Phenelzine (BioDeep_00000405985)
Main id: BioDeep_00000003165
代谢物信息卡片
Phenelzine
化学式: C8H12N2 (136.1)
中文名称: 苯乙基肼, 苯乙肼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CCNN
InChI: InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AF - Monoamine oxidase inhibitors, non-selective
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:8060
- KEGG: C07430
- KEGGdrug: D08349
- PubChem: 3675
- DrugBank: DB00780
- ChEMBL: CHEMBL1089
- MeSH: Phenelzine
- CAS: 14847-47-3
- CAS: 51-71-8
- MoNA: FiehnHILIC002239
- MoNA: FiehnHILIC000670
- PubChem: 9634
- NIKKAJI: J4.125D
- KNApSAcK: 8060
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Rachel L Hill, Indrapal N Singh, Juan A Wang, Jacqueline R Kulbe, Edward D Hall. Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats.
Experimental neurology.
2020 08; 330(?):113322. doi:
10.1016/j.expneurol.2020.113322. [PMID: 32325157] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Josep Mercader, Agustín G Sabater, Sophie Le Gonidec, Pauline Decaunes, Alice Chaplin, Saioa Gómez-Zorita, Fermín I Milagro, Christian Carpéné. Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet.
The Journal of pharmacology and experimental therapeutics.
2019 11; 371(2):555-566. doi:
10.1124/jpet.119.259895. [PMID: 31270215] - Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov. Prediction of Severity of Drug-Drug Interactions Caused by Enzyme Inhibition and Activation.
Molecules (Basel, Switzerland).
2019 Oct; 24(21):. doi:
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Chemico-biological interactions.
2019 May; 304(?):139-147. doi:
10.1016/j.cbi.2019.03.003. [PMID: 30857888] - Rachel L Hill, Indrapal N Singh, Juan A Wang, Edward D Hall. Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury.
Journal of neurotrauma.
2019 04; 36(8):1231-1251. doi:
10.1089/neu.2018.5946. [PMID: 30358485] - Ayman G Mustafa, Othman Al-Shboul, Mahmoud A Alfaqih, Mohammad A Al-Qudah, Ahmed N Al-Dwairi. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
Archives of physiology and biochemistry.
2018 Dec; 124(5):418-423. doi:
10.1080/13813455.2017.1415939. [PMID: 29256275] - Christian Carpéné, Saioa Gómez-Zorita, Alice Chaplin, Josep Mercader. Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice.
International journal of molecular sciences.
2018 Sep; 19(10):. doi:
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British journal of pharmacology.
2018 06; 175(12):2428-2440. doi:
10.1111/bph.14211. [PMID: 29582416] - Jacqueline R Kulbe, Indrapal N Singh, Juan A Wang, John E Cebak, Edward D Hall. Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats.
Journal of neurotrauma.
2018 06; 35(11):1280-1293. doi:
10.1089/neu.2017.5353. [PMID: 29336204] - John E Cebak, Indrapal N Singh, Rachel L Hill, Juan A Wang, Edward D Hall. Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection.
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