Ketoleucine (BioDeep_00000405339)

Main id: BioDeep_00000003211

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4-methyl-2-oxopentanoic acid

化学式: C6H10O3 (130.063)
中文名称: 4-甲基-2-氧戊酸, 4-甲基-2-氧代戊酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(=O)C(=O)O
InChI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)

描述信息

A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid), an abnormal metabolite, is both a neurotoxin and a metabotoxin.

同义名列表

6 个代谢物同义名

4-methyl-2-oxopentanoic acid; Ketoleucine; 4-Methyl-2-oxovaleric acid; α-Ketoisocaproic acid; 4-Methyl-2-oxopentanoate; 4-Methyl-2-oxopentanoic acid



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, EIF4E, EIF4EBP1, GCK, MTOR, PRKX
Peripheral membrane protein 3 CTSB, GCK, MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 9 AKT1, ALB, CS, EIF4E, EIF4EBP1, GCK, MTOR, PLCZ1, PRKX
cytosol 10 AKT1, ALB, EIF4E, EIF4EBP1, GCK, GLS, MTOR, PLCZ1, PRKCQ, SST
dendrite 1 MTOR
nuclear body 1 EIF4E
phagocytic vesicle 1 MTOR
centrosome 2 ALB, SLC16A1
nucleoplasm 6 AKT1, BCAT2, GCK, MTOR, PLCZ1, PRKX
Cell membrane 2 AKT1, SLC16A1
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Multi-pass membrane protein 2 KCNA3, SLC16A1
Golgi apparatus membrane 2 GCK, MTOR
Synapse 2 GLS, SLC16A1
cell cortex 1 AKT1
cell junction 1 SLC16A1
glutamatergic synapse 3 AKT1, EIF4E, KCNA3
Golgi apparatus 2 ALB, LTBR
Golgi membrane 3 GCK, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 SST
postsynapse 2 AKT1, EIF4E
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 1 GLS
Lysosome 2 CTSB, MTOR
plasma membrane 6 AKT1, GCG, KCNA3, LTBR, PRKCQ, SLC16A1
Membrane 5 AKT1, CS, KCNA3, MTOR, SLC16A1
apical plasma membrane 2 CTSB, SLC16A1
axon 2 CCK, KCNA3
basolateral plasma membrane 2 GCK, SLC16A1
extracellular exosome 5 ALB, CS, CTSB, EIF4E, SLC16A1
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, CCK, CTSB, GCG, INS, SST
perinuclear region of cytoplasm 4 CTSB, EIF4E, KCNA3, PLCZ1
mitochondrion 4 BCAT2, CS, GCK, GLS
protein-containing complex 2 AKT1, ALB
intracellular membrane-bounded organelle 1 SLC16A1
Microsome membrane 1 MTOR
pronucleus 1 PLCZ1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 5 ALB, CCK, GCG, INS, SST
extracellular region 6 ALB, CCK, CTSB, GCG, INS, SST
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 CS
mitochondrial matrix 3 BCAT2, CS, GLS
Extracellular side 1 CTSB
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 CTSB
microtubule cytoskeleton 1 AKT1
nucleolus 1 PLCZ1
Cytoplasm, P-body 1 EIF4E
P-body 1 EIF4E
cell-cell junction 1 AKT1
vesicle 1 AKT1
postsynaptic membrane 1 KCNA3
Apical cell membrane 2 CTSB, SLC16A1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 KCNA3
spindle 1 AKT1
GABA-ergic synapse 1 SST
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 CTSB
lateral plasma membrane 1 SLC16A1
nuclear speck 1 EIF4E
ciliary basal body 2 AKT1, ALB
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 EIF4E
Secreted, extracellular space 1 CTSB
[Isoform 1]: Mitochondrion 1 GLS
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 2 GCK, SLC16A1
[Isoform 2]: Cell membrane 1 KCNA3
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Melanosome 1 CTSB
Cytoplasm, Stress granule 1 EIF4E
cytoplasmic stress granule 1 EIF4E
Nucleus speckle 1 EIF4E
basal plasma membrane 1 SLC16A1
voltage-gated potassium channel complex 1 KCNA3
ficolin-1-rich granule lumen 1 CTSB
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, GCG, INS
platelet alpha granule lumen 1 ALB
chromatoid body 1 EIF4E
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
[Isoform 1]: Cell membrane 1 KCNA3
eukaryotic translation initiation factor 4F complex 1 EIF4E
[Isoform 3]: Mitochondrion 1 GLS
Cytoplasmic vesicle, phagosome 1 MTOR
RISC complex 1 EIF4E
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
peptidase inhibitor complex 1 CTSB
[Glucagon-like peptide 1]: Secreted 1 GCG
sperm head 1 PLCZ1
Nucleus, nuclear body 1 EIF4E
endolysosome lumen 1 CTSB
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
ciliary transition fiber 1 ALB


文献列表

  • Ângela Beatris Zemniaçak, Rafael Teixeira Ribeiro, Camila Vieira Pinheiro, Sâmela de Azevedo Cunha, Tailine Quevedo Tavares, Ediandra Tissot Castro, Guilhian Leipnitz, Moacir Wajner, Alexandre Umpierrez Amaral. In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury. Molecular neurobiology. 2023 Nov; ?(?):. doi: 10.1007/s12035-023-03718-9. [PMID: 37910283]
  • Tae Jun Park, Seung Yeon Park, Hyun Jung Lee, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung. α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes. Biochemical and biophysical research communications. 2022 05; 603(?):109-115. doi: 10.1016/j.bbrc.2022.03.010. [PMID: 35279461]
  • Xin Tang, Lulu Chang, Shujie Gu, Hao Zhang, Yong Q Chen, Haiqin Chen, Jianxin Zhao, Wei Chen. Role of beta-isopropylmalate dehydrogenase in lipid biosynthesis of the oleaginous fungus Mortierella alpina. Fungal genetics and biology : FG & B. 2021 07; 152(?):103572. doi: 10.1016/j.fgb.2021.103572. [PMID: 34015432]
  • Gabriella A M Ten Have, Lisa Jansen, Marieke G Schooneman, Marielle P K J Engelen, Nicolaas E P Deutz. Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and β-hydroxy β-methylbutyric acid across multiple organs in the pig. American journal of physiology. Endocrinology and metabolism. 2021 03; 320(3):E629-E640. doi: 10.1152/ajpendo.00384.2020. [PMID: 33522397]
  • Hémelin R Farias, Joice R Gabriel, Maria Laura Cecconi, Isabela S Lemos, Victoria L de Rezende, Letícia B Wessler, Mariane B Duarte, Giselli Scaini, Jade de Oliveira, Emilio L Streck. The metabolic effect of α-ketoisocaproic acid: in vivo and in vitro studies. Metabolic brain disease. 2021 01; 36(1):185-192. doi: 10.1007/s11011-020-00626-y. [PMID: 33034842]
  • Yinzhao Zhong, Bo Song, Changbing Zheng, Fengna Li, Xiangfeng Kong, Yehui Duan, Jinping Deng. α-Ketoisocaproate and β-hydroxy-β-methyl butyrate regulate fatty acid composition and lipid metabolism in skeletal muscle of growing pigs. Journal of animal physiology and animal nutrition. 2019 May; 103(3):846-857. doi: 10.1111/jpn.13077. [PMID: 30775808]
  • Yehui Duan, Lingyu Zhang, Fengna Li, Qiuping Guo, Cimin Long, Yulong Yin, Xiangfeng Kong, Mijun Peng, Wence Wang. β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs. Food & function. 2018 Sep; 9(9):4836-4846. doi: 10.1039/c8fo00898a. [PMID: 30137075]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Claudia Grajeda-Iglesias, Oren Rom, Shadi Hamoud, Nina Volkova, Tony Hayek, Niroz Abu-Saleh, Michael Aviram. Leucine supplementation attenuates macrophage foam-cell formation: Studies in humans, mice, and cultured macrophages. BioFactors (Oxford, England). 2018 May; 44(3):245-262. doi: 10.1002/biof.1415. [PMID: 29399895]
  • Giacomo Garibotto, Daniela Verzola, Monica Vettore, Paolo Tessari. The contribution of muscle, kidney, and splanchnic tissues to leucine transamination in humans. Canadian journal of physiology and pharmacology. 2018 Apr; 96(4):382-387. doi: 10.1139/cjpp-2017-0439. [PMID: 28892650]
  • Caroline Hall, Ian Grayson. Genotoxicity and sub-chronic toxicity of MYOLUTION® (branched chain keto acids). Regulatory toxicology and pharmacology : RTP. 2017 Nov; 90(?):133-143. doi: 10.1016/j.yrtph.2017.09.004. [PMID: 28888959]
  • Paolo Tessari. Leucine Transamination Is Lower in Middle-Aged Compared with Younger Adults. The Journal of nutrition. 2017 11; 147(11):2025-2030. doi: 10.3945/jn.117.250852. [PMID: 28931590]
  • Luciane Taschetto, Giselli Scaini, Hugo G Zapelini, Ândrea C Ramos, Giulia Strapazzon, Vanessa M Andrade, Gislaine Z Réus, Monique Michels, Felipe Dal-Pizzol, João Quevedo, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Streck. Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters and cognitive and noncognitive behaviors. Metabolic brain disease. 2017 10; 32(5):1507-1518. doi: 10.1007/s11011-017-0035-z. [PMID: 28550500]
  • Edith Renguet, Audrey Ginion, Roselle Gélinas, Laurent Bultot, Julien Auquier, Isabelle Robillard Frayne, Caroline Daneault, Jean-Louis Vanoverschelde, Christine Des Rosiers, Louis Hue, Sandrine Horman, Christophe Beauloye, Luc Bertrand. Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake. American journal of physiology. Heart and circulatory physiology. 2017 Aug; 313(2):H432-H445. doi: 10.1152/ajpheart.00738.2016. [PMID: 28646031]
  • Dillon K Walker, John J Thaden, Agata Wierzchowska-McNew, Marielle P K J Engelen, Nicolaas E P Deutz. Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jan; 1040(?):233-238. doi: 10.1016/j.jchromb.2016.11.010. [PMID: 27856194]
  • Davis S Sonnet, Monique N O'Leary, Mark A Gutierrez, Steven M Nguyen, Samiha Mateen, Yuehmei Hsu, Kylie P Mitchell, Antonio J Lopez, Jerry Vockley, Brian K Kennedy, Arvind Ramanathan. Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD. Scientific reports. 2016 07; 6(?):28775. doi: 10.1038/srep28775. [PMID: 27373929]
  • Sathyavageeswaran Shreeram, Subbarayan Ramesh, Jithesh K Puthan, Gayathri Balakrishnan, Ramachandran Subramanian, Murali Todime Reddy, Suzette L Pereira. Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats. Experimental gerontology. 2016 07; 80(?):6-11. doi: 10.1016/j.exger.2016.03.021. [PMID: 27073170]
  • Miriam S W Wisniewski, Milena Carvalho-Silva, Lara M Gomes, Hugo G Zapelini, Patrícia F Schuck, Gustavo C Ferreira, Giselli Scaini, Emilio L Streck. Intracerebroventricular administration of α-ketoisocaproic acid decreases brain-derived neurotrophic factor and nerve growth factor levels in brain of young rats. Metabolic brain disease. 2016 Apr; 31(2):377-83. doi: 10.1007/s11011-015-9768-8. [PMID: 26586008]
  • Katsumi Shibata, Momoka Sakamoto. Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans. Journal of nutritional science and vitaminology. 2016; 62(4):220-228. doi: 10.3177/jnsv.62.220. [PMID: 27725406]
  • Katsumi Shibata, Chifumi Nakata, Tsutomu Fukuwatari. High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. Bioscience, biotechnology, and biochemistry. 2016; 80(2):304-12. doi: 10.1080/09168451.2015.1083395. [PMID: 26745680]
  • Kota Fukai, Sei Harada, Miho Iida, Ayako Kurihara, Ayano Takeuchi, Kazuyo Kuwabara, Daisuke Sugiyama, Tomonori Okamura, Miki Akiyama, Yuji Nishiwaki, Yuko Oguma, Asako Suzuki, Chizuru Suzuki, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi. Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men. PloS one. 2016; 11(10):e0164877. doi: 10.1371/journal.pone.0164877. [PMID: 27741291]
  • Andrew D James, Waseema Patel, Zohra Butt, Magretta Adiamah, Raga Dakhel, Ayse Latif, Carolina Uggenti, Eileithyia Swanton, Hiromi Imamura, Ajith K Siriwardena, Jason I E Bruce. The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP. The Journal of biological chemistry. 2015 Oct; 290(41):24760-71. doi: 10.1074/jbc.m115.668707. [PMID: 26294767]
  • Anthony J Lee, David W A Beno, Xiaolin Zhang, Robin Shapiro, Mark Mason, Tanita Mason-Bright, Bruce Surber, Neilé K Edens. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite. Amino acids. 2015 May; 47(5):917-24. doi: 10.1007/s00726-015-1920-6. [PMID: 25618754]
  • Xiaoya Huang, Yuan Zhong, Zhongping Huang, Chen Jin, Lili Wang, Zaifa Pan. [Simultaneous determination of five active components of compound α-ketoacid tablet in human urine by ion-pair reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2015 Feb; 33(2):169-73. doi: 10.3724/sp.j.1123.2014.10024. [PMID: 25989690]
  • Donald F Stec, Suwan Wang, Cody Stothers, Josh Avance, Deon Denson, Raymond Harris, Paul Voziyan. Alterations of urinary metabolite profile in model diabetic nephropathy. Biochemical and biophysical research communications. 2015 Jan; 456(2):610-4. doi: 10.1016/j.bbrc.2014.12.003. [PMID: 25499815]
  • Hester Vlaardingerbroek, Jorine A Roelants, Denise Rook, Kristien Dorst, Henk Schierbeek, Andras Vermes, Marijn J Vermeulen, Johannes B van Goudoever, Chris H P van den Akker. Adaptive regulation of amino acid metabolism on early parenteral lipid and high-dose amino acid administration in VLBW infants - a randomized, controlled trial. Clinical nutrition (Edinburgh, Scotland). 2014 Dec; 33(6):982-90. doi: 10.1016/j.clnu.2014.01.002. [PMID: 24461877]
  • M Sakko, C Moore, L Novak-Frazer, V Rautemaa, T Sorsa, P Hietala, A Järvinen, P Bowyer, L Tjäderhane, R Rautemaa. 2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species. Mycoses. 2014 Apr; 57(4):214-21. doi: 10.1111/myc.12145. [PMID: 24125484]
  • Hiroyuki Hachiya, Yoshikazu Miura, Ken-Ichi Inoue, Kyung Hwa Park, Masayoshi Takeuchi, Keiichi Kubota. Advanced glycation end products impair glucose-induced insulin secretion from rat pancreatic β-cells. Journal of hepato-biliary-pancreatic sciences. 2014 Feb; 21(2):134-41. doi: 10.1002/jhbp.12. [PMID: 23798335]
  • Rajavel Elango, Karen Chapman, Mahroukh Rafii, Ronald O Ball, Paul B Pencharz. Determination of the tolerable upper intake level of leucine in acute dietary studies in young men. The American journal of clinical nutrition. 2012 Oct; 96(4):759-67. doi: 10.3945/ajcn.111.024471. [PMID: 22952178]
  • Yoshikazu Miura, Yuichi Hori, Shinzo Kimura, Hiroyuki Hachiya, Yuichirou Sakurai, Kenichi Inoue, Tokihiko Sawada, Keiichi Kubota. Triphenyltin impairs insulin secretion by decreasing glucose-induced NADP(H) and ATP production in hamster pancreatic β-cells. Toxicology. 2012 Sep; 299(2-3):165-71. doi: 10.1016/j.tox.2012.05.021. [PMID: 22664483]
  • Isabel Garcia-Perez, Alma Villaseñor, Anisha Wijeyesekera, Joram M Posma, Zhirong Jiang, Jeremiah Stamler, Peter Aronson, Robert Unwin, Coral Barbas, Paul Elliott, Jeremy Nicholson, Elaine Holmes. Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. Journal of proteome research. 2012 Sep; 11(9):4425-35. doi: 10.1021/pr2012544. [PMID: 22594923]
  • Laura Brugnara, Maria Vinaixa, Serafín Murillo, Sara Samino, Miguel Angel Rodriguez, Antoni Beltran, Carles Lerin, Gareth Davison, Xavier Correig, Anna Novials. Metabolomics approach for analyzing the effects of exercise in subjects with type 1 diabetes mellitus. PloS one. 2012; 7(7):e40600. doi: 10.1371/journal.pone.0040600. [PMID: 22792382]
  • Kristina Gruden, Matjaž Hren, Ana Herman, Andrej Blejec, Tanja Albrecht, Joachim Selbig, Chris Bauer, Johannes Schuchardt, Michal Or-Guil, Klemen Zupančič, Urban Svajger, Borut Stabuc, Alojz Ihan, Andreja Nataša Kopitar, Maja Ravnikar, Miomir Knežević, Primož Rožman, Matjaž Jeras. A 'crossomics' study analysing variability of different components in peripheral blood of healthy caucasoid individuals. PloS one. 2012; 7(1):e28761. doi: 10.1371/journal.pone.0028761. [PMID: 22253695]
  • Ulf J Eriksson, Parri Wentzel. Diabetic embryopathy. Methods in molecular biology (Clifton, N.J.). 2012; 889(?):425-36. doi: 10.1007/978-1-61779-867-2_26. [PMID: 22669680]
  • Antje Bruckbauer, Michael B Zemel. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutrition & metabolism. 2011 Dec; 8(?):91. doi: 10.1186/1743-7075-8-91. [PMID: 22185590]
  • Marko Sysi-Aho, Andrey Ermolov, Peddinti V Gopalacharyulu, Abhishek Tripathi, Tuulikki Seppänen-Laakso, Johanna Maukonen, Ismo Mattila, Suvi T Ruohonen, Laura Vähätalo, Laxman Yetukuri, Taina Härkönen, Erno Lindfors, Janne Nikkilä, Jorma Ilonen, Olli Simell, Maria Saarela, Mikael Knip, Samuel Kaski, Eriika Savontaus, Matej Orešič. Metabolic regulation in progression to autoimmune diabetes. PLoS computational biology. 2011 Oct; 7(10):e1002257. doi: 10.1371/journal.pcbi.1002257. [PMID: 22046124]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jennifer Keiser, Jürg Utzinger, Elaine Holmes. Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni. Parasites & vectors. 2011 Sep; 4(?):179. doi: 10.1186/1756-3305-4-179. [PMID: 21929782]
  • Lei Gong, Nelly Aranibar, Yong-Hae Han, Youcai Zhang, Lloyd Lecureux, Vasanthi Bhaskaran, Purnima Khandelwal, Curtis D Klaassen, Lois D Lehman-McKeeman. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Aug; 122(2):587-97. doi: 10.1093/toxsci/kfr114. [PMID: 21561886]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jürg Utzinger, Elaine Holmes, Oliver Balmer. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. The American journal of tropical medicine and hygiene. 2011 Jan; 84(1):91-8. doi: 10.4269/ajtmh.2011.10-0402. [PMID: 21212208]
  • Sandrine P Claus, Sandrine L Ellero, Bernard Berger, Lutz Krause, Anne Bruttin, Jérôme Molina, Alain Paris, Elizabeth J Want, Isabelle de Waziers, Olivier Cloarec, Selena E Richards, Yulan Wang, Marc-Emmanuel Dumas, Alastair Ross, Serge Rezzi, Sunil Kochhar, Peter Van Bladeren, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Colonization-induced host-gut microbial metabolic interaction. mBio. 2011; 2(2):e00271-10. doi: 10.1128/mbio.00271-10. [PMID: 21363910]
  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Alexandros Pechlivanis, Sarantos Kostidis, Ploutarchos Saraslanidis, Anatoli Petridou, George Tsalis, Vassilis Mougios, Helen G Gika, Emmanuel Mikros, Georgios A Theodoridis. (1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine. Journal of proteome research. 2010 Dec; 9(12):6405-16. doi: 10.1021/pr100684t. [PMID: 20932058]
  • U Schönhusen, A Flöter, P Junghans, E Albrecht, K J Petzke, R Zitnan, P Guilloteau, C C Metges, H M Hammon. Morphology, proliferation, and ribonucleic acid and fractional protein syntheses in the small intestinal mucosa of young goats fed soy protein-based diets with or without amino acid supplementation. Journal of dairy science. 2010 Sep; 93(9):4165-79. doi: 10.3168/jds.2009-2917. [PMID: 20723691]
  • Junfang Wu, Wenxin Xu, Zhenping Ming, Huifen Dong, Huiru Tang, Yulan Wang. Metabolic changes reveal the development of schistosomiasis in mice. PLoS neglected tropical diseases. 2010 Aug; 4(8):. doi: 10.1371/journal.pntd.0000807. [PMID: 20824219]
  • Jeffery Escobar, Jason W Frank, Agus Suryawan, Hanh V Nguyen, Cynthia G Van Horn, Susan M Hutson, Teresa A Davis. Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs. The Journal of nutrition. 2010 Aug; 140(8):1418-24. doi: 10.3945/jn.110.123042. [PMID: 20534881]
  • L D Mastrandrea, S M Sessanna, A Del Toro, S G Laychock. ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets. Journal of lipid research. 2010 Aug; 51(8):2171-80. doi: 10.1194/jlr.m000802. [PMID: 20371493]
  • William S Crim, Runpei Wu, Jeffrey D Carter, Banumathi K Cole, Anthony P Trace, Raghavendra G Mirmira, Charles Kunsch, Jerry L Nadler, Craig S Nunemaker. AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Molecular and cellular endocrinology. 2010 Jul; 323(2):246-55. doi: 10.1016/j.mce.2010.02.041. [PMID: 20211684]
  • Gregory S Maloney, Andrej Kochevenko, Denise M Tieman, Takayuki Tohge, Uri Krieger, Dani Zamir, Mark G Taylor, Alisdair R Fernie, Harry J Klee. Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato. Plant physiology. 2010 Jul; 153(3):925-36. doi: 10.1104/pp.110.154922. [PMID: 20435740]
  • Jasmina Saric, Jia V Li, Jonathan R Swann, Jürg Utzinger, Gail Calvert, Jeremy K Nicholson, Stephan Dirnhofer, Maggie J Dallman, Magda Bictash, Elaine Holmes. Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents. Journal of proteome research. 2010 May; 9(5):2255-64. doi: 10.1021/pr901019z. [PMID: 20092362]
  • Anthony Schilmiller, Feng Shi, Jeongwoon Kim, Amanda L Charbonneau, Daniel Holmes, A Daniel Jones, Robert L Last. Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines. The Plant journal : for cell and molecular biology. 2010 May; 62(3):391-403. doi: 10.1111/j.1365-313x.2010.04154.x. [PMID: 20113441]
  • Alexandre Umpierrez Amaral, Guilhian Leipnitz, Carolina Gonçalves Fernandes, Bianca Seminotti, Patrícia Fernanda Schuck, Moacir Wajner. Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain. Brain research. 2010 Apr; 1324(?):75-84. doi: 10.1016/j.brainres.2010.02.018. [PMID: 20153737]
  • Hideki Matsumoto, Keiichi Akita, Ryosei Sakai, Yoshiharu Shimomura. Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate. Analytical biochemistry. 2010 Apr; 399(1):1-6. doi: 10.1016/j.ab.2009.12.017. [PMID: 20018161]
  • Markus Karl Wiltafsky, Michael Walter Pfaffl, Franz Xaver Roth. The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. The British journal of nutrition. 2010 Apr; 103(7):964-76. doi: 10.1017/s0007114509992212. [PMID: 20196890]
  • ". Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS biology. 2010 Feb; 8(2):e1000313. doi: 10.1371/journal.pbio.1000313. [PMID: 20186266]
  • Maria Lúcia Bonfleur, Emerielle Cristine Vanzela, Rosane Aparecida Ribeiro, Gabriel de Gabriel Dorighello, Carolina Prado de França Carvalho, Carla Beatriz Collares-Buzato, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Helena Coutinho Franco de Oliveira. Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity. Biochimica et biophysica acta. 2010 Feb; 1801(2):183-90. doi: 10.1016/j.bbalip.2009.10.012. [PMID: 19913637]
  • Itay Gonda, Einat Bar, Vitaly Portnoy, Shery Lev, Joseph Burger, Arthur A Schaffer, Ya'akov Tadmor, Shimon Gepstein, James J Giovannoni, Nurit Katzir, Efraim Lewinsohn. Branched-chain and aromatic amino acid catabolism into aroma volatiles in Cucumis melo L. fruit. Journal of experimental botany. 2010 Feb; 61(4):1111-23. doi: 10.1093/jxb/erp390. [PMID: 20065117]
  • Tanja Knill, Michael Reichelt, Christian Paetz, Jonathan Gershenzon, Stefan Binder. Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation. Plant molecular biology. 2009 Oct; 71(3):227-39. doi: 10.1007/s11103-009-9519-5. [PMID: 19597944]
  • F Lahnsteiner. The role of free amino acids in semen of rainbow trout Oncorhynchus mykiss and carp Cyprinus carpio. Journal of fish biology. 2009 Sep; 75(4):816-33. doi: 10.1111/j.1095-8649.2009.02317.x. [PMID: 20738581]
  • Carolyn M Slupsky, Andriy Cheypesh, Danny V Chao, Hao Fu, Kathryn N Rankin, Thomas J Marrie, Paige Lacy. Streptococcus pneumoniae and Staphylococcus aureus pneumonia induce distinct metabolic responses. Journal of proteome research. 2009 Jun; 8(6):3029-36. doi: 10.1021/pr900103y. [PMID: 19368345]
  • William J Zinnanti, Jelena Lazovic, Kathleen Griffin, Kristen J Skvorak, Harbhajan S Paul, Gregg E Homanics, Maria C Bewley, Keith C Cheng, Kathryn F Lanoue, John M Flanagan. Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease. Brain : a journal of neurology. 2009 Apr; 132(Pt 4):903-18. doi: 10.1093/brain/awp024. [PMID: 19293241]
  • Jacob M Wilson, Jeong-Su Kim, Sang-Rok Lee, John A Rathmacher, Brett Dalmau, J Derek Kingsley, Heather Koch, Anssi H Manninen, Raz Saadat, Lynn B Panton. Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Nutrition & metabolism. 2009 Feb; 6(?):6. doi: 10.1186/1743-7075-6-6. [PMID: 19193206]
  • Etienne de Montmollin, Jerome Aboab, Arnaud Mansart, Djillali Annane. Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Critical care (London, England). 2009; 13(5):230. doi: 10.1186/cc8026. [PMID: 19863760]
  • Roman Kand'ár, Pavla Záková, Jana Jirosová, Michaela Sladká. Determination of branched chain amino acids, methionine, phenylalanine, tyrosine and alpha-keto acids in plasma and dried blood samples using HPLC with fluorescence detection. Clinical chemistry and laboratory medicine. 2009; 47(5):565-72. doi: 10.1515/cclm.2009.123. [PMID: 19290779]
  • A B Crujeiras, D Parra, E Goyenechea, I Abete, P González-Muniesa, J A Martínez. Energy restriction in obese subjects impact differently two mitochondrial function markers. Journal of physiology and biochemistry. 2008 Sep; 64(3):211-9. doi: 10.1007/bf03178844. [PMID: 19244935]
  • Jasmina Saric, Jia V Li, Yulan Wang, Jennifer Keiser, Jake G Bundy, Elaine Holmes, Jürg Utzinger. Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. PLoS neglected tropical diseases. 2008 Jul; 2(7):e254. doi: 10.1371/journal.pntd.0000254. [PMID: 18596973]
  • Michael J MacDonald, Scott W Stoker, Noaman M Hasan. Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria. Molecular and cellular biochemistry. 2008 Jun; 313(1-2):195-202. doi: 10.1007/s11010-008-9757-x. [PMID: 18414997]
  • Cláudia Funchal, Francine Tramontina, André Quincozes dos Santos, Daniela Fraga de Souza, Carlos Alberto Gonçalves, Regina Pessoa-Pureur, Moacir Wajner. Effect of the branched-chain alpha-keto acids accumulating in maple syrup urine disease on S100B release from glial cells. Journal of the neurological sciences. 2007 Sep; 260(1-2):87-94. doi: 10.1016/j.jns.2007.04.011. [PMID: 17499767]
  • K Nakashima, Y Yakabe, A Ishida, M Yamazaki, H Abe. Suppression of myofibrillar proteolysis in chick skeletal muscles by alpha-ketoisocaproate. Amino acids. 2007 Sep; 33(3):499-503. doi: 10.1007/s00726-006-0404-0. [PMID: 16998714]
  • Steven Patterson, Siobhan M J Scullion, Jane T McCluskey, Peter R Flatt, Neville H McClenaghan. Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents. Diabetes/metabolism research and reviews. 2007 May; 23(4):324-34. doi: 10.1002/dmrr.699. [PMID: 17089371]
  • L B Pupim, P J Flakoll, T A Ikizler. Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. European journal of clinical nutrition. 2007 May; 61(5):686-9. doi: 10.1038/sj.ejcn.1602578. [PMID: 17180156]
  • Alexander I Shestopalov, Bruce S Kristal. Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria. Neurochemical research. 2007 Apr; 32(4-5):947-51. doi: 10.1007/s11064-007-9291-3. [PMID: 17342410]
  • Michael J MacDonald. Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells. The Journal of biological chemistry. 2007 Mar; 282(9):6043-52. doi: 10.1074/jbc.m606652200. [PMID: 17210580]
  • André Wajner, Cristiane Bürger, Carlos Severo Dutra-Filho, Moacir Wajner, Angela Terezinha de Souza Wyse, Clóvis Milton Duval Wannmacher. Synaptic plasma membrane Na(+), K (+)-ATPase activity is significantly reduced by the alpha-keto acids accumulating in maple syrup urine disease in rat cerebral cortex. Metabolic brain disease. 2007 Mar; 22(1):77-88. doi: 10.1007/s11011-007-9046-5. [PMID: 17295076]
  • M Fex, M Dekker Nitert, N Wierup, F Sundler, C Ling, H Mulder. Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet. Diabetologia. 2007 Jan; 50(1):74-83. doi: 10.1007/s00125-006-0464-4. [PMID: 17093947]
  • Lisa S Chow, Robert C Albright, Maureen L Bigelow, Gianna Toffolo, Claudio Cobelli, K Sreekumaran Nair. Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures. American journal of physiology. Endocrinology and metabolism. 2006 Oct; 291(4):E729-36. doi: 10.1152/ajpendo.00003.2006. [PMID: 16705065]
  • Michael J Toth, Cynthia K Sites, Dwight E Matthews. Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy. American journal of physiology. Endocrinology and metabolism. 2006 Sep; 291(3):E639-46. doi: 10.1152/ajpendo.00050.2006. [PMID: 16684855]
  • Piero Portincasa, Ignazio Grattagliano, Bernhard H Lauterburg, Vincenzo O Palmieri, Giuseppe Palasciano, Frans Stellaard. Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis. Clinical science (London, England : 1979). 2006 Aug; 111(2):135-43. doi: 10.1042/cs20050346. [PMID: 16603025]
  • Jacob Wilson, Gabriel J Wilson. Contemporary issues in protein requirements and consumption for resistance trained athletes. Journal of the International Society of Sports Nutrition. 2006 Jun; 3(?):7-27. doi: 10.1186/1550-2783-3-1-7. [PMID: 18500966]
  • Berrin Oguzhan, Ying Zhang, Karim Louchami, Philippe Courtois, Laurence Portois, Jean-Michel Chardigny, Willy J Malaisse, Yvon A Carpentier, Abdullah Sener. Pancreatic islet function in omega3 fatty acid-depleted rats: Glucose metabolism and nutrient-stimulated insulin release. Endocrine. 2006 Jun; 29(3):457-66. doi: 10.1385/endo:29:3:457. [PMID: 16943585]
  • S Patterson, P R Flatt, L Brennan, P Newsholme, N H McClenaghan. Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. The Journal of endocrinology. 2006 May; 189(2):301-10. doi: 10.1677/joe.1.06537. [PMID: 16648297]
  • Cláudia Funchal, Patrícia Fernanda Schuck, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Carmem Gottfried, Regina Pessoa-Pureur, Moacir Wajner. Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease. Cellular and molecular neurobiology. 2006 Feb; 26(1):67-79. doi: 10.1007/s10571-006-9098-9. [PMID: 16633902]
  • Cláudia Funchal, Ariane Zamoner, André Quincozes dos Santos, Maria Beatriz Moretto, João B T Rocha, Moacir Wajner, Regina Pessoa-Pureur. Evidence that intracellular Ca2+ mediates the effect of alpha-ketoisocaproic acid on the phosphorylating system of cytoskeletal proteins from cerebral cortex of immature rats. Journal of the neurological sciences. 2005 Nov; 238(1-2):75-82. doi: 10.1016/j.jns.2005.06.013. [PMID: 16111708]
  • Benjamin F Miller, Jens L Olesen, Mette Hansen, Simon Døssing, Regina M Crameri, Rasmus J Welling, Henning Langberg, Allan Flyvbjerg, Michael Kjaer, John A Babraj, Kenneth Smith, Michael J Rennie. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. The Journal of physiology. 2005 Sep; 567(Pt 3):1021-33. doi: 10.1113/jphysiol.2005.093690. [PMID: 16002437]
  • Cláudia Funchal, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Ariane Zamoner, Carmem Gottfried, Moacir Wajner, Regina Pessoa-Pureur. Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells. Metabolic brain disease. 2005 Sep; 20(3):205-17. doi: 10.1007/s11011-005-7208-x. [PMID: 16167198]
  • Cláudia Funchal, Ariane Zamoner, André Quincozes dos Santos, Samanta Oliveira Loureiro, Moacir Wajner, Regina Pessoa-Pureur. Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP. Neurochemical research. 2005 Sep; 30(9):1139-46. doi: 10.1007/s11064-005-7709-3. [PMID: 16292507]
  • Ken A van Someren, Adam J Edwards, Glyn Howatson. Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. International journal of sport nutrition and exercise metabolism. 2005 Aug; 15(4):413-24. doi: 10.1123/ijsnem.15.4.413. [PMID: 16286672]
  • M A Zocco, C Di Campli, R Gaspari, M Candelli, E C Nista, L Zileri Dal Verme, G Di Gioacchino, A Santoliquido, R Flore, P Tondi, R Proietti, P Pola, G Gasbarrini, A Gasbarrini. Improvement of mitochondrial function evaluated by ketoisocaproic acid breath test in patients with HCV infection undergoing albumin dialysis. Transplantation proceedings. 2005 Jul; 37(6):2554-6. doi: 10.1016/j.transproceed.2005.06.018. [PMID: 16182741]
  • Raquel Bridi, César A Braun, Giovanni K Zorzi, Clóvis M D Wannmacher, Moacir Wajner, Eduardo G Lissi, Carlos Severo Dutra-Filho. alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats. Metabolic brain disease. 2005 Jun; 20(2):155-67. doi: 10.1007/s11011-005-4152-8. [PMID: 15938133]
  • Kaori Matsuzaki, Hisanori Kato, Ryosei Sakai, Sakino Toue, Michiko Amao, Takeshi Kimura. Transcriptomics and metabolomics of dietary leucine excess. The Journal of nutrition. 2005 06; 135(6 Suppl):1571S-5S. doi: 10.1093/jn/135.6.1571s. [PMID: 15930471]
  • Michela Novelli, Simona Piaggi, Vincenzo De Tata. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced impairment of glucose-stimulated insulin secretion in isolated rat pancreatic islets. Toxicology letters. 2005 Apr; 156(2):307-14. doi: 10.1016/j.toxlet.2004.12.004. [PMID: 15737493]
  • Daniel Cuthbertson, Kenneth Smith, John Babraj, Graham Leese, Tom Waddell, Philip Atherton, Henning Wackerhage, Peter M Taylor, Michael J Rennie. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Mar; 19(3):422-4. doi: 10.1096/fj.04-2640fje. [PMID: 15596483]
  • Miguel Sáenz de Pipaón, José Quero, Darcos J L Wattimena, Pieter J J Sauer. Effect of two amino acid solutions on leucine turnover in preterm infants. Biology of the neonate. 2005; 87(4):236-41. doi: 10.1159/000083389. [PMID: 15655314]
  • Cláudia Funchal, Carmem Gottfried, Lúcia Maria Vieira De Almeida, Moacir Wajner, Regina Pessoa-Pureur. Evidence that the branched-chain alpha-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex. Glia. 2004 Nov; 48(3):230-40. doi: 10.1002/glia.20072. [PMID: 15390119]
  • Lara B Pupim, Paul J Flakoll, T Alp Ikizler. Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. Journal of the American Society of Nephrology : JASN. 2004 Jul; 15(7):1920-6. doi: 10.1097/01.asn.0000128969.86268.c0. [PMID: 15213282]
  • Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, Ryuichi Konno, Takao Hashimoto. Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. American journal of physiology. Endocrinology and metabolism. 2004 Jul; 287(1):E160-5. doi: 10.1152/ajpendo.00397.2003. [PMID: 15026304]
  • Stéphane Walrand, Christelle Guillet, Pierre Gachon, Paulette Rousset, Christophe Giraudet, Marie-Paule Vasson, Yves Boirie. Protein synthesis rates of human PBMC and PMN can be determined simultaneously in vivo by using small blood samples. American journal of physiology. Cell physiology. 2004 Jun; 286(6):C1474-8. doi: 10.1152/ajpcell.00563.2002. [PMID: 14749219]
  • Giacomo Garibotto, Antonella Sofia, Cristina Robaudo, Stefano Saffioti, Maria Rita Sala, Daniela Verzola, Monica Vettore, Rodolfo Russo, Vanessa Procopio, Giacomo Deferrari, Paolo Tessari. Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. Journal of the American Society of Nephrology : JASN. 2004 Jun; 15(6):1606-15. doi: 10.1097/01.asn.0000127865.26968.36. [PMID: 15153572]
  • G Tajima, H Yofune, A D Bahagia Febriani, Y Nishimura, H Ono, N Sakura. A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography. Journal of inherited metabolic disease. 2004; 27(5):633-9. doi: 10.1023/b:boli.0000042988.31581.ed. [PMID: 15669679]
  • Miguel Sáenz de Pipaón, Ron H T VanBeek, Luc J J Zimmermann, Darcos J L Wattimena, José Quero, Pieter J J Sauer. Effects of antenatal steroids on protein metabolism in preterm infants on the first day of life. The Journal of pediatrics. 2004 Jan; 144(1):75-80. doi: 10.1016/j.jpeds.2003.10.017. [PMID: 14722522]