7-Aminocephalosporanic acid (BioDeep_00000406519)

Main id: BioDeep_00000003764

 

natural product


代谢物信息卡片


7-Aminocephalosporanic acid

化学式: C10H12N2O5S (272.0467)
中文名称: 7-氨基头孢烷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)N
InChI: InChI=1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

同义名列表

2 个代谢物同义名

7-Aminocephalosporanic acid; 7-Aminocephalosporanic acid



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADRA2C, CAT, DAO, GAD2, GLA, HAS1, HMGB1, NEDD9, NPPA, PFDN5, PTGS2, TBX20
Peripheral membrane protein 5 CYP27A1, DAO, GAD2, HMGB1, PTGS2
Endoplasmic reticulum membrane 4 GLA, HSP90B1, PON1, PTGS2
Mitochondrion membrane 1 CYP27A1
Nucleus 5 HMGB1, HSP90B1, NEDD9, PFDN5, TBX20
cytosol 7 CAT, DAO, GAD2, HSP90B1, LIPE, NEDD9, PFDN5
trans-Golgi network 1 POSTN
nucleoplasm 2 HMGB1, NEDD9
Cell membrane 4 ADRA2C, DAO, HMGB1, LIPE
Lipid-anchor 1 GAD2
Cytoplasmic side 1 GAD2
lamellipodium 1 NEDD9
Multi-pass membrane protein 2 ADRA2C, HAS1
Golgi apparatus membrane 1 GAD2
cell cortex 1 NEDD9
cell surface 1 HMGB1
Golgi apparatus 4 GLA, HAS1, NEDD9, POSTN
Golgi membrane 1 GAD2
mitochondrial inner membrane 1 CYP27A1
neuromuscular junction 1 POSTN
neuronal cell body 1 GAD2
presynaptic membrane 1 GAD2
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 3 DAO, GAD2, LIPE
Lysosome 2 GLA, NPC2
endosome 2 ADRA2C, HMGB1
plasma membrane 7 ADRA2C, DAO, GAD2, HAS1, HMGB1, IGHE, NEDD9
presynaptic active zone 1 DAO
synaptic vesicle membrane 1 GAD2
Membrane 5 CAT, GLA, HAS1, HSP90B1, LIPE
axon 1 GAD2
basolateral plasma membrane 1 NEDD9
caveola 2 LIPE, PTGS2
extracellular exosome 7 CAT, CPVL, DAO, GLA, HSP90B1, NPC2, PON1
endoplasmic reticulum 4 HMGB1, HSP90B1, NPC2, PTGS2
extracellular space 7 DAO, HMGB1, IGHE, NPC2, NPPA, PON1, POSTN
lysosomal lumen 2 GLA, NPC2
perinuclear region of cytoplasm 2 GAD2, HSP90B1
bicellular tight junction 1 DAO
mitochondrion 2 CAT, CYP27A1
protein-containing complex 4 CAT, HSP90B1, NPPA, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 IGHE
Secreted 5 DAO, HMGB1, NPC2, NPPA, POSTN
extracellular region 9 CAT, DAO, GLA, HMGB1, HSP90B1, IGHE, NPC2, NPPA, PON1
mitochondrial matrix 2 CAT, CYP27A1
Extracellular side 2 DAO, HMGB1
Cell projection, cilium 1 NEDD9
Secreted, extracellular space, extracellular matrix 1 POSTN
high-density lipoprotein particle 1 PON1
perikaryon 1 NPPA
cytoplasmic vesicle 1 GAD2
midbody 1 HSP90B1
Cell projection, lamellipodium 1 NEDD9
Mitochondrion inner membrane 1 CYP27A1
Cell junction, focal adhesion 1 NEDD9
Cytoplasm, cytoskeleton 1 NEDD9
focal adhesion 3 CAT, HSP90B1, NEDD9
spindle 1 NEDD9
GABA-ergic synapse 1 GAD2
extracellular matrix 1 POSTN
Peroxisome 2 CAT, DAO
Peroxisome matrix 2 CAT, DAO
peroxisomal matrix 2 CAT, DAO
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 HSP90B1, NPPA, POSTN
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 NEDD9
chromatin 1 TBX20
IgE immunoglobulin complex 1 IGHE
cell projection 3 DAO, GAD2, NPPA
mitotic spindle 1 NEDD9
Chromosome 1 HMGB1
Cytoplasm, cytoskeleton, cilium basal body 1 NEDD9
Secreted, extracellular space 1 DAO
spindle pole 1 NEDD9
Cytoplasm, cell cortex 1 NEDD9
blood microparticle 1 PON1
Basolateral cell membrane 1 NEDD9
[Isoform 2]: Cell membrane 1 IGHE
Cytoplasm, cytoskeleton, spindle pole 1 NEDD9
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 GAD2
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 PFDN5
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
endoplasmic reticulum lumen 2 HSP90B1, PTGS2
transcription repressor complex 1 HMGB1
specific granule lumen 1 DAO
azurophil granule lumen 2 GLA, NPC2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GLA
immunological synapse 1 NEDD9
Sarcoplasmic reticulum lumen 1 HSP90B1
endoplasmic reticulum-Golgi intermediate compartment 2 GLA, HMGB1
prefoldin complex 1 PFDN5
condensed chromosome 1 HMGB1
inhibitory synapse 1 GAD2
[Isoform 3]: Cell membrane 1 IGHE
spherical high-density lipoprotein particle 1 PON1
endocytic vesicle lumen 1 HSP90B1
[Long-acting natriuretic peptide]: Secreted 1 NPPA
[Vessel dilator]: Secreted 1 NPPA
[Kaliuretic peptide]: Secreted 1 NPPA
[Urodilatin]: Secreted 1 NPPA
[Atrial natriuretic peptide]: Secreted 1 NPPA
[Atriopeptin-3]: Secreted 1 NPPA
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
endoplasmic reticulum chaperone complex 1 HSP90B1
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 GAD2
[Enhancer of filamentation 1 p55]: Cytoplasm, cytoskeleton, spindle 1 NEDD9


文献列表

  • Weitao Zhang, Hanyue Xue, Chen Zhou, Zuguo Zheng, Mingming Xing, Hang Chu, Ping Li, Naixia Zhang, Yongjun Dang, Xiaojun Xu. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis. Biochemical and biophysical research communications. 2022 09; 622(?):184-191. doi: 10.1016/j.bbrc.2022.07.033. [PMID: 35932530]
  • Petra Luckner, Matthias Brandsch. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2005 Jan; 59(1):17-24. doi: 10.1016/j.ejpb.2004.07.008. [PMID: 15567297]
  • Loredano Pollegioni, Laura Caldinelli, Gianluca Molla, Silvia Sacchi, Mirella S Pilone. Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources. Biotechnology progress. 2004 Mar; 20(2):467-73. doi: 10.1021/bp034206q. [PMID: 15058991]
  • Wei Zhang, Xi Huang, Guoping Zhao, Weihong Jiang. Affinity labeled glutaryl-7-amino cephalosporanic acid acylase C130 can hydrolyze the inhibitor during crystallization. Biochemical and biophysical research communications. 2004 Jan; 313(3):555-8. doi: 10.1016/j.bbrc.2003.11.154. [PMID: 14697226]
  • Songcheng Zhu, Yunliu Yang, Guoping Zhao, Weihong Jiang. A rapid and specific method to screen environmental microorganisms for cephalosporin acylase activity. Journal of microbiological methods. 2003 Jul; 54(1):131-5. doi: 10.1016/s0167-7012(03)00013-7. [PMID: 12732432]
  • Patricia A Arndt, George Garratty. Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other: cephalosporins and penicillin. American journal of clinical pathology. 2002 Aug; 118(2):256-62. doi: 10.1309/jfje-vukn-221t-g6ev. [PMID: 12162687]
  • X Li, W Zhang, X Mao, X Cai, Y L Yang, G P Zhao, W H Jiang. [Establishment of detective systems for GL-7ACA acylase expression]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2001 Nov; 17(6):673-7. doi: . [PMID: 11910763]
  • D Monti, G Carrea, S Riva, E Baldaro, G Frare. Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase. Biotechnology and bioengineering. 2000 Oct; 70(2):239-44. doi: 10.1002/1097-0290(20001020)70:2<239::aid-bit13>3.0.co;2-i. [PMID: 10972935]
  • T Shimizu, S Souma, N Nagakura, T Masuzawa, Y Iwamoto, Y Yanagihara. Epitope analysis of aztreonam by antiaztreonam monoclonal antibodies and possible consequences in beta-lactams hypersensitivity. International archives of allergy and immunology. 1992; 98(4):392-7. doi: 10.1159/000236216. [PMID: 1384868]
  • M JAGO. ANTIBACTERIAL ACTIVITY OF SOME DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID AGAINST STAPHYLOCOCCUS AUREUS AND SYNERGISM BETWEEN THESE AND OTHER ANTIBIOTICS. British journal of pharmacology and chemotherapy. 1964 Feb; 22(?):22-33. doi: 10.1111/j.1476-5381.1964.tb01540.x. [PMID: 14126054]
  • C W GODZESKI, G BRIER, D E PAVEY. Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique. Applied microbiology. 1963 Mar; 11(?):122-7. doi: 10.1128/am.11.2.122-127.1963. [PMID: 13963283]