1-Methylxanthine (BioDeep_00000408276)

Main id: BioDeep_00000001203

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


1-Methylxanthine

化学式: C6H6N4O2 (166.0491)
中文名称: 3,7-二氢-1-甲基-1H-嘌呤-2,6-二酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(=O)C2=C(NC1=O)N=CN2
InChI: InChI=1S/C6H6N4O2/c1-10-5(11)3-4(8-2-7-3)9-6(10)12/h2H,1H3,(H,7,8)(H,9,12)

描述信息

MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; MVOYJPOZRLFTCP-UHFFFAOYSA-N_STSL_0033_1-Methylxanthine_0500fmol_180410_S2_LC02_MS02_41; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP)[1]. 1-Methylxanthine enhances the radiosensitivity of tumor cells[2].
1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP)[1]. 1-Methylxanthine enhances the radiosensitivity of tumor cells[2].

同义名列表

2 个代谢物同义名

1-Methylxanthine; 1-Methylxanthine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 13 ADH5, ALB, CCNB1, CDC25C, CHEK2, CYP1A1, CYP2A6, CYP2D6, CYP2E1, CYP3A4, EMP2, NAT2, XDH
Peripheral membrane protein 2 CYP1A1, CYP2E1
Endoplasmic reticulum membrane 6 CYP1A1, CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A4
Nucleus 6 ALB, CCNB1, CDC25C, CHEK2, EMP2, NAT2
cytosol 7 ADH5, ALB, CCNB1, CDC25C, GPT, NAT2, XDH
centrosome 2 ALB, CCNB1
nucleoplasm 3 CCNB1, CDC25C, CHEK2
Cell membrane 4 EMP2, GPR83, NAT2, TNF
Multi-pass membrane protein 4 EMP2, GPR83, NAT2, SLC22A6
Golgi apparatus membrane 1 EMP2
cell surface 2 EMP2, TNF
Golgi apparatus 3 ALB, CHEK2, EMP2
Golgi membrane 2 EMP2, INS
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuronal cell body 2 NAT2, TNF
plasma membrane 5 EMP2, GPR83, NAT2, SLC22A6, TNF
Membrane 7 CCNB1, CYP2A6, CYP2D6, CYP3A4, EMP2, NAT2, SLC22A6
apical plasma membrane 1 EMP2
axon 1 NAT2
basolateral plasma membrane 2 NAT2, SLC22A6
caveola 1 SLC22A6
extracellular exosome 5 ADH5, ALB, GPT, NAT2, SLC22A6
endoplasmic reticulum 2 ALB, CYP2D6
extracellular space 4 ALB, INS, TNF, XDH
perinuclear region of cytoplasm 2 CDC25C, EMP2
mitochondrion 3 ADH5, CYP1A1, CYP2D6
protein-containing complex 2 ALB, SLC22A6
intracellular membrane-bounded organelle 6 CYP1A1, CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP3A4
Microsome membrane 5 CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP3A4
Secreted 2 ALB, INS
extracellular region 3 ALB, INS, TNF
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 1 CCNB1
anchoring junction 1 ALB
transcription regulator complex 1 NAT2
external side of plasma membrane 1 TNF
cytoplasmic vesicle 1 EMP2
apical part of cell 1 EMP2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 EMP2
Cytoplasm, perinuclear region 1 EMP2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Membrane raft 2 EMP2, TNF
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
PML body 1 CHEK2
mitochondrial intermembrane space 1 CDC25C
ciliary basal body 1 ALB
cilium 1 GPR83
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 2 ALB, CCNB1
blood microparticle 1 ALB
non-motile cilium 1 GPR83
Basolateral cell membrane 1 SLC22A6
endosome lumen 1 INS
basal plasma membrane 1 SLC22A6
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
outer kinetochore 1 CCNB1
cytoplasmic microtubule 1 CYP2A6
Basal cell membrane 1 SLC22A6
external side of apical plasma membrane 1 NAT2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cyclin B1-CDK1 complex 1 CCNB1
NatA complex 1 NAT2
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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