Lipoic Acid (BioDeep_00000405442)

Main id: BioDeep_00000014422

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1,2-dithiolane-3R-pentanoic acid

化学式: C8H14O2S2 (206.0435)
中文名称: (R)-(+)-α-硫辛酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCC(=O)O)C[C@@H]1CCSS1
InChI: InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)

描述信息

A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D018977 - Micronutrients > D014815 - Vitamins
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

同义名列表

12 个代谢物同义名

Lipoic Acid; 1,2-dithiolane-3R-pentanoic acid; alpha-(+)-Lipoic acid; R-(+)-Thioctic acid; alpha-Lipoic acid; R-(+)-Lipoic acid; (R)-Lipoic acid; (R)-(+)-Lipoate; R-Lipoic acid; (R)-Lipoate; (R)-(+)-α-Lipoic acid; (R)-Lipoate



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, ALB, AXIN2, CASP3, CAT, FASN, HPGDS, NFE2L2, NOS3, VEGFA
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 HMOX1
Nucleus 11 ACHE, AKT1, ALB, AXIN2, CASP3, DLD, HMOX1, NFE2L2, NOS3, PPARA, VEGFA
cytosol 11 AKT1, ALB, AXIN2, CASP3, CAT, FASN, HMOX1, HPGDS, LIPA, NFE2L2, NOS3
centrosome 3 ALB, AXIN2, NFE2L2
nucleoplasm 9 AKT1, CASP3, GLDC, HMOX1, HPGDS, LIPA, NFE2L2, NOS3, PPARA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 ACHE, AKT1, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 AKT1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 6 ACHE, ALB, FASN, NFE2L2, NOS3, VEGFA
Golgi membrane 2 INS, NOS3
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 LIPA
acrosomal vesicle 1 DLD
plasma membrane 8 ACHE, AKT1, AXIN2, FASN, GLDC, NFE2L2, NOS3, TNF
Membrane 6 ACHE, AKT1, CAT, FASN, HMOX1, VEGFA
caveola 1 NOS3
extracellular exosome 3 ALB, CAT, FASN
endoplasmic reticulum 3 ALB, HMOX1, VEGFA
extracellular space 7 ACHE, ALB, HMOX1, IL6, INS, TNF, VEGFA
lysosomal lumen 1 LIPA
perinuclear region of cytoplasm 3 ACHE, HMOX1, NOS3
adherens junction 1 VEGFA
mitochondrion 3 CAT, DLD, GLDC
protein-containing complex 3 AKT1, ALB, CAT
intracellular membrane-bounded organelle 3 CAT, HPGDS, LIPA
postsynaptic density 1 CASP3
Secreted 5 ACHE, ALB, IL6, INS, VEGFA
extracellular region 7 ACHE, ALB, CAT, IL6, INS, TNF, VEGFA
mitochondrial outer membrane 1 HMOX1
Mitochondrion matrix 1 DLD
mitochondrial matrix 3 CAT, DLD, GLDC
Extracellular side 1 ACHE
anchoring junction 1 ALB
motile cilium 1 DLD
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
ciliary basal body 2 AKT1, ALB
chromatin 2 NFE2L2, PPARA
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cytoskeleton 1 NOS3
centriole 1 ALB
Cytoplasmic vesicle, secretory vesicle, acrosome 1 DLD
spindle pole 1 ALB
blood microparticle 1 ALB
Cell projection, cilium, flagellum 1 DLD
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 LIPA
endosome lumen 1 INS
Melanosome 1 FASN
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 2 ALB, VEGFA
pyruvate dehydrogenase complex 1 DLD
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
oxoglutarate dehydrogenase complex 1 DLD
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
acetyltransferase complex 1 DLD
acrosomal matrix 1 DLD
branched-chain alpha-ketoacid dehydrogenase complex 1 DLD
oxoadipate dehydrogenase complex 1 DLD
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
glycine cleavage complex 1 GLDC
glycogen granule 1 FASN
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kai Yang, Bing Bai, Jiaqi Lei, Xinyang Yu, Shaolong Qi, Yangfan Wang, Feihe Huang, Zaizai Tong, Guocan Yu. Biodegradable Lipid-Modified Poly(Guanidine Thioctic Acid)s: A Fortifier of Lipid Nanoparticles to Promote the Efficacy and Safety of mRNA Cancer Vaccines. Journal of the American Chemical Society. 2024 May; 146(17):11679-11693. doi: 10.1021/jacs.3c14010. [PMID: 38482849]
  • Haixia Xiong, Peili Zhang, Dongcheng Wang, Zhimin Zhou, Jianjun Sun, Mingfang Diao. A silk-based hydrogel containing dexamethasone and lipoic acid microcrystals for local delivery to the inner ear. Colloids and surfaces. B, Biointerfaces. 2024 May; 237(?):113855. doi: 10.1016/j.colsurfb.2024.113855. [PMID: 38513298]
  • Licheng Wu, Liyun Xing, Ruinan Wu, Xiaoxing Fan, Mingjie Ni, Xin Xiao, Zhou Zhou, Lian Li, Jingyuan Wen, Yuan Huang. Lipoic acid-mediated oral drug delivery system utilizing changes on cell surface thiol expression for the treatment of diabetes and inflammatory diseases. Journal of materials chemistry. B. 2024 Apr; 12(16):3970-3983. doi: 10.1039/d3tb02899b. [PMID: 38563351]
  • Madeline C Tompach, Charlotte K Gridley, Sida Li, John M Clark, Yeonhwa Park, Alicia R Timme-Laragy. Comparing the effects of developmental exposure to alpha lipoic acid (ALA) and perfluorooctanesulfonic acid (PFOS) in zebrafish (Danio rerio). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 Apr; 186(?):114560. doi: 10.1016/j.fct.2024.114560. [PMID: 38432440]
  • Kriti Kushwaha, Debojyoti Mandal, Navneet Khurana, Jeena Gupta. Nephro-protective effects of alpha-lipoic acid in type I diabetes. Journal of biochemical and molecular toxicology. 2024 Apr; 38(4):e23712. doi: 10.1002/jbt.23712. [PMID: 38602238]
  • P Prathima, K Venkaiah, M Hanuma Reddy, Jangampalli Adi Pradeepkiran, S B Sainath. Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress. Reproductive toxicology (Elmsford, N.Y.). 2024 Apr; 125(?):108555. doi: 10.1016/j.reprotox.2024.108555. [PMID: 38342389]
  • T Wei, Y Ding, J Zhang, J Li, H Zhang, P Kang, N Zhang. [Correlation of serum ferredoxin 1 and lipoic acid levels with severity of coronary artery disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2024 Feb; 44(2):308-316. doi: 10.12122/j.issn.1673-4254.2024.02.13. [PMID: 38501416]
  • Brenda Laky, Corinna Bruckmann, Julian Blumenschein, Gerlinde Durstberger, Hady Haririan. Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial. Journal of periodontology. 2024 Feb; 95(2):101-113. doi: 10.1002/jper.23-0115. [PMID: 37439597]
  • Naima Hafeez Mian, Muhammad Azeem, Qasim Ali, Saqib Mahmood, Muhammad Sohail Akram. Alpha lipoic acid mitigates adverse impacts of drought stress on growth and yield of mungbean: photosynthetic pigments, and antioxidative defense mechanism. PeerJ. 2024; 12(?):e17191. doi: 10.7717/peerj.17191. [PMID: 38699184]
  • Yahya M Hodeeb, Emad M El-Rewiny, Abdullah M Gaafar, Ahmed N Zayed, Mohamed S Hasan, Mohamed L Elsaie. The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study. Human fertility (Cambridge, England). 2023 Dec; 26(5):949-957. doi: 10.1080/14647273.2021.2025271. [PMID: 35023797]
  • Mateusz Zwierz, Adrian Chabowski, Klaudia Sztolsztener. α-Lipoic acid - a promising agent for attenuating inflammation and preventing steatohepatitis in rats fed a high-fat diet. Archives of biochemistry and biophysics. 2023 Nov; 750(?):109811. doi: 10.1016/j.abb.2023.109811. [PMID: 37926405]
  • Walaa El-Houseiny, Ahmed H Arisha, Mohamed M M Metwally, Abdel-Wahab A Abdel-Warith, Elsayed M Younis, Simon J Davies, Bayan A Hassan, Yasmina M Abd-Elhakim. Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105598. doi: 10.1016/j.pestbp.2023.105598. [PMID: 37945227]
  • Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li. α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway. Ecotoxicology and environmental safety. 2023 Oct; 266(?):115533. doi: 10.1016/j.ecoenv.2023.115533. [PMID: 37806127]
  • Lucia Longhitano, Alfio Distefano, Angela Maria Amorini, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Anna Nicolosi, Amer M Alanazi, Concetta Saoca, Vincenzo Macaione, M'hammed Aguennouz, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Giovanni Li Volti, Giacomo Lazzarino. (+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914491. [PMID: 37833939]
  • Jinping Li, Dayun Tuo, Gunan Guo, Jinfeng Gan. Aberrant expression of cuproptosis‑related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma. Journal of cancer research and clinical oncology. 2023 Sep; ?(?):. doi: 10.1007/s00432-023-05325-6. [PMID: 37668796]
  • Cheng Shen, Xueheng Chen, Yong Cao, Yanyan Du, Xuan Xu, Qingjing Wu, Lizhi Lin, Yiran Qin, Runqi Meng, Lijun Gan, Jinguo Zhang. Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage via the ALDH2-associated PINK/Parkin Pathway. Journal of cardiovascular pharmacology. 2023 Sep; ?(?):. doi: 10.1097/fjc.0000000000001480. [PMID: 37657070]
  • Jennifer K Frediani, Asim A Lal, Esther Kim, Sharon L Leslie, David W Boorman, Vinita Singh. The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review. Pain practice : the official journal of World Institute of Pain. 2023 Aug; ?(?):. doi: 10.1111/papr.13291. [PMID: 37654090]
  • Y Pei, Y-Y Liu, M Sun, J Zheng, T-T Zhou, B Wang, H Hu, Z-L Wang. Beneficial effects of pioglitazone and α-lipoic acid in patients with polycystic ovaries syndrome. European review for medical and pharmacological sciences. 2023 Aug; 27(15):7118-7126. doi: 10.26355/eurrev_202308_33285. [PMID: 37606122]
  • Qian Zheng, Pengfei Ma, Pan Yang, Suzhen Zhai, Meina He, Xiangming Zhang, Qiuxia Tu, Ling Jiao, Lan Ye, Zhanhui Feng, Chunlin Zhang. Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in Parkinson's disease. Neuroscience letters. 2023 Jun; 810(?):137346. doi: 10.1016/j.neulet.2023.137346. [PMID: 37308056]
  • Maria Sofia Molonia, Antonio Speciale, Claudia Muscarà, Federica Lina Salamone, Antonella Saija, Francesco Cimino. Low concentrations of α-lipoic acid reduce palmitic acid-induced alterations in murine hypertrophic adipocytes. Natural product research. 2023 May; ?(?):1-10. doi: 10.1080/14786419.2023.2207137. [PMID: 37129014]
  • Marta Talaverón-Rey, Mónica Álvarez-Córdoba, Irene Villalón-García, Suleva Povea-Cabello, Juan M Suárez-Rivero, David Gómez-Fernández, Ana Romero-González, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, Paula Cilleros-Holgado, Diana Reche-López, Rocío Piñero-Pérez, José A Sánchez-Alcázar. Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels. Orphanet journal of rare diseases. 2023 04; 18(1):80. doi: 10.1186/s13023-023-02687-5. [PMID: 37046296]
  • Jian Zhang, Yuan Zhao, Yidan Zhang, Ya Gao, Shuyue Li, Cui Chang, Xuan Gao, Jingru Zhao, Guofeng Yang. Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus. Neuroscience letters. 2023 02; 798(?):137098. doi: 10.1016/j.neulet.2023.137098. [PMID: 36708754]
  • Xinrong Pei, Fangyan Hu, Zehui Hu, Feiya Luo, Xiaoling Li, Shuxia Xing, Lei Sun, Dingxin Long. Neuroprotective Effect of α-Lipoic Acid against Aβ25-35-Induced Damage in BV2 Cells. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031168. [PMID: 36770835]
  • Cristiane Simões Coelho Britto Ramos, Vivian Alves Pereira da Silva, Lanna Beatriz Neves Silva Corrêa, Renato de Souza Abboud, Gilson Teles Boaventura, Mauricio Alves Chagas. Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats. Journal of dietary supplements. 2023; 20(3):444-458. doi: 10.1080/19390211.2021.2004290. [PMID: 34806528]
  • Babatunde Fasipe, Andre Faria, Ismail Laher. Potential for Novel Therapeutic Uses of Alpha Lipoic Acid. Current medicinal chemistry. 2023; 30(35):3942-3954. doi: 10.2174/0929867329666221006115329. [PMID: 36201272]
  • David Nunes De Lima, Carlos Winston Luz Costa Filho, Ilgner Justa Frota, Alissandra Lima Barbosa de Oliveira, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Eugênio de Moura Campos, Mônica Collares, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Danielle S Macêdo, Lia Lira Olivier Sanders. α-Lipoic Acid as Adjunctive Treatment for Schizophrenia: A Randomized Double-Blind Study. Journal of clinical psychopharmacology. 2023 Jan; 43(1):39-45. doi: 10.1097/jcp.0000000000001639. [PMID: 36584248]
  • Mahmoud A E Hassan, Wael A Khalil, Sameh A Abdelnour, Reham Mokhtar Aman. Supplementation of Alpha-lipoic acid-loaded nanoliposomes in semen extender improves freezability of buffalo spermatozoa. Scientific reports. 2022 12; 12(1):22464. doi: 10.1038/s41598-022-26960-y. [PMID: 36577772]
  • Yangfei Zhao, Xueyan Liu, Chen Liang, Ting Pei, Mingyue Guo, Jundong Wang, Jianhai Zhang. α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis. Journal of agricultural and food chemistry. 2022 Dec; 70(50):15962-15971. doi: 10.1021/acs.jafc.2c07484. [PMID: 36459405]
  • Wen-Sen He, Yuying Sun, Zhishuo Li, Haonan Yang, Junjie Li, Qingzhi Wang, Chen Tan, Bin Zou. Enhanced antioxidant capacity of lipoic acid in different food systems through lipase-mediated esterification with phytosterols. Journal of the science of food and agriculture. 2022 Dec; 102(15):7115-7125. doi: 10.1002/jsfa.12073. [PMID: 35704042]
  • A N Sasunova, A A Goncharov, S V Morozov, V A Isakov. [Modification of dietary patterns in patients with non-alcoholic steatohepatitis]. Terapevticheskii arkhiv. 2022 Oct; 94(8):973-978. doi: 10.26442/00403660.2022.08.201773. [PMID: 36286977]
  • Xiang Huang, Meihua Yang, Jiaxing Guo, Jiachen Liu, Guangming Chu, Yingchun Xu. Genome-Wide Survey and Analysis of Microsatellites in Waterlily, and Potential for Polymorphic Marker Development. Genes. 2022 10; 13(10):. doi: 10.3390/genes13101782. [PMID: 36292667]
  • Bo He, Zhigang Wang, Régis Moreau. Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells. The Journal of nutritional biochemistry. 2022 10; 108(?):109087. doi: 10.1016/j.jnutbio.2022.109087. [PMID: 35691593]
  • I Koca, M Ucar, H O Arik, M Yilmaz, R Dokuyucu. Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis. European review for medical and pharmacological sciences. 2022 10; 26(20):7404-7412. doi: 10.26355/eurrev_202210_30009. [PMID: 36314310]
  • Sam Cho, Seok Jin Hong, Sung Hun Kang, YongKeun Park, Sung Kyun Kim. Alpha-Lipoic Acid Attenuates Apoptosis and Ferroptosis in Cisplatin-Induced Ototoxicity via the Reduction of Intracellular Lipid Droplets. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810981. [PMID: 36142894]
  • Klaudia Sztolsztener, Katarzyna Hodun, Adrian Chabowski. α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet. Biochimica et biophysica acta. Molecular basis of disease. 2022 09; 1868(9):166440. doi: 10.1016/j.bbadis.2022.166440. [PMID: 35569738]
  • George J Dugbartey, Quinsker L Wonje, Karl K Alornyo, Ismaila Adams, Deborah E Diaba. Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes. Biochemical pharmacology. 2022 09; 203(?):115179. doi: 10.1016/j.bcp.2022.115179. [PMID: 35853498]
  • Marta Wołosowicz, Patrycja Dajnowicz-Brzezik, Bartłomiej Łukaszuk, Ewa Żebrowska, Mateusz Maciejczyk, Anna Zalewska, Irena Kasacka, Adrian Chabowski. Diverse impact of N-acetylcysteine or alpha-lipoic acid supplementation during high-fat diet regime on fatty acid transporters in visceral and subcutaneous adipose tissue. Advances in medical sciences. 2022 Sep; 67(2):216-228. doi: 10.1016/j.advms.2022.05.001. [PMID: 35594763]
  • George J Dugbartey, Karl K Alornyo, Deborah E Diaba, Ismaila Adams. Activation of renal CSE/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113386. doi: 10.1016/j.biopha.2022.113386. [PMID: 35834985]
  • Dehui Kong, Alaa A Saqer, Matheus Carpinelli de Jesus, Nemat Khan, Alun Jones, Joanne T Blanchfield, Maree T Smith, Craig M Williams. Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic & medicinal chemistry. 2022 09; 69(?):116889. doi: 10.1016/j.bmc.2022.116889. [PMID: 35779512]
  • Portia Keabetswe Lekhanya, Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials. BMJ open. 2022 08; 12(8):e065630. doi: 10.1136/bmjopen-2022-065630. [PMID: 36008079]
  • Yujin Lee, Joo Weon Lim, Hyeyoung Kim. α‑lipoic acid inhibits cerulein/resistin‑induced expression of interleukin‑6 by activating peroxisome proliferator‑activated receptor‑γ in pancreatic acinar cells. Molecular medicine reports. 2022 Aug; 26(2):. doi: 10.3892/mmr.2022.12780. [PMID: 35730599]
  • Raquel Martins-Noguerol, Sebastien Acket, Manuel Adrián Troncoso-Ponce, Rafael Garcés, Mónica Venegas-Calerón, Joaquín J Salas, Enrique Martínez-Force, Antonio Javier Moreno-Pérez. Characterization and impact of sunflower plastidial octanoyltransferases (Helianthus annuus L.) on oil composition. Journal of plant physiology. 2022 Jul; 274(?):153730. doi: 10.1016/j.jplph.2022.153730. [PMID: 35623270]
  • Min Li, Yidi Kong, Yingqian Lai, Xueqin Wu, Jiawen Zhang, Xiaotian Niu, Guiqin Wang. The effects of dietary supplementation of α-lipoic acid on the growth performance, antioxidant capacity, immune response, and disease resistance of northern snakehead, Channa argus. Fish & shellfish immunology. 2022 Jul; 126(?):57-72. doi: 10.1016/j.fsi.2022.05.029. [PMID: 35598741]
  • Heena Khan, Thakur Gurjeet Singh, Randhir Singh Dahiya, Mohamed M Abdel-Daim. α-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective. Neurochemical research. 2022 Jul; 47(7):1853-1864. doi: 10.1007/s11064-022-03598-w. [PMID: 35445914]
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