5-Aminoimidazole-4-carboxamide (BioDeep_00000405723)
Main id: BioDeep_00000001258
PANOMIX_OTCML-2023
代谢物信息卡片
5-Aminoimidazole-4-carboxamide
化学式: C4H6N4O (126.0542)
中文名称: 5-氨基咪唑-4-甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=C(N1)C(=O)N)N
InChI: InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8)
描述信息
An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.
5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:2030
- KEGG: C04051
- PubChem: 9679
- ChEMBL: CHEMBL1610
- MeSH: Aminoimidazole Carboxamide
- CAS: 360-97-4
- MoNA: FiehnHILIC002546
- MoNA: FiehnHILIC001011
- MoNA: FiehnHILIC000118
- MetaboLights: MTBLC2030
- PubChem: 6752
- PDB-CCD: 5AC
- 3DMET: B00671
- NIKKAJI: J37.792I
- RefMet: 5-Aminoimidazole-4-carboxamide
- medchemexpress: HY-41461
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 28511 - Pogostemon cablin: 10.1021/JF304466T
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahmet Cetinkaya, Sadi Yusufbeyoglu, S Irem Kaya, Ayse Baldemir Kilic, Esen Bellur Atici, Sibel A Ozkan. Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib.
Mikrochimica acta.
2024 05; 191(6):322. doi:
10.1007/s00604-024-06404-2. [PMID: 38730044] - Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.
BMC pulmonary medicine.
2024 May; 24(1):224. doi:
10.1186/s12890-024-03014-9. [PMID: 38720270] - Xueru Yin, Pengfei Li, Zongwei Wang, Jing Wang, Anfei Fang, Binnian Tian, Yuheng Yang, Yang Yu, Chaowei Bi. Binding Mode and Molecular Mechanism of the Two-Component Histidine Kinase Bos1 of Botrytis cinerea to Fludioxonil and Iprodione.
Phytopathology.
2024 Apr; 114(4):770-779. doi:
10.1094/phyto-07-23-0241-r. [PMID: 38598410] - Ye-Rang Yun, Ji-Eun Lee. Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice.
Nutrition research (New York, N.Y.).
2024 Apr; 124(?):43-54. doi:
10.1016/j.nutres.2024.01.013. [PMID: 38367426] - Grace Stephany Mendoza Solano, Nancy Beatriz Andrioli. Genotoxic effects induced by iprodione and tebuconazole in meristematic cells of Allium cepa: responses dependent on concentration and exposure time.
Environmental science and pollution research international.
2024 Mar; 31(11):17289-17298. doi:
10.1007/s11356-024-32351-9. [PMID: 38340299] - Weitao Hu, Guilan Chen, Wenbin Yuan, Chen Guo, Fasheng Liu, Shouhua Zhang, Zigang Cao. Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway.
Ecotoxicology and environmental safety.
2024 Jan; 270(?):115911. doi:
10.1016/j.ecoenv.2023.115911. [PMID: 38181604] - Xiandong Zhu, Feixiang Duan, Yan Zhang, Xiaowu Wang, Yongqiang Wang, Jiawei Chen, Lanyu Zhang, Minmin Wu, Zhuo Pan, Bicheng Chen. Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.
International immunopharmacology.
2022 Oct; 111(?):109165. doi:
10.1016/j.intimp.2022.109165. [PMID: 35987144] - Sayoko Oiki, Takashi Yaguchi, Syun-Ichi Urayama, Daisuke Hagiwara. Wide distribution of resistance to the fungicides fludioxonil and iprodione in Penicillium species.
PloS one.
2022; 17(1):e0262521. doi:
10.1371/journal.pone.0262521. [PMID: 35100282] - Mikhail V Samsonov, Nikita V Podkuychenko, Asker Y Khapchaev, Eugene E Efremov, Elena V Yanushevskaya, Tatiana N Vlasik, Vadim Z Lankin, Iurii S Stafeev, Maxim V Skulachev, Marina V Shestakova, Alexander V Vorotnikov, Vladimir P Shirinsky. AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010211. [PMID: 35008640] - Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon. AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
The European respiratory journal.
2021 12; 58(6):. doi:
10.1183/13993003.03694-2020. [PMID: 34049949] - Yong-Kyu Kim, Hye Kyoung Hong, Hyo Soon Yoo, Sung Pyo Park, Kyu Hyung Park. AICAR upregulates ABCA1/ABCG1 expression in the retinal pigment epithelium and reduces Bruch's membrane lipid deposit in ApoE deficient mice.
Experimental eye research.
2021 12; 213(?):108854. doi:
10.1016/j.exer.2021.108854. [PMID: 34808137] - Dan-Meng Zheng, Zhen-Ni An, Ming-Hao Ge, Dong-Zhuo Wei, Ding-Wen Jiang, Xue-Jiao Xing, Xiao-Lei Shen, Chang Liu. Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.
Lipids in health and disease.
2021 Nov; 20(1):151. doi:
10.1186/s12944-021-01576-9. [PMID: 34727932] - B Vandanmagsar, Y Yu, C Simmler, T N Dang, P Kuhn, A Poulev, D M Ribnicky, G F Pauli, Z E Floyd. Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112188. doi:
10.1016/j.biopha.2021.112188. [PMID: 34563947] - Qi Lai, Xiaofang Sun, Lianshan Li, Da Li, Minghua Wang, Haiyan Shi. Toxicity effects of procymidone, iprodione and their metabolite of 3,5-dichloroaniline to zebrafish.
Chemosphere.
2021 Jun; 272(?):129577. doi:
10.1016/j.chemosphere.2021.129577. [PMID: 33465616] - Yuning Pang, Xiang Xu, Xiaojun Xiang, Yongnan Li, Zengqi Zhao, Jiamin Li, Shengnan Gao, Qiangde Liu, Kangsen Mai, Qinghui Ai. High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism.
Nutrients.
2021 May; 13(6):. doi:
10.3390/nu13061740. [PMID: 34063748] - Sitai Liang, Bijaya K Nayak, Kristine S Vogel, Samy L Habib. TP63 Is Significantly Upregulated in Diabetic Kidney.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084070. [PMID: 33920782] - Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu. Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Mar; 149(?):112029. doi:
10.1016/j.fct.2021.112029. [PMID: 33508418] - Shokoufeh Hashempour, Nahid Shahabadi, Aishat Adewoye, Brennen Murphy, Camaray Rouse, Brian A Salvatore, Christopher Stratton, Elahe Mahdavian. Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225410. [PMID: 33228044] - Francis Ramond, Marlène Rio, Bénédicte Héron, Apolline Imbard, Sandrine Marie, Kareen Billiemaz, Anne-Sophie Denommé-Pichon, Paul Kuentz, Irène Ceballos, Monique Piraud, Marie-Françoise Vincent, Renaud Touraine. AICA-ribosiduria due to ATIC deficiency: Delineation of the phenotype with three novel cases, and long-term update on the first case.
Journal of inherited metabolic disease.
2020 11; 43(6):1254-1264. doi:
10.1002/jimd.12274. [PMID: 32557644] - Yanli Bian, Juan Wang, Fengmao Liu, Biming Mao, Hongwei Huang, Jingyi Xu, Xiaohan Li, Yangyang Guo. Residue behavior and removal of iprodione in garlic, green garlic, and garlic shoot.
Journal of the science of food and agriculture.
2020 Oct; 100(13):4705-4713. doi:
10.1002/jsfa.10527. [PMID: 32458444] - Jiwon Park, Yunkyoung Lee, Eun-Hye Jung, Sang-Min Kim, Hyeongjin Cho, Inn-Oc Han. Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 10; 1865(10):158764. doi:
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Journal of natural products.
2020 08; 83(8):2469-2476. doi:
10.1021/acs.jnatprod.0c00394. [PMID: 32786881] - Vinicius Sartori Fioresi, Bárbara de Cássia Ribeiro Vieira, José Marcello Salabert de Campos, Tatiana da Silva Souza. Cytogenotoxic activity of the pesticides imidacloprid and iprodione on Allium cepa root meristem.
Environmental science and pollution research international.
2020 Aug; 27(22):28066-28076. doi:
10.1007/s11356-020-09201-5. [PMID: 32405953] - Ambreen Maqsood, Chaorong Wu, Sunny Ahmar, Haiyan Wu. Cytological and Gene Profile Expression Analysis Reveals Modification in Metabolic Pathways and Catalytic Activities Induce Resistance in Botrytis cinerea Against Iprodione Isolated From Tomato.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144865. [PMID: 32660143] - José M López, Esther L Outtrim, Rong Fu, Diane J Sutcliffe, Rosa J Torres, H A Jinnah. Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease.
Proceedings of the National Academy of Sciences of the United States of America.
2020 06; 117(22):12071-12079. doi:
10.1073/pnas.2003475117. [PMID: 32430324] - A Katsoula, S Vasileiadis, M Sapountzi, Dimitrios G Karpouzas. The response of soil and phyllosphere microbial communities to repeated application of the fungicide iprodione: accelerated biodegradation or toxicity?.
FEMS microbiology ecology.
2020 06; 96(6):. doi:
10.1093/femsec/fiaa056. [PMID: 32221586] - Jonathan Kopel, Kei Higuchi, Bojana Ristic, Toshihiro Sato, Sabarish Ramachandran, Vadivel Ganapathy. The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.
Scientific reports.
2020 05; 10(1):8536. doi:
10.1038/s41598-020-65621-w. [PMID: 32444674] - Wan-Long Tsai, Chien-Ning Hsu, You-Lin Tain. Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study.
Nutrients.
2020 Feb; 12(2):. doi:
10.3390/nu12020448. [PMID: 32053935] - Maya W Haaker, Hedwig S Kruitwagen, Arie B Vaandrager, Martin Houweling, Louis C Penning, Martijn R Molenaar, Monique E van Wolferen, Loes A Oosterhoff, Bart Spee, J Bernd Helms. Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system.
Journal of veterinary internal medicine.
2020 Jan; 34(1):132-138. doi:
10.1111/jvim.15670. [PMID: 31830357] - J-M Li, W Lu, J Ye, Y Han, H Chen, L-S Wang. Association between expression of AMPK pathway and adiponectin, leptin, and vascular endothelial function in rats with coronary heart disease.
European review for medical and pharmacological sciences.
2020 01; 24(2):905-914. doi:
10.26355/eurrev_202001_20075. [PMID: 32016997] - Luping Yang, Yijing Jiang, Lihong Shi, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin. AMPK: Potential Therapeutic Target for Alzheimer's Disease.
Current protein & peptide science.
2020; 21(1):66-77. doi:
10.2174/1389203720666190819142746. [PMID: 31424367] - Ran Hee Choi, Abigail McConahay, Mackenzie B Johnson, Ha-Won Jeong, Ho-Jin Koh. Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism.
Biochemical and biophysical research communications.
2019 11; 519(3):633-638. doi:
10.1016/j.bbrc.2019.09.049. [PMID: 31540695] - Mamoru Tanida, Yusaku Iwasaki, Naoki Yamamoto. Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats.
In vivo (Athens, Greece).
2019 Nov; 33(6):1827-1832. doi:
10.21873/invivo.11675. [PMID: 31662509] - Christelle Viglino, Bernard Foglia, Christophe Montessuit. Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids.
Pflugers Archiv : European journal of physiology.
2019 09; 471(9):1219-1234. doi:
10.1007/s00424-019-02285-0. [PMID: 31152240] - Hirohide Takemura, Jae-Hoon Choi, Nobuo Matsuzaki, Yuki Taniguchi, Jing Wu, Hirofumi Hirai, Reiko Motohashi, Tomohiro Asakawa, Kazutada Ikeuchi, Makoto Inai, Toshiyuki Kan, Hirokazu Kawagishi. A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice.
Scientific reports.
2019 07; 9(1):9899. doi:
10.1038/s41598-019-46312-7. [PMID: 31289299] - Sreenath Nair, Anne M Strohecker, Avinash K Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M Beedle, Rajgopal Govindarajan. Adult stem cell deficits drive Slc29a3 disorders in mice.
Nature communications.
2019 07; 10(1):2943. doi:
10.1038/s41467-019-10925-3. [PMID: 31270333] - Paula Mauri Bernardes, Larissa Fonseca Andrade-Vieira, Francielen Barroso Aragão, Adésio Ferreira, Marcia Flores da Silva Ferreira. Toxicological effects of comercial formulations of fungicides based on procymidone and iprodione in seedlings and root tip cells of Allium cepa.
Environmental science and pollution research international.
2019 Jul; 26(20):21013-21021. doi:
10.1007/s11356-019-04636-x. [PMID: 31119539] - Qianqian Liang, Baochun Li, Junchen Wang, Panrong Ren, Lirong Yao, Yaxiong Meng, Erjing Si, Xunwu Shang, Huajun Wang. PGPBS, a mitogen-activated protein kinase kinase, is required for vegetative differentiation, cell wall integrity, and pathogenicity of the barley leaf stripe fungus Pyrenophora graminea.
Gene.
2019 May; 696(?):95-104. doi:
10.1016/j.gene.2019.02.032. [PMID: 30779945] - Jian Hu, Yuxin Zhou, Tao Gao, Jiamei Geng, Yuan Dai, Haiyan Ren, Kurt Lamour, Xili Liu. Resistance risk assessment for fludioxonil in Sclerotinia homoeocarpa in China.
Pesticide biochemistry and physiology.
2019 May; 156(?):123-128. doi:
10.1016/j.pestbp.2019.02.011. [PMID: 31027571] - Tim Sobolevsky, Brian Ahrens. Urinary concentrations of AICAR and mannitol in athlete population.
Drug testing and analysis.
2019 Mar; 11(3):530-535. doi:
10.1002/dta.2557. [PMID: 30548818] - Azaj Ahmed, Anas Shamsi, Mohd Shahnawaz Khan, Fohad Mabood Husain, Bilqees Bano. Probing the interaction of human serum albumin with iprodione, a fungicide: spectroscopic and molecular docking insight.
Journal of biomolecular structure & dynamics.
2019 03; 37(4):857-862. doi:
10.1080/07391102.2018.1442252. [PMID: 29475407] - Bodokhsuren Tsogbadrakh, Hyunjin Ryu, Kyung Don Ju, Jinho Lee, Sohyun Yun, Kyung-Sang Yu, Hyo Jin Kim, Curie Ahn, Kook-Hwan Oh. AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway.
Biochemical and biophysical research communications.
2019 02; 509(3):680-686. doi:
10.1016/j.bbrc.2018.12.159. [PMID: 30616891] - Menglong Cong, Shun He, Jun Zhang, Chaoxi Luo, Fuxing Zhu. Hormetic Effects of Mixtures of Carbendazim and Iprodione on the Virulence of Botrytis cinerea.
Plant disease.
2019 Jan; 103(1):95-101. doi:
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PloS one.
2019; 14(2):e0212458. doi:
10.1371/journal.pone.0212458. [PMID: 30817767] - Meng Zhang, Yuan Yuan, Qing Wang, Xiaobo Li, Jiuzhang Men, Mingxin Lin. The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα.
Bioscience reports.
2018 12; 38(6):. doi:
10.1042/bsr20180644. [PMID: 30291215] - W X Yin, M Adnan, Y Shang, Y Lin, C X Luo. Sensitivity of Botrytis cinerea From Nectarine/Cherry in China to Six Fungicides and Characterization of Resistant Isolates.
Plant disease.
2018 12; 102(12):2578-2585. doi:
10.1094/pdis-02-18-0244-re. [PMID: 30299208] - Christian Berg, Marcus Hill, Chelsea Bonetti, Gary C Mitchell, Bibek Sharma. The effects of iprodione fungicide on survival, behavior, and brood development of honeybees (Apis mellifera L.) after one foliar application during flowering on mustard.
Environmental toxicology and chemistry.
2018 12; 37(12):3086-3094. doi:
10.1002/etc.4272. [PMID: 30229986] - Zhifa Wang, Yukun Cao, Qiang Yin, Yuehu Han, Yunya Wang, Guocheng Sun, Hailong Zhu, Ming Xu, Chunhu Gu. Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.
Cardiovascular therapeutics.
2018 Dec; 36(6):e12482. doi:
10.1111/1755-5922.12482. [PMID: 30632675] - Jianlong Gao, Rui Xiong, Dan Xiong, Wenxing Zhao, Sheng Zhang, Tao Yin, Xinhua Zhang, Guozhen Jiang, Zhengyu Yin. The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Medical science monitor : international medical journal of experimental and clinical research.
2018 Nov; 24(?):8533-8543. doi:
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Applied and environmental microbiology.
2018 11; 84(22):. doi:
10.1128/aem.01536-18. [PMID: 30194100] - Sitai Liang, Edward A Medina, Boajie Li, Samy L Habib. Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer.
Molecular oncology.
2018 11; 12(11):1917-1934. doi:
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American journal of physiology. Endocrinology and metabolism.
2018 11; 315(5):E995-E1004. doi:
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American journal of physiology. Heart and circulatory physiology.
2018 10; 315(4):H826-H837. doi:
10.1152/ajpheart.00052.2018. [PMID: 29979626] - Philipp Glosse, Martina Feger, Kerim Mutig, Hong Chen, Frank Hirche, Ahmed Abdallah Hasan, Mohamed M S Gaballa, Berthold Hocher, Florian Lang, Michael Föller. AMP-activated kinase is a regulator of fibroblast growth factor 23 production.
Kidney international.
2018 09; 94(3):491-501. doi:
10.1016/j.kint.2018.03.006. [PMID: 29861059] - Juliana S Baggio, Natalia A Peres, Lilian Amorim. Sensitivity of Botrytis cinerea Isolates from Conventional and Organic Strawberry Fields in Brazil to Azoxystrobin, Iprodione, Pyrimethanil, and Thiophanate-Methyl.
Plant disease.
2018 Sep; 102(9):1803-1810. doi:
10.1094/pdis-08-17-1221-re. [PMID: 30125196] - Yingying Song, Lili Li, Chao Li, Zengbin Lu, Xingyuan Men, Fajun Chen. Evaluating the Sensitivity and Efficacy of Fungicides with Different Modes of Action Against Botryosphaeria dothidea.
Plant disease.
2018 Sep; 102(9):1785-1793. doi:
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European journal of pharmacology.
2018 Aug; 833(?):100-108. doi:
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Plant disease.
2018 Aug; 102(8):1520-1526. doi:
10.1094/pdis-09-17-1470-re. [PMID: 30673418] - Yabing Duan, Tao Li, Xuemei Xiao, Jian Wu, Shengkun Li, Jianxin Wang, Mingguo Zhou. Pharmacological characteristics of the novel fungicide pyrisoxazole against Sclerotinia sclerotiorum.
Pesticide biochemistry and physiology.
2018 Jul; 149(?):61-66. doi:
10.1016/j.pestbp.2018.05.010. [PMID: 30033017] - Azaj Ahmed, Anas Shamsi, Bilqees Bano. Deciphering the toxic effects of iprodione, a fungicide and malathion, an insecticide on thiol protease inhibitor isolated from yellow Indian mustard seeds.
Environmental toxicology and pharmacology.
2018 Jul; 61(?):52-60. doi:
10.1016/j.etap.2018.05.019. [PMID: 29852369] - Michael Mendler, Stefan Kopf, Jan B Groener, Christin Riedinger, Thomas H Fleming, Peter P Nawroth, Jürgen G Okun. Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.
Acta diabetologica.
2018 Jun; 55(6):585-592. doi:
10.1007/s00592-018-1130-2. [PMID: 29546577] - Dong Fu, Jennifer Lippincott-Schwartz. Monitoring the Effects of Pharmacological Reagents on Mitochondrial Morphology.
Current protocols in cell biology.
2018 06; 79(1):e45. doi:
10.1002/cpcb.45. [PMID: 29924486] - Xinwei Li, Yu Li, Hongyan Ding, Jihong Dong, Renhe Zhang, Dan Huang, Lin Lei, Zhe Wang, Guowen Liu, Xiaobing Li. Insulin suppresses the AMPK signaling pathway to regulate lipid metabolism in primary cultured hepatocytes of dairy cows.
The Journal of dairy research.
2018 May; 85(2):157-162. doi:
10.1017/s002202991800016x. [PMID: 29785900] - Nicolas O Jørgensen, Jørgen F P Wojtaszewski, Rasmus Kjøbsted. Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle.
International journal of molecular sciences.
2018 Apr; 19(4):. doi:
10.3390/ijms19041201. [PMID: 29662023] - Rosalyn D Abbott, Francis E Borowsky, Carlo A Alonzo, Adam Zieba, Irene Georgakoudi, David L Kaplan. Variability in responses observed in human white adipose tissue models.
Journal of tissue engineering and regenerative medicine.
2018 03; 12(3):840-847. doi:
10.1002/term.2572. [PMID: 28879656] - Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yang. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
Bioscience reports.
2018 02; 38(1):. doi:
10.1042/bsr20170862. [PMID: 29222348] - Nadia Boudaba, Allison Marion, Camille Huet, Rémi Pierre, Benoit Viollet, Marc Foretz. AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
EBioMedicine.
2018 Feb; 28(?):194-209. doi:
10.1016/j.ebiom.2018.01.008. [PMID: 29343420] - David G Lassiter, Carolina Nylén, Rasmus J O Sjögren, Alexander V Chibalin, Harriet Wallberg-Henriksson, Erik Näslund, Anna Krook, Juleen R Zierath. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.
Diabetologia.
2018 02; 61(2):424-432. doi:
10.1007/s00125-017-4451-8. [PMID: 29022062] - Kathryn Glaser, Peter Dickie, Derek Neilson, Alexander Osborn, Belinda Hsi Dickie. Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.
Lymphatic research and biology.
2018 Feb; 16(1):43-55. doi:
10.1089/lrb.2017.0033. [PMID: 29346025] - C Buisson, C Frelat, C Mongongu, N Martinat, M Audran. Implementation of AICAR analysis by GC-C-IRMS for anti-doping purposes.
Drug testing and analysis.
2017 Nov; 9(11-12):1704-1712. doi:
10.1002/dta.2322. [PMID: 29032594] - Bo Kou, Wei Liu, Xu Xu, Yang Yang, Qiuyue Yi, Fengwei Guo, Jianpeng Li, Jinsong Zhou, Qingshan Kou. Autophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells.
Oncology reports.
2017 Nov; 38(5):3137-3143. doi:
10.3892/or.2017.5988. [PMID: 29048631] - Jenny K Y Wong, Wai Him Kwok, George H M Chan, Timmy L S Choi, Emmie N M Ho, Murielle Jaubert, Ludovic Bailly-Chouriberry, Yves Bonnaire, Adam Cawley, H Ming Williams, John Keledjian, Lydia Brooks, Adam Chambers, Yuanyuan Lin, Terence S M Wan. Doping control study of AICAR in post-race urine and plasma samples from horses.
Drug testing and analysis.
2017 Sep; 9(9):1363-1371. doi:
10.1002/dta.2205. [PMID: 28407446] - Lucas Adrian, Matthias Lenski, Klaus Tödter, Jörg Heeren, Michael Böhm, Ulrich Laufs. AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.
Lipids.
2017 09; 52(9):737-750. doi:
10.1007/s11745-017-4285-7. [PMID: 28825205] - Lindsey R Klingbeil, Paul Kim, Giovanna Piraino, Michael O'Connor, Paul W Hake, Vivian Wolfe, Basilia Zingarelli. Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock.
American journal of respiratory cell and molecular biology.
2017 05; 56(5):585-596. doi:
10.1165/rcmb.2016-0118oc. [PMID: 28085510] - Xiao-Yu Cheng, Yang-Yang Li, Cheng Huang, Jun Li, Hong-Wei Yao. AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema.
Oncotarget.
2017 Apr; 8(14):22513-22523. doi:
10.18632/oncotarget.15116. [PMID: 28186975] - Jing Wang, Ang Ma, Ming Zhao, Haibo Zhu. AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Atherosclerosis.
2017 03; 258(?):97-107. doi:
10.1016/j.atherosclerosis.2017.01.036. [PMID: 28235712] - Zhengguang Wang, Fangyuan Xiong, Xiaoshan Wang, Yijun Qi, Haoyuan Yu, Yong Zhu, Huaqing Zhu. Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer.
Oncotarget.
2017 Feb; 8(7):11105-11113. doi:
10.18632/oncotarget.14364. [PMID: 28052040] - Hyunkyu Sang, James T Popko, Taehyun Chang, Geunhwa Jung. Molecular Mechanisms Involved in Qualitative and Quantitative Resistance to the Dicarboximide Fungicide Iprodione in Sclerotinia homoeocarpa Field Isolates.
Phytopathology.
2017 02; 107(2):198-207. doi:
10.1094/phyto-05-16-0211-r. [PMID: 27642797] - Dzmitry Matsiukevich, Giovanna Piraino, Lindsey R Klingbeil, Paul W Hake, Vivian Wolfe, Michael O'Connor, Basilia Zingarelli. The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine Hemorrhagic Shock.
Shock (Augusta, Ga.).
2017 01; 47(1):70-78. doi:
10.1097/shk.0000000000000730. [PMID: 27513082] - So-Young Lee, Jun Mo Kang, Dong-Jin Kim, Seon Hwa Park, Hye Yun Jeong, Yu Ho Lee, Yang Gyun Kim, Dong Ho Yang, Sang Ho Lee. PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control.
Journal of diabetes research.
2017; 2017(?):6483572. doi:
10.1155/2017/6483572. [PMID: 28409163] - Tomohiro Suzuki, Naoki Yamamoto, Jae-Hoon Choi, Tomoyuki Takano, Yohei Sasaki, Yurika Terashima, Akinobu Ito, Hideo Dohra, Hirofumi Hirai, Yukino Nakamura, Kentaro Yano, Hirokazu Kawagishi. The biosynthetic pathway of 2-azahypoxanthine in fairy-ring forming fungus.
Scientific reports.
2016 12; 6(?):39087. doi:
10.1038/srep39087. [PMID: 27991529] - Samy L Habib, Anamika Yadav, Dawit Kidane, Robert H Weiss, Sitai Liang. Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage.
Cell cycle (Georgetown, Tex.).
2016 Nov; 15(22):3048-3059. doi:
10.1080/15384101.2016.1231259. [PMID: 27611085] - Mohammad M Al-Bataineh, Hui Li, Kazuhiro Ohmi, Fan Gong, Allison L Marciszyn, Sajid Naveed, Xiaoqing Zhu, Dietbert Neumann, Qi Wu, Lei Cheng, Robert A Fenton, Núria M Pastor-Soler, Kenneth R Hallows. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells.
American journal of physiology. Renal physiology.
2016 11; 311(5):F890-F900. doi:
10.1152/ajprenal.00308.2016. [PMID: 27534994] - Guido A Gualdoni, Katharina A Mayer, Lisa Göschl, Nicole Boucheron, Wilfried Ellmeier, Gerhard J Zlabinger. The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2016 11; 30(11):3800-3809. doi:
10.1096/fj.201600522r. [PMID: 27492924] - Roopa Rai, Monali Banerjee, Darren H Wong, Emma McCullagh, Ashu Gupta, Shailendra Tripathi, Eduardo Riquelme, Ramnivas Jangir, Shyamraj Yadav, Mohd Raja, Pankaj Melkani, Vikas Dixit, Umesh Patil, Ritesh Shrivastava, Sandip Middya, Felipe Olivares, Javier Guerrero, Arjun Surya, Son M Pham, Sebastián Bernales, Andrew A Protter, David T Hung, Sarvajit Chakravarty. Temozolomide analogs with improved brain/plasma ratios - Exploring the possibility of enhancing the therapeutic index of temozolomide.
Bioorganic & medicinal chemistry letters.
2016 10; 26(20):5103-5109. doi:
10.1016/j.bmcl.2016.08.064. [PMID: 27614414] - K Perdan-Pirkmajer, S Pirkmajer, M Thevis, A Thomas, S Praprotnik, A Hočevar, Ž Rotar, N Gašperšič, S Sodin-Šemrl, J Žibert, J Omersel, A V Chibalin, M Tomšič, A Ambrožič. Methotrexate reduces HbA1c concentration but does not produce chronic accumulation of ZMP in patients with rheumatoid or psoriatic arthritis.
Scandinavian journal of rheumatology.
2016 Oct; 45(5):347-55. doi:
10.3109/03009742.2015.1105290. [PMID: 26726793] - Bo Chen, Jin Li, Haibo Zhu. AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway.
Vascular pharmacology.
2016 10; 85(?):1-10. doi:
10.1016/j.vph.2015.08.012. [PMID: 26297684] - Wilfred Lieberthal, Meiyi Tang, Mark Lusco, Mersema Abate, Jerrold S Levine. Preconditioning mice with activators of AMPK ameliorates ischemic acute kidney injury in vivo.
American journal of physiology. Renal physiology.
2016 10; 311(4):F731-F739. doi:
10.1152/ajprenal.00541.2015. [PMID: 27252492] - M T Mutengwe, L Chidamba, L Korsten. Pesticide Residue Monitoring on South African Fresh Produce Exported over a 6-Year Period.
Journal of food protection.
2016 10; 79(10):1759-1766. doi:
10.4315/0362-028x.jfp-16-022. [PMID: 28221852] - Irina I Zaitseva, Sergei V Zaitsev, Per-Olof Berggren. The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.
Investigational new drugs.
2016 08; 34(4):522-9. doi:
10.1007/s10637-016-0362-7. [PMID: 27221730] - M López-Yoldi, R Castilla-Madrigal, M P Lostao, A Barber, J Prieto, J A Martínez, M Bustos, M J Moreno-Aliaga. Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells.
Acta physiologica (Oxford, England).
2016 07; 217(3):217-26. doi:
10.1111/apha.12674. [PMID: 26972986] - Wai Him Kwok, Timmy L S Choi, Karen Y Kwok, George H M Chan, Jenny K Y Wong, Terence S M Wan. Doping control analysis of 46 polar drugs in horse plasma and urine using a 'dilute-and-shoot' ultra high performance liquid chromatography-high resolution mass spectrometry approach.
Journal of chromatography. A.
2016 Jun; 1451(?):41-49. doi:
10.1016/j.chroma.2016.05.002. [PMID: 27180888] - Quancai Sun, Weipeng Qi, Jeremy J Yang, Kyong Sup Yoon, John M Clark, Yeonhwa Park. Fipronil promotes adipogenesis via AMPKα-mediated pathway in 3T3-L1 adipocytes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Jun; 92(?):217-23. doi:
10.1016/j.fct.2016.04.011. [PMID: 27103584] - Shuna Cui, Rabeay Y A Hassan, Anna Heintz-Buschart, Ursula Bilitewski. Regulation of Candida albicans Interaction with Macrophages through the Activation of HOG Pathway by Genistein.
Molecules (Basel, Switzerland).
2016 Jan; 21(2):162. doi:
10.3390/molecules21020162. [PMID: 26828477] - Jing Li, Jun Song, Heidi L Weiss, Todd Weiss, Courtney M Townsend, B Mark Evers. Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells.
Molecular endocrinology (Baltimore, Md.).
2016 Jan; 30(1):26-36. doi:
10.1210/me.2015-1094. [PMID: 26528831] - Omar Abdul-Rahman, Endre Kristóf, Quang-Minh Doan-Xuan, András Vida, Lilla Nagy, Ambrus Horváth, József Simon, Tamás Maros, István Szentkirályi, Lehel Palotás, Tamás Debreceni, Péter Csizmadia, Tamás Szerafin, Tamás Fodor, Magdolna Szántó, Attila Tóth, Borbála Kiss, Zsolt Bacsó, Péter Bai. AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype.
PloS one.
2016; 11(6):e0157644. doi:
10.1371/journal.pone.0157644. [PMID: 27322180] - Elżbieta Wołejko, Bożena Łozowicka, Piotr Kaczyński, Magdalena Jankowska, Jolanta Piekut. The influence of effective microorganisms (EM) and yeast on the degradation of strobilurins and carboxamides in leafy vegetables monitored by LC-MS/MS and health risk assessment.
Environmental monitoring and assessment.
2016 Jan; 188(1):64. doi:
10.1007/s10661-015-5022-4. [PMID: 26718945] - Elizabeth Moreno-Arriola, Mohammed El Hafidi, Daniel Ortega-Cuéllar, Karla Carvajal. AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
PloS one.
2016; 11(1):e0148089. doi:
10.1371/journal.pone.0148089. [PMID: 26824904] - Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee. AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells.
Molecular and cellular endocrinology.
2015 Oct; 414(?):148-55. doi:
10.1016/j.mce.2015.07.031. [PMID: 26254015]
