Lipoic Acid (BioDeep_00000405442)
Main id: BioDeep_00000014422
PANOMIX_OTCML-2023
代谢物信息卡片
1,2-dithiolane-3R-pentanoic acid
化学式: C8H14O2S2 (206.0435184)
中文名称: (R)-(+)-α-硫辛酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCC(=O)O)C[C@@H]1CCSS1
InChI: InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
描述信息
A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D018977 - Micronutrients > D014815 - Vitamins
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
同义名列表
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:16494
- ChEBI: CHEBI:30314
- KEGG: C16241
- PubChem: 6112
- DrugBank: DB00166
- ChEMBL: CHEMBL134342
- LipidMAPS: LMFA01130001
- MeSH: Thioctic Acid
- KNApSAcK: C00000754
- CAS: 1200-22-2
- MoNA: FiehnHILIC002802
- MoNA: FiehnHILIC001300
- MoNA: HMDB0001451_ms_ms_1581
- MoNA: HMDB0001451_ms_ms_1580
- MoNA: HMDB0001451_ms_ms_1582
- MetaboLights: MTBLC16494
- MetaboLights: MTBLC30314
- PubChem: 47205549
- PDB-CCD: LPA
- NIKKAJI: J9.331I
- RefMet: Lipoic acid
- medchemexpress: HY-18733
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 4081 - Solanum lycopersicum: 10.1038/SDATA.2014.29
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kai Yang, Bing Bai, Jiaqi Lei, Xinyang Yu, Shaolong Qi, Yangfan Wang, Feihe Huang, Zaizai Tong, Guocan Yu. Biodegradable Lipid-Modified Poly(Guanidine Thioctic Acid)s: A Fortifier of Lipid Nanoparticles to Promote the Efficacy and Safety of mRNA Cancer Vaccines.
Journal of the American Chemical Society.
2024 May; 146(17):11679-11693. doi:
10.1021/jacs.3c14010. [PMID: 38482849] - Haixia Xiong, Peili Zhang, Dongcheng Wang, Zhimin Zhou, Jianjun Sun, Mingfang Diao. A silk-based hydrogel containing dexamethasone and lipoic acid microcrystals for local delivery to the inner ear.
Colloids and surfaces. B, Biointerfaces.
2024 May; 237(?):113855. doi:
10.1016/j.colsurfb.2024.113855. [PMID: 38513298] - Licheng Wu, Liyun Xing, Ruinan Wu, Xiaoxing Fan, Mingjie Ni, Xin Xiao, Zhou Zhou, Lian Li, Jingyuan Wen, Yuan Huang. Lipoic acid-mediated oral drug delivery system utilizing changes on cell surface thiol expression for the treatment of diabetes and inflammatory diseases.
Journal of materials chemistry. B.
2024 Apr; 12(16):3970-3983. doi:
10.1039/d3tb02899b. [PMID: 38563351] - Madeline C Tompach, Charlotte K Gridley, Sida Li, John M Clark, Yeonhwa Park, Alicia R Timme-Laragy. Comparing the effects of developmental exposure to alpha lipoic acid (ALA) and perfluorooctanesulfonic acid (PFOS) in zebrafish (Danio rerio).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2024 Apr; 186(?):114560. doi:
10.1016/j.fct.2024.114560. [PMID: 38432440] - Kriti Kushwaha, Debojyoti Mandal, Navneet Khurana, Jeena Gupta. Nephro-protective effects of alpha-lipoic acid in type I diabetes.
Journal of biochemical and molecular toxicology.
2024 Apr; 38(4):e23712. doi:
10.1002/jbt.23712. [PMID: 38602238] - P Prathima, K Venkaiah, M Hanuma Reddy, Jangampalli Adi Pradeepkiran, S B Sainath. Antioxidant effects of α-lipoic acid against epididymal oxidative damage in adult offspring rats exposed to maternal hypothyroidism stress.
Reproductive toxicology (Elmsford, N.Y.).
2024 Apr; 125(?):108555. doi:
10.1016/j.reprotox.2024.108555. [PMID: 38342389] - T Wei, Y Ding, J Zhang, J Li, H Zhang, P Kang, N Zhang. [Correlation of serum ferredoxin 1 and lipoic acid levels with severity of coronary artery disease].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2024 Feb; 44(2):308-316. doi:
10.12122/j.issn.1673-4254.2024.02.13. [PMID: 38501416] - Brenda Laky, Corinna Bruckmann, Julian Blumenschein, Gerlinde Durstberger, Hady Haririan. Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial.
Journal of periodontology.
2024 Feb; 95(2):101-113. doi:
10.1002/jper.23-0115. [PMID: 37439597] - Naima Hafeez Mian, Muhammad Azeem, Qasim Ali, Saqib Mahmood, Muhammad Sohail Akram. Alpha lipoic acid mitigates adverse impacts of drought stress on growth and yield of mungbean: photosynthetic pigments, and antioxidative defense mechanism.
PeerJ.
2024; 12(?):e17191. doi:
10.7717/peerj.17191. [PMID: 38699184] - Yahya M Hodeeb, Emad M El-Rewiny, Abdullah M Gaafar, Ahmed N Zayed, Mohamed S Hasan, Mohamed L Elsaie. The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study.
Human fertility (Cambridge, England).
2023 Dec; 26(5):949-957. doi:
10.1080/14647273.2021.2025271. [PMID: 35023797] - Mateusz Zwierz, Adrian Chabowski, Klaudia Sztolsztener. α-Lipoic acid - a promising agent for attenuating inflammation and preventing steatohepatitis in rats fed a high-fat diet.
Archives of biochemistry and biophysics.
2023 Nov; 750(?):109811. doi:
10.1016/j.abb.2023.109811. [PMID: 37926405] - Walaa El-Houseiny, Ahmed H Arisha, Mohamed M M Metwally, Abdel-Wahab A Abdel-Warith, Elsayed M Younis, Simon J Davies, Bayan A Hassan, Yasmina M Abd-Elhakim. Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis.
Pesticide biochemistry and physiology.
2023 Nov; 196(?):105598. doi:
10.1016/j.pestbp.2023.105598. [PMID: 37945227] - Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li. α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway.
Ecotoxicology and environmental safety.
2023 Oct; 266(?):115533. doi:
10.1016/j.ecoenv.2023.115533. [PMID: 37806127] - Lucia Longhitano, Alfio Distefano, Angela Maria Amorini, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Anna Nicolosi, Amer M Alanazi, Concetta Saoca, Vincenzo Macaione, M'hammed Aguennouz, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Giovanni Li Volti, Giacomo Lazzarino. (+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis.
International journal of molecular sciences.
2023 Sep; 24(19):. doi:
10.3390/ijms241914491. [PMID: 37833939] - Jinping Li, Dayun Tuo, Gunan Guo, Jinfeng Gan. Aberrant expression of cuproptosis‑related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma.
Journal of cancer research and clinical oncology.
2023 Sep; ?(?):. doi:
10.1007/s00432-023-05325-6. [PMID: 37668796] - Cheng Shen, Xueheng Chen, Yong Cao, Yanyan Du, Xuan Xu, Qingjing Wu, Lizhi Lin, Yiran Qin, Runqi Meng, Lijun Gan, Jinguo Zhang. Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage via the ALDH2-associated PINK/Parkin Pathway.
Journal of cardiovascular pharmacology.
2023 Sep; ?(?):. doi:
10.1097/fjc.0000000000001480. [PMID: 37657070] - Jennifer K Frediani, Asim A Lal, Esther Kim, Sharon L Leslie, David W Boorman, Vinita Singh. The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review.
Pain practice : the official journal of World Institute of Pain.
2023 Aug; ?(?):. doi:
10.1111/papr.13291. [PMID: 37654090] - Y Pei, Y-Y Liu, M Sun, J Zheng, T-T Zhou, B Wang, H Hu, Z-L Wang. Beneficial effects of pioglitazone and α-lipoic acid in patients with polycystic ovaries syndrome.
European review for medical and pharmacological sciences.
2023 Aug; 27(15):7118-7126. doi:
10.26355/eurrev_202308_33285. [PMID: 37606122] - Qian Zheng, Pengfei Ma, Pan Yang, Suzhen Zhai, Meina He, Xiangming Zhang, Qiuxia Tu, Ling Jiao, Lan Ye, Zhanhui Feng, Chunlin Zhang. Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in Parkinson's disease.
Neuroscience letters.
2023 Jun; 810(?):137346. doi:
10.1016/j.neulet.2023.137346. [PMID: 37308056] - Maria Sofia Molonia, Antonio Speciale, Claudia Muscarà, Federica Lina Salamone, Antonella Saija, Francesco Cimino. Low concentrations of α-lipoic acid reduce palmitic acid-induced alterations in murine hypertrophic adipocytes.
Natural product research.
2023 May; ?(?):1-10. doi:
10.1080/14786419.2023.2207137. [PMID: 37129014] - Marta Talaverón-Rey, Mónica Álvarez-Córdoba, Irene Villalón-García, Suleva Povea-Cabello, Juan M Suárez-Rivero, David Gómez-Fernández, Ana Romero-González, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, Paula Cilleros-Holgado, Diana Reche-López, Rocío Piñero-Pérez, José A Sánchez-Alcázar. Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels.
Orphanet journal of rare diseases.
2023 04; 18(1):80. doi:
10.1186/s13023-023-02687-5. [PMID: 37046296] - Jian Zhang, Yuan Zhao, Yidan Zhang, Ya Gao, Shuyue Li, Cui Chang, Xuan Gao, Jingru Zhao, Guofeng Yang. Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus.
Neuroscience letters.
2023 02; 798(?):137098. doi:
10.1016/j.neulet.2023.137098. [PMID: 36708754] - Xinrong Pei, Fangyan Hu, Zehui Hu, Feiya Luo, Xiaoling Li, Shuxia Xing, Lei Sun, Dingxin Long. Neuroprotective Effect of α-Lipoic Acid against Aβ25-35-Induced Damage in BV2 Cells.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031168. [PMID: 36770835] - Cristiane Simões Coelho Britto Ramos, Vivian Alves Pereira da Silva, Lanna Beatriz Neves Silva Corrêa, Renato de Souza Abboud, Gilson Teles Boaventura, Mauricio Alves Chagas. Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats.
Journal of dietary supplements.
2023; 20(3):444-458. doi:
10.1080/19390211.2021.2004290. [PMID: 34806528] - Babatunde Fasipe, Andre Faria, Ismail Laher. Potential for Novel Therapeutic Uses of Alpha Lipoic Acid.
Current medicinal chemistry.
2023; 30(35):3942-3954. doi:
10.2174/0929867329666221006115329. [PMID: 36201272] - David Nunes De Lima, Carlos Winston Luz Costa Filho, Ilgner Justa Frota, Alissandra Lima Barbosa de Oliveira, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Eugênio de Moura Campos, Mônica Collares, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Danielle S Macêdo, Lia Lira Olivier Sanders. α-Lipoic Acid as Adjunctive Treatment for Schizophrenia: A Randomized Double-Blind Study.
Journal of clinical psychopharmacology.
2023 Jan; 43(1):39-45. doi:
10.1097/jcp.0000000000001639. [PMID: 36584248] - Mahmoud A E Hassan, Wael A Khalil, Sameh A Abdelnour, Reham Mokhtar Aman. Supplementation of Alpha-lipoic acid-loaded nanoliposomes in semen extender improves freezability of buffalo spermatozoa.
Scientific reports.
2022 12; 12(1):22464. doi:
10.1038/s41598-022-26960-y. [PMID: 36577772] - Yangfei Zhao, Xueyan Liu, Chen Liang, Ting Pei, Mingyue Guo, Jundong Wang, Jianhai Zhang. α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis.
Journal of agricultural and food chemistry.
2022 Dec; 70(50):15962-15971. doi:
10.1021/acs.jafc.2c07484. [PMID: 36459405] - Wen-Sen He, Yuying Sun, Zhishuo Li, Haonan Yang, Junjie Li, Qingzhi Wang, Chen Tan, Bin Zou. Enhanced antioxidant capacity of lipoic acid in different food systems through lipase-mediated esterification with phytosterols.
Journal of the science of food and agriculture.
2022 Dec; 102(15):7115-7125. doi:
10.1002/jsfa.12073. [PMID: 35704042] - A N Sasunova, A A Goncharov, S V Morozov, V A Isakov. [Modification of dietary patterns in patients with non-alcoholic steatohepatitis].
Terapevticheskii arkhiv.
2022 Oct; 94(8):973-978. doi:
10.26442/00403660.2022.08.201773. [PMID: 36286977] - Xiang Huang, Meihua Yang, Jiaxing Guo, Jiachen Liu, Guangming Chu, Yingchun Xu. Genome-Wide Survey and Analysis of Microsatellites in Waterlily, and Potential for Polymorphic Marker Development.
Genes.
2022 10; 13(10):. doi:
10.3390/genes13101782. [PMID: 36292667] - Bo He, Zhigang Wang, Régis Moreau. Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells.
The Journal of nutritional biochemistry.
2022 10; 108(?):109087. doi:
10.1016/j.jnutbio.2022.109087. [PMID: 35691593] - I Koca, M Ucar, H O Arik, M Yilmaz, R Dokuyucu. Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis.
European review for medical and pharmacological sciences.
2022 10; 26(20):7404-7412. doi:
10.26355/eurrev_202210_30009. [PMID: 36314310] - Sam Cho, Seok Jin Hong, Sung Hun Kang, YongKeun Park, Sung Kyun Kim. Alpha-Lipoic Acid Attenuates Apoptosis and Ferroptosis in Cisplatin-Induced Ototoxicity via the Reduction of Intracellular Lipid Droplets.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810981. [PMID: 36142894] - Klaudia Sztolsztener, Katarzyna Hodun, Adrian Chabowski. α-lipoic acid ameliorates inflammation state and oxidative stress by reducing the content of bioactive lipid derivatives in the left ventricle of rats fed a high-fat diet.
Biochimica et biophysica acta. Molecular basis of disease.
2022 09; 1868(9):166440. doi:
10.1016/j.bbadis.2022.166440. [PMID: 35569738] - George J Dugbartey, Quinsker L Wonje, Karl K Alornyo, Ismaila Adams, Deborah E Diaba. Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes.
Biochemical pharmacology.
2022 09; 203(?):115179. doi:
10.1016/j.bcp.2022.115179. [PMID: 35853498] - Marta Wołosowicz, Patrycja Dajnowicz-Brzezik, Bartłomiej Łukaszuk, Ewa Żebrowska, Mateusz Maciejczyk, Anna Zalewska, Irena Kasacka, Adrian Chabowski. Diverse impact of N-acetylcysteine or alpha-lipoic acid supplementation during high-fat diet regime on fatty acid transporters in visceral and subcutaneous adipose tissue.
Advances in medical sciences.
2022 Sep; 67(2):216-228. doi:
10.1016/j.advms.2022.05.001. [PMID: 35594763] - George J Dugbartey, Karl K Alornyo, Deborah E Diaba, Ismaila Adams. Activation of renal CSE/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113386. doi:
10.1016/j.biopha.2022.113386. [PMID: 35834985] - Dehui Kong, Alaa A Saqer, Matheus Carpinelli de Jesus, Nemat Khan, Alun Jones, Joanne T Blanchfield, Maree T Smith, Craig M Williams. Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain.
Bioorganic & medicinal chemistry.
2022 09; 69(?):116889. doi:
10.1016/j.bmc.2022.116889. [PMID: 35779512] - Portia Keabetswe Lekhanya, Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials.
BMJ open.
2022 08; 12(8):e065630. doi:
10.1136/bmjopen-2022-065630. [PMID: 36008079] - Yujin Lee, Joo Weon Lim, Hyeyoung Kim. α‑lipoic acid inhibits cerulein/resistin‑induced expression of interleukin‑6 by activating peroxisome proliferator‑activated receptor‑γ in pancreatic acinar cells.
Molecular medicine reports.
2022 Aug; 26(2):. doi:
10.3892/mmr.2022.12780. [PMID: 35730599] - Raquel Martins-Noguerol, Sebastien Acket, Manuel Adrián Troncoso-Ponce, Rafael Garcés, Mónica Venegas-Calerón, Joaquín J Salas, Enrique Martínez-Force, Antonio Javier Moreno-Pérez. Characterization and impact of sunflower plastidial octanoyltransferases (Helianthus annuus L.) on oil composition.
Journal of plant physiology.
2022 Jul; 274(?):153730. doi:
10.1016/j.jplph.2022.153730. [PMID: 35623270] - Min Li, Yidi Kong, Yingqian Lai, Xueqin Wu, Jiawen Zhang, Xiaotian Niu, Guiqin Wang. The effects of dietary supplementation of α-lipoic acid on the growth performance, antioxidant capacity, immune response, and disease resistance of northern snakehead, Channa argus.
Fish & shellfish immunology.
2022 Jul; 126(?):57-72. doi:
10.1016/j.fsi.2022.05.029. [PMID: 35598741] - Heena Khan, Thakur Gurjeet Singh, Randhir Singh Dahiya, Mohamed M Abdel-Daim. α-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective.
Neurochemical research.
2022 Jul; 47(7):1853-1864. doi:
10.1007/s11064-022-03598-w. [PMID: 35445914] - Patrycja Dajnowicz-Brzezik, Ewa Żebrowska, Mateusz Maciejczyk, Anna Zalewska, Adrian Chabowski. The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2022 May; 56(3):239-253. doi:
10.33594/000000528. [PMID: 35524549] - Sujan Banik, Kohei Yamada, Hideyuki Sato, Satomi Onoue. Development of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin.
Molecular pharmaceutics.
2022 05; 19(5):1468-1476. doi:
10.1021/acs.molpharmaceut.2c00009. [PMID: 35353535] - Heba H Metwaly, Shadia A Fathy, Mehrevan M Abdel Moneim, Manal A Emam, Ahmed F Soliman, Mehrez E El-Naggar, Enayat A Omara, Mona A El-Bana. Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity.
Toxicology mechanisms and methods.
2022 May; 32(4):268-279. doi:
10.1080/15376516.2021.1998275. [PMID: 34697995] - George J Dugbartey, Karl K Alornyo, Benoit B N'guessan, Stephen Atule, Samuel D Mensah, Samuel Adjei. Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 May; 149(?):112818. doi:
10.1016/j.biopha.2022.112818. [PMID: 35286963] - Hossam G Tohamy, Mohamed A Lebda, Kadry M Sadek, Mohamed S Elfeky, Yasser S El-Sayed, Dalia H Samak, Heba S Hamed, Tarek K Abouzed. Biochemical, molecular and cytological impacts of alpha-lipoic acid and Ginkgo biloba in ameliorating testicular dysfunctions induced by silver nanoparticles in rats.
Environmental science and pollution research international.
2022 May; 29(25):38198-38211. doi:
10.1007/s11356-021-18441-y. [PMID: 35067888] - Shengfu Jiao, Yuxia Dong, Xiang Chang, Yanan Wu, Haifeng Li. Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy: A protocol for a parallel, randomized, double-blind, controlled clinical trial.
Medicine.
2022 Apr; 101(17):e29080. doi:
10.1097/md.0000000000029080. [PMID: 35512068] - Xian-Hui Shao, Xiao Yang, Yue Zhou, Qing-Chang Xia, Yun-Ping Lu, Xiao Yan, Chen Chen, Ting-Ting Zheng, Lin-Lin Zhang, Yu-Ning Ma, Yu-Xia Ma, Shu-Zhong Gao. Antibacterial, wearable, transparent tannic acid-thioctic acid-phytic acid hydrogel for adhesive bandages.
Soft matter.
2022 Apr; 18(14):2814-2828. doi:
10.1039/d2sm00058j. [PMID: 35322837] - Fagen Li, Ke Cao, Maoyun Wang, Yi Liu, Yin Zhang. Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway.
Bioengineered.
2022 04; 13(4):10111-10122. doi:
10.1080/21655979.2022.2063664. [PMID: 35435117] - D Z Abdel Hamid, Y A Nienaa, T M Mostafa. Alpha-lipoic acid improved anemia, erythropoietin resistance, maintained glycemic control, and reduced cardiovascular risk in diabetic patients on hemodialysis: a multi-center prospective randomized controlled study.
European review for medical and pharmacological sciences.
2022 04; 26(7):2313-2329. doi:
10.26355/eurrev_202204_28461. [PMID: 35442486] - Tatiana de Queiroz Oliveira, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramos Soares, Natássia Lopes Cunha, Charliene Freire Xavier Vieira, Carlos Venício Jataí Gadelha Filho, Glautemberg de Almeida Viana, Gabriela Mariângela Farias De Oliveira, Danielle Silveira Macedo, Silvânia Maria Mendes Vasconcelos. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Behavioural brain research.
2022 02; 419(?):113667. doi:
10.1016/j.bbr.2021.113667. [PMID: 34798169] - Nail Tekin Onder, Selim Alcay, Zekariya Nur. Effects of alpha-lipoic acid on ram semen cryopreservation and post-thaw life span.
Andrologia.
2022 Feb; 54(1):e14249. doi:
10.1111/and.14249. [PMID: 34553400] - Radoslaw Piotr Radzki, Marek Bienko, Dariusz Wolski, Tomasz Oniszczuk, Agnieszka Radzka-Pogoda, Pawel Polak, Andrzej Borzecki, Mateusz Stasiak. Lipoic acid (LA) dose-dependently protects bone losses in the mandible of rats during the development of osteopenia by inhibiting oxidative stress and promoting bone formation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Feb; 146(?):112467. doi:
10.1016/j.biopha.2021.112467. [PMID: 34891114] - Tiffany N Caza, Christopher P Larsen. Lipoic acid in neural epidermal growth factor-like 1-associated membranous nephropathy: more than a coincidence?.
Kidney international.
2022 02; 101(2):418-419. doi:
10.1016/j.kint.2021.12.001. [PMID: 35065693] - Jinnan Dong, Yuhong Wang, Shaona Yi, Tiantian Zhao, Yan Xu. α-Lipoic acid ameliorates renal fibrosis in diabetic rats through TGF-β1/Smads signaling pathway.
Minerva medica.
2022 02; 113(1):216-218. doi:
10.23736/s0026-4806.20.07235-3. [PMID: 33555156] - Manoj Kumar Mishra, Jianxiong Wang, Reza Mirzaei, Rigel Chan, Helvira Melo, Ping Zhang, Chang-Chun Ling, Aldo Bruccoleri, Lin Tang, V Wee Yong. A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology.
Cells.
2022 01; 11(3):. doi:
10.3390/cells11030440. [PMID: 35159249] - Shing-Hwa Huang, Shun-Li Kuo, Shyi-Jou Chen, Jeng-Rong Lin, Yuan-Wu Chen, Zhi-Jie Hong, Huey-Kang Sytwu, Gu-Jiun Lin. Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031169. [PMID: 35163121] - Mahnaz Rezaei Kelishadi, Amirmansour Alavi Naeini, Fariborz Khorvash, Gholamreza Askari, Zahra Heidari. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines.
Scientific reports.
2022 01; 12(1):271. doi:
10.1038/s41598-021-04397-z. [PMID: 34997178] - Manal A Othman, Heba A Mubarak, Manal M Sayed. Ameliorative role of alpha-lipoic acid in renal cortical structural damage, induced by limb ischemia-reperfusion injury in the rat.
Ultrastructural pathology.
2022 Jan; 46(1):110-121. doi:
10.1080/01913123.2022.2035875. [PMID: 35135431] - Giuseppe Derosa, Angela D'Angelo, Paola Stefania Preti, Pamela Maffioli. Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid, Vitis vinifera L. and Ginkgo biloba, Compared to Placebo, Avanafil or a Combination of Nutraceutical Plus Avanafil in Males With Type 2 Diabetes Mellitus With Erectile Dysfunction.
Frontiers in endocrinology.
2022; 13(?):847240. doi:
10.3389/fendo.2022.847240. [PMID: 35464055] - Elena Vakali, Dimitrios Rigopoulos, Andres E Carrillo, Andreas D Flouris, Petros C Dinas. Effects of Alpha-lipoic Acid Supplementation on Human Diabetic Nephropathy: A Systematic Review and Meta-analysis.
Current diabetes reviews.
2022; 18(6):e140921196457. doi:
10.2174/1573399817666210914103329. [PMID: 34521329] - Ayse Kocak, Cemre Ural, Duygu Harmanci, Mehmet Asi Oktan, Aysan Afagh, Sulen Sarioglu, Osman Yilmaz, Merih Birlik, Gul Guner Akdogan, Zahide Cavdar. Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis through the repression of NADPH Oxidase 4 and TGF-β1/Smad3 signaling pathways.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065975. doi:
10.1177/09603271211065975. [PMID: 35187969] - Mateusz Maciejczyk, Ewa Żebrowska, Miłosz Nesterowicz, Małgorzata Żendzian-Piotrowska, Anna Zalewska. α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats.
Oxidative medicine and cellular longevity.
2022; 2022(?):7450514. doi:
10.1155/2022/7450514. [PMID: 35391928] - Zahraa Abdul Sater, Cheryl Cero, Anne E Pierce, Hannah J Lea, Houssein Abdul Sater, Kenneth Y Zhu, Naili Liu, Yinyan Ma, Oksana Gavrilova, Aaron M Cypess. Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.
Obesity (Silver Spring, Md.).
2022 01; 30(1):153-164. doi:
10.1002/oby.23309. [PMID: 34825496] - Yasser A Khadrawy, Noha M Khoder, Hussein G Sawie, Hayat M Sharada, Eman N Hosny, Mohga S Abdulla. The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat.
Neuroendocrinology.
2022; 112(11):1129-1142. doi:
10.1159/000524367. [PMID: 35354137] - Yuki Hashimoto, Katsuhiko Yoshizawa, Yuka Kaido, Akiko Takenouchi, Keiji Terao, Hiroyuki Yasui, Yutaka Yoshikawa. Exercise Performance Upregulatory Effect of R-α-Lipoic Acid with γ-Cyclodextrin.
Nutrients.
2021 Dec; 14(1):. doi:
10.3390/nu14010021. [PMID: 35010896] - Rebecca I Spain, Nicole K Andeen, Pamela C Gibson, Mary H Samuels, Cynthia D Morris, Andrew J Solomon, Richard Solomon, Carin Waslo, Rupali S Avasare. Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)-associated membranous nephropathy.
Kidney international.
2021 12; 100(6):1208-1213. doi:
10.1016/j.kint.2021.10.010. [PMID: 34662650] - Masoome Mandani, Bita Badehnoosh, Farideh Jalali-Mashayekhi, Bahareh Tavakoli-Far, Ali Khosrowbeygi. Alpha-lipoic acid supplementation effects on serum values of some oxidative stress biomarkers in women with gestational diabetes.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2021 Dec; 37(12):1111-1115. doi:
10.1080/09513590.2021.1963955. [PMID: 34369837] - Min Li, Yidi Kong, Xueqin Wu, Zhuang Yin, Xiaotian Niu, Guiqin Wang. Dietary α-lipoic acid can alleviate the bioaccumulation, oxidative stress, cell apoptosis, and inflammation induced by lead (Pb) in Channa argus.
Fish & shellfish immunology.
2021 Dec; 119(?):249-261. doi:
10.1016/j.fsi.2021.10.010. [PMID: 34653663] - Hongrui Zhang, Gaiqing Yang, Hao Li, Linfeng Wang, Tong Fu, Gaiying Li, Tengyun Gao. Effects of dietary supplementation with alpha-lipoic acid on apparent digestibility and serum metabolome alterations of sheep in summer.
Tropical animal health and production.
2021 Oct; 53(5):505. doi:
10.1007/s11250-021-02917-7. [PMID: 34622337] - Mahsa Mahmoudinezhad, Mahdieh Abbasalizad Farhangi. Alpha lipoic acid supplementation affects serum lipids in a dose and duration-dependent manner in different health status.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2021 Oct; ?(?):. doi:
10.1024/0300-9831/a000732. [PMID: 34605276] - J Wang, D L Clark, S K Jacobi, S G Velleman. Alpha-tocopherol acetate and alpha lipoic acid may mitigate the development of wooden breast myopathy in broilers at an early age.
British poultry science.
2021 Oct; 62(5):749-758. doi:
10.1080/00071668.2021.1927985. [PMID: 33988058] - Fatemeh Haidari, Javad Mohammadi-Asl, Maria Kavianpour, Mohammadreza Dadfar, Hossein Khadem Haghighian. Effect of lipoic acid supplementation on gene expression and activity of glutathione S-transferase enzyme in infertile men.
Human fertility (Cambridge, England).
2021 Oct; 24(4):276-283. doi:
10.1080/14647273.2019.1639221. [PMID: 31291793] - Shuyi Liao, Wenmin Yang, Ting Yu, Lu Dai, Xiaoliang Liu, Jiangping Zhang, Jinghong Zhao, Chi Liu. Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Biomolecules.
2021 09; 11(9):. doi:
10.3390/biom11091370. [PMID: 34572583] - Cara L Field, Sophie T Whoriskey, Xianguo Zhao, Mark G Papich. PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Sep; 52(3):872-879. doi:
10.1638/2020-0223. [PMID: 34687502] - Tapan Behl, Amit Gupta, Aayush Sehgal, Sanchay Sharma, Sukhbir Singh, Neelam Sharma, Camelia Cristina Diaconu, Abbas Rahdar, Abdul Hafeez, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau. A spotlight on underlying the mechanism of AMPK in diabetes complications.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 Sep; 70(9):939-957. doi:
10.1007/s00011-021-01488-5. [PMID: 34319417] - Ghadha Ibrahim Fouad, Mohamed R Mousa. The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Molecular and cellular biochemistry.
2021 Sep; 476(9):3433-3448. doi:
10.1007/s11010-021-04173-7. [PMID: 33973131] - Weijia Peng, Zeyu Zhu, Yang Yang, Jiawei Hou, Junfeng Lu, Chen Chen, Fang Liu, Rongbiao Pi. N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Brain research bulletin.
2021 09; 174(?):250-259. doi:
10.1016/j.brainresbull.2021.06.014. [PMID: 34171402] - Mahnaz Rezaei Kelishadi, Amirmansour Alavi Naeini, Gholamreza Askari, Fariborz Khorvash, Zahra Heidari. The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial.
International journal of clinical practice.
2021 Sep; 75(9):e14455. doi:
10.1111/ijcp.14455. [PMID: 34105866] - Fangfang Sun, Deqi Jiang, Juanjuan Cai. Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis.
BMC endocrine disorders.
2021 Aug; 21(1):178. doi:
10.1186/s12902-021-00844-0. [PMID: 34465338] - Zahide Cavdar, Mehmet Asi Oktan, Cemre Ural, Ayse Kocak, Meryem Calisir, Cihan Heybeli, Serkan Yildiz, Seda Ozbal, Sevki Arslan, Bekir Ugur Ergur, Osman Yilmaz, Caner Cavdar. Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2021 Aug; 96(6):409-417. doi:
10.1080/10520295.2020.1812001. [PMID: 32921159] - Hsueh-Hsiao Wang, Cheng-An J Lin, Ya-Ming Tseng, Hsin-I Lee, Yi-Nan Lee, Hung-I Yeh, Po-Sheng Yang, Hsien-Yu Peng, Yih-Jer Wu. Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway.
Nanomedicine : nanotechnology, biology, and medicine.
2021 08; 36(?):102427. doi:
10.1016/j.nano.2021.102427. [PMID: 34174418] - Dan Wu, Hezuo Liu, Yang Liu, Wei Wei, Qi Sun, Deliang Wen, Lihong Jia. Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Aug; 154(?):112307. doi:
10.1016/j.fct.2021.112307. [PMID: 34058234] - Luc Rochette, Steliana Ghibu. Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22157979. [PMID: 34360751] - Shihui Guo, Kai Yan, Xi Fang, Yingdong Ni, Wenqiang Ma, Ruqian Zhao. α-Lipoic Acid Alleviates Hepatic Lipid Deposition by Inhibiting FASN Expression via miR-3548 in Rats.
Nutrients.
2021 Jul; 13(7):. doi:
10.3390/nu13072331. [PMID: 34371841] - Lidia V Kravchenko, Ilya V Aksenov, Nikolay S Nikitin, Galina V Guseva, Ludmila I Avrenyeva, Nikita V Trusov, Anastasia S Balakina, Victor A Tutelyan. Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet.
Nutrients.
2021 Jun; 13(6):. doi:
10.3390/nu13061999. [PMID: 34200615] - Elham Sharifi-Zahabi, Hadi Abdollahzad, Seyed Mostafa Nachvak, Jalal Moloudi, Mohammad Reza Golpayegani, Sahar Asiaei, Laya Rezavand, Zeynab Iraji, Khadijeh Jamshidi. Effects of alpha lipoic acid on iron overload, lipid profile and oxidative stress indices in β-thalassemia major patients: A cross-over randomised controlled clinical trial.
International journal of clinical practice.
2021 Jun; 75(6):e14062. doi:
10.1111/ijcp.14062. [PMID: 33527721] - Hafiz Muhammad Rashad Javeed, Mazhar Ali, Milan Skalicky, Fahim Nawaz, Rafi Qamar, Atique Ur Rehman, Maooz Faheem, Muhammad Mubeen, Muhammad Mohsin Iqbal, Muhammad Habib Ur Rahman, Pavla Vachova, Marian Brestic, Alaa Baazeem, Ayman El Sabagh. Lipoic Acid Combined with Melatonin Mitigates Oxidative Stress and Promotes Root Formation and Growth in Salt-Stressed Canola Seedlings (Brassica napus L.).
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113147. [PMID: 34070241] - Bíborka Nádró, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, György Paragh, Péter Kempler, Mariann Harangi, Ferenc Sztanek. Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy.
The Journal of international medical research.
2021 May; 49(5):3000605211012213. doi:
10.1177/03000605211012213. [PMID: 34041950] - Mingzhe Li, Baoan Ning, Tianhui Wang. The mechanism and prevention of mitochondrial injury after exercise.
Journal of physiology and biochemistry.
2021 May; 77(2):215-225. doi:
10.1007/s13105-021-00802-3. [PMID: 33650090] - Mehmet Asi Oktan, Cihan Heybeli, Cemre Ural, Ayse Kocak, Gokcen Bilici, Zahide Cavdar, Seda Ozbal, Sevki Arslan, Osman Yilmaz, Caner Cavdar. Alpha-lipoic acid alleviates colistin nephrotoxicity in rats.
Human & experimental toxicology.
2021 May; 40(5):761-771. doi:
10.1177/0960327120966043. [PMID: 33111558] - Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu. Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes.
Redox biology.
2021 05; 41(?):101948. doi:
10.1016/j.redox.2021.101948. [PMID: 33774475] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Elahe Zarini-Gakiye, Nima Sanadgol, Kazem Parivar, Gholamhassan Vaezi. Alpha-lipoic acid ameliorates tauopathy-induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor.
Metabolic brain disease.
2021 04; 36(4):669-683. doi:
10.1007/s11011-021-00679-7. [PMID: 33547995] - Sébastien Le Garf, Brigitte Sibille, Isabelle Mothe-Satney, Cyril Eininger, Philippe Fauque, Joseph Murdaca, Giulia Chinetti, Jaap G Neels, Anne-Sophie Rousseau. Alpha-lipoic acid supplementation increases the efficacy of exercise- and diet-induced obesity treatment and induces immunometabolic changes in female mice and women.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 04; 35(4):e21312. doi:
10.1096/fj.202001817rr. [PMID: 33742689] - Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur. Alpha-lipoic acid may ameliorate testicular damage by targeting dox-induced altered antioxidant parameters, mitofusin-2 and apoptotic gene expression.
Andrologia.
2021 Apr; 53(3):e13990. doi:
10.1111/and.13990. [PMID: 33529370]