani, Maria Grazia Di Milia, Alessia Fioravanti, Francesco Mari, Fabio Vaiano. 3-MeO-PCP intoxication in two young men: First in vivo detection in Italy.
Forensic science international.
2017 May; 274(?):7-12. doi:
10.1016/j.forsciint.2016.12.028. [PMID: 28057371] - Monika Zidkova, Tomas Hlozek, Martin Balik, Ondrej Kopecky, Pavel Tesinsky, Jan Svanda, Marie Anna Balikova. Two Cases of Non-fatal Intoxication with a Novel Street Hallucinogen: 3-Methoxy-Phencyclidine.
Journal of analytical toxicology.
2017 May; 41(4):350-354. doi:
10.1093/jat/bkx009. [PMID: 28158698] - Dan Ma, Paul C Guest. Generation of the Acute Phencyclidine Rat Model for Proteomic Studies of Schizophrenia.
Advances in experimental medicine and biology.
2017; 974(?):257-261. doi:
10.1007/978-3-319-52479-5_23. [PMID: 28353244] - Julian A A Michely, Sascha K Manier, Achim T Caspar, Simon D Brandt, Jason Wallach, Hans H Maurer. New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, 'LC-(High Resolution)-MSn' and 'LC-(High Resolution)-MS/MS'.
Current neuropharmacology.
2017; 15(5):692-712. doi:
10.2174/1570159x14666161018151716. [PMID: 27758707] - Pritsana Piyabhan, Supaporn Wannasiri, Jarinyaporn Naowaboot. Bacopa monnieri (Brahmi) improved novel object recognition task and increased cerebral vesicular glutamate transporter type 3 in sub-chronic phencyclidine rat model of schizophrenia.
Clinical and experimental pharmacology & physiology.
2016 12; 43(12):1234-1242. doi:
10.1111/1440-1681.12658. [PMID: 27562725] - Brandon Stamper, Waseem Gul, Murrell Godfrey, Shahbaz W Gul, Mahmoud A ElSohly. LC-MS-MS Method for the Analysis of Miscellaneous Drugs in Wastewater During Football Games III.
Journal of analytical toxicology.
2016 Oct; 40(8):694-699. doi:
10.1093/jat/bkw081. [PMID: 27562966] - Thomas G Rosano, Patrice Y Ohouo, John J LeQue, Scott M Freeto, Michelle Wood. Definitive Drug and Metabolite Screening in Urine by UPLC-MS-MS Using a Novel Calibration Technique.
Journal of analytical toxicology.
2016 Oct; 40(8):628-638. doi:
10.1093/jat/bkw050. [PMID: 27562968] - Duncan A A MacLaren, Richard W Browne, Jessica K Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, Stewart D Clark. Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.
eNeuro.
2016 Sep; 3(5):. doi:
10.1523/eneuro.0219-16.2016. [PMID: 27822508] - Ryan Gallagher, Jonathan Dangers, Stephen L Thornton. Do trauma patients with phencyclidine-positive urine drug screens have increased morbidity or mortality?.
The American journal of emergency medicine.
2016 Jun; 34(6):1066-8. doi:
10.1016/j.ajem.2016.03.022. [PMID: 27037134] - Fumiya Tatsuki, Genshiro A Sunagawa, Shoi Shi, Etsuo A Susaki, Hiroko Yukinaga, Dimitri Perrin, Kenta Sumiyama, Maki Ukai-Tadenuma, Hiroshi Fujishima, Rei-ichiro Ohno, Daisuke Tone, Koji L Ode, Katsuhiko Matsumoto, Hiroki R Ueda. Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals.
Neuron.
2016 Apr; 90(1):70-85. doi:
10.1016/j.neuron.2016.02.032. [PMID: 26996081] - Henry Sershen, Audrey Hashim, David S Dunlop, Raymond F Suckow, Tom B Cooper, Daniel C Javitt. Modulating NMDA Receptor Function with D-Amino Acid Oxidase Inhibitors: Understanding Functional Activity in PCP-Treated Mouse Model.
Neurochemical research.
2016 Feb; 41(1-2):398-408. doi:
10.1007/s11064-016-1838-8. [PMID: 26857796] - Eric G Mohler, Zhiyong Ding, Lynne E Rueter, Douglas Chapin, Damon Young, Rouba Kozak. Cross-site strain comparison of pharmacological deficits in the touchscreen visual discrimination test.
Psychopharmacology.
2015 Nov; 232(21-22):4033-41. doi:
10.1007/s00213-015-4012-0. [PMID: 26177580] - Iain M McIntyre, Amber Trochta, Ray D Gary, Alina Storey, Jennifer Corneal, Bethann Schaber. A Fatality Related to Two Novel Hallucinogenic Compounds: 4-Methoxyphencyclidine and 4-Hydroxy-N-methyl-N-ethyltryptamine.
Journal of analytical toxicology.
2015 Nov; 39(9):751-5. doi:
10.1093/jat/bkv089. [PMID: 26265285] - Matilda Bäckberg, Olof Beck, Anders Helander. Phencyclidine analog use in Sweden--intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project.
Clinical toxicology (Philadelphia, Pa.).
2015 Nov; 53(9):856-64. doi:
10.3109/15563650.2015.1079325. [PMID: 26295489] - Owen Dyer. Senior citizens were routinely tested for 'angel dust' in scam that led to $256m settlement.
BMJ (Clinical research ed.).
2015 Oct; 351(?):h5743. doi:
10.1136/bmj.h5743. [PMID: 26507075] - Paul Dominici, Kathryn Kopec, Rashmi Manur, Abdullah Khalid, Kathia Damiron, Adam Rowden. Phencyclidine Intoxication Case Series Study.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2015 Sep; 11(3):321-5. doi:
10.1007/s13181-014-0453-9. [PMID: 25502414] - Hendrik Wesseling, Elizabeth J Want, Paul C Guest, Hassan Rahmoune, Elaine Holmes, Sabine Bahn. Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.
Journal of proteome research.
2015 Aug; 14(8):3174-87. doi:
10.1021/acs.jproteome.5b00105. [PMID: 26043028] - Héctor Torres-Gómez, Kirstin Lehmkuhl, Bastian Frehland, Constantin Daniliuc, Dirk Schepmann, Christina Ehrhardt, Bernhard Wünsch. Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Bioorganic & medicinal chemistry.
2015 Aug; 23(15):4277-4285. doi:
10.1016/j.bmc.2015.06.030. [PMID: 26145819] - Shigeyuki Chaki, Toshiharu Shimazaki, Jun-Ichi Karasawa, Takeshi Aoki, Ayaka Kaku, Michihiko Iijima, Daiji Kambe, Shuji Yamamoto, Yasunori Kawakita, Tsuyoshi Shibata, Kumi Abe, Taketoshi Okubo, Yoshinori Sekiguchi, Shigeru Okuyama. Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia.
Psychopharmacology.
2015 Aug; 232(15):2849-61. doi:
10.1007/s00213-015-3920-3. [PMID: 25869273] - Akiko Matsuura, Yuko Fujita, Masaomi Iyo, Kenji Hashimoto. Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine.
Acta neuropsychiatrica.
2015 Jun; 27(3):159-67. doi:
10.1017/neu.2015.1. [PMID: 25648314] - Yumi Shirai, Yuko Fujita, Ryota Hashimoto, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Tamaki Ishima, Hiroyuki Suganuma, Yusuke Ushida, Masatoshi Takeda, Kenji Hashimoto. Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood.
PloS one.
2015; 10(6):e0127244. doi:
10.1371/journal.pone.0127244. [PMID: 26107664] - Scott D Gleason, Akihiko Kato, Hai H Bui, Linda K Thompson, Sabrina N Valli, Patrick V Stutz, Ming-Shang Kuo, Julie F Falcone, Wesley H Anderson, Xia Li, Jeffrey M Witkin. Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.
CNS & neurological disorders drug targets.
2015; 14(5):612-26. doi:
10.2174/1871527314666150429114818. [PMID: 25921737] - Nichole D Bynum, Katherine N Moore, Megan Grabenauer. Evaluation of laser diode thermal desorption-tandem mass spectrometry (LDTD-MS-MS) in forensic toxicology.
Journal of analytical toxicology.
2014 Oct; 38(8):528-35. doi:
10.1093/jat/bku084. [PMID: 25217542] - A V Hinson, V Schlünssen, G Agodokpessi, T Sigsgaards, B Fayomi. The prevalence of byssinosis among cotton workers in the north of Benin.
The international journal of occupational and environmental medicine.
2014 Oct; 5(4):194-200. doi:
". [PMID: 25270009] - Celia Kjaerby, Brian V Broberg, Uffe Kristiansen, Nils Ole Dalby. Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats.
Cerebral cortex (New York, N.Y. : 1991).
2014 Sep; 24(9):2522-32. doi:
10.1093/cercor/bht109. [PMID: 23613110] - Pritsana Piyabhan, Thanitsara Wetchateng. Neuroprotective effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDAR1 immunodensity in the prefrontal cortex, striatum and hippocampus of sub-chronic phencyclidine rat model of schizophrenia.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2014 Aug; 97 Suppl 8(?):S50-5. doi:
. [PMID: 25518293] - Matthias Fischer, Stefan Unterecker, Jürgen Deckert. False-positive phencyclidine drug screenings during psychopharmacologic treatment.
The Journal of clinical psychiatry.
2014 Jul; 75(7):728-30. doi:
10.4088/jcp.13cr08955. [PMID: 25093470] - Hironao Takebayashi, Naoki Yamamoto, Asami Umino, Toru Nishikawa. Identification of developmentally regulated PCP-responsive non-coding RNA, prt6, in the rat thalamus.
PloS one.
2014; 9(6):e97955. doi:
10.1371/journal.pone.0097955. [PMID: 24886782] - Wataru Hamaguchi, Naoyuki Masuda, Kiyohiro Samizu, Takuma Mihara, Kaori Takama, Toshihiro Watanabe. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors.
Chemical & pharmaceutical bulletin.
2014; 62(12):1200-13. doi:
10.1248/cpb.c14-00509. [PMID: 25450629] - Min Ma, Qian Ren, Yuko Fujita, Tamaki Ishima, Ji-Chun Zhang, Kenji Hashimoto. Effects of AS2586114, a soluble epoxide hydrolase inhibitor, on hyperlocomotion and prepulse inhibition deficits in mice after administration of phencyclidine.
Pharmacology, biochemistry, and behavior.
2013 Sep; 110(?):98-103. doi:
10.1016/j.pbb.2013.06.005. [PMID: 23792539] - Arvind Rengarajan, Michael E Mullins. How often do false-positive phencyclidine urine screens occur with use of common medications?.
Clinical toxicology (Philadelphia, Pa.).
2013 Jul; 51(6):493-6. doi:
10.3109/15563650.2013.801982. [PMID: 23697457] - Christine Moore, Dennis Crouch. Oral fluid for the detection of drugs of abuse using immunoassay and LC-MS/MS.
Bioanalysis.
2013 Jun; 5(12):1555-69. doi:
10.4155/bio.13.115. [PMID: 23795933] - Gábor Gaszner, Andrea Bartha. Psychiatric intensive care of dementia praecox.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.
2013 Jun; 15(2):118-21. doi:
NULL. [PMID: 23817362] - Giorgia De Paoli, Simon D Brandt, Jason Wallach, Roland P Archer, Derrick J Pounder. From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices.
Journal of analytical toxicology.
2013 Jun; 37(5):277-83. doi:
10.1093/jat/bkt023. [PMID: 23552616] - James W Price. Creatinine normalization of workplace urine drug tests: does it make a difference?.
Journal of addiction medicine.
2013 Mar; 7(2):129-32. doi:
10.1097/adm.0b013e318283698c. [PMID: 23370934] - Andrew M King, Jennifer L Pugh, Nathan B Menke, Matthew D Krasowski, Michael J Lynch, Anthony F Pizon. Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay.
The American journal of emergency medicine.
2013 Feb; 31(2):444.e5-9. doi:
10.1016/j.ajem.2012.05.028. [PMID: 22944551] - Tadeusz Halatek, Piotr Lutz, Jan Stetkiewicz, Aleksander Krajnow, Edyta Wieczorek, Radoslaw Swiercz, Maria Szymczak, Wojciech Wasowicz. Comparison of neurobehavioral and biochemical effects in rats exposed to dusts from copper smelter plant at different locations.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2013; 48(9):1000-11. doi:
10.1080/10934529.2013.773198. [PMID: 23573920] - Bryan L Roth, Simon Gibbons, Warunya Arunotayanun, Xi-Ping Huang, Vincent Setola, Ric Treble, Les Iversen. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
PloS one.
2013; 8(3):e59334. doi:
10.1371/journal.pone.0059334. [PMID: 23527166] - Diego Airado-Rodríguez, Carmen Cruces-Blanco, Ana M García-Campaña. Dispersive liquid-liquid microextraction prior to field-amplified sample injection for the sensitive analysis of 3,4-methylenedioxymethamphetamine, phencyclidine and lysergic acid diethylamide by capillary electrophoresis in human urine.
Journal of chromatography. A.
2012 Dec; 1267(?):189-97. doi:
10.1016/j.chroma.2012.10.011. [PMID: 23141624] - Tihomir Stojković, Nevena V Radonjić, Milica Velimirović, Gordana Jevtić, Vera Popović, Mirjana Doknić, Nataša D Petronijević. Risperidone reverses phencyclidine induced decrease in glutathione levels and alterations of antioxidant defense in rat brain.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Oct; 39(1):192-9. doi:
10.1016/j.pnpbp.2012.06.013. [PMID: 22735395] - Fumio Moriya. [Preliminary comparative study on the usefulness of instant-view'TM M-1 and Triage DOA in testing for drugs-of-abuse in forensic urine samples].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2012 Sep; 25(3):243-6. doi:
NULL. [PMID: 23057404] - Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel, Dave A Luckenbaugh, Nancy E Brutsche, Lobna Ibrahim, Carlos A Zarate, Donald E Mager, Irving W Wainer. Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.
British journal of clinical pharmacology.
2012 Aug; 74(2):304-14. doi:
10.1111/j.1365-2125.2012.04198.x. [PMID: 22295895] - Agnes Ernst, Dan Ma, Isabel Garcia-Perez, Tsz M Tsang, Wolfgang Kluge, Emanuel Schwarz, Paul C Guest, Elaine Holmes, Zoltan Sarnyai, Sabine Bahn. Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.
Journal of proteome research.
2012 Jul; 11(7):3704-14. doi:
10.1021/pr300197d. [PMID: 22613019] - Hieu M Phan, Keith Yoshizuka, Daryl J Murry, Paul J Perry. Drug testing in the workplace.
Pharmacotherapy.
2012 Jul; 32(7):649-56. doi:
10.1002/j.1875-9114.2011.01089.x. [PMID: 22605533] - Katsuya Harada, Kazuhiro Nakato, Junko Yarimizu, Mayako Yamazaki, Masahiko Morita, Shinji Takahashi, Masaki Aota, Kyoko Saita, Hitoshi Doihara, Yuichiro Sato, Takayuki Yamaji, Keni Ni, Nobuya Matsuoka. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.
European journal of pharmacology.
2012 Jun; 685(1-3):59-69. doi:
10.1016/j.ejphar.2012.04.013. [PMID: 22542656] - Milly E Attema-de Jonge, Suzanne Y G Peeters, Eric J F Franssen. Performance of three point-of-care urinalysis test devices for drugs of abuse and therapeutic drugs applied in the emergency department.
The Journal of emergency medicine.
2012 Jun; 42(6):682-91. doi:
10.1016/j.jemermed.2011.01.031. [PMID: 21911284] - Binh T Ly, Stephen L Thornton, Colleen Buono, Judith A Stone, Alan H B Wu. False-positive urine phencyclidine immunoassay screen result caused by interference by tramadol and its metabolites.
Annals of emergency medicine.
2012 Jun; 59(6):545-7. doi:
10.1016/j.annemergmed.2011.08.013. [PMID: 21924518] - Kerry A Waters, Tania O Stean, Beverley Hammond, David J Virley, Neil Upton, James N C Kew, Ishrut Hussain. Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition.
Behavioural brain research.
2012 Mar; 228(1):211-8. doi:
10.1016/j.bbr.2011.12.009. [PMID: 22189656] - Simon Gibbons. 'Legal highs'--novel and emerging psychoactive drugs: a chemical overview for the toxicologist.
Clinical toxicology (Philadelphia, Pa.).
2012 Jan; 50(1):15-24. doi:
10.3109/15563650.2011.645952. [PMID: 22248120] - István Gyertyán, Béla Kiss, Katalin Sághy, Judit Laszy, Györgyi Szabó, Tamás Szabados, Larisza I Gémesi, Gabriella Pásztor, Mária Zájer-Balázs, Margit Kapás, Eva Ágai Csongor, György Domány, Károly Tihanyi, Zsolt Szombathelyi. Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.
Neurochemistry international.
2011 Nov; 59(6):925-35. doi:
10.1016/j.neuint.2011.07.002. [PMID: 21767587] - Justin L Poklis, Bethany Guckert, Carl E Wolf, Alphonse Poklis. Evaluation of a new phencyclidine enzyme immunoassay for the detection of phencyclidine in urine with confirmation by high-performance liquid chromatography-tandem mass spectrometry.
Journal of analytical toxicology.
2011 Sep; 35(7):481-6. doi:
10.1093/anatox/35.7.481. [PMID: 21871157] - Adrian Newman-Tancredi, Mark S Kleven. Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.
Psychopharmacology.
2011 Aug; 216(4):451-73. doi:
10.1007/s00213-011-2247-y. [PMID: 21394633] - Marina N Fogaça, Ruth F Santos-Galduróz, Jaqueline K Eserian, José Carlos F Galduróz. The effects of polyunsaturated fatty acids in alcohol dependence treatment--a double-blind, placebo-controlled pilot study.
BMC clinical pharmacology.
2011 Jul; 11(?):10. doi:
10.1186/1472-6904-11-10. [PMID: 21787433] - Guohua Li, Susan P Baker, Qi Zhao, Joanne E Brady, Barbara H Lang, George W Rebok, Charles DiMaggio. Drug violations and aviation accidents: findings from the US mandatory drug testing programs.
Addiction (Abingdon, England).
2011 Jul; 106(7):1287-92. doi:
10.1111/j.1360-0443.2011.03388.x. [PMID: 21306594] - L Martínez Sánchez, J Velasco Rodríguez, F Panzino Occhiuzzo, M Simó Nebot, O García Algar, C Luaces Cubells. [Phencyclidine in urine toxicology screening: a dangerous false positive].
Anales de pediatria (Barcelona, Spain : 2003).
2011 Jun; 74(6):418-9. doi:
10.1016/j.anpedi.2011.01.029. [PMID: 21393079] - Angèle Consoli, Karine Ronen, Isabelle An-Gourfinkel, Martine Barbeau, Donata Marra, Nathalie Costedoat-Chalumeau, Delphine Montefiore, Philippe Maksud, Olivier Bonnot, Adrien Didelot, Zahir Amoura, Marie Vidailhet, David Cohen. Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report.
Child and adolescent psychiatry and mental health.
2011 May; 5(1):15. doi:
10.1186/1753-2000-5-15. [PMID: 21569502] - Peter Hindersson, Torben Breindahl. [Is testing for 'angel dust' meaningful?].
Ugeskrift for laeger.
2011 May; 173(19):1379. doi:
NULL. [PMID: 21776627] - David M Bassan, Freidoon Erdmann, Ralf Krüll. Quantitative determination of 43 common drugs and drugs of abuse in human serum by HPLC-MS/MS.
Analytical and bioanalytical chemistry.
2011 Apr; 400(1):43-50. doi:
10.1007/s00216-011-4784-y. [PMID: 21331485] - Nima Majlesi, David C Lee, Sayed S Ali. Dextromethorphan abuse masquerading as a recurrent seizure disorder.
Pediatric emergency care.
2011 Mar; 27(3):210-1. doi:
10.1097/pec.0b013e31820d8dc1. [PMID: 21378523] - H Y Meltzer, B W Massey. The role of serotonin receptors in the action of atypical antipsychotic drugs.
Current opinion in pharmacology.
2011 Feb; 11(1):59-67. doi:
10.1016/j.coph.2011.02.007. [PMID: 21420906] - Markus R Meyer, Hans H Maurer. Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.
Pharmacogenomics.
2011 Feb; 12(2):215-33. doi:
10.2217/pgs.10.171. [PMID: 21332315] - Jichun Zhang, Jin Wu, Jun Toyohara, Yuko Fujita, Hongxian Chen, Kenji Hashimoto. Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain.
PloS one.
2011; 6(6):e21322. doi:
10.1371/journal.pone.0021322. [PMID: 21731704] - Eva M Marco, María S García-Gutiérrez, Francisco-Javier Bermúdez-Silva, Fabricio A Moreira, Francisco Guimarães, Jorge Manzanares, María-Paz Viveros. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.
Frontiers in behavioral neuroscience.
2011; 5(?):63. doi:
10.3389/fnbeh.2011.00063. [PMID: 22007164] - Marion Yger, Jean-Antoine Girault. DARPP-32, Jack of All Trades… Master of Which?.
Frontiers in behavioral neuroscience.
2011; 5(?):56. doi:
10.3389/fnbeh.2011.00056. [PMID: 21927600] - Fabiana da Silva Alves, Erik Boot, Nicole Schmitz, Aart Nederveen, Jacob Vorstman, Christina Lavini, Petra J Pouwels, Petra Pouwels, Lieuwe de Haan, Don Linszen, Therese van Amelsvoort. Proton magnetic resonance spectroscopy in 22q11 deletion syndrome.
PloS one.
2011; 6(6):e21685. doi:
10.1371/journal.pone.0021685. [PMID: 21738766] - Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser, Brian Lord, Timothy W Lovenberg, Ruggero Galici. Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
PloS one.
2011; 6(6):e20210. doi:
10.1371/journal.pone.0020210. [PMID: 21701689] - Naomi Haruta, Hideaki Iizuka, Kana Ishii, Shunsuke Yoshihara, Hideaki Ichiba, Takeshi Fukushima. Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan.
Proceedings of the Japan Academy. Series B, Physical and biological sciences.
2011; 87(10):641-8. doi:
10.2183/pjab.87.641. [PMID: 22156410] - Maurice J C M Magnée, Victor A F Lamme, Monique G M de Sain-van der Velden, Jacob A S Vorstman, Chantal Kemner. Proline and COMT status affect visual connectivity in children with 22q11.2 deletion syndrome.
PloS one.
2011; 6(10):e25882. doi:
10.1371/journal.pone.0025882. [PMID: 21998713] - Liliana L Jorge, Caroline C Feres, Vitor Ep Teles. Topical preparations for pain relief: efficacy and patient adherence.
Journal of pain research.
2010 Dec; 4(?):11-24. doi:
10.2147/jpr.s9492. [PMID: 21386951] - Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy R Zahniser, Boris Tabakoff, W Michael Zawada. Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption.
Stem cell research & therapy.
2010 Dec; 1(5):36. doi:
10.1186/scrt36. [PMID: 21122109] - Jennifer Kaufling, Elisabeth Waltisperger, Romain Bourdy, Antoine Valera, Pierre Veinante, Marie-José Freund-Mercier, Michel Barrot. Pharmacological recruitment of the GABAergic tail of the ventral tegmental area by acute drug exposure.
British journal of pharmacology.
2010 Dec; 161(8):1677-91. doi:
10.1111/j.1476-5381.2010.00984.x. [PMID: 21087442] - Matthew J Geraci, James Peele, Stacey L McCoy, Brad Elias. Phencyclidine false positive induced by lamotrigine (Lamictal®) on a rapid urine toxicology screen.
International journal of emergency medicine.
2010 Nov; 3(4):327-31. doi:
10.1007/s12245-010-0235-3. [PMID: 21373301] - Guohua Li, Joanne E Brady, Charles DiMaggio, Susan P Baker, George W Rebok. Validity of suspected alcohol and drug violations in aviation employees.
Addiction (Abingdon, England).
2010 Oct; 105(10):1771-5. doi:
10.1111/j.1360-0443.2010.03051.x. [PMID: 20712820] - Peter R Stout, Nichole D Bynum, Cynthia M Lewallen, John M Mitchell, Michael R Baylor, Jeri D Ropero-Miller. A comparison of the validity of gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry analysis of urine samples II: amphetamine, methamphetamine, (±)-3,4-methylenedioxyamphetamine, (±)-3,4-methylenedioxymethamphetamine, (±)-3,4-methylenedioxyethylamphetamine, phencyclidine, and (±)-11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol.
Journal of analytical toxicology.
2010 Oct; 34(8):430-43. doi:
10.1093/jat/34.8.430. [PMID: 21819787] - Edward F Domino. Taming the ketamine tiger. 1965.
Anesthesiology.
2010 Sep; 113(3):678-84. doi:
10.1097/aln.0b013e3181ed09a2. [PMID: 20693870] - Jorn Arnt, Benny Bang-Andersen, Ben Grayson, Franklin P Bymaster, Michael P Cohen, Neil W DeLapp, Bruno Giethlen, Mads Kreilgaard, David L McKinzie, Joanna C Neill, David L Nelson, Søren M Nielsen, Mette N Poulsen, John M Schaus, Louise M Witten. Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
The international journal of neuropsychopharmacology.
2010 Sep; 13(8):1021-33. doi:
10.1017/s1461145710000659. [PMID: 20569520] - Nancy C Brahm, Lynn L Yeager, Mark D Fox, Kevin C Farmer, Tony A Palmer. Commonly prescribed medications and potential false-positive urine drug screens.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Aug; 67(16):1344-50. doi:
10.2146/ajhp090477. [PMID: 20689123]