Metrifonate (BioDeep_00000404964)

Main id: BioDeep_00000002324

 

natural product


代谢物信息卡片


Pesticide1_Trichlorfon_C4H8Cl3O4P_Cekufon

化学式: C4H8Cl3O4P (255.9225788)
中文名称: 敌百虫标准溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC
InChI: InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3

描述信息

P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02B - Antitrematodals > P02BB - Organophosphorous compounds
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

3 个代谢物同义名

Metrifonate; TRICHLORFON; Pesticide1_Trichlorfon_C4H8Cl3O4P_Cekufon



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hui-Hui Meng, Wen-Ya Liu, Wen-Long Zhao, Qi Zheng, Jun-Song Wang. Study on the acute toxicity of trichlorfon and its breakdown product dichlorvos to goldfish (Carassius auratus) based on 1H NMR metabonomics. Environmental science and pollution research international. 2023 Dec; 30(60):125664-125676. doi: 10.1007/s11356-023-31012-7. [PMID: 38001290]
  • Yang Zhao, Shipo Li, Duncan James Lessing, Weihua Chu. The attenuating effects of synbiotic containing Cetobacterium somerae and Astragalus polysaccharide against trichlorfon-induced hepatotoxicity in crucian carp (Carassius carassius). Journal of hazardous materials. 2023 Sep; 461(?):132621. doi: 10.1016/j.jhazmat.2023.132621. [PMID: 37748306]
  • Chao Zhang, Feng He, Lanzhou Chen. Phytoremediation of cadmium-trichlorfon co-contaminated water by Indian mustard (Brassica juncea): growth and physiological responses. International journal of phytoremediation. 2023 Jul; ?(?):1-10. doi: 10.1080/15226514.2023.2237119. [PMID: 37463105]
  • Jianlu Zhang, Mingzhen Zhu, Qijun Wang, Hui Yang. The Combined Use of Copper Sulfate and Trichlorfon Exerts Stronger Toxicity on the Liver of Zebrafish. International journal of molecular sciences. 2023 Jul; 24(13):. doi: 10.3390/ijms241311203. [PMID: 37446380]
  • Qiqiang Li, Peiying Wang, Caihua Zou, Fei Ge, Feng Li, Yun Liu, Dayi Zhang, Jiang Tian. Dynamics of dominant rhizospheric microbial communities responsible for trichlorfon absorption and translocation in maize seedlings. Journal of hazardous materials. 2023 Jun; 451(?):131096. doi: 10.1016/j.jhazmat.2023.131096. [PMID: 36893602]
  • Cassiano Ricardo Schavinski, Maurício Beux Dos Santos, James Eduardo Lago Londero, Marcelo Carvalho da Rocha, Aline Monique Blank do Amaral, Nathalia Quintero Ruiz, Giovana da Silva Leandro, Vania Lucia Loro, André Passaglia Schuch. Effects of isolated and combined exposures of Boana curupi (Anura: Hylidae) tadpoles to environmental doses of trichlorfon and ultraviolet radiation. Mutation research. Genetic toxicology and environmental mutagenesis. 2022 Nov; 883-884(?):503549. doi: 10.1016/j.mrgentox.2022.503549. [PMID: 36462791]
  • Gaoqiong Deng, Hengye Chen, Qiong Shi, Lixue Ren, Ke Liang, Wanjun Long, Wei Lan, Xiaole Han, Yuanbin She, Haiyan Fu. Colorimetric assay based on peroxidase-like activity of dodecyl trimethylammonium bromide-tetramethyl zinc (4-pyridinyl) porphyrin for detection of organophosphorus pesticides. Mikrochimica acta. 2022 09; 189(10):375. doi: 10.1007/s00604-022-05430-2. [PMID: 36074197]
  • Matheus Gomes da Cruz, Gabriela Tomas Jerônimo, Sunique Poá Cordeiro Bentes, Ligia Uribe Gonçalves. Trichlorfon is effective against Dawestrema cycloancistrium and does not alter the physiological parameters of arapaima (Arapaima gigas): A large Neotropical fish from the Amazon. Journal of fish diseases. 2022 Jan; 45(1):203-212. doi: 10.1111/jfd.13549. [PMID: 34779526]
  • Soo J Woo. Temperature-dependent pharmacokinetics of trichlorfon in common carp (Cyprinus carpio L.) after bath immersion therapy. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):820-828. doi: 10.1111/jvp.12978. [PMID: 33973248]
  • Matheus D Baldissera, Carine F Souza, Altevir R Viana, Aleksandro S da Silva, Bernardo Baldisserotto. Protective role of rutin dietary supplementation mediated by purinergic signaling in spleen of silver catfish Rhamdia quelen exposed to organophosphate pesticide trichlorfon. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Jun; 244(?):109006. doi: 10.1016/j.cbpc.2021.109006. [PMID: 33610818]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Matheus D Baldissera, Carine F Souza, Renato Zanella, Osmar D Prestes, Adriana D Meinhart, Aleksandro S Da Silva, Bernardo Baldisserotto. Behavioral impairment and neurotoxic responses of silver catfish Rhamdia quelen exposed to organophosphate pesticide trichlorfon: Protective effects of diet containing rutin. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Jan; 239(?):108871. doi: 10.1016/j.cbpc.2020.108871. [PMID: 32814146]
  • HuaTao Li, YuTing Ma, Ying Liu, Min Wu, Jiao Long, XiaoQin Jing, SiShun Zhou, Ping Yuan, Jun Jiang. Integrated biomarker parameters response to the toxic effects of high stocking density, CuSO4, and trichlorfon on fish and protective role mediated by Angelica sinensis extract. Fish physiology and biochemistry. 2020 Oct; 46(5):1679-1698. doi: 10.1007/s10695-020-00821-9. [PMID: 32557080]
  • Soo Ji Woo, Joon Ki Chung. Effects of trichlorfon on oxidative stress, neurotoxicity, and cortisol levels in common carp, Cyprinus carpio L., at different temperatures. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2020 Mar; 229(?):108698. doi: 10.1016/j.cbpc.2019.108698. [PMID: 31884009]
  • Chao Zhang, Yue Tao, Shuangxi Li, Tan Ke, Panpan Wang, Sijie Wei, Lanzhou Chen. Bioremediation of cadmium-trichlorfon co-contaminated soil by Indian mustard (Brassica juncea) associated with the trichlorfon-degrading microbe Aspergillus sydowii: Related physiological responses and soil enzyme activities. Ecotoxicology and environmental safety. 2020 Jan; 188(?):109756. doi: 10.1016/j.ecoenv.2019.109756. [PMID: 31711776]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Eduardo Robson Duarte, Abigair Duarte Matias, Gabriela Almeida Bastos, Roberta Cordeiro Maia, Valdo Soares Martins, Ana Cláudia Maia Soares, Fernando Dos Santos Magaço, Neide Judith Faria de Oliveira, Thiago Alves Xavier Dos Santos. Anthelmintic efficacy of trichlorfon and blood parameters of young lambs infected with Haemonchus contortus. Veterinary parasitology. 2019 Aug; 272(?):40-43. doi: 10.1016/j.vetpar.2019.06.015. [PMID: 31395203]
  • Matheus D Baldissera, Carine F Souza, Sharine N Descovi, Renato Zanella, Osmar D Prestes, Aleksandro S da Silva, Bernardo Baldisserotto. Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2019 Apr; 218(?):8-13. doi: 10.1016/j.cbpc.2018.12.006. [PMID: 30550875]
  • Matheus D Baldissera, Carine F Souza, Sharine N Descovi, Renato Zanella, Osmar D Prestes, Antonio F I M de Matos, Aleksandro S da Silva, Bernardo Baldisserotto, Anderson Gris, Ricardo E Mendes. Disturbance of energetic homeostasis and oxidative damage provoked by trichlorfon as relevant toxicological mechanisms using silver catfish as experimental model. Chemico-biological interactions. 2019 Feb; 299(?):94-100. doi: 10.1016/j.cbi.2018.11.015. [PMID: 30481498]
  • Soo Ji Woo, Na Young Kim, Shin Hu Kim, Sang Jung Ahn, Jung Soo Seo, Sung Hee Jung, Mi Young Cho, Joon Ki Chung. Toxicological effects of trichlorfon on hematological and biochemical parameters in Cyprinus carpio L. following thermal stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2018 Jul; 209(?):18-27. doi: 10.1016/j.cbpc.2018.03.001. [PMID: 29530824]
  • Yu Ma, Bo Li, Yang Ke, Yongan Zhang, Yuhui Zhang. Transcriptome analysis of Rana chensinensis liver under trichlorfon stress. Ecotoxicology and environmental safety. 2018 Jan; 147(?):487-493. doi: 10.1016/j.ecoenv.2017.09.016. [PMID: 28910747]
  • Mohammad Ahmad, Murad A Mubaraki, Mohammed Ali M Marie. In vitro effect of metrifonate on the indices of oxidative stress in Gigantocotyle explanatum. Microbial pathogenesis. 2017 Sep; 110(?):409-413. doi: 10.1016/j.micpath.2017.07.007. [PMID: 28705749]
  • Bo Li, Yu Ma, Yu H Zhang. Oxidative stress and hepatotoxicity in the frog, Rana chensinensis, when exposed to low doses of trichlorfon. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2017 Jul; 52(7):476-482. doi: 10.1080/03601234.2017.1303321. [PMID: 28541126]
  • Jie Li, Juxiu Lu, Xuguang Qiao, Zhixiang Xu. A study on biomimetic immunoassay-capillary electrophoresis method based on molecularly imprinted polymer for determination of trace trichlorfon residue in vegetables. Food chemistry. 2017 Apr; 221(?):1285-1290. doi: 10.1016/j.foodchem.2016.11.028. [PMID: 27979090]
  • Xiao-Jun Chen, Ya-jun Ren, Zhi-yuan Meng, Chun-liang Lu, Hao-tian Gu, Yi-qing Zhuang. Dissipation kinetics, safety evaluation, and preharvest interval assessment of trichlorfon application on rice. Environmental monitoring and assessment. 2016 May; 188(5):266. doi: 10.1007/s10661-016-5264-9. [PMID: 27048491]
  • M Enis Yonar, Serpil Mişe Yonar, Ayşegül Pala, Sibel Silici, Naim Sağlam. Trichlorfon-induced haematological and biochemical changes in Cyprinus carpio: ameliorative effect of propolis. Diseases of aquatic organisms. 2015 Jun; 114(3):209-16. doi: 10.3354/dao02866. [PMID: 26036828]
  • Francine P Venturini, Fernanda D Moraes, Lucas R X Cortella, Priscila A Rossi, Claudinei Cruz, Gilberto Moraes. Metabolic effects of trichlorfon (Masoten®) on the neotropical freshwater fish pacu (Piaractus mesopotamicus). Fish physiology and biochemistry. 2015 Feb; 41(1):299-309. doi: 10.1007/s10695-014-9983-y. [PMID: 25192665]
  • Qinghua Tang, Xiujuan Shi, Xiaolin Hou, Jie Zhou, Zhixiang Xu. Development of molecularly imprinted electrochemical sensors based on Fe3O4@MWNT-COOH/CS nanocomposite layers for detecting traces of acephate and trichlorfon. The Analyst. 2014 Dec; 139(24):6406-13. doi: 10.1039/c4an01514b. [PMID: 25325612]
  • Christine V Kramer, Fan Zhang, David Sinclair, Piero L Olliaro. Drugs for treating urinary schistosomiasis. The Cochrane database of systematic reviews. 2014 Aug; ?(8):CD000053. doi: 10.1002/14651858.cd000053.pub3. [PMID: 25099517]
  • Tao Zhao, Qingqing Wang, Jie Li, Xuguang Qiao, Zhixiang Xu. Study on an electrochromatography method based on organic-inorganic hybrid molecularly imprinted monolith for determination of trace trichlorfon in vegetables. Journal of the science of food and agriculture. 2014 Aug; 94(10):1974-80. doi: 10.1002/jsfa.6511. [PMID: 24323896]
  • Maria Isabel Mataqueiro, Laura Satiko Okada Nakaghi, Patrícia Kii Yamada, Guilherme de Camargo Ferraz, Antonio de Queiroz-Neto, Georgino Honorato DeOliveira. Degradation, residual determination, and cholinesterase activity of triclorfon in Piaractus mesopotamicus Holmberg (PACU) 1887. Journal of toxicology and environmental health. Part A. 2014; 77(1-3):125-32. doi: 10.1080/15287394.2013.866928. [PMID: 24555653]
  • WeiNa Xu, WenBin Liu, XianPing Shao, GuangZhen Jiang, XianngFei Li. Effect of trichlorfon on hepatic lipid accumulation in crucian carp Carassius auratus gibelio. Journal of aquatic animal health. 2012 Sep; 24(3):185-94. doi: 10.1080/08997659.2012.675937. [PMID: 22897202]
  • WeiNa Xu, WenBin Liu, KangLe Lu, YangYang Jiang, GuiFeng Li. Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo. Fish physiology and biochemistry. 2012 Jun; 38(3):769-75. doi: 10.1007/s10695-011-9559-z. [PMID: 21986809]
  • Zhihong Lin, Jie Gu, Jin Xiu, Tingyan Mi, Jie Dong, Jyoti Kumar Tiwari. Traditional chinese medicine for senile dementia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):692621. doi: 10.1155/2012/692621. [PMID: 21808655]
  • Willayat Yousuf Wani, Satish Gudup, Aditya Sunkaria, Amanjit Bal, Parvinder Pal Singh, Ramesh J L Kandimalla, Deep Raj Sharma, Kiran Dip Gill. Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain. Neuropharmacology. 2011 Dec; 61(8):1193-201. doi: 10.1016/j.neuropharm.2011.07.008. [PMID: 21784090]
  • César Fiel, Maricel Guzmán, Pedro Steffan, Edgardo Rodriguez, Olegario Prieto, Chandra Bhushan. The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina. Parasitology research. 2011 Aug; 109 Suppl 1(?):S139-48. doi: 10.1007/s00436-011-2410-8. [PMID: 21739383]
  • Gökhan Eraslan, Murat Kanbur, Sibel Silici, Mürsel Karabacak. Beneficial effect of pine honey on trichlorfon induced some biochemical alterations in mice. Ecotoxicology and environmental safety. 2010 Jul; 73(5):1084-91. doi: 10.1016/j.ecoenv.2010.02.017. [PMID: 20303175]
  • Kirti S Kulkarni, S B Kasture, S A Mengi. Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats. Indian journal of pharmacology. 2010 Jun; 42(3):168-73. doi: 10.4103/0253-7613.66841. [PMID: 20871769]
  • Wei-Na Xu, Wen-Bin Liu, Zhao-Pu Liu. Trichlorfon-induced apoptosis in hepatocyte primary cultures of Carassius auratus gibelio. Chemosphere. 2009 Nov; 77(7):895-901. doi: 10.1016/j.chemosphere.2009.08.043. [PMID: 19775726]
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  • Georgino Honorato de Oliveira, Vanessa Moreira, Sheila Patricia Ribeiro Goes. Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfon. Toxicology letters. 2002 Dec; 136(2):143-50. doi: 10.1016/s0378-4274(02)00295-3. [PMID: 12425964]
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